# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Receptor, Fibroblast Growth Factor, Type 2

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Phex Phosphate Regulating Neutral Endopeptidase

# awardsAndHonors[].label
ASBMR John Haddad Young Investigator Award

# publications[].label
Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene.

# publications[].label
Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues.

# publications[].label
Corrigendum to novel approaches for two and three dimensional multiplexed imaging of osteocytes Bone 76 (2015) [129-140].

# publications[].label
Inactivation of Fam20b in the neural crest-derived mesenchyme of mouse causes multiple craniofacial defects.

# publications[].label
Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus.

# publications[].label
Collagen Dynamics During the Process of Osteocyte Embedding and Mineralization.

# publications[].label
Key proteolytic cleavage site and full-length form of DSPP.

# publications[].label
Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia.

# publications[].label
Nuclear localization of DMP1 proteins suggests a role in intracellular signaling.

# publications[].label
Protective roles of DMP1 in high phosphate homeostasis.

# publications[].label
Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development.

# publications[].label
Constitutive expression of spliced XBP1 causes perinatal lethality in mice.

# publications[].label
Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype.

# publications[].label
Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice.

# publications[].label
Mouse Dspp frameshift model of human dentinogenesis imperfecta.

# publications[].label
Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression.

# publications[].label
Dmp1-deficient mice develop dwarfism, chondrodysplasia, and exhibit disorganized bone mineralization during postnatal development.

# publications[].label
Identification of cis-DNA regions controlling Bmp4 expression during tooth morphogenesis in vivo.

# publications[].label
Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells.

# publications[].label
In vitro and in vivo study on osteocyte-specific mechanical signaling pathways.

# publications[].label
Immortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics.

# publications[].label
Differential regulation of dentin matrix protein 1 expression during odontogenesis.

# publications[].label
DMP1-targeted Cre expression in odontoblasts and osteocytes.

# publications[].label
Novel approaches for two and three dimensional multiplexed imaging of osteocytes.

# publications[].label
High-Phosphate Diet Improved the Skeletal Development of Fam20c-Deficient Mice.

# publications[].label
Tooth agenesis in a family and homozygous PAX9 mutation in exon 3: a case report.

# publications[].label
Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice.

# publications[].label
Live imaging of collagen deposition during skin development and repair in a collagen I - GFP fusion transgenic zebrafish line.

# publications[].label
FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner.

# publications[].label
DMP1 processing is essential to dentin and jaw formation.

# publications[].label
FAM20A is a golgi-localized Type II transmembrane protein.

# publications[].label
Effect of high phosphate diet on the formation of dentin in Fam20c-deficient mice.

# publications[].label
Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice.

# publications[].label
Identification of full-length dentin matrix protein 1 in dentin and bone.

# publications[].label
The 57 kDa C-terminal fragment of dentin matrix protein 1 (DMPI) retains all biological activity: Osteocytic regulation of Pi homeostasis through FGF23.

# publications[].label
FAM20C plays an essential role in the formation of murine teeth.

# publications[].label
Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry-Tagged Collagen Constructs.

# publications[].label
The LPV Motif Is Essential for the Efficient Export of Secretory DMP1 From the Endoplasmic Reticulum.

# publications[].label
The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis.

# publications[].label
Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo.

# publications[].label
Transgenic expression of dentin phosphoprotein inhibits skeletal development.

# publications[].label
Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null mice.

# publications[].label
Molecular studies on the roles of Runx2 and Twist1 in regulating FGF signaling.

# publications[].label
Failure to process dentin sialophosphoprotein into fragments leads to periodontal defects in mice.

# publications[].label
Partial Blocking of Mouse DSPP Processing by Substitution of Gly451–Asp452 Bond Suggests the Presence of Secondary Cleavage Site(s)

# publications[].label
Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo.

# publications[].label
E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation.

# publications[].label
TWIST1 promotes the odontoblast-like differentiation of dental stem cells.

# publications[].label
Abrogation of epithelial BMP2 and BMP4 causes Amelogenesis Imperfecta by reducing MMP20 and KLK4 expression.

# publications[].label
Unique roles of phosphorus in endochondral bone formation and osteocyte maturation.

# publications[].label
Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis.

# publications[].label
Dissection of promoter control modules that direct Bmp4 expression in the epithelium-derived components of hair follicles.

# publications[].label
Functional evaluation of a novel tooth agenesis-associated bone morphogenetic protein 4 prodomain mutation.

# publications[].label
DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis.

# publications[].label
FGF23 in skeletal modeling and remodeling.

# publications[].label
The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development.

# publications[].label
Twist1- and Twist2-haploinsufficiency results in reduced bone formation.

# publications[].label
Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.

# publications[].label
Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice.

# publications[].label
Inactivation of FAM20B causes cell fate changes in annulus fibrosus of mouse intervertebral disc and disc defects via the alterations of TGF- and MAPK signaling pathways.

# publications[].label
Overexpressing the NH2-terminal fragment of dentin sialophosphoprotein (DSPP) aggravates the periodontal defects in Dspp knockout mice.

# publications[].label
The specific role of FAM20C in amelogenesis.

# publications[].label
DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype.

# publications[].label
Enamel Defects Associated With Dentin Sialophosphoprotein Mutation in Mice.

# publications[].label
Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice.

# publications[].label
Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation.

# publications[].label
The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment.

# publications[].label
Pre-odontoblasts, odontoblasts, or "odontocytes" - Reply

# publications[].label
FAM20A is essential for amelogenesis, but is dispensable for dentinogenesis.

# publications[].label
Use of the transgenic approach to determine the role of DMP1 in phosphate regulation.

# publications[].label
Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis.

# publications[].label
Studies of the DMP1 57-kDa functional domain both in vivo and in vitro.

# researcherOn[].label
Dentin Sialophosphoprotein (DSPP) and Unfolded Protein Response (UPR) in Dentinogensis Imperfecta (DGI) and Odontoblast Function

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Dental and Craniofacial Research

# researcherOn[].label
Identification and Function of nuDMP1 in Odontoblast Differentiation

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Dental and Craniofacial Research

# researcherOn[].label
Functions of Family with Sequence Similarity 20 - Member C (FAM20C) and Member A (FAM20A) in Amelogenesis and Dentinogenesis

# researcherOn[].awardedBy.label
National Institute of Dental and Craniofacial Research - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M University College of Dentistry; Biomedical Sciences; 3302 Gaston Avenue

# etdChairOf[].label
Liang, Tian (2018-08). Molecular Pathogenesis of Dentinogenesis Imperfecta Associated with Dentin Sialophosphoprotein Mutations. Doctoral Dissertation.