# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
I am Professor in the Department of Psychiatry at Texas A&M Health Sciences Center and affiliate faculty member at the Virginia Institute for Psychiatric and Behavioral Genetics (VIPBG) at Virginia Commonwealth University (VCU). As a clinician-scientist, I have participate in patient care, clinical teaching, and research activities. Before coming to TAMU in 2019, I directed the VCU Anxiety Disorders Specialty Clinic for 19 years, providing residency training and patient care via the assessment and treatment of all the major anxiety and related disorders. My research efforts focus on the epidemiology, genetics, and biology of the anxiety and related internalizing disorders. I have extensive experience applying advanced statistical genetic methodology to these questions via analyses conducted in twin, family, and population-based samples. My recent projects include conducting meta-analyses of genomewide association data on anxiety spectrum disorders (ANGST GWAS project, R01MH087646 and PGC-ANX project, R01MH113665), examining the effects of novel candidate genes derived from GWAS on internalizing psychopathology (R01MH039096), and collecting and analyzing endophenotypic measures underlying the development of internalizing disorders in a juvenile twin sample (R01MH098055). My research has been funded by NIH and private foundation grants. I am founding co-chair of the PGC-ANX Working Group which provides active collaborations with anxiety and depression researchers around the world.

# keywords[]
National Institute Of Mental Health (u.s.)

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Drug-Related Side Effects And Adverse Reactions

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2.3 Psychological, Social And Economic Factors

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Serotonin Plasma Membrane Transport Proteins

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Diagnostic And Statistical Manual Of Mental Disorders

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Diagnostic And Statistical Manual Of Mental Disorders

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3214 Pharmacology And Pharmaceutical Sciences

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Cyclic Nucleotide Phosphodiesterases, Type 4

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2.5 Research Design And Methodologies (aetiology)

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Diagnostic And Statistical Manual Of Mental Disorders

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3214 Pharmacology And Pharmaceutical Sciences

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Texas Youth Depression And Suicide Research Network (tx-ydsrn)

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Cyclic AMP Response Element-Binding Protein

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United States Food And Drug Administration

# keywords[]
National Institute Of Mental Health (u.s.)

# keywords[]
2.3 Psychological, Social And Economic Factors

# keywords[]
Diagnostic And Statistical Manual Of Mental Disorders

# keywords[]
Diagnostic And Statistical Manual Of Mental Disorders

# educationAndTraining[].organization.label
Virginia Commonwealth University - (Richmond, Virginia, United States)

# educationAndTraining[].organization.label
Columbia University - (New York, New York, United States)

# educationAndTraining[].organization.label
Yale University - (New Haven, Connecticut, United States)

# educationAndTraining[].organization.label
Yale University - (New Haven, Connecticut, United States)

# publications[].label
The genetics of anxiety-related negative valence system traits.

# publications[].label
The structure of genetic and environmental risk factors for fears and phobias.

# publications[].label
The structure of posttraumatic stress symptoms in youth with and without obsessive-compulsive disorder: New insights using factor and network analysis

# publications[].label
Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.

# publications[].label
METHYLOME-WIDE ASSOCIATION STUDY OF ANXIETY DISORDERS

# publications[].label
Psychiatric genetics in the diverse landscape of Latin American populations.

# publications[].label
The genetic covariation between fear conditioning and self-report fears.

# publications[].label
Resting Heart Rate Variability (HRV) in Adolescents and Young Adults from a Genetically-Informed Perspective.

# publications[].label
Childhood separation anxiety disorder and adult onset panic attacks share a common genetic diathesis.

# publications[].label
Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia, agoraphobia, and animal phobia.

# publications[].label
Assessing Stakeholder Perceptions of the Utility of Genetic Information for the Clinical Care of Mental Health Disorders: We Have a Will but Need to See the Way.

# publications[].label
A Multivariate Genome-Wide Association Study of Anxiety Disorders

# publications[].label
The Genetic and Environmental Relationship Between Childhood Behavioral Inhibition and Preadolescent Anxiety.

# publications[].label
Direct, indirect and pleiotropic effects of candidate genes on internalizing disorder psychopathology.

# publications[].label
The nosologic relationship between generalized anxiety disorder and major depression.

# publications[].label
Pediatric anxiety associated with altered facial emotion recognition.

# publications[].label
Meta-Analysis of Genome-Wide Association Studies of Anxiety Disorders

# publications[].label
The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders

# publications[].label
Neurobiology and Genetics of Generalized Anxiety Disorder

# publications[].label
An association between Epac-1 gene variants and anxiety and depression in two independent samples.

# publications[].label
Intergenerational transmission of parental neuroticism to emotional problems in 8-year-old children: Genetic and environmental influences.

# publications[].label
Genetic and environmental influences on cortisol reactivity to a psychosocial stressor in adolescents and young adults.

# publications[].label
Maximum Likelihood Estimation of Genetic, Environmental and Phenotypic Factor Scores

# publications[].label
A Developmental Twin Study of Emotion Recognition and Its Negative Affective Clinical Correlates.

# publications[].label
Anxiety symptoms and children's eye gaze during fear learning.

# publications[].label
Generalised Anxiety Disorder--A Twin Study of Genetic Architecture, Genome-Wide Association and Differential Gene Expression.

# publications[].label
A major role for common genetic variation in anxiety disorders.

# publications[].label
Test-retest reliability of the facial expression labeling task.

# publications[].label
Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders.

# publications[].label
Extraversion and neuroticism as indices of genetic and environmental risk for social phobia

# publications[].label
Different genetic factors underlie fear conditioning and episodic memory.

# publications[].label
Intergenerational Transmission of Parental Neuroticism to Emotional Problems in 8-Year Old Children: Genetic and Environmental Mechanisms

# publications[].label
Association study between GABA receptor genes and anxiety spectrum disorders.

# publications[].label
The impact of generalized anxiety disorder and stressful life events on risk for major depressive episodes.

# publications[].label
Genetic and environmental influences on alpha amylase stress reactivity and shared genetic covariation with cortisol.

# publications[].label
Using Alternative Definitions of Controls to Increase Statistical Power in GWAS.

# publications[].label
A multivariate genetic analysis of the use of tobacco, alcohol, and caffeine in a population based sample of male and female twins.

# publications[].label
The AVPR1A gene and substance use disorders: association, replication, and functional evidence.

# publications[].label
44. GENOME-WIDE ASSOCIATION META-ANALYSIS OF ANXIETY SYMPTOMS IN 493,764 INDIVIDUALS

# publications[].label
Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies.

# publications[].label
Generalized Anxiety Disorder Across the Lifespan: An Integrative Approach.

# publications[].label
A twin study of the genetics of fear conditioning.

# publications[].label
The impact of childhood parental loss on risk for mood, anxiety and substance use disorders in a population-based sample of male twins.

# publications[].label
Intergenerational transmission of parental neuroticism to offspring neuroticism, anxiety, and depression

# publications[].label
A Major Role for Common Genetic Variation in Anxiety Disorders

# publications[].label
A whole genome association study of neuroticism using DNA pooling.

# publications[].label
Chapter 5.6 The genetics of human anxiety disorders

# publications[].label
Age-Related Differences in the Structure of Genetic and Environmental Contributions to Types of Peer Victimization.

# publications[].label
Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts.

# publications[].label
Physical similarity and the equal-environment assumption in twin studies of psychiatric disorders.

# publications[].label
Genetic underpinnings of callous-unemotional traits and emotion recognition in children, adolescents, and emerging adults.

# publications[].label
Support for involvement of glutamate decarboxylase 1 and neuropeptide Y in anxiety susceptibility.

# publications[].label
SA16A MAJOR ROLE FOR COMMON GENETIC VARIATION IN ANXIETY DISORDERS

# publications[].label
The risk of overweight in children and adolescents with major mental illness.

# publications[].label
160. Multivariate Approaches to Complex Genetic Phenotypes: Anxiety Disorders & PTSD

# publications[].label
Follow-up association study of novel neuroticism gene MAMDC1.

# publications[].label
Genetics of anxiety disorders: Genetic epidemiological and molecular studies in humans.

# publications[].label
Genetic association study between RGS2 and anxiety-related phenotypes.

# publications[].label
An epigenome-wide association study of early-onset major depression in monozygotic twins.

# publications[].label
Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism.

# publications[].label
HOW REDEFINING CONTROL STATUS IN GWAS AFFECTS STATISTICAL POWER

# publications[].label
Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.

# publications[].label
Correction: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research.

# publications[].label
Assessment of generalized anxiety disorder diagnostic criteria in the National Comorbidity Survey and Virginia Adult Twin Study of Psychiatric and Substance Use Disorders.

# publications[].label
Clinical characteristics of latent classes of CO2 hypersensitivity in adolescents and young adults.

# publications[].label
Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.

# publications[].label
The genetic underpinnings of callous-unemotional traits: A systematic research review.

# publications[].label
Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety.

# publications[].label
A Population-Based Twin Study of Childhood Irritability and Internalizing Syndromes.

# publications[].label
Cannabinoid receptor 1 gene association with nicotine dependence.

# publications[].label
The shared genetics of trait neuroticism and mood and anxiety disorders

# publications[].label
The genetic and environmental structure of fear and anxiety in juvenile twins.

# publications[].label
Endorsement frequencies and factor structure of DSM-III-R and DSM-IV Generalized Anxiety Disorder symptoms in women: implications for future research, classification, clinical practice and comorbidity.

# publications[].label
Genome-wide association study of shared liability to anxiety disorders in Army STARRS.

# publications[].label
A review and meta-analysis of the genetic epidemiology of anxiety disorders.

# publications[].label
Testing the effect of season of birth on familial risk for schizophrenia and related disorders.

# publications[].label
Latent Internalizing Risk Factors Predict Functional Connectivity in Juvenile Twins

# publications[].label
Meta-analysis of genome-wide association studies of anxiety disorders.

# publications[].label
Obsessive compulsive symptom dimensions and neuroticism: An examination of shared genetic and environmental risk.

# publications[].label
Pilot multimodal twin imaging study of generalized anxiety disorder.

# publications[].label
ANXIETY GENETICS: UPDATES ON GENOME-WIDE ASSOCIATION, METHYLOME-WIDE ASSOCIATION, AND CHILDHOOD RISK

# publications[].label
A population-based twin study of generalized anxiety disorder in men and women

# publications[].label
Twin Study of Early-Onset Major Depression Finds DNA Methylation Enrichment for Neurodevelopmental Genes

# publications[].label
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.

# publications[].label
Clinical Correlates of Carbon Dioxide Hypersensitivity in Children.

# publications[].label
Genetic association study of the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders

# publications[].label
The Inventory of Callous-Unemotional Traits (ICU) in Children: Reliability and Heritability.

# publications[].label
Differential Associations of Distress Tolerance and Anxiety Sensitivity With Adolescent Internalizing Psychopathology.

# publications[].label
Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism.

# publications[].label
The Twin Study of Negative Valence Emotional Constructs.

# publications[].label
The clinical presentation of major depressive disorder in youth with co-occurring obsessive-compulsive disorder.

# publications[].label
Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders.

# publications[].label
Quantifying Dispositional Fear as Threat Sensitivity: Development and Initial Validation of a Model-Based Scale Measure.

# publications[].label
Using Alternative Definitions of Controls to Increase Statistical Power in GWAS.

# publications[].label
Association study of CREB1 with Major Depressive Disorder and related phenotypes.

# publications[].label
UPDATED GENOME-WIDE ASSOCIATION STUDY FROM THE PGC ANXIETY DISORDERS WORKING GROUP

# publications[].label
The effects of anxiety, substance use and conduct disorders on risk of major depressive disorder.

# publications[].label
Genetic association between RGS1 and internalizing disorders.

# publications[].label
Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research.

# publications[].label
Validation of candidate anxiety disorder genes using a carbon dioxide challenge task.

# publications[].label
Citalopram, QTc interval prolongation, and torsade de pointes. How should we apply the recent FDA ruling?

# publications[].label
Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.

# publications[].label
Altered Effective Connectivity of Central Autonomic Network in Response to Negative Facial Expression in Adults With Cannabis Use Disorder.

# publications[].label
Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women.

# publications[].label
Clinical correlates of anxious depression in youth from the Texas Youth Depression and Suicide Research Network (TX-YDSRN).

# publications[].label
Posttraumatic stress disorder: clinical features, pathophysiology, and treatment.

# publications[].tags
16 Peace, Justice and Strong Institutions

# publications[].label
Confirmatory factor structure and psychometric properties of the Multidimensional Peer Victimization Scale.

# publications[].label
Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.

# publications[].label
Advances in molecular genetics of panic disorder.

# publications[].label
Genetic and environmental risk structure of internalizing psychopathology in youth.

# publications[].label
Baseline brain function in the preadolescents of the ABCD Study.

# publications[].label
Rates of Incidental Findings in Brain Magnetic Resonance Imaging in Children.

# publications[].label
USING STRUCTURAL EQUATION MODELING (SEM) METHODS TO EXAMINE GENOME-WIDE ASSOCIATIONS WITH A LATENT NEUROTICISM FACTOR AND ITEM-SPECIFIC RESIDUALS

# publications[].label
Genetic and Environmental Influences on Cortisol Reactivity to a Psychosocial Stressor in Adolescents and Young Adults

# publications[].label
A population-based twin study of the relationship between neuroticism and internalizing disorders.

# publications[].label
Measurement invariance of the Screen for Child Anxiety Related Emotional Disorders (SCARED) across ethnicity, age, and sex among youth with depression

# publications[].label
Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.

# publications[].label
Shared and Distinct Brain Regions in Anxiety, Depression, and Neuroticism: A Multi-Phenotypic Approach Using Data from the UK Biobank

# publications[].label
Cell-Type Specific Methylome-Wide Association Study of Anxiety Disorders

# publications[].label
A genomewide association study of citalopram response in major depressive disorder-a psychometric approach.

# publications[].label
A population-based twin study of generalized anxiety disorder in men and women.

# publications[].label
Genome-wide and gene-based association studies of anxiety disorders in European and African American samples.

# publications[].label
Psychophysiology of threat response, paradigm shifts in psychiatry, and RDoC: Implications for genetic investigation of psychopathology.

# publications[].label
Methylome-wide association study of anxiety disorders.

# publications[].label
Genetic and environmental contributions to the relationship between education and anxiety disorders - a twin study.

# publications[].label
Psychometric properties of the GAD-7 and PROMIS-Anxiety-4a among youth with depression and suicidality: Results from the Texas youth depression and suicide research network.

# publications[].label
Genetic and Environmental Contributions of Negative Valence Systems to Internalizing Pathways.

# publications[].label
The structure of genetic and environmental risk factors for anxiety disorders in men and women.

# publications[].label
Fear-potentiated startle response as an endophenotype: Evaluating metrics and methods for genetic applications.

# publications[].label
A case of aripiprazole-related tardive akathisia and its treatment with ropinirole.

# publications[].label
Substance use patterns in 9-10 year olds: Baseline findings from the adolescent brain cognitive development (ABCD) study.

# publications[].label
What is the genetic relationship between anxiety and depression?

# publications[].label
Heritability, stability, and prevalence of tonic and phasic irritability as indicators of disruptive mood dysregulation disorder.

# publications[].label
Circularly and elliptically polarized microwave ionization of Na Rydberg atoms

# publications[].label
Resting-State Directional Connectivity and Anxiety and Depression Symptoms in Adult Cannabis Users.

# publications[].label
Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.

# publications[].label
A twin study of the genetics of fear conditioning.

# publications[].label
Meta-analysis of genome-wide association studies of anxiety disorders.

# publications[].label
Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D.

# publications[].label
Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths.

# publications[].label
Fear conditioning and self-report fear ratings: Genetic and environmental sources of covariation

# publications[].label
Image processing and analysis methods for the Adolescent Brain Cognitive Development Study.

# publications[].label
Image processing and analysis methods for the Adolescent Brain Cognitive Development Study

# publications[].label
Latent structure of negative valence measures in childhood.

# publications[].label
Association between glutamic acid decarboxylase (GAD) genes and mood and anxiety disorders

# publications[].label
Identification and validation of mixed anxiety-depression.

# publications[].label
Parenting and risk for mood, anxiety and substance use disorders: a study in population-based male twins.

# publications[].label
Test-retest reliability and validity of a frustration paradigm and irritability measures.

# publications[].label
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.

# publications[].label
Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism.

# publications[].label
Latent Internalizing Risk Factors Predict Functional Connectivity in Juvenile Twins

# publications[].label
Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism (vol 11, pg 752, 2006)

# publications[].label
Co-morbid major depression and generalized anxiety disorders in the National Comorbidity Survey follow-up.

# publications[].label
Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis.

# publications[].label
Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders.

# researcherOn[].label
Genome-wide association studies of anxiety spectrum phenotypes: Furthering the PGC Anxiety Disorders Working Group

# researcherOn[].awardedBy.label
National Institute of Mental Health - (Bethesda, Maryland, United States)

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine