# overview
Dr. Isaac Adjei's goals are to advance translatable strategies to understand, treat and diagnose cancer, and in the process educate the next generation of scientists. His research focuses on developing drug delivery systems that improve outcomes for advanced-stage cancer. He also studies the mechanisms of tumor immune evasion using three-dimensional tumor models, with the goal of developing novel strategies to reactivate the immune system against tumors.

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# educationAndTraining[].organization.label
Case Western Reserve University - (Cleveland, Ohio, United States)

# awardsAndHonors[].label
1,000 Inspiring Black Scientists in America

# publications[].label
Reversing Hypoxia with PLGA-Encapsulated Manganese Dioxide Nanoparticles Improves Natural Killer Cell Response to Tumor Spheroids.

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Vascular bifurcation influences the protein corona composition on nanoparticles and impacts their cellular uptake.

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Targeted Nanomedicine to Treat Bone Metastasis.

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Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress.

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Chapter Four Oxidative Stress and Biomaterials The Inflammatory Link

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Inhibition of bone loss with surface-modulated, drug-loaded nanoparticles in an intraosseous model of prostate cancer.

# publications[].label
Engineered Three-Dimensional Tumor Models to Study Natural Killer Cell Suppression.

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MANGANESE DIOXIDE NANOPARTICLES MODULATE OXIDATIVE STRESS AND PROTECT CARTILAGE FROM INTERLEUKIN-1 beta INDUCED DEGRADATION

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Nanoparticle-mediated p53 gene therapy for tumor inhibition.

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MULTIFUNCTIONAL NANOPARTICLES FOR IMPROVING FUNCTION AND MULTIMODAL TRACKING OF MESENCHYMAL STEM CELLS FOR OSTEOARTHRITIS TREATMENT

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Nanoparticles: cellular uptake and cytotoxicity.

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Macroporous 3D scaffolds for studying MSC migration and differentiation within cartilage defects

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Modulation of the tumor microenvironment for cancer treatment: a biomaterials approach.

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Oxidative Stress and Biomaterials: The Inflammatory Link

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Magnetically Responsive Polymeric Microparticles for the Triggered Delivery of a Complex Mixture of Human Placental Proteins.

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Multifunctional nanoparticles for intracellular drug delivery and photoacoustic imaging of mesenchymal stem cells.

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Advancements in the delivery of epigenetic drugs.

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Nanoparticle Properties for Delivery to Cartilage: The Implications of Disease State, Synovial Fluid, and Off-Target Uptake.

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Functional recovery of natural killer cell activity by nanoparticlemediated delivery of transforming growth factor beta 2 small interfering RNA

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Selective biophysical interactions of surface modified nanoparticles with cancer cell lipids improve tumor targeting and gene therapy.

# publications[].label
Engineering the glioblastoma microenvironment with bioactive nanoparticles for effective immunotherapy.

# publications[].label
Heterogeneity in nanoparticles influences biodistribution and targeting.

# publications[].label
Optimizing Oxygen-Production Kinetics of Manganese Dioxide Nanoparticles Improves Hypoxia Reversal and Survival in Mice with Bone Metastases.

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MANGANESE DIOXIDE NANOPARTICLES MITIGATE OXIDATIVE STRESS IN OSTEOARTHRITIC CARTILAGE

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Optical imaging to map blood-brain barrier leakage.

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A Method for Quantification of Penetration of Nanoparticles through Skin Layers Using Near-Infrared Optical Imaging

# websites[].label
Translational and Innovative Nanomedicine Lab