# overview
Dr. Akhilesh K. Gaharwar is the Tim and Amy Leach Professor in the Department of Biomedical Engineering and Presidential Impact Fellow at Texas A&M University. He received his Ph.D. in Biomedical Engineering from Purdue University and completed his postdoctoral training from the Massachusetts Institute of Technology (MIT) and Harvard University. The goal of his lab is to design new biomaterials for regenerative medicine and biomanufacturing. In particular, his lab is leveraging principles from materials science, cell biology, additive biomanufacturing, and high throughput genomics to design smart and responsive biomaterials, with wide-ranging applications in the field of bioengineering. His research program is supported by NIH, NSF, and DoD. Dr. Gaharwar has authored over 155 journal articles, accumulating more than 20,000 citations and an h-index of 74. His research accomplishments are recognized by numerous national and international awards, including the NIH New Innovator Award (DP2), Texas A&M University President Impact Fellow, Dean of Engineering Excellence Award, TEES Research Impact Award, Cellular and Molecular Bioengineering (CMBE) Rising Star Award, CMBE Young Innovator Award, and Dimitris Chorafas Foundation Award. Dr. Gaharwar is Fellow of the Biomedical Engineering Society (BMES), American Institute for Medical and Biological Engineering (AIMBE), and senior member of National Academy of Inventors (NAI). He is an Associate Editor of ACS Applied Materials and Interfaces, while also being a board member for eight other top-tier scientific journals.

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Preterm, Low Birth Weight And Health Of The Newborn

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Perinatal Period - Conditions Originating In Perinatal Period

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Physical Injury - Accidents And Adverse Effects

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3403 Macromolecular And Materials Chemistry

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3403 Macromolecular And Materials Chemistry

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Growth Hormone Secretagogue Receptor (ghs-r)

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Stem Cell Research - Induced Pluripotent Stem Cell

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Stem Cell Research - Induced Pluripotent Stem Cell - Human

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Stem Cell Research - Nonembryonic - Human

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Stem Cell Research - Nonembryonic - Non-human

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3403 Macromolecular And Materials Chemistry

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Physical Injury - Accidents And Adverse Effects

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Digital Light Processing (dlp) 3d Printing

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Platelet Endothelial Cell Adhesion Molecule-1

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3403 Macromolecular And Materials Chemistry

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Stem Cell Research - Nonembryonic - Non-human

# educationAndTraining[].organization.label
Purdue University - (West Lafayette, Indiana, United States)

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Harvard University - (Cambridge, Massachusetts, United States)

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National Institute of Technology - (Oslo, Norway)

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Massachusetts Institute of Technology - (Cambridge, Massachusetts, United States)

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Indian Institute of Technology Bombay - (Mumbai, India)

# publications[].label
Self-assembled, ellipsoidal polymeric nanoparticles for intracellular delivery of therapeutics.

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Nanocomposite polymer biomaterials for tissue repair of bone and cartilage: A material science perspective

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Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs.

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Microfluidic fabrication of cell adhesive chitosan microtubes.

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3D Biomaterial Microarrays for Regenerative Medicine: Current State-of-the-Art, Emerging Directions and Future Trends.

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PMSE 452-Structure and mechanical properties of PEO-Laponite films made from gels

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Engineered extracellular vesicles with synthetic lipids via membrane fusion to establish efficient gene delivery.

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Sequential Thiol-Ene and Tetrazine Click Reactions for the Polymerization and Functionalization of Hydrogel Microparticles.

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Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates.

# publications[].publisher
Proceedings of the National Academy of Sciences

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Highly extensible, tough, and elastomeric nanocomposite hydrogels from poly(ethylene glycol) and hydroxyapatite nanoparticles.

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Correction to "High-Throughput 3D-Printed Model of the Feto-Maternal Interface for the Discovery and Development of Preterm Birth Therapies".

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Nanoengineered biomimetic hydrogels for guiding human stem cell osteogenesis in three dimensional microenvironments.

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Delayed presentation of post traumatic diaphragmatic hernia.

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Mechanically Tough Pluronic F127/Laponite Nanocomposite Hydrogels from Covalently and Physically Cross-Linked Networks

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Injectable shear-thinning nanoengineered hydrogels for stem cell delivery.

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Exvivo engineered immune organoids for controlled germinal centerreactions.

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Mechanically Stiff Nanocomposite Hydrogels at Ultralow Nanoparticle Content.

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Dual-stimuli responsive PNiPAM microgel achieved via layer-by-layer assembly: magnetic and thermoresponsive.

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Cold Plasma Reticulation of Shape Memory Embolic Tissue Scaffolds.

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Vacancy-Driven Gelation Using Defect-Rich Nanoassemblies of 2D Transition Metal Dichalcogenides and Polymeric Binder for Biomedical Applications.

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Global trends in clinical trials involving engineered biomaterials.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Nanoengineered Bioinks: Printing Therapeutic Proteins in 3D using Nanoengineered Bioink to Control and Direct Cell Migration (Adv. Healthcare Mater. 11/2019)

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Nanoengineered injectable hydrogels for wound healing application.

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Hydrogel Bioink Reinforcement for Additive Manufacturing: A Focused Review of Emerging Strategies.

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Nanoclay-enriched poly(-caprolactone) electrospun scaffolds for osteogenic differentiation of human mesenchymal stem cells.

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Nanoengineered Ionic-Covalent Entanglement (NICE) Bioinks for 3D Bioprinting.

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Self-assembled Hydrogel Fiber Bundles from Oppositely Charged Polyelectrolytes Mimic Micro-/nanoscale Hierarchy of Collagen.

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Atomic vacancies of molybdenum disulfide nanoparticles stimulate mitochondrial biogenesis.

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Engineering complex tissue-like microgel arrays for evaluating stem cell differentiation.

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Particlepolymer interactions for 3D printing material design

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Dissociation of nanosilicates induces downstream endochondral differentiation gene expression program.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

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Inorganic Biomaterials Shape the Transcriptome Profile to Induce Endochondral Differentiation.

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Nanoengineered Ink for Designing 3D Printable Flexible Bioelectronics.

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2D Covalent Organic Frameworks for Biomedical Applications

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3D Printed Electronic Skin for Strain, Pressure and Temperature Sensing

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PHYS 443-Magnetic nanoparticles encapsulated within a biocompatible thermoresponsive polymer

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Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response.

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Advances in Nanotechnology for the Treatment of Osteoporosis.

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Electrically Conductive MoS2 Reinforced Polyacrylonitrile Nanofibers for Biomedical Applications

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2D layered nanomaterials for therapeutics delivery.

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Dynamically Cross-Linked Granular Hydrogels for 3D Printing and Therapeutic Delivery.

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Bone Bioprinting: Advancing Frontiers in Bone Bioprinting (Adv. Healthcare Mater. 7/2019)

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Human tumor microenvironment chip evaluates the consequences of platelet extravasation and combinatorial antitumor-antiplatelet therapy in ovarian cancer.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

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Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair.

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Layer-by-layer assembly of a magnetic nanoparticle shell on a thermoresponsive microgel core

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Shear-thinning nanocomposite hydrogels for the treatment of hemorrhage.

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Development of Biomedical Polymer-Silicate Nanocomposites: A Materials Science Perspective

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Elastomeric and mechanically stiff nanocomposites from poly(glycerol sebacate) and bioactive nanosilicates.

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Silicone-containing thermoresponsive membranes to form an optical glucose biosensor.

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Assessment of using laponite cross-linked poly(ethylene oxide) for controlled cell adhesion and mineralization.

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Improving the Oxidative Stability of Shape Memory Polyurethanes Containing Tertiary Amines by the Presence of Isocyanurate TrioIs

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Bioglass incorporated methacrylated collagen bioactive ink for 3D printing of bone tissue.

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Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips.

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1.4.8 Biomedical Applications of Additive Manufacturing

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Nanoengineered Osteoinductive Bioink for 3D Bioprinting Bone Tissue.

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Photocrosslinked nanocomposite hydrogels from PEG and silica nanospheres: structural, mechanical and cell adhesion characteristics.

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Generalizing hydrogel microparticles into a new class of bioinks for extrusion bioprinting.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Emerging Trends in Biomaterials Research.

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Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates.

# publications[].label
Widespread changes in transcriptome profile of human mesenchymal stem cells induced by 2D nanosilicates

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Designing Cost-Effective, Open-Source, Multi-Head Bioprinters via Conversion of Hobby-Grade 3D Printers

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Polymer-Coated Extracellular Vesicles for Selective Codelivery of Chemotherapeutics and siRNA to Cancer Cells.

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Nanostructured Hydrogels for Tissue Engineering and Regenerative Medicine

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Physically crosslinked nanocomposites from silicate-crosslinked PEO: mechanical properties and osteogenic differentiation of human mesenchymal stem cells.

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PMSE 476-New bionanocomposite fibers from PEO and silicate cross-linkers

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Pectin Methacrylate (PEMA) and Gelatin-Based Hydrogels for Cell Delivery: Converting Waste Materials into Biomaterials.

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Nanomaterials in Tissue Engineering: Fabrication and Applications

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Engineering elastomeric and mechanically stiff nanocomposite by covalently crosslinking poly(glycerol sebacate) and silicate nanoplatelets

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2D Nanoclay for Biomedical Applications: Regenerative Medicine, Therapeutic Delivery, and Additive Manufacturing.

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Advanced Bioinks for 3D Printing: A Materials Science Perspective.

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Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells.

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Correction to "Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage".

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Printing therapeutics in 3d using nanoengineered bioink

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Injectable, Self-healing, and 3D Printable Dynamic Hydrogels

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Bioactive nanoengineered hydrogels for bone tissue engineering: a growth-factor-free approach.

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PGS:Gelatin nanofibrous scaffolds with tunable mechanical and structural properties for engineering cardiac tissues.

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Bioprinting 101: Design, Fabrication, and Evaluation of Cell-Laden 3D Bioprinted Scaffolds.

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Bivalent metal ions modulate human mesenchymal stem cell osteogenic differentiation

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Anisotropic poly (glycerol sebacate)-poly (-caprolactone) electrospun fibers promote endothelial cell guidance.

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Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders.

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Engineered biomaterials for in situ tissue regeneration

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Engineered Nanomaterials for Infection Control and Healing Acute and Chronic Wounds.

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Protein structure and bioactivity upon adsorption and desorption from nanosilicate sustained release delivery devices.

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A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells.

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Angiogenesis: 2D Nanosilicates Loaded with Proangiogenic Factors Stimulate Endothelial Sprouting (Adv. Biosys. 7/2018)

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Clickable PEG hydrogel microspheres as building blocks for 3D bioprinting.

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Elastomeric nanocomposite scaffolds made from poly(glycerol sebacate) chemically crosslinked with carbon nanotubes.

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Microscale Technologies for Cell Engineering

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Granular Biphasic Colloidal Hydrogels for 3D Bioprinting.

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Elastomeric nanocomposite scaffolds made from poly (glycerol sebacate) chemically crosslinked with carbon nanotubes.

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3D Bioprinted Multicellular Vascular Models.

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4D Printing of Engineered Living Materials

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Elastomeric and mechanically stiff nanocomposite for bone tissue engineering

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Combinatorial Screening of Nanoclay-Reinforced Hydrogels: A Glimpse of the "Holy Grail" in Orthopedic Stem Cell Therapy?

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Addition of chitosan to silicate cross-linked PEO for tuning osteoblast cell adhesion and mineralization.

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Light-Triggered In Situ Gelation of Hydrogels using 2D Molybdenum Disulfide (MoS2 ) Nanoassemblies as Crosslink Epicenter.

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Superhydrophobic states of 2D nanomaterials controlled by atomic defects can modulate cell adhesion.

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Development of bio-nanocomposite hydrogels based on silicate cross-linked Peo for tissue engineering

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2D Covalent Organic Framework Direct Osteogenic Differentiation of Stem Cells.

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Multiscale modeling of vascular pathophysiology using 3d bioprinting

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Tuning cell adhesion by incorporation of charged silicate nanoparticles as cross-linkers to polyethylene oxide.

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Correction: Superhydrophobic states of 2D nanomaterials controlled by atomic defects can modulate cell adhesion.

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Inorganic ions activate lineage-specific gene regulatory networks.

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Antimicrobial Activity of Metal and Metal-Oxide Based Nanoparticles

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Nano-bio interactions of 2D molybdenum disulfide.

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2D Nanosilicate for additive manufacturing: Rheological modifier, sacrificial ink and support bath

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Shear-Thinning and Thermo-Reversible Nanoengineered Inks for 3D Bioprinting.

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Rapid Osteogenic Enhancement of Stem Cells in Human Bone Marrow Using a Glycogen-Synthease-Kinase-3-Beta Inhibitor Improves Osteogenic Efficacy In Vitro and In Vivo.

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Nanoengineered polymeric biomaterials for musculoskeletal tissue engineering: A growth-factor-free approach

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Magnetic nanoparticles encapsulated within a thermoresponsive polymer.

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Self-Assembly of Block Heterochiral Peptides into Helical Tapes.

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Designing the Next Generation of Biomaterials through Nanoengineering.

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Laponite-Based Nanocomposite Hydrogels for Drug Delivery Applications.

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Correction to "Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates".

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Microscale Bioadhesive Hydrogel Arrays for Cell Engineering Applications.

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Cell GHS-R Regulates Insulin Secretion and Sensitivity.

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Emerging trends in multiscale modeling of vascular pathophysiology: Organ-on-a-chip and 3D printing.

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Elastomeric and tough nanocomposite hydrogels from double cross-linked polymer networks

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Assessment of Local Heterogeneity in Mechanical Properties of Nanostructured Hydrogel Networks.

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DSC-Differentiated Hepatocytes for Treatment of Liver Diseases

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Nanoengineered Osteoinductive and Elastomeric Scaffolds for Bone Tissue Engineering.

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Matrix stiffness drives drop like nuclear deformation and lamin A/C tension-dependent YAP nuclear localization.

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Defect driven gelation of 2D nano-assemblies and polymeric binder for bone tissue engineering

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Effect of biodegradation and de novo matrix synthesis on the mechanical properties of valvular interstitial cell-seeded polyglycerol sebacate-polycaprolactone scaffolds.

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Emerging 2D Nanomaterials for Biomedical Applications.

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Advancing Frontiers in Bone Bioprinting.

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Injectable nanoengineered stimuli-responsive hydrogels for on-demand and localized therapeutic delivery.

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Nanomaterials for Engineering Stem Cell Responses.

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Self-Oscillating 3D Printed Hydrogel Shapes

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Advanced Nanomaterials: Promises for Improved Dental Tissue Regeneration

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Gradient nanocomposite hydrogels for interface tissue engineering.

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Material assembly from collective action of shape-changing polymers.

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Multi-leveled Nanosilicate Implants Can Facilitate Near-Perfect Bone Healing.

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Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells.

# publications[].label
Conditioning of 3D Printed Nanoengineered Ionic-Covalent Entanglement Scaffolds with iP-hMSCs Derived Matrix.

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Comparison of Photo Cross Linkable Gelatin Derivatives and Initiators for Three-Dimensional Extrusion Bioprinting.

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Sustained and prolonged delivery of protein therapeutics using 2d nanosilicates

# publications[].label
Transparent, elastomeric and tough hydrogels from poly(ethylene glycol) and silicate nanoparticles.

# publications[].label
Effect of ionic strength on shear-thinning nanoclay-polymer composite hydrogels.

# publications[].label
2D Nanosilicates Loaded with Proangiogenic Factors Stimulate Endothelial Sprouting

# publications[].label
High-Throughput 3D-Printed Model of the Feto-Maternal Interface for the Discovery and Development of Preterm Birth Therapies.

# publications[].label
Coiled Coil Crosslinked Alginate Hydrogels Dampen Macrophage-Driven Inflammation.

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ChemInform Abstract: TwoDimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects

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Nanobio Interface Between Proteins and 2D Nanomaterials.

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Correction to "Bioactive Nanoengineered Hydrogels for Bone Tissue Engineering: A Growth-Factor-Free Approach".

# publications[].label
Photocrosslinkable and elastomeric hydrogels for bone regeneration.

# publications[].label
Nanoengineered Colloidal Inks for 3D Bioprinting.

# publications[].label
3D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineering.

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Corrigendum to "Nanoengineered injectable hydrogels for wound healing application" [Acta Biomaterialia 2018, 70, 35-47].

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Two-dimensional metal organic frameworks for biomedical applications.

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Silicate cross-linked bio-nanocomposite hydrogels from PEO and chitosan.

# publications[].label
Nanoengineered biomaterials for repair and regeneration of orthopedic tissue interfaces.

# publications[].label
Microscale Technologies for Engineering Complex Tissue Structures

# publications[].label
Hyperbranched polyester hydrogels with controlled drug release and cell adhesion properties.

# publications[].label
Correction to "Nanoengineered Ink for Designing 3D Printable Flexible Bioelectronics".

# publications[].label
Intra-Articular Injectable Biomaterials for Cartilage Repair and Regeneration.

# publications[].label
Elastomeric Cell-Laden Nanocomposite Microfibers for Engineering Complex Tissues

# publications[].label
The osteogenic differentiation of SSEA-4 sub-population of human adipose derived stem cells using silicate nanoplatelets.

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Oxygen-Generating Photo-Cross-Linkable Hydrogels Support Cardiac Progenitor Cell Survival by Reducing Hypoxia-Induced Necrosis.

# publications[].label
Reinforcement of osteogenesis with nanofabricated hydroxyapatite and GelMA nanocomposite

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Correction to "Assessment of Local Heterogeneity in Mechanical Properties of Nanostructured Hydrogel Networks".

# publications[].label
Photothermal modulation of human stem cells using light-responsive 2D nanomaterials.

# publications[].publisher
Proceedings of the National Academy of Sciences

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Brillouin microspectroscopy of nanostructured biomaterials: Photonics assisted tailoring of mechanical properties

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Development of Nanosilicate-Hydrogel Composites for Sustained Delivery of Charged Biopharmaceutics.

# publications[].label
Multiscale Engineered Heterogeneous Hydrogel Composites for Digital Light Processing 3D Printing.

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Printing Therapeutic Proteins in 3D using Nanoengineered Bioink to Control and Direct Cell Migration.

# publications[].label
Two-Dimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects.

# publications[].label
Nanosilicates promote angiogenesis through activation of ROS-mediated WNT/-catenin pathway.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Amphiphilic beads as depots for sustained drug release integrated into fibrillar scaffolds.

# publications[].label
Omics-based approaches to guide the of biomaterials

# researcherOn[].label
Two dimensional Nanomaterials for Cartilage Regeneration

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Mineralomics : Designing mineral based therapeutics to control and direct cell function

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
3D Bioprinting of Complex Tissue Structures Using Nanoengineered Ionic-Covalent Entanglement (NICE) Bioinks

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# researcherOn[].label
Nanoengineered bone repair scaffolds generated from stem cells and their secreted products for improved spinal fusion

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Arthritis and Musculoskeletal and Skin Diseases

# streetAddress
Texas A&M University; Biomedical Engineering; 3120 TAMU

# inTheNews[].label
Texas A&M lab engineers 3D-functional bone tissues

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Texas A&M Researchers Light Cells Using Nanosheets For Cancer Treatment

# inTheNews[].label
Texas A&M Lab Develops 3D-Functional Bone Tissues

# etdChairOf[].label
Lee, Hung Pang (2022-12). Injectable Hydrogels for Therapeutic Delivery and 3D Printing. Doctoral Dissertation.

# etdChairOf[].label
Carrow, James Kenning (2018-08). Engineering Stem Cell Responses with Two-Dimensional Nanomaterials. Doctoral Dissertation.

# etdChairOf[].label
Jalili, Nima A (2016-08). Nanoengineered Injectable Hydrogels for On-Demand and Localized Therapeutic Delivery. Master's Thesis.

# etdChairOf[].label
Davis, Ryan (2022-08). Shear-thinning Granular Hydrogels as Injectable Biomaterials for Cartilage Repair. Master's Thesis.

# etdChairOf[].label
Gold, Karli Ayn (2020-05). 3D Printed Blood Vessels for Translational Medicine. Doctoral Dissertation.

# etdChairOf[].label
Arun Kumar, Shreedevi (2021-08). Engineering Drug Delivery Platforms for Cancer and Infectious Diseases. Doctoral Dissertation.

# etdChairOf[].label
Wilson, Scott Andrew (2017-08). Designing Advanced Bioinks for 3D Printing Complex Tissue Structures. Master's Thesis.

# etdChairOf[].label
Chimene, David Calvin (2019-12). Nanoengineered Ionic-Covalent Entanglement (NICE) Reinforced Bioinks for 3D Bioprinting. Doctoral Dissertation.

# etdChairOf[].label
Cross, Lauren M. (2018-12). Bioactive Nanosilicates for Orthopedic Tissue Regeneration. Doctoral Dissertation.

# etdChairOf[].label
Javaid, Rukhma (2023-08). Fibrous/Hydrogel Composite Scaffolds for Tissue Engineering Applications. Master's Thesis.

# etdChairOf[].label
Kerativitayanan, Punyavee (2015-12). Bioactive and Elastomeric Scaffolds: A Growth-Factor-Free Approach for Bone Tissue Engineering. Master's Thesis.

# etdChairOf[].label
Peak, Charles W (2018-05). Nanoengineered Biomaterials for Cell and Therapeutic Delivery. Doctoral Dissertation.

# etdChairOf[].label
Nayak, Biswadeep (2021-12). Developing a Three-Dimensional (3D) Bioprinted Tumor Model. Master's Thesis.

# etdChairOf[].label
Kishan, Alysha Prem (2017-12). Development of Tunable Electrospun Scaffolds For Tissue Engineering Applications. Doctoral Dissertation.

# etdChairOf[].label
Whitely Jr, Michael Edward (2018-08). Development of PolyHIPE Grafts for Guided Bone Regeneration. Doctoral Dissertation.

# etdChairOf[].label
Rajput, Satyam (2020-05). Two-Dimensional (2D) Nanosilicates for Additive Manufacturing: Ink, Support-Bath and Sacrificial Ink. Master's Thesis.