# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Dr. Huang is currently an Assistant Professor at the Center for Epigenetics and Disease Prevention, Institute of Biosciences & Technology, Texas A&M University. Her long-term goal is to elucidate the molecular basis of epigenetic changes in the human genome and to develop novel therapies by targeting aberrant DNA methylation and demethylation associated with human diseases, including cancer, immunoinflammatory and cardiovascular diseases.

Dr. Huang's laboratory is focused on elucidating the physiological and pathophysiological functions of TET2 protein and its 5-methylcytosine oxidation products (5hmC, 5fC and 5caC) in cancer and development (Nature Genet 2014; Trends in Genetics 2014).

# keywords[]
Calcium Release-activated Calcium (crac) Channel

# keywords[]
Calcium Release Activated Calcium Channels

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Calcium Release Activated Calcium Channels

# keywords[]
Calcium Release Activated Calcium Channels

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Calcium Release-activated Calcium (crac) Channel

# keywords[]
Calcium Release Activated Calcium Channels

# educationAndTraining[].organization.label
Zhejiang University - (Hangzhou, Zhejiang, China)

# educationAndTraining[].organization.label
Georgia State University - (Atlanta, Georgia, United States)

# publications[].label
[Current progress in study of sphingolipids].

# publications[].label
Calmodulin mediates the Ca2+-dependent regulation of Cx44 gap junctions.

# publications[].label
Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation

# publications[].label
The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels.

# publications[].label
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.

# publications[].label
Connections between TET proteins and aberrant DNA modification in cancer.

# publications[].label
Genetically encoded tags for real time dissection of protein assembly in living cells.

# publications[].label
Intelligent cell-based therapies for cancer and autoimmune disorders.

# publications[].label
Tet2 inactivation enhances the anti-tumor activity of tumor-infiltrating lymphocytes (TILs) to curtail melanoma growth

# publications[].label
Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.

# publications[].label
ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer.

# publications[].label
Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Store-Operated Calcium Entry Mediated byORAIand STIM.

# publications[].label
Optogenetics for transcriptional programming and genetic engineering.

# publications[].label
Calmodulin regulates Ca2+-sensing receptor-mediated Ca2+ signaling and its cell surface expression.

# publications[].label
The anti-CMS technique for genome-wide mapping of 5-hydroxymethylcytosine.

# publications[].label
Optogenetic toolkit for precise control of calcium signaling.

# publications[].label
Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells.

# publications[].label
Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC.

# publications[].label
A molecular toolbox for interrogation of membrane contact sites.

# publications[].label
Publisher Correction: Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas.

# publications[].label
Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety.

# publications[].label
Large conserved domains of low DNA methylation maintained by Dnmt3a.

# publications[].label
TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation.

# publications[].label
Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation.

# publications[].label
Repurposing salicylic acid as a versatile inducer of proximity.

# publications[].label
An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1.

# publications[].label
The GLIB technique for genome-wide mapping of 5-hydroxymethylcytosine.

# publications[].label
Targeting epigenetic regulatory machinery to overcome cancer therapy resistance.

# publications[].label
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.

# publications[].label
Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas.

# publications[].label
Rewiring Calcium Signaling for Precise Transcriptional Reprogramming.

# publications[].label
Multiple Ca(2+)-binding sites in the extracellular domain of the Ca(2+)-sensing receptor corresponding to cooperative Ca(2+) response.

# publications[].label
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.

# publications[].label
Global epigenomic reconfiguration during mammalian brain development.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing.

# publications[].label
Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling.

# publications[].label
Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium.

# publications[].label
The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development.

# publications[].label
A probabilistic generative model for quantification of DNA modifications enables analysis of demethylation pathways.

# publications[].label
Developing sensors for real-time measurement of high Ca2+ concentrations.

# publications[].label
Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling.

# publications[].label
Optical control of membrane tethering and interorganellar communication at nanoscales.

# publications[].label
Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development.

# publications[].label
Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms.

# publications[].label
A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+.

# publications[].label
Identification of the calmodulin binding domain of connexin 43.

# publications[].label
New functions for DNA modifications by TET-JBP.

# publications[].label
Structural basis for effects of CpA modifications on C/EBP binding of DNA.

# publications[].label
Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Calcium Entry Channels in Non-Excitable Cells

# publications[].label
Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca influx.

# publications[].label
[Protective effects of adenovirus-mediated hepatocyte growth factor on injury of rat cortex neurons].

# publications[].label
Engineering of a bona fide light-operated calcium channel.

# publications[].label
P68 RNA helicase is a nucleocytoplasmic shuttling protein.

# publications[].label
A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells.

# publications[].label
Engineered Cross-Linking to Study the Pore Architecture of the CRAC Channel.

# publications[].label
Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development

# publications[].label
Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor.

# publications[].label
STIM1 gates the store-operated calcium channel ORAI1 in vitro.

# publications[].label
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering.

# publications[].label
Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Biomolecular condensates in immune cell fate.

# publications[].label
KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells.

# publications[].label
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.

# publications[].label
Ten-Eleven Translocation Ablation Impairs Cardiac Differentiation of Mouse Embryonic Stem Cells.

# publications[].label
Preferential CEBP binding to T:G mismatches and increased C-to-T human somatic mutations.

# publications[].label
Designing caspase-3 sensors for imaging of apoptosis in living cells.

# publications[].label
Intronic non-CG DNA hydroxymethylation and alternative mRNA splicing in honey bees.

# publications[].label
p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance.

# publications[].label
Control of Foxp3 stability through modulation of TET activity.

# publications[].label
A cysteine-rich metal-binding domain from rubella virus non-structural protein is essential for viral protease activity and virus replication.

# publications[].label
Calcium store refilling and STIM activation in STIM- and Orai-deficient cell lines.

# publications[].label
Multimeric transcription factor BCL11A utilizes two zinc-finger tandem arrays to bind clustered short sequence motifs.

# publications[].label
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.

# publications[].label
TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells.

# publications[].label
Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis.

# publications[].label
Molecular Determinants for STIM1 Activation During Store- Operated Ca2+ Entry.

# publications[].label
Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine.

# publications[].label
Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy.

# publications[].label
A lipidomic study of the effects of N-methyl-N'-nitro-N-nitrosoguanidine on sphingomyelin metabolism.

# publications[].label
Designing protease sensors for real-time imaging of trypsin activation in pancreatic cancer cells.

# publications[].label
Elevated Adenosine Induces Placental DNA Hypomethylation Independent of A2B Receptor Signaling in Preeclampsia.

# publications[].label
Calcium-dependent association of calmodulin with the rubella virus nonstructural protease domain.

# publications[].label
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

# publications[].label
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth.

# publications[].label
Adaptive Convergence of Methylomes Reveals Epigenetic Drivers and Boosters of Repeated Relapses in Patient-matched Childhood Ependymomas and Identifies Targets for Anti-Recurrence Therapies

# researcherOn[].label
Epigenetic Signatures of Developmental Reprogramming in Target and Surrogate Tissues

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Role of TET dioxygenase associated immune mechanisms in cardiac injury and repair

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Heart, Lung, and Blood Institute

# researcherOn[].label
Molecular toolkit for single-cell oxi-mC analysis

# researcherOn[].awardedBy.label
National Institute of General Medical Sciences - (Bethesda, Maryland, United States)

# researcherOn[].label
Role of TET proteins during cardiac lineage specification

# researcherOn[].awardedBy.label
American Heart Association - (New York, New York, United States)

# researcherOn[].label
TET-Mediated Epigenetic Regulation in Cardiac Development

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Heart, Lung, and Blood Institute

# researcherOn[].label
Molecular Control of Calcium Influx at the ER-Plasma Membrane Junctions

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# streetAddress
Texas A&M Health Science Center; Ibt - Cedp - Dashwood; 1201 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine

# inTheNews[].label
Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma

# inTheNews[].label
Scientists Develop Highly Effective Detection Strategy For Childhood Brain Tumors

# inTheNews[].label
Highly effective tumor detection strategy for common childhood brain tumors