{
"id" : "nd7ed0926",
"class" : "Person",
"name" : "Huang, Yun",
"primaryEmail" : "yun.huang@tamu.edu",
"phone" : "1 713 677 7484",
"orcidId" : "0000-0001-5950-9168",
"preferredTitle" : "Associate Professor",
"positions" : [ {
"id" : "na9c815ad",
"label" : "Associate Professor",
"type" : "FacultyPosition",
"organizations" : [ {
"id" : "n4260b8d6",
"label" : "Institute of Biosciences and Technology",
"parent" : [ {
"id" : "nd14d726a",
"label" : "School of Medicine"
} ]
} ]
} ],
"overview" : "Dr. Huang is currently an Assistant Professor at the Center for Epigenetics and Disease Prevention, Institute of Biosciences & Technology, Texas A&M University. Her long-term goal is to elucidate the molecular basis of epigenetic changes in the human genome and to develop novel therapies by targeting aberrant DNA methylation and demethylation associated with human diseases, including cancer, immunoinflammatory and cardiovascular diseases.
Dr. Huang's laboratory is focused on elucidating the physiological and pathophysiological functions of TET2 protein and its 5-methylcytosine oxidation products (5hmC, 5fC and 5caC) in cancer and development (Nature Genet 2014; Trends in Genetics 2014).",
"hrJobTitle" : "Associate Professor",
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"Sphingolipids", "ErbB Receptors", "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization", "Cells, Cultured", "Humans", "Disease Models, Animal", "Immunomodulation", "32 Biomedical And Clinical Sciences", "3204 Immunology", "T-Lymphocytes", "Melanoma", "Infrared Rays", "Nanotechnology", "Bioengineering", "Animals", "Dendritic Cells", "Calcium Signaling", "Macrophages", "Optogenetics", "Mice", "Cancer", "Stromal Interaction Molecules", "Calcium Release Activated Calcium Channels", "Cryptochrome", "Calcium", "Optogenetics", "Immune Response", "Humans", "Light", "Lov2", "Calcium Signaling", "STIM1", "Animals", "Calcium Release-activated Calcium (crac) Channel", "Leukemia, Myeloid, Acute", "Humans", "Mutation", "Cell Line", "Myelodysplastic Syndromes", "Mice, Inbred C57BL", "Mice", "DNA, Neoplasm", "CpG Islands", "Biocatalysis", "Mutant Proteins", "DNA Methylation", "Animals", "Hydroxylation", "5-Methylcytosine", "Cell Differentiation", "DNA-Binding Proteins", "Proto-Oncogene 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"Anti-Bacterial Agents", "Hematological Malignancies", "Proto-Oncogene Proteins", "CD4-Positive T-Lymphocytes", "Antibiotics", "Loss Of Function Mutation", "Dioxygenases", "Gene Expression Profiling", "Gene Knockout Techniques", "Female", "DNA-Binding Proteins", "Epigenetics", "Signal Transduction", "Tumor Necrosis Factor-alpha", "Hematologic Neoplasms", "Disease Models, Animal", "Tet2", "Mice", "Inflammation", "Cytokines", "Animals", "Mutation", "RhoA GTP-Binding Protein", "Humans", "Cell Cycle", "DNA Methylation", "Female", "GTP Phosphohydrolases", "Mice", "Homeostasis", "Dioxygenases", "Oxidoreductases", "CD4-Positive T-Lymphocytes", "5-Methylcytosine", "Epigenesis, Genetic", "Animals", "Phosphorylation", "Cell Proliferation", "Proto-Oncogene Proteins", "Signal Transduction", "Rho GTP-Binding Proteins", "DNA-Binding Proteins", "T-Lymphocytes", "Male", "DNA", "Mutation", "CCAAT-Enhancer-Binding Proteins", "Protein Binding", "Guanine", "Protein Domains", "Binding Sites", "Cytosine", 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Differentiation", "DNA Methylation", "Proto-Oncogene Proteins", "Forkhead Transcription Factors", "Cytosine", "Animals", "Humans", "Male", "Ascorbic Acid", "Calcium", "Virus Replication", "Models, Molecular", "Zinc", "Binding Sites", "Cysteine", "Viral Nonstructural Proteins", "Protein Binding", "Protein Structure, Tertiary", "Amino Acid Motifs", "Serine", "Mutagenesis, Site-Directed", "Endopeptidases", "Rubella Virus", "Crystallography, X-Ray", "Binding Sites", "Models, Molecular", "Humans", "Mutagenesis", "Peptide Mapping", "Signal Transduction", "Receptors, Metabotropic Glutamate", "Calcium", "Glutamic Acid", "Algorithms", "Protein Structure, Tertiary", "SOCE", "Cell Membrane", "Protein Transport", "Humans", "HEK293 Cells", "Orai1", "ORAI1 Protein", "Calcium", "Endoplasmic Reticulum", "Protein Multimerization", "Stromal Interaction Molecule 1", "2-APB", "Calcium Signaling", "STIM1", "ORAI1 Protein", "Stromal Interaction Molecule 1", "Calcium", "Calcium Signaling", "Cell Membrane", 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"Amino Acid Sequence", "Nuclear Magnetic Resonance, Biomolecular", "Protein Structure, Tertiary", "Extracellular Space", "Transcriptional Reprogramming", "Protein Transport", "Cell Nucleus", "CRISPR-Cas Systems", "Calcium Signaling", "Optogenetics", "Transcription, Genetic", "Humans", "Calcium Release Activated Calcium Channels", "Nfat", "HEK293 Cells", "Synthetic Biology", "Genome Editing", "Crispr/cas9", "Light", "Gene Expression Regulation", "Hela Cells", "Calcium", "Mice", "Mice, Knockout", "Hematopoiesis", "Cell Line", "Humans", "Hematologic Neoplasms", "Metabolomics", "Mutation", "Genetic Predisposition To Disease", "Genetic Association Studies", "Isocitrate Dehydrogenase", "Chromatin Immunoprecipitation Sequencing", "Animals", "Disease Models, Animal", "Dna (cytosine-5-)-methyltransferases", "Cell Transformation, Neoplastic", "Metabolome", "Histones", "Gene Expression Profiling", "Dna Methyltransferase 3a", "DNA Methylation", "DNA-Binding Proteins", "Cells, Cultured", "Receptors, Erythropoietin", "Dna Methyltransferase 3a", "Cell Transformation, Neoplastic", "Dna (cytosine-5-)-methyltransferases", "Mice, Knockout", "DNA Methylation", "Cell Lineage", "Gene Expression Regulation", "Hematopoietic Stem Cells", "Cell Differentiation", "Kruppel-Like Transcription Factors", "Proto-Oncogene Proteins", "Mice", "Animals", "Dioxygenases", "Signal Transduction", "Carbamoyl-phosphate Synthase (glutamine-hydrolyzing)", "Protein-protein Interaction", "Orai1", "Aspartate Carbamoyltransferase", "Store-operated Calcium Entry", "FRET", "Microscopy, Confocal", "Amino Acid Sequence", "Protein Multimerization", "Structure-Activity Relationship", "STIM1", "Calcium", "Calcium
Release-activated Calcium Channel", "Humans", "Imaging", "Cell Line", "Dihydroorotase", "Ion Channel Gating", "Models, Molecular", "Calcium Signaling", "Protein Binding", "Calcium Channels", "Stromal Interaction Molecule 1", "Protein Interaction Domains And Motifs", "Thymine", "Cytosine", "Arginine", "Protein Interaction Domains And Motifs", "Protein Binding", "Mutation", "Transcription Factor 4", "Sequence Homology, Amino Acid", "Hyperventilation", "Electrophoretic Mobility Shift Assay", "Escherichia Coli", "Models, Molecular", "Binding Sites", "Gene Expression", "Humans", "Intellectual Disability", "Amino Acid Sequence", "Cloning, Molecular", "Facies", "Recombinant Proteins", "Protein Conformation, Alpha-helical", "Nucleotide Motifs", "Sequence Alignment", "DNA", "Gene Expression Regulation, Developmental", "Base Sequence", "Mice", "X Chromosome Inactivation", "Animals", "5-Methylcytosine", "Epigenomics", "Humans", "Epigenesis, Genetic", "DNA Methylation", "Cytosine", "Frontal Lobe", "Genome-Wide Association Study", "Conserved Sequence", "Mice, Inbred C57BL", "Longevity", "Adult", "Catalytic Domain", "Hydrolysis", "Pancreatic Neoplasms", "Cattle", "Molecular Probes", "Green Fluorescent Proteins", "Molecular Sequence Data", "Animals", "Peptide Hydrolases", "Trypsin", "Amino Acid Sequence", "Cell Line, Tumor", "Enzyme Activation", "Protein Engineering", "Humans", "Drug Design", "Methylnitronitrosoguanidine", "Amnion", "Sphingomyelins", "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization", "Lipid Metabolism", "Cell Line", "Gene Expression Profiling", "Gene Expression Regulation", "Humans", "Sulfites", "5-Methylcytosine", "Cytosine", "Chromatography, Liquid", "Mass Spectrometry", "Polymerase Chain Reaction", "Base Sequence", "Molecular Sequence Data", "Preeclampsia", "Epigenetics", "Pregnancy", "Pre-Eclampsia", "DNA Methylation", "Epigenomics", "Autoantibodies", "Enzyme Replacement Therapy", "Placenta", "Adenosine", "Dna Hypomethylation", "Mice", "Cells, Cultured", "Treatment Outcome", "Trophoblasts", "Animals", "Adenosine Deaminase", "Humans", "Female", "Disease Models, Animal", "Arabidopsis Proteins", "Neoplasms", "ORAI1 Protein", "Luminescent Proteins", "Neoplasm Proteins", "Recombinant Proteins", "Cryptochromes", "Ion Channel Gating", "Calcium", "High-Throughput Nucleotide Sequencing", "HEK293 Cells", "Optogenetics", "Mutation", "Protein Engineering", "Stromal Interaction Molecule 1", "Humans", "Signal Transduction", "Structure-Activity Relationship", "Bacterial Proteins", "Viral Nonstructural Proteins", "Protein Structure, Tertiary", "Rubella Virus", "Animals", "Magnetic Resonance Spectroscopy", "Zinc", "Calmodulin", "Peptides", "Vero Cells", "Calcium", "Chlorocebus Aethiops", "Binding Sites", "Mutagenesis, Site-Directed", "Cysteine Proteases", "Spectrometry, Fluorescence", "Rna, Long Noncoding", "RNA", "Gene Expression Regulation, Neoplastic", "RNA Processing, Post-Transcriptional", "RNA, Messenger", "Transcriptome", "Rna Modifications", "RNA, Transfer", "Animals", "Epitranscriptome", "Neoplasms", "Gene Expression Profiling", "RNA, Ribosomal", "Humans", "Epigenesis, Genetic", "Adenosine", "Cancer", "Dna Methyltransferase 3a", "DNA-Binding Proteins", "Enhancer Of Zeste Homolog 2 Protein", "Humans", "Chromosome Aberrations", "Dna (cytosine-5-)-methyltransferases", "Aged, 80 And Over", "Polycomb Repressive Complex 2", "Male", "Mutation", "Aged", "Histone Demethylases", "Nuclear Proteins", "Middle Aged", "Leukemia, Myelomonocytic, Chronic", "DNA Mutational Analysis", "Female", "Transcription Factors", "Adult", "Survival Analysis", "Gene Expression Regulation, Leukemic", "Phenylalanine", "Binding Sites", "Amino Acid", "Molecular Sequence Data", "Sequence Alignment", "Humans", "Protein Structure, Tertiary", "Calcium", "Thermodynamics", "Cooperativity", "G Protein-coupled Receptors (gpcr)", "Principal Component Analysis", "Calcium Imaging", "Intracellular Space", "Calcium Signaling", "Calcium-sensing Receptor", "Amino Acid Sequence", "HEK293 Cells", "Molecular Dynamics Simulation", "Mutation", "Mutant Proteins", "Calcium Oscillation", "Receptors, Calcium-sensing", "Dna Modification Methylases", "Histones", "DNA Methylation", "Protein Isoforms", "Mice", "Animals", "5-methylcytosine Oxidation", "Sequence Analysis, DNA", "Cytosine", "DNA", "Hierarchical Modeling", "Bs-seq/oxbs-seq/tab-seq/fcab-seq/cab-seq/redbs-seq/mab-seq", "5-Methylcytosine", "Tet Proteins", "Bisulfite Sequencing", "Humans", "DNA-Binding Proteins", "Oxidation-Reduction", "Embryonic Stem Cells", "DNA Methylation", "Bayesian Analysis", "Bayes Theorem" ],
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