# positions[].organizations[].label
Center for Infectious and Inflammatory Diseases

# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Our laboratory is studying the molecular mechanisms of innate immune recognition by identification and analysis of receptors involved in innate immune recognition and activated signaling pathways. We are particularly interested in the recently identified family of Toll-like receptors, which play a critical role in the mounting of innate immune responses. We wish to understand the mechanisms by which TLRs recognize different pathogen associate molecular patterns (PAMPs), as well as the regulatory mechanisms of TLR signal pathways that lead to NF- k B activation. We are also interested in studying the important links between chronic infection, inflammation and cancer by utilizing biochemical as well as whole animal approaches.

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Hypoxia-Inducible Factor 1, Alpha Subunit

# educationAndTraining[].organization.label
Yale University - (New Haven, Connecticut, United States)

# educationAndTraining[].organization.label
University of Hong Kong - (Hong Kong, Hong Kong, China)

# educationAndTraining[].organization.label
Howard Hughes Medical Institute - (Chevy Chase, Maryland, United States)

# publications[].label
Telomerase activity in gestational trophoblastic disease.

# publications[].label
Transcriptional regulation of Tlr11 gene expression in epithelial cells.

# publications[].label
Prevalence of HPV infection in esophageal squamous cell carcinoma in Chinese patients and its relationship to the p53 gene mutation.

# publications[].label
USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase.

# publications[].label
Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: a prospective clinico-pathological study and survival analysis of 70 patients.

# publications[].label
Immortalization of human prostate epithelial cells by HPV 16 E6/E7 open reading frames.

# publications[].label
A novel Toll-like receptor that recognizes vesicular stomatitis virus.

# publications[].label
Tumor necrosis factor-alpha induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation.

# publications[].label
LMP1 of Epstein-Barr virus induces proliferation of primary mouse embryonic fibroblasts and cooperatively transforms the cells with a p16-insensitive CDK4 oncogene.

# publications[].label
Homeobox A11 hypermethylation indicates unfavorable prognosis in breast cancer.

# publications[].label
Effect of insulin-like growth factor 1 on PHA-stimulated cord blood mononuclear cell telomerase activity.

# publications[].label
Presence of human papillomavirus in esophageal squamous cell carcinomas of Hong Kong Chinese and its relationship with p53 gene mutation.

# publications[].label
Phospholipase C2 (PLC2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses.

# publications[].label
Delineating the Role of Toll-Like Receptors in Inflammatory Bowel Disease.

# publications[].label
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.

# publications[].label
Clinical significance of telomerase activation and telomeric restriction fragment (TRF) in cervical cancer.

# publications[].label
Toll-like receptors and prostate cancer.

# publications[].label
IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response.

# publications[].label
A reliable detachable balloon that prevents abdominal cavity contamination during transrectal natural orifice transluminal endoscopic surgery.

# publications[].label
Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13.

# publications[].label
Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression.

# publications[].label
Circulating tumor cells (CTCs) detected by triple-marker EpCAM, CK19, and hMAM RT-PCR and their relation to clinical outcome in metastatic breast cancer patients.

# publications[].label
Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines.

# publications[].label
Up-regulation of Toll-like Receptor 9 in Osteosarcoma.

# publications[].label
Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a.

# publications[].label
A toll-like receptor that prevents infection by uropathogenic bacteria.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
TLR11 activation of dendritic cells by a protozoan profilin-like protein.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Genomic structure, chromosomal mapping, and promoter region analysis of murine uridine phosphorylase gene.

# publications[].label
Neuroprotection by IFN- via astrocyte-secreted IL-6 in acute neuroinflammation.

# publications[].label
Uridine phosphorylase association with vimentin. Intracellular distribution and localization.

# publications[].label
A High-Quality Biobank Supports Breast Cancer Research in Harbin, China.

# publications[].label
A mouse model of Salmonella typhi infection.

# publications[].label
Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update.

# publications[].label
p53-dependent suppression of uridine phosphorylase gene expression through direct promoter interaction.

# publications[].label
Expression profile of senescence-associated beta-galactosidase and activation of telomerase in human ovarian surface epithelial cells undergoing immortalization.

# publications[].label
Toll-like Receptors and Inflammatory Bowel Disease.

# publications[].label
Hypoxia-Induced TPM2 Methylation is Associated with Chemoresistance and Poor Prognosis in Breast Cancer.

# publications[].label
MAP1S Protein Regulates the Phagocytosis of Bacteria and Toll-like Receptor (TLR) Signaling.

# publications[].label
Transcriptional regulation of the novel Toll-like receptor Tlr13.

# publications[].label
Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression.

# publications[].label
Toll-like receptor 11 (TLR11) prevents Salmonella penetration into the murine Peyer patches.

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M Health Science Center; Ibt-Ciid-Hook; 1201 TAMUS

# organizations[]
Center for Infectious and Inflammatory Diseases

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine