# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Our research focuses on understanding the mechanisms by which immune system activation causes organ dysfunction and various forms of hypertension.

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Perinatal Period - Conditions Originating In Perinatal Period

# keywords[]
Ryanodine Receptor Calcium Release Channel

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Receptors, Transforming Growth Factor Beta

# keywords[]
Ryanodine Receptor Calcium Release Channel

# keywords[]
Platelet Endothelial Cell Adhesion Molecule-1

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Drug-Related Side Effects And Adverse Reactions

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
Ryanodine Receptor Calcium Release Channel

# keywords[]
Platelet Endothelial Cell Adhesion Molecule-1

# keywords[]
Hypoxia-Inducible Factor 1, Alpha Subunit

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
Ryanodine Receptor Calcium Release Channel

# keywords[]
Immune System Immunologic Factors Pregnancy

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
Receptors, Transforming Growth Factor Beta

# keywords[]
Perinatal Period - Conditions Originating In Perinatal Period

# educationAndTraining[].organization.label
University of Wisconsin-Extension - (Madison, Wisconsin, United States)

# educationAndTraining[].organization.label
Augusta University - (Augusta, Georgia, United States)

# educationAndTraining[].organization.label
Gustavus Adolphus College - (Saint Peter, Minnesota, United States)

# awardsAndHonors[].label
Distinguished Alumni Award - Graduate School

# publications[].label
Elevated Salt or Angiotensin II Levels Induce CD38+ Innate Immune Cells in the Presence of Granulocyte-Macrophage Colony Stimulating Factor.

# publications[].label
Genetically inducing renal lymphangiogenesis attenuates hypertension in mice.

# publications[].label
Genetically Induced Renal Lymphangiogenesis Prevents the Development of L-NAME Hypertension in Mice.

# publications[].label
Abstract 095: CD74 Deficient Mice are Resistant to Toll-Like Receptor-Induced Preeclampsia

# publications[].label
Regulation of the Anti-Inflammatory Cytokines Interleukin-4 and Interleukin-10 during Pregnancy.

# publications[].label
Time restricted feeding decreases renal innate immune cells and blood pressure in hypertensive mice.

# publications[].label
Metabolomic Study To Identify Common Metabolites In Two Different Mouse Models Of Hypertension

# publications[].label
Endothelial Cell-Specific Genetic Deletion of FKBP12 Leads to Vascular TGF-beta Receptor Activation, Remodeling, Inflammation, and Hypertension

# publications[].label
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages.

# publications[].label
Decreased endothelium-dependent relaxation and altered eNOS in FKBP12.6 deficient mice

# publications[].label
Immunosuppression ameliorates hypertension, endothelial dysfunction, and proteinuria in a rat model of preeclampsia

# publications[].label
Abstract 098: Augmenting Renal Lymphatic Vessel Density Prevents Salt-sensitive Hypertension in Mice

# publications[].label
Therapeutic Induction of Renal Lymphatic Expansion Attenuates Blood Pressure in Mice With L-NAME Hypertension

# publications[].label
Phenylalanine improves dilation and blood pressure in GTP cyclohydrolase inhibition-induced hypertensive rats.

# publications[].label
Abstract P145: Renal Inflammation and Injury is Associated with Increased Lymphangiogenesis in Hypertension

# publications[].label
Abstract 545: PLacental eXpanded (PLX) Cell Treatment Ameliorates Preeclampsia Induced by TLR3 or TLR7 Activation in Mice

# publications[].label
Altered Testicular Macrophage Polarization Is Associated With Reproductive Dysfunction In Hypertensive Mice

# publications[].label
Phosphorylation of cardiac Myosin-binding protein-C is a critical mediator of diastolic function.

# publications[].label
Tacrolimus reduces nitric oxide synthase function by binding to FKBP rather than by its calcineurin effect.

# publications[].label
Double-Stranded RNA Receptor Activation Causes Preeclampsia and Decreases NFAT5 Expression by Increasing Placental miRNA-210

# publications[].label
Depletion of MHC class II invariant chain peptide or - T-cells ameliorates experimental preeclampsia.

# publications[].label
PLacental eXpanded (PLX) Cell Treatment Ameliorates Preeclampsia Induced by TLR3 or TLR7 Activation in Mice

# publications[].label
Sepiapterin decreases vasorelaxation in nitric oxide synthase inhibition-induced hypertension.

# publications[].label
Augmenting Renal Lymphatic Vessel Density Prevents Salt-sensitive Hypertension in Mice.

# publications[].label
Left ventricular structure and function in obese adolescents: relations to cardiovascular fitness, percent body fat, and visceral adiposity, and effects of physical training.

# publications[].label
778: Excessive placental Toll-like receptor 7/8 signaling contributes to human and experimental preeclampsia

# publications[].label
Midodrine prevents post-spaceflight orthostatic intolerance when administered 1 hour before tilt test

# publications[].label
Renal Inflammation and Injury is Associated with Increased Lymphangiogenesis in Hypertension

# publications[].label
FK506 binding protein 12 deficiency in endothelial and hematopoietic cells decreases regulatory T cells and causes hypertension.

# publications[].label
Resibufogenin Prevents the Manifestations of Preeclampsia in an Animal Model of the Syndrome

# publications[].label
Pin1 deficiency causes endothelial dysfunction and hypertension.

# publications[].label
Combined Interleukin-4 and Interleukin-10 Treatment Prevents Preeclampsia in Mice

# publications[].label
Identification of Cyr61 and Tfgbi as Hypertensive Renal LEC Genes.

# publications[].label
Marinobufagenin inhibits proliferation and migration of cytotrophoblast and CHO cells.

# publications[].label
Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Abstract 065: Decreasing Blood Pressure In Mice With Salt-Sensitive Hypertension Changes Renal Immune Cell Populations

# publications[].label
Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads.

# publications[].label
Abstract 208: TLR3-Induced Placental miR-210 Down-Regulates the STAT6/IL-4 Pathway

# publications[].label
Abstract 179: TLR3 Deficiency Attenuates Preeclampsia-Like Symptoms in Mice

# publications[].label
Interleukin-10 reduces inflammation, endothelial dysfunction, and blood pressure in hypertensive pregnant rats.

# publications[].label
Both maternal and placental toll-like receptor activation are necessary for the full development of proteinuric hypertension in mice.

# publications[].label
GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats.

# publications[].label
Abstract 143: Enhancing Renal Lymphatic Vessel Density Blunts Both Salt-Sensitive and Angiotensin II-Dependent Hypertension in Mice

# publications[].label
Cotreatment with interleukin 4 and interleukin 10 modulates immune cells and prevents hypertension in pregnant mice.

# publications[].label
Toll-Like Receptor 3 Activation Induces Hypertension and Endothelial Dysfunction Only in Pregnant Mice

# publications[].label
Inhibition of the Prolyl Isomerase Pin1 Increases eNOS Ser116 Phosphorylation, Endothelial Dysfunction, and Blood Pressure

# publications[].label
Abstract 024: Genetically Inducing Renal Lymphangiogenesis Prevents Angiotensin II-Induced Hypertension in Mice

# publications[].label
Serial exercise performance in children with surgically corrected congenital aortic stenosis.

# publications[].label
Abstract 460: IL-33 Treatment Prevents Cyclosporine A-Induced Hypertension, Endothelial Dysfunction, and Vascular Remodeling in Mice

# publications[].label
The immunosuppressive drugs rapamycin and FK506 decrease vasodilation by increasing PKCbetaI-mediated phosphorylation of eNOS Thr495

# publications[].label
Uncoupled endothelial nitric oxide synthase and oxidative stress in a rat model of pregnancy-induced hypertension.

# publications[].label
Renal inflammation and injury are associated with lymphangiogenesis in hypertension.

# publications[].label
Abstract P132: A Kidney-Targeted Nanoparticle To Augment Renal Lymphatic Density Decreases Blood Pressure In Mice With L-NAME- And Angiotensin II-Induced Hypertension

# publications[].label
Common Metabolites in Two Different Hypertensive Mouse Models: A Serum and Urine Metabolome Study.

# publications[].label
Regulatory T-Cell Augmentation or Interleukin-17 Inhibition Prevents Calcineurin Inhibitor-Induced Hypertension in Mice.

# publications[].label
Altered FKBP12/12.6 decreases NO production by increasing cPKCmediated phosphorylation of eNOS at thr495

# publications[].label
FK506 Induces Renal Arteriolar Hyalinosis via SMAD2/3 Activation in Mice

# publications[].label
Abstract 459: Myeloid-Derived Suppressor Cells (MDSCs) Prevent Cyclosporine A-Induced Vascular and Renal Endothelial Cell Injury

# publications[].label
Augmenting Renal Lymphatic Density Prevents Angiotensin II-Induced Hypertension in Male and Female Mice.

# publications[].label
IL-33 Treatment Prevents Cyclosporine A-Induced Hypertension, Endothelial Dysfunction, and Vascular Remodeling in Mice

# publications[].label
Enhancing Renal Lymphatic Vessel Density Blunts Both Salt-Sensitive and Angiotensin II-Dependent Hypertension in Mice

# publications[].label
Methods and products for treating preeclampsia and modulating blood pressure

# publications[].label
Is IL-12 pro-inflammatory or anti-inflammatory? Depends on the blood pressure.

# publications[].label
PLX-PAD cell treatment mitigate toll-like receptor induced preeclampsia symptomology in mice

# publications[].label
CARDIAC MYOSIN BINDING PROTEIN-C PHOSPHORYLATION ENHANCES DIASTOLIC FUNCTION DESPITE AGING

# publications[].label
Imbalance Of M1/M2 Macrophages In Ovaries Of Hypertensive Mice Is Associated With Reproductive Dysfunction And Lymphangiogenesis

# publications[].label
796: The role of single-stranded RNA in the development of preeclampsia

# publications[].label
A Kidney-Targeted Nanoparticle to Augment Renal Lymphatic Density Decreases Blood Pressure in Hypertensive Mice.

# publications[].label
Enhancing Renal Lymphatic Expansion Prevents Hypertension in Mice.

# publications[].label
Abstract P110: Differential Gene Expression Associated With Ccn1-positive Renal Cells In Murine Hypertensive Models

# publications[].label
Plasma volume restoration with salt tablets and water after bed rest prevents orthostatic hypotension and changes in supine hemodynamic and endocrine variables.

# publications[].label
The immunophilin inhibitor juglone decreases NO bioavailability and vasodilation by inhibiting glutathione S-transferase

# publications[].label
Alteration of the renin-angiotensin system in a rat model of preeclampsia

# publications[].label
Abstract P146: Testicular Inflammation Is Associated With Immune Cell Infiltration And Lymphangiogenesis In L-NAME-induced Hypertension

# publications[].label
Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension.

# publications[].label
Abstract P166: Identification of Cyr61 and Tfgbi as Hypertensive Renal LEC Genes

# publications[].label
Mechanisms of FK506-induced decrease in nitric oxide production and endothelial function

# publications[].label
Abstract 7: Both Maternal Systemic and Paternal-Derived Placental Trophoblast TLR3 Activation Are Necessary for the Development of Preeclampsia in Mice

# publications[].label
Short-duration spaceflight does not prolong QTc intervals in male astronauts.

# publications[].label
Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

# publications[].label
FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure.

# publications[].label
Similar Placental miRNA Expression Profiles in Mice with Toll-Like Receptor 3-Induced Gestational Hypertension and Women with Preeclampsia

# publications[].label
Interleukin 10 deficiency exacerbates toll-like receptor 3-induced preeclampsia-like symptoms in mice.

# publications[].label
Abstract P086: Blood Pressure And Salt Differentially Regulate Testicular Immune Cell Populations In Hypertensive Mice

# publications[].label
Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblast function.

# publications[].label
Genetically Inducing Renal Lymphangiogenesis Prevents Angiotensin II-Induced Hypertension in Mice

# publications[].label
Immune cell trafficking, lymphatics and hypertension.

# publications[].label
Abstract P3020: Therapeutic Induction of Renal Lymphatic Expansion Attenuates Blood Pressure in Mice With L-NAME Hypertension

# publications[].label
Abstract P339: Genetically Induced Renal Lymphangiogenesis Prevents the Development of L-NAME Hypertension in Mice

# publications[].label
Retinoic Acid Prevents the Hypertension, Endothelial Dysfunction, and Decrease in Regulatory T Cells Caused by Immunosuppressive Drugs

# publications[].label
Hypertensive Stimuli Indirectly Stimulate Mouse Mesometrial Lymphangiogenesis Through Immune Cells

# publications[].label
Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury.

# publications[].publisher
Ovid Technologies (Wolters Kluwer Health)

# publications[].label
Human placenta-derived stromal cells decrease inflammation, placental injury and blood pressure in hypertensive pregnant mice.

# publications[].label
High Dose Vardenafil Blunts the Hypertensive Effects of Toll-Like Receptor 3 Activation During Pregnancy

# publications[].label
Abstract P183: Myeloid-Derived Suppressor Cells Prevent Cyclosporine A-Induced Hypertension, Endothelial Dysfunction, and Renal Injury in Mice

# publications[].label
Interleukin-4 deficiency induces mild preeclampsia in mice.

# publications[].label
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of lowering blood pressure.

# publications[].label
Midodrine prescribed to improve recurrent post-spaceflight orthostatic hypotension.

# publications[].label
Hypertensive Stimuli Indirectly Stimulate Lymphangiogenesis through Immune Cell Secreted Factors.

# publications[].label
Interleukin-17 Causes Endothelial Dysfunction by Increasing Rho Kinase-Mediated Phosphorylation of eNOS Thr495

# publications[].label
Resibufogenin prevents the manifestations of preeclampsia in an animal model of the syndrome.

# publications[].label
Microbiome-associated Metabolites Are Altered In Mouse Models Of Hypertension

# publications[].label
Recent Advances in Immunity and Hypertension.

# publications[].label
Sodium, Interstitium, Lymphatics, and Hypertension-A Tale of Hydraulics: Salt Series.

# publications[].publisher
Ovid Technologies (Wolters Kluwer Health)

# publications[].label
Displacement of FKBP12 and 12.6 from ryanodine receptors abolishes endothelial nitric oxide production and augments blood pressure

# publications[].label
Interleukin-4 Treatment Prevents Toll-Like Receptor 3-Induced Gestational Hypertension and Endothelial Dysfunction in Mice

# publications[].label
Abstract P178: Depletion of Gamma-Delta T Cells Protects Against Toll-Like Receptor-Induced Preeclampsia in Mice

# publications[].label
GTP cyclohydrolase 1 downregulation contributes to glucocorticoid hypertension in rats.

# publications[].label
769: Activation of double-stranded rna receptors contributes to preeclampsia

# publications[].label
Increased nitric oxide synthase activity and Hsp90 association in skeletal muscle following chronic exercise

# publications[].label
Time-restricted Feeding Attenuates Hypertension In Mice

# publications[].label
Indole Propionic Acid Increases T Regulatory Cells and Decreases T Helper 17 Cells and Blood Pressure in Mice with Salt-Sensitive Hypertension.

# publications[].label
The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway.

# publications[].label
Myeloid-Derived Suppressor Cells (MDSCs) Prevent Cyclosporine A-Induced Vascular and Renal Endothelial Cell Injury

# publications[].label
742: IL-4 KO mice exhibit gestational hypertension which is augmented following dsRNA-induced maternal immune system activation

# publications[].label
Do double-stranded RNA receptors play a role in preeclampsia?

# publications[].label
Toll-like receptor 3 activation during pregnancy elicits preeclampsia-like symptoms in rats.

# publications[].label
Removal of FKBP12/12.6 from endothelial ryanodine receptors leads to an intracellular calcium leak and endothelial dysfunction.

# publications[].label
Genetic Deletion of Interleukin-4 or Interleukin-10 Causes Preeclampsia by Differentially Modulating Immune Cells in Mice

# publications[].label
Four Pathways Involving Innate Immunity in the Pathogenesis of Preeclampsia.

# publications[].label
Toll-like receptor activation, vascular endothelial function, and hypertensive disorders of pregnancy.

# publications[].label
Abstract 173: Depletion of CLIP+ Immune Cells Prevents Toll-Like Receptor-Induced Preeclampsia in Mice

# publications[].label
Update on Immune Mechanisms in Hypertension.

# publications[].label
Abstract 448: Cyclosporine A-Induced Increases in Th17 Cells, Endothelial Dysfunction, and Blood Pressure are Prevented by IL-17 Inhibition

# publications[].label
Deficiency of miR-155 Attenuates TLR3-Induced Preeclampsia-Like Symptoms in Mice

# publications[].label
Increased nitric oxide synthase activity and Hsp90 association in skeletal muscle following chronic exercise.

# publications[].label
Endothelial cell transforming growth factor- receptor activation causes tacrolimus-induced renal arteriolar hyalinosis.

# publications[].label
Impaired vasodilation and nitric oxide synthase activity in glucocorticoid-induced hypertension.

# publications[].label
Protein kinase CbetaII-mediated phosphorylation of endothelial nitric oxide synthase threonine 495 mediates the endothelial dysfunction induced by FK506 (tacrolimus).

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Both Maternal Systemic and Paternal-Derived Placental Trophoblast TLR3 Activation Are Necessary for the Development of Preeclampsia in Mice

# publications[].label
Abstract 668: Deficiency of miR-155 Attenuates TLR3-Induced Preeclampsia-Like Symptoms in Mice

# publications[].label
Myeloid-Derived Suppressor Cells Ameliorate Cyclosporine A-Induced Hypertension in Mice.

# publications[].label
MYELOID-DERIVED SUPPRESSOR CELLS (MDSCS) PREVENT CYCLOSPORINE A-INDUCED HYPERTENSION AND VASCULAR AND RENAL TOXICITY

# researcherOn[].label
Determining how microbiota-derived tryptophan metabolites regulate lymphocyte function in hypertension

# researcherOn[].awardedBy.label
American Heart Association - (New York, New York, United States)

# researcherOn[].label
Role of Immune Cells in Immunosuppressive Drug-Induced Hypertension

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Heart, Lung, and Blood Institute

# researcherOn[].label
Texas A&M College of Medicine Developing and Readying Underrepresented Minority Researchers (DRUMR) Summer Research Program

# researcherOn[].awardedBy.label
National Institute of Diabetes and Digestive and Kidney Diseases - (Bethesda, Maryland, United States)

# researcherOn[].label
Role of renal lymphatics in blood pressure regulation

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Texas A&M Health Science Center Summer Research Program-AHA SURF Program

# researcherOn[].awardedBy.label
American Heart Association - (New York, New York, United States)

# researcherOn[].awardedBy.label
American Heart Association - (New York, New York, United States)

# streetAddress
Texas A&M Health Science Center; Medical Physiology; MREBII, 2412

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine