# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Our lab has been examining the biology of MSCs with a view to developing rapid molecular markers and tests for evaluating/purifying maximally efficacious cultures of MSCs.  The group also specializes in bone repair by MSCs. Based on detailed characterization of the molecular mechanism of osteoblast differentiation by MSCs, a novel and effective bone regeneration strategy has been developed.   Additionally, we are currently examining the effects of various small molecules and immunological strategies for the safe and effective inhibition of Dkk-1 activity in bone tumors.We have recently established methods to model bone-tumor interactions using bioreactors that simulate microgravity.

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell - Human

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Networking And Information Technology R&d (nitrd)

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
OSTEOGENICALLY ENHANCED MESENCHYMAL STEM CELLS

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
Tulane University - (New Orleans, Louisiana, United States)

# educationAndTraining[].organization.label
University of Manchester - (Manchester, Manchester, United Kingdom)

# educationAndTraining[].organization.label
Wellcome Centre for Cell-Matrix Research - (Manchester, United Kingdom)

# educationAndTraining[].organization.label
University of York - (York, York, United Kingdom)

# awardsAndHonors[].label
Tulane University Competitive Research Award.

# awardsAndHonors[].label
Junior Faculty Research Excellence Award

# publications[].label
How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow.

# publications[].label
The promise of canonical Wnt signaling modulators in enhancing bone repair.

# publications[].label
Development of a 3D Type I Collagen Assay to Evaluate Chondrogenesis of Canine Bone Marrow-Derived Mesenchymal Stem Cells

# publications[].label
The effects of the Er:YAG laser on trabecular bone micro-architecture: Comparison with conventional dental drilling by micro-computed tomographic and histological techniques.

# publications[].label
One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
In-vitro characterization of canine multipotent stromal cells isolated from synovium, bone marrow, and adipose tissue: a donor-matched comparative study.

# publications[].label
Use of Osteogenically Enhanced Mesenchymal Stem Cells and Their Cell-Derived Matrices for Bone Tissue Engineering

# publications[].label
The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow.

# publications[].label
Advances in myeloma therapy: breaking the cycle

# publications[].label
Metaphyseal chondrodysplasia type Schmid mutations are predicted to occur in two distinct three-dimensional clusters within type X collagen NC1 domains that retain the ability to trimerize.

# publications[].label
Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90.

# publications[].label
Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation.

# publications[].label
An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction.

# publications[].label
Canine Mesenchymal Stromal Cell-Mediated Bone Regeneration is Enhanced in the Presence of Sub-Therapeutic Concentrations of BMP-2 in a Murine Calvarial Defect Model.

# publications[].label
Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma.

# publications[].label
Human mesenchymal stem cell-derived matrices for enhanced osteoregeneration.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Interplay between degradability and integrin signaling on mesenchymal stem cell function within porous poly(Ethylene glycol) microgel scaffolds

# publications[].label
Conditioning of 3D Printed Nanoengineered Ionic-Covalent Entanglement Scaffolds with iP-hMSCs Derived Matrix.

# publications[].label
Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of osteoinhibition.

# publications[].label
Risk modelling of fires and explosions in open-sided offshore platform modules

# publications[].label
CD133 identifies a human bone marrow stem/progenitor cell sub-population with a repertoire of secreted factors that protect against stroke.

# publications[].label
Author Correction: Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma.

# publications[].label
Erratum: iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers.

# publications[].label
Comparison of the anti-inflammatory effects of induced pluripotent stem cell-derived and bone marrow-derived mesenchymal stromal cells in a murine model of corneal injury.

# publications[].label
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies.

# publications[].label
Stem Cell-Derived Live Bone Mimics for Superior Spinal Arthrodesis

# publications[].label
Integrated microfluidic system for the processing of membrane proteins isolated from stem cells

# publications[].label
A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma.

# publications[].label
Bone Marrow Aspirate Quality from the Anterior Iliac Crest in Relationship to Age, Gender and Tobacco Use

# publications[].label
Potential of modulating Wnt signaling pathway toward the development of bone anabolic agent.

# publications[].label
Human Mesenchymal Stem Cell-Derived Matrices for Enhanced Osteoregeneration (vol 4, 149er5, 2012)

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Pharmaceutical inhibition of glycogen synthetase kinase-3 reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft model.

# publications[].label
MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Enhanced engraftment of mesenchymal stem cells in a cutaneous wound model by culture in allogenic species-specific serum and administration in fibrin constructs.

# publications[].label
Accelerated Bone Healing in Calvarial and Femoral Defects with Injectable Microcarriers that Mimic the Osteogenic Niche

# publications[].label
How stem cell composition in bone marrow aspirate relates to clinical outcomes when used for cervical spine fusion.

# publications[].label
A three-dimensional (3D), serum-free, Collagen Type I system for chondrogenesis of canine bone marrow-derived multipotent stromal cells (cMSCs).

# publications[].label
Mechanisms of mesenchymal stem/stromal cell function.

# publications[].label
A scalable system for generation of mesenchymal stem cells derived from induced pluripotent cells employing bioreactors and degradable microcarriers.

# publications[].label
Widespread changes in transcriptome profile of human mesenchymal stem cells induced by 2D nanosilicates

# publications[].label
Compositions of mesenchymal stem cells to regenerate bone

# publications[].label
Preparation of osteogenic matrices from cultured cells.

# publications[].label
Creating Physicochemical Gradients in Modular Microporous Annealed Particle Hydrogels via a Microfluidic Method.

# publications[].label
Leukemia inhibitory factor secretion is a predictor and indicator of early progenitor status in adult bone marrow stromal cells.

# publications[].label
Dkk-1-derived synthetic peptides and lithium chloride for the control and recovery of adult stem cells from bone marrow.

# publications[].label
Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs).

# publications[].label
Short Term Culture of Human Mesenchymal Stem Cells with Commercial Osteoconductive Carriers Provides Unique Insights into Biocompatibility.

# publications[].label
Quantification of Escherichia coli genomic DNA contamination in recombinant protein preparations by polymerase chain reaction and affinity-based collection.

# publications[].label
Equal expression of typ X collagen mRNA fom mutant and wild type COL10A1 alleles in growth plate cartilage from a patient with metaphyseal chondrodysplasia type Schmid.

# publications[].label
The efficacy of acquired humoral and cellular immunity in the prevention and therapy of experimental fungal infections.

# publications[].label
Repeated intra-articular injection of allogeneic mesenchymal stem cells causes an adverse response compared to autologous cells in the equine model.

# publications[].label
Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy.

# publications[].label
Fundamentals of Culture and Characterization of Mesenchymal Stem/Progenitor Cells (MSCs) from Bone Marrow Stroma

# publications[].label
Interplay between degradability and integrin signaling on mesenchymal stem cell function within poly(ethylene glycol) based microporous annealed particle hydrogels.

# publications[].label
Custom Imaging Chamber for Multimodal Volumetric Microscopy

# publications[].label
Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1.

# publications[].label
Characterization of a pluripotent stem cell-derived matrix with powerful osteoregenerative capabilities.

# publications[].label
Pharmaceutical Induction of ApoE Secretion

# publications[].label
Automated mesenchymal stem cell segmentation and machine learning-based phenotype classification using morphometric and textural analysis.

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Rapid Osteogenic Enhancement of Stem Cells in Human Bone Marrow Using a Glycogen-Synthease-Kinase-3-Beta Inhibitor Improves Osteogenic Efficacy In Vitro and In Vivo.

# publications[].label
Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It.

# publications[].label
Volumetric Imaging of Human Mesenchymal Stem Cells (hMSCs) for Non-Destructive Quantification of 3D Cell Culture Growth

# publications[].label
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies.

# publications[].label
Dissociation of nanosilicates induces downstream endochondral differentiation gene expression program.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Time-lapse microscopic observation of non-dividing cells in cultured human osteosarcoma MG-63 cell line.

# publications[].label
Adult bone marrow stem/progenitor cells (MSCs) are preconditioned by microenvironmental "niches" in culture: a two-stage hypothesis for regulation of MSC fate.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Theobromine Upregulates Osteogenesis by Human Mesenchymal Stem Cells In Vitro and Accelerates Bone Development in Rats.

# publications[].label
Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells.

# publications[].label
An allograft generated from adult stem cells and their secreted products efficiently fuses vertebrae in immunocompromised athymic rats and inhibits local immune responses.

# publications[].label
Canine Mesenchymal Stem Cell-Mediated Bone Regeneration is Enhanced in the Presence of Sub-Therapeutic Concentrations of Rhbmp-2 in a Murine Critical-Sized Calvarial Defect

# publications[].label
Editorial: Approaches That Foster a Pro-Regenerative Environment.

# publications[].label
Optimizing a Critical Gap Femoral Defect Model for Objective Assessment of Bone Regeneration in Dogs

# publications[].label
Scalable manufacture of therapeutic mesenchymal stromal cell products on customizable microcarriers in vertical wheel bioreactors that improve direct visualization, product harvest, and cost.

# publications[].label
The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice.

# publications[].label
Morphological cell image analysis for real-time monitoring of stem cell culture

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Donor Site Morbidity and In Vitro Analysis of the Osteogenic Potential of Bone Marrow Aspirate Concentrate from the Anterior Iliac Crest

# publications[].label
MM-induced osteolysis: partners in crime.

# publications[].label
An unexpected role for a Wnt-inhibitor: Dickkopf-1 triggers a novel cancer survival mechanism through modulation of aldehyde-dehydrogenase-1 activity.

# publications[].label
The efficacy of acquired humoral and cellular immunity in the prevention and therapy of experimental fungal infections

# publications[].label
More progress defining the crosstalk between multiple myeloma and mesenchymal stem cells of the bone marrow.

# publications[].label
A simple critical-sized femoral defect model in mice.

# publications[].label
In vitro MSC function is related to clinical reaction in vivo.

# publications[].label
Morpholino-driven transcriptional blockade of Dkk-1 in experimental osteosarcoma inhibits bone damage and tumor expansion by multiple mechanisms.

# publications[].label
iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers.

# publications[].label
Assays of osteogenic differentiation by cultured human mesenchymal stem cells.

# publications[].label
Bone regeneration with osteogenically enhanced mesenchymal stem cells and their extracellular matrix proteins.

# publications[].label
Mesenchymal stem cells and supports for tissue regeneration, repair and reconstruction

# publications[].label
U-Net based image segmentation of mesenchymal stem cells

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Mesenchymal Stem Cells: From Culture to Clinic

# publications[].label
Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Mimicking the Organic and Inorganic Composition of Anabolic Bone Enhances Human Mesenchymal Stem Cell Osteoinduction and Scaffold Mechanical Properties.

# publications[].label
Angle-stable interlocking nailing in a canine critical-sized femoral defect model for bone regeneration studies: In pursuit of the principle of the 3R's.

# publications[].label
Morpholino-driven blockade of Dkk-1 in osteosarcoma inhibits bone damage and tumour expansion by multiple mechanisms.

# publications[].label
Optimizing In Vitro Osteogenesis in Canine Autologous and Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells with Dexamethasone and BMP-2.

# researcherOn[].label
Collaborative Research:  Enhancing Bone Regeneration by Mimicking the Osteogenic Niche

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# researcherOn[].label
Advanced Methods for Mimicking the Osteogenic Niche to Heal Bone

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Arthritis and Musculoskeletal and Skin Diseases

# researcherOn[].label
Nanoengineered bone repair scaffolds generated from stem cells and their secreted products for improved spinal fusion

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Arthritis and Musculoskeletal and Skin Diseases

# researcherOn[].label
Impact of the Anti-PEG Response on the Efficacy of PEG Hydrogel-Mediated Bone Regeneration

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Arthritis and Musculoskeletal and Skin Diseases

# researcherOn[].label
Targeting a Growth and Survival Pathway in Bone Tumor Cells.

# researcherOn[].awardedBy.label
Cancer Prevention and Research Institute of Texas - (Austin, Texas, United States)

# researcherOn[].label
Preparation and Distribution of Adult Stem Cells

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
An unlikely therapeutic target for malignant bone disease: Dkk-1 activates a stress resistance mechanism in bone tumor cells

# researcherOn[].awardedBy.label
Cancer Prevention and Research Institute of Texas - (Austin, Texas, United States)

# researcherOn[].label
I-CORPS: Stem Cell-Derived Scaffolds For Spinal Fusion And Maxillofacial Bone Repair

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# streetAddress
Texas A&M Health Science Center; Regenerative Medicine; 1114 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine

# inTheNews[].label
Primitive Stem Cells Could Be Used For Complicated Bone Fractures

# inTheNews[].label
Texas A&M Researchers Use 3D-Printed Biomaterials Laced With Stem Cells To Create Superior Bone Grafts

# inTheNews[].label
New hydrogels wither while stem cells flourish for tissue repair

# etdChairOf[].label
Silveira, Catrina J (2021-04). Fibroblast growth factor and its role in the chondrogenesis of canine mesenchymal stromal cells in three-dimensional collagen scaffolds. Master's Thesis.

# etdChairOf[].label
Mc Neill, Eoin (2019-12). Extracellular Matrix Secreted by Osteogenically Enhanced Mesenchymal Stem Cells Recapitulates the Osteogenic Microenvironment. Doctoral Dissertation.