# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# overview
Most bacterial viruses (phages) cause lysis of their host cell to release the progeny virions. Large phages elaborate an enzyme ("endolysin") to degrade the cell wall and also a small membrane protein ("holin"). The holin accumulates in the membrane and then, at a precisely scheduled time, suddenly forms a hole to allow release of endolysin through the cytoplasmic membrane to gain access to the wall. We use molecular genetics and biochemistry to study how this small protein is able to act as a molecular "clock" and punch holes in membranes. Small phages make single proteins which cause host lysis in a different way. This strategy is to target the host cell wall synthesis machinery; that is, the virus makes a "protein antibiotic" that causes lysis in the same way as antibiotics like penicillin by inhibiting an enzyme in the multi-step pathway of murein biosynthesis. Thus, when the infected cell tries to divide, it blows up, or lyses, because it can't make the new cell wall between the daughter cells. Remarkably, each of three different, small phages blocks a different step in the pathway. These small lysis proteins are models for a completely new class of antibacterial antibiotics. Also, the E. coli SlyD protein is required for this mode of lysis in one case. SlyD is a member of an ubiquitous family of proteins related to human "immunophilins," the targets of immune-suppression drugs. We study SlyD to learn about the role of this class of proteins in biology.

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
Consensus Development Conferences As Topic

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
3102 Bioinformatics And Computational Biology

# educationAndTraining[].organization.label
Rice University - (Houston, Texas, United States)

# educationAndTraining[].organization.label
The University of Texas at Dallas - (Richardson, Texas, United States)

# publications[].label
Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection.

# publications[].label
Functional bacteriorhodopsin is efficiently solubilized and delivered to membranes by the chaperonin GroEL.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Mutational analysis of the S21 pinholin.

# publications[].label
Identification and characterization of the Pasteurella haemolytica leukotoxin.

# publications[].label
Characterization of a tailocin from Burkholderia

# publications[].label
Purification and biochemical characterization of the lambda holin.

# publications[].label
Deletion analysis resolves cell-binding and lytic domains of the Pasteurella leukotoxin.

# publications[].label
The lambda holin accumulates beyond the lethal triggering concentration under hyperexpression conditions

# publications[].label
Phage of sulfate reducing bacteria isolated from high saline environment

# publications[].label
Phage remediation of microbe-induced corrosion

# publications[].label
Holins: form and function in bacteriophage lysis

# publications[].label
S gene expression and the timing of lysis by bacteriophage lambda.

# publications[].label
Thiol protection in membrane protein purifications: a study with phage holins.

# publications[].label
ssRNA phage penetration triggers detachment of the F-pilus.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Solubilization and delivery by GroEL of megadalton complexes of the lambda holin.

# publications[].label
Pneumonic pasteurellosis: examination of typable and untypable Pasteurella haemolytica strains for leukotoxin production, plasmid content, and antimicrobial susceptibility.

# publications[].label
Complete Genome Sequence of Staphylococcus aureus Siphophage Lorac.

# publications[].label
Regulation of ribosomal protein synthesis in Escherichia coli B/r.

# publications[].label
Spanin function requires subunit homodimerization through intermolecular disulfide bonds.

# publications[].label
A protein antibiotic in the phage Qbeta virion: diversity in lysis targets.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
FLUCTUATION-ENHANCED CHEMICAL/BIOLOGICAL SENSING AND PROMPT IDENTIFICATION OF BACTERIA BY SENSING OF PHAGE-TRIGGERED ION CASCADE (SEPTIC)

# publications[].label
Cloning and Characterization of a Hemolysin Gene from Actinobacillus (Haemophilus) pleuropneumoniae

# publications[].label
Nano device for monitoring electrical fluctuations on bacteria scale

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Complete Genome Sequence of Achromobacter xylosoxidans Myophage Mano.

# publications[].label
Secretion of the Pasteurella leukotoxin by Escherichia coli.

# publications[].label
slyD, a host gene required for phi X174 lysis, is related to the FK506-binding protein family of peptidyl-prolyl cis-trans-isomerases.

# publications[].label
Micron-scale holes terminate the phage infection cycle.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Genetic evidence that the bacteriophage phi X174 lysis protein inhibits cell wall synthesis.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Phages will out: strategies of host cell lysis.

# publications[].label
Noise for health: Phage-based rapid bacterial identification method

# publications[].label
Evolutionary dominance of holin lysis systems derives from superior genetic malleability.

# publications[].label
Biochemical and genetic evidence for three transmembrane domains in the class I holin, lambda S.

# publications[].label
Plasmid expression vector using the lambda late promoter.

# publications[].label
Cryo-Electron Microscopy of the  Bacteriophage Holin S105

# publications[].label
Major Trauma Centres: are Vascular Surgeons missing a training opportunity?

# publications[].label
Suppressor Analysis of the Fusogenic Lambda Spanins.

# publications[].label
A broad host range tailocin from Burkholderia

# publications[].label
The N-terminal transmembrane domain of lambda S is required for holin but not antiholin function.

# publications[].label
MS2 Lysis of Escherichia coli Depends on Host Chaperone DnaJ.

# publications[].label
Transcription in bacteria at different DNA concentrations.

# publications[].label
A(2) expression and assembly regulates lysis in Q infections.

# publications[].label
The C-terminal sequence of the lambda holin constitutes a cytoplasmic regulatory domain.

# publications[].label
Complete Genome Sequence of Burkholderia gladioli Phage Maja.

# publications[].label
The Actinobacillus pleuropneumoniae hemolysin determinant: unlinked appCA and appBD loci flanked by pseudogenes.

# publications[].label
The Last r Locus Unveiled: T4 RIII Is a Cytoplasmic Antiholin.

# publications[].label
Holins: the protein clocks of bacteriophage infections.

# publications[].label
Role of ribosomal protein S12 in peptide chain elongation: analysis of pleiotropic, streptomycin-resistant mutants of Escherichia coli.

# publications[].label
Complete Genome Sequences of Lambdoid Phages 21, 434, and 434B and Several Lambda Hybrids.

# publications[].label
Structural basis of Acinetobacter type IV pili targeting by an RNA virus.

# publications[].label
Transposition of the kanamycin-resistance transposon Tn903.

# publications[].label
Divergence and mosaicism among virulent soil phages of the Burkholderia cepacia complex.

# publications[].label
Complete Genome Sequences of Staphylococcus epidermidis Myophages Quidividi, Terranova, and Twillingate.

# publications[].label
Physics behind the new technique "Sensing of phage-triggered ion cascades" (SEPTIC) for the prompt identification of bacteria

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Differential expression of the cytotoxic and hemolytic activities of the ApxIIA toxin from Actinobacillus pleuropneumoniae.

# publications[].label
Mutational analysis of slyD, an Escherichia coli gene encoding a protein of the FKBP immunophilin family.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Phage-encoded cationic antimicrobial peptide required for lysis.

# publications[].label
Oligohistidine tag mutagenesis of the lambda holin gene.

# publications[].label
The essential Escherichia coli apolipoprotein N-acyltransferase (Lnt) exists as an extracytoplasmic thioester acyl-enzyme intermediate.

# publications[].label
A viral protein antibiotic inhibits lipid II flippase activity.

# publications[].label
Periplasmic domains define holin-antiholin interactions in t4 lysis inhibition.

# publications[].label
Role of phages in the pathogenesis of Burkholderia, or 'Where are the toxin genes in Burkholderia phages?'.

# publications[].label
Two beginnings for a single purpose: the dual-start holins in the regulation of phage lysis.

# publications[].label
The lambda holin accumulates beyond the lethal triggering concentration under hyperexpression conditions.

# publications[].label
Genetic and biochemical analysis of dimer and oligomer interactions of the lambda S holin.

# publications[].label
Phage lysis: do we have the hole story yet?

# publications[].label
DOMINANCE IN LAMBDA-S MUTATIONS AND EVIDENCE FOR TRANSLATIONAL CONTROL

# publications[].label
Burkholderia cenocepacia phage BcepMu and a family of Mu-like phages encoding potential pathogenesis factors.

# publications[].label
Efficacy of bacteriophage therapy in a model of Burkholderia cenocepacia pulmonary infection.

# publications[].label
Mutational analysis of the MS2 lysis protein L.

# publications[].label
Phage spanins: diversity, topological dynamics and gene convergence.

# publications[].label
Therapeutic and prophylactic application of phages to control Pierce's disease

# publications[].label
Complete Genome Sequence of Alcaligenes faecalis Phage Piluca.

# publications[].label
Characterization of the dual start motif of a class II holin gene.

# publications[].label
P2 growth restriction on an rpoC mutant is suppressed by alleles of the Rz1 homolog lysC.

# publications[].label
Synthesis of two bacteriophage lambda S proteins in an in vivo system.

# publications[].label
Characterization of novel virulent broad-host-range phages of Xylella fastidiosa and Xanthomonas.

# publications[].label
The lysis protein E of phi X174 is a specific inhibitor of the MraY-catalyzed step in peptidoglycan synthesis.

# publications[].label
Protein determinants of phage T4 lysis inhibition.

# publications[].label
Complete Genome Sequence of Klebsiella pneumoniae Myophage Muenster.

# publications[].label
Separable domains define target cell specificities of an RTX hemolysin from Actinobacillus pleuropneumoniae.

# publications[].label
Genetic analysis of the T4 holin: timing and topology.

# publications[].label
PHI-X174-E COMPLEMENTS LAMBDA-S AND R-DYSFUNCTION FOR HOST-CELL LYSIS

# publications[].label
Mapping the pinhole formation pathway of S21.

# publications[].label
A signal-arrest-release sequence mediates export and control of the phage P1 endolysin.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Genomes and characterization of phages Bcep22 and BcepIL02, founders of a novel phage type in Burkholderia cenocepacia.

# publications[].label
Use of regulated cell lysis in a lethal genetic selection in Escherichia coli: identification of the autoinducer-binding region of the LuxR protein from Vibrio fischeri ATCC 7744.

# publications[].label
Galaxy and Apollo as a biologist-friendly interface for high-quality cooperative phage genome annotation.

# publications[].label
Phage Lysis: Multiple Genes for Multiple Barriers.

# publications[].label
MICROBIOLOGY. Phage therapy redux--What is to be done?

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Localization and Regulation of the T1 Unimolecular Spanin.

# publications[].label
The DNA between Rz and cosR in bacteriophage lambda is nonessential.

# publications[].label
Initiation and termination of deoxyribonucleic acid replication in bacteria after a stepwise increase in the velocity of replication.

# publications[].label
Visualization of pinholin lesions in vivo.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A Broad-Host-Range Tailocin from Burkholderia cenocepacia.

# publications[].label
The Caulobacter crescentus phage phiCbK: genomics of a canonical phage.

# publications[].label
Comparative genomics of Acinetobacter baumannii and therapeutic bacteriophages from a patient undergoing phage therapy.

# publications[].label
Dual translational initiation sites control function of the lambda S gene.

# publications[].label
Purification of hybrid beta-galactosidase proteins encoded by phi X174 E phi lacZ and Escherichia coli prlA phi lacZ: a general method for the isolation of lacZ fusion polypeptides produced in low amounts.

# publications[].label
Regulation of a muralytic enzyme by dynamic membrane topology.

# publications[].label
Complete Genome Sequence of Rhizobium japonicum Podophage Pasto.

# publications[].label
Mutational analysis of bacteriophage lambda lysis gene S.

# publications[].label
An ancient player unmasked: T4 rI encodes a t-specific antiholin.

# publications[].label
Rapid de novo evolution of lysis genes in single-stranded RNA phages.

# publications[].label
Deletion and fusion analysis of the phage phi X174 lysis gene E.

# publications[].label
Polypeptide-chain-elongation rate in Escherichia coli B/r as a function of growth rate.

# publications[].label
Estimation of detection limits of the phage-invasion based identification of bacteria

# publications[].label
Conservation of a dual-start motif in P22 lysis gene regulation.

# publications[].label
Phage lysis: three steps, three choices, one outcome.

# publications[].label
Genomic and proteomic features of mycobacteriophage SWU1 isolated from China soil.

# publications[].label
Characterization of plasmids with antimicrobial resistant genes in pasteurella haemolytica a1

# publications[].label
Disulfide isomerization after membrane release of its SAR domain activates P1 lysozyme.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Patterning a nanowell sensor biochip for specific and rapid detection of bacteria

# publications[].label
Lysis protein S of phage lambda functions in Saccharomyces cerevisiae.

# publications[].label
Inhibitory mechanism of the Q lysis protein A2.

# publications[].label
The pinholin of lambdoid phage 21: control of lysis by membrane depolarization.

# publications[].label
Complete Genome Sequence of Stenotrophomonas maltophilia Siphophage Silvanus.

# publications[].label
Gene fusion in vivo using transductional cointegrates.

# publications[].label
Genomic and functional analyses of Rhodococcus equi phages ReqiPepy6, ReqiPoco6, ReqiPine5, and ReqiDocB7.

# publications[].label
Functional analysis of the phage T4 holin in a lambda context.

# publications[].label
Analysis of enzyme induction in bacteria.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Transposition mutagenesis of bacteriophage lambda: a new gene affecting cell lysis.

# publications[].label
Characterization of a Novel Tectivirus Phage Toil and Its Potential as an Agent for Biolipid Extraction.

# publications[].label
Phi X174 lysis requires slyD, a host gene which is related to the FKBP family of peptidyl-prolyl cis-trans isomerases.

# publications[].label
Complete Genome Sequence of Rhizobium phaseoli Podophage Palo.

# publications[].label
Stimulation of glucose catabolism in Escherichia coli by a potential futile cycle.

# publications[].label
Complete Genome Sequence of Enterococcus faecalis Siphophage Sigurd.

# publications[].label
2004 ASM Conference on the New Phage Biology: the 'Phage Summit'.

# publications[].label
Topological dynamics of holins in programmed bacterial lysis.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
The Global Reciprocal Reprogramming between Mycobacteriophage SWU1 and Mycobacterium Reveals the Molecular Strategy of Subversion and Promotion of Phage Infection.

# publications[].label
S gene product: identification and membrane localization of a lysis control protein.

# publications[].label
Functional analysis of a class I holin, P2 Y.

# publications[].label
Complete Genome Sequence of Stenotrophomonas maltophilia Myophage Marzo.

# publications[].label
Bacteriophage lysis: mechanism and regulation.

# publications[].label
Complete genomic analysis of Escherichia phage Mangalyan infecting Escherichia fergusonii.

# publications[].label
Dimerization between the holin and holin inhibitor of phage lambda.

# publications[].label
Holins: form and function in bacteriophage lysis.

# publications[].label
Genomic and Biochemical Characterization of Acinetobacter Podophage Petty Reveals a Novel Lysis Mechanism and Tail-Associated Depolymerase Activity.

# publications[].label
Evaluation of the interaction of phi X174 gene products E and K in E-mediated lysis of Escherichia coli.

# publications[].label
The determination of the efficiency of energy dispersive X-ray spectrometers by a new reference material.

# publications[].label
The lethal lambda S gene encodes its own inhibitor.

# publications[].label
Complementation and characterization of the nested Rz and Rz1 reading frames in the genome of bacteriophage lambda.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
The T4 RI antiholin has an N-terminal signal anchor release domain that targets it for degradation by DegP.

# publications[].label
MECHANISMS OF DIFFERENTIATION IN SHALLOW MAFIC ALKALINE INTRUSIONS, AS ILLUSTRATED IN THE BIG-BEND AREA, WESTERN TEXAS

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
The final step in the phage infection cycle: the Rz and Rz1 lysis proteins link the inner and outer membranes.

# publications[].label
Cultivation of lipid-producing bacteria with lignocellulosic biomass: effects of inhibitory compounds of lignocellulosic hydrolysates.

# publications[].label
Phi X174 E complements lambda S and R dysfunction for host cell lysis.

# publications[].label
Complete Genome Sequence of Bradyrhizobium japonicum Podophage Paso.

# publications[].label
DUAL START MOTIF IN 2 LAMBDOID S-GENES UNRELATED TO LAMBDA-S

# publications[].label
Stable micron-scale holes are a general feature of canonical holins.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
"Fatal scream" of bacteria infected by phages: Nanoscale detection of bacteriophage triggered ion cascade

# publications[].label
The Escherichia coli FKBP-type PPIase SlyD is required for the stabilization of the E lysis protein of bacteriophage phi X174.

# publications[].label
Structures of Q virions, virus-like particles, and the Q-MurA complex reveal internal coat proteins and the mechanism of host lysis.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
The multicomponent antirestriction system of phage P1 is linked to capsid morphogenesis.

# publications[].label
Thiol protection in membrane protein purifications: A study with phage holins

# publications[].label
Asymmetric cryo-EM structure of the canonical Allolevivirus Q reveals a single maturation protein and the genomic ssRNA in situ.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Molecular genetics of bacteria and phages, 2001.

# publications[].label
Regulation of a phage endolysin by disulfide caging.

# publications[].label
Active Bax and Bak are functional holins.

# publications[].label
Bacteriophages of wastewater foaming-associated filamentous Gordonia reduce host levels in raw activated sludge.

# publications[].label
Nanoscale detection of bacteriophage triggered ion cascade

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease.

# publications[].label
The holin of bacteriophage lambda forms rings with large diameter.

# publications[].label
A dominant mutation in the bacteriophage lambda S gene causes premature lysis and an absolute defective plating phenotype.

# publications[].label
Synthesis time of beta-galactosidase in Escherichia coli B/r as a function of growth rate.

# publications[].label
Balanced production of 30S and 50S ribosomal proteins after a nutritional shift-up.

# publications[].label
Cloning, sequencing and expression of a pasteur el la haemolytica al gene encoding a purk-iike protein

# publications[].label
Breaking free: "protein antibiotics" and phage lysis.

# publications[].label
Control of gluconeogenic growth by pps and pck in Escherichia coli.

# publications[].label
Dual start motif in two lambdoid S genes unrelated to lambda S.

# publications[].label
Genetic Analysis of the Lambda Spanins Rz and Rz1: Identification of Functional Domains.

# publications[].label
Rz/Rz1 lysis gene equivalents in phages of Gram-negative hosts.

# publications[].label
The phage meeting: Classical venue, new momentum.

# publications[].label
Parallel multicopy-suppressor screens reveal convergent evolution of phage-encoded single gene lysis proteins

# publications[].label
Translational efficiency of phi X174 lysis gene E is unaffected by upstream translation of the overlapping gene D reading frame.

# publications[].label
Purification and functional characterization of phiX174 lysis protein E.

# publications[].label
Asymmetric binding of membrane proteins to GroEL.

# publications[].label
Relation between growth and replication in bacteria.

# publications[].label
Spatial and temporal control of lysis by the lambda holin.

# publications[].label
Visualization of Membrane Proteins in GroEL

# publications[].label
Genomic and biological analysis of phage Xfas53 and related prophages of Xylella fastidiosa.

# publications[].label
The hydrodynamic and conformational properties of denatured proteins in dilute solutions.

# publications[].label
Phage single-gene lysis: Finding the weak spot in the bacterial cell wall.

# publications[].label
An apparatus for rapid sampling of growing cell cultures.

# publications[].label
Genetic analysis of MraY inhibition by the phiX174 protein E.

# researcherOn[].label
Implementing Galaxy for Community-based Phage Genomics

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# researcherOn[].label
NIH Clinical Center and the Center for Phage Technology

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.label
National Institute of General Medical Sciences - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
FFATA:  Lipid Production and Extraction for Biodiesel

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# researcherOn[].label
Bacteriophage biology: fundamentals and applications to combating bacteria in agriculture and health

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# streetAddress
Texas A&M University; Biochemistry & Biophysics; 2128 TAMU

# organizations[]
College of Agriculture and Life Sciences

# schools[]
College of Agriculture and Life Sciences

# etdChairOf[].label
Sekar, Giridhar (2014-10). NMR Studies of Membrane Associating Peptides and Implications in Autotransporter Function. Doctoral Dissertation.

# etdChairOf[].label
Moussa, Samir (2012-10). Deciphering Lysis and its Regulation in Bacteriophage T4. Doctoral Dissertation.

# etdChairOf[].label
Sperber, Anthony Michael (2017-12). Characterization of YisK, a Cell Shape Modifier and Enzyme in Bacillus subtilis. Doctoral Dissertation.

# etdChairOf[].label
Reddy Chinnaswamy, Sreedhar (2011-08). De Novo Initiated RNA Synthesis by the Hepatitis C Virus RNA-dependent RNA Polymerase. Doctoral Dissertation.

# etdChairOf[].label
Chamakura, Karthik Reddy (2017-05). Evolved to Break Free: Evolution and Diversity in Single Gene Lysis. Doctoral Dissertation.

# etdChairOf[].label
To, Kam Ho (2013-11). Biochemical and Genetic Characterization of Bacteriophage Holins. Doctoral Dissertation.

# etdChairOf[].label
Park, Taehyun (2009-05). Biochemical and genetic characterization of bacteriophage 21 holin: S21 as a membrane protein and beyond. Doctoral Dissertation.

# etdChairOf[].label
Reed, Catrina Anne (2012-10). Characterization of A2: The Lysis Protein of ssRNA Phage Qbeta. Doctoral Dissertation.

# etdChairOf[].label
McIntosh, Brenley Kathleen (2009-05). Bacteriophage ms2 l protein:  genetic and biochemical characterization. Doctoral Dissertation.

# etdChairOf[].label
Kongari, Ramchander Rohit (2018-08). The Role of Spanins in Outer Membrane Disruption. Doctoral Dissertation.

# etdChairOf[].label
Cahill, Jesse L (2017-11). Molecular, Genetic, and Biochemical Analysis of Phage Lambda Lysis. Doctoral Dissertation.

# etdChairOf[].label
Berry, Joel Dallas (2011-08). The Final Step in Phage Lysis:  The Role of the Rz-Rz1 Spanin Complex in the Disruption of the Outer Membrane. Doctoral Dissertation.

# etdChairOf[].label
Dewey, Jill Sayes (2011-10). Characterization of the Bacteriophage Lambda Holin and Its Membrane Lesion. Doctoral Dissertation.

# etdChairOf[].label
White, Rebecca Lynn (2009-05). What makes the lysis clock tick? A study of the bacteriophage holin. Doctoral Dissertation.

# etdChairOf[].label
Pang, Ting (2011-08). Exploring the Pinhole: Biochemical and Genetic Studies on the Prototype Pinholin, S21. Doctoral Dissertation.

# etdChairOf[].label
Kuty, Gabriel (2012-02). SAR Endolysin Regulation in dsDNA Phage Lysis of Gram-Negative Hosts. Doctoral Dissertation.

# etdChairOf[].label
Tran, Tram Anh Thi (2009-05). Bacteriophage T4 lysis and lysis inhibition: molecular basis of an ancient story. Doctoral Dissertation.

# etdChairOf[].label
Chen, Yi (2016-08). Regulation of Phage Lysis:  Diverse Strategies and Targets. Doctoral Dissertation.

# etdChairOf[].label
Zheng, Yi (2010-07). The phiX174 Lysis Protein E: a Protein Inhibitor of the Conserved Translocase MraY. Doctoral Dissertation.

# etdChairOf[].label
Vranish, James Nicholas (2015-04). Development of Fluorescent Reporters for Monitoring Fe-S Cluster Transfer Reactions and Discerning the Role of Glutaredoxin Proteins in Fe-S Cluster Assembly. Doctoral Dissertation.

# etdChairOf[].label
Deaton, John Franklin (2004-11). Solubilization and functional analysis of the lambda holin. Doctoral Dissertation.

# etdChairOf[].label
Langlais, Carrie-Lynn (2009-05). Understanding the lytic domain of A2: the maturation protein of ssRNA bacteriophage QBeta. Doctoral Dissertation.

# etdChairOf[].label
Xu, Min (2005-11). Bacteriophage P1: a new paradigm for control of phage lysis. Doctoral Dissertation.