# overview
My research efforts have been in Statistics, Computer Science, and their applications to Biomedical Research and Bioinformatics. I have been working on the design and analysis of complex computer models since 2004. I developed statistical approaches for modeling the output from complex computer codes having quantitative and qualitative inputs, as well as the calibration and tuning for computer models. My recent research includes modeling cancer survivorship data, modeling epidemiological data, and applying statistical learning tools to the early detection of ovarian cancer.

# keywords[]
Clinical Trials And Supportive Activities

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Fanconi Anemia Complementation Group Proteins

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6 Evaluation Of Treatments And Therapeutic Interventions

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Clinical Trials And Supportive Activities

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3.1 Primary Prevention Interventions To Modify Behaviours Or Promote Wellbeing

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3 Prevention Of Disease And Conditions, And Promotion Of Well-being

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4.2 Evaluation Of Markers And Technologies

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Clinical Trials And Supportive Activities

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6 Evaluation Of Treatments And Therapeutic Interventions

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Alzheimer's Disease And Related Dementia

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3 Prevention Of Disease And Conditions, And Promotion Of Well-being

# keywords[]
3.1 Primary Prevention Interventions To Modify Behaviours Or Promote Wellbeing

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
4.2 Evaluation Of Markers And Technologies

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Diabetes Self-management Education And Support

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

# educationAndTraining[].organization.label
The Ohio State University - (Columbus, Ohio, United States)

# educationAndTraining[].organization.label
The Ohio State University - (Columbus, Ohio, United States)

# educationAndTraining[].organization.label
Beijing University of Technology - (Beijing, Beijing, China)

# publications[].label
Impact of a Behavioral Intervention on Diet, Eating Patterns, Self-Efficacy, and Social Support.

# publications[].label
Intensity-modulated radiation therapy as primary treatment for oropharyngeal squamous cell carcinoma.

# publications[].label
Educational Value of Digital Whole Slides Accompanying Published Online Pathology Journal Articles: A Multi-Institutional Study.

# publications[].publisher
Archives of Pathology and Laboratory Medicine

# publications[].label
Abstract 1352: Epithelial-mesenchymal transition (EMT) gene variants influence epithelial ovarian cancer risk in women of European, African and Asian ancestry.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Completion lymphadenectomy for a positive sentinel node biopsy in melanoma patients is not associated with a survival benefit.

# publications[].label
Reproducibility and Robustness of a Liver Microphysiological System PhysioMimix LC12 under Varying Culture Conditions and Cell Type Combinations.

# publications[].label
Quantitative and pathologist-read comparison of the heterogeneity of programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer.

# publications[].label
Smooth Muscle-Alpha Actin R149C Pathogenic Variant Downregulates Integrin Recruitment at Cell-Matrix Adhesions and Decreases Cellular Contractility.

# publications[].label
Regression in melanoma is significantly associated with a lower regional recurrence rate and better recurrence-free survival.

# publications[].label
Analgesic effects of a retrobulbar block with 0.75% ropivacaine in dogs undergoing enucleation.

# publications[].label
How to run survival-endpoint phase II trials with 25% to 40% fewer patients.

# publications[].publisher
American Society of Clinical Oncology (ASCO)

# publications[].label
Bortezomib salvage followed by a Phase I/II study of bortezomib plus high-dose melphalan and tandem autologous transplantation for patients with primary resistant myeloma.

# publications[].label
Analysis of reproducibility and robustness of OrganoPlate 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs.

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Osteosarcoma in pediatric patients and young adults: a single institution retrospective review of presentation, therapy, and outcome.

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Connexin 43 is a potential prognostic biomarker for ewing sarcoma/primitive neuroectodermal tumor.

# publications[].label
ASO Visual Abstract: Is There a Relationship Between Tumor-Infiltrating Lymphocytes (TILs) and Regression in Melanoma?

# publications[].label
CAREGIVING BURDENS OF TASK TIME AND TASK DIFFICULTY AMONG PAID AND UNPAID CAREGIVERS OF PERSONS LIVING WITH DEMENTIA

# publications[].label
Effect of prophylactic fluconazole on oral mucositis and candidiasis during radiation therapy for head-and-neck cancer.

# publications[].label
Child Tobacco Smoke Exposure, Indoor Home Characteristics, and Housing Stability among a National Sample of U.S. Children.

# publications[].label
CHANGES IN PHYSICAL ACTIVITY ASSOCIATED WITH A NOVEL HEALTH AND WELLNESS PROGRAM FOR AT-RISK OLDER INDIVIDUALS

# publications[].label
Testing violations of the exponential assumption in cancer clinical trials with survival endpoints.

# publications[].label
Bayesian-frequentist hybrid approach for skew-normal nonlinear mixed-effects joint models in the presence of covariates measured with errors

# publications[].label
Patient preferences regarding incidental genomic findings discovered during tumor profiling.

# publications[].label
Consequences of Axillary Ultrasound in Patients with T2 or Greater Invasive Breast Cancers

# publications[].label
Completion Lymphadenectomy for a Positive Sentinel Node Biopsy in Melanoma Patients is Not Associated with a Survival Benefit

# publications[].label
Abstract P5-11-03: Development of an interactive text messaging tool to improve adherence with adjuvant endocrine therapy: Breast cancer endocrine therapy adherence (BETA) pilot study

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Telomere Length and Preterm Birth in Pregnant Mexican-Origin Women.

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A phase II clinical trial of sunitinib following hepatic transarterial embolization for metastatic neuroendocrine tumors.

# publications[].label
ORAL01.01: A Prospective, Multi-Institutional Assessment of Four Assays for PD-L1 Expression in NSCLC by Immunohistochemistry Topic: Pathology

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Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non-Small-Cell Lung Cancer.

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Rank-based tests for identifying multiple genetic variants associated with quantitative traits.

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WORSENING OF DEPRESSIVE SYMPTOMATOLOGY SINCE BEFORE COVID-19 AMONG CAREGIVERS OF PERSONS LIVING WITH DEMENTIA

# publications[].label
Clinical and dosimetric predictors of radiation pneumonitis in a large series of patients treated with stereotactic body radiation therapy to the lung.

# publications[].label
Bilingual problem-solving training for caregivers of adults with dementia: A randomized, factorial-design protocol for the CaDeS trial.

# publications[].label
Viral Clearance and Neuroinflammation in Acute TMEV Infection Vary by Host Genetic Background.

# publications[].label
IMPACT OF A BEHAVIORAL INTERVENTION ON DIET, EATING PATTERNS, SELF-EFFICACY, AND SOCIAL SUPPORT: TEXERCISE SELECT

# publications[].label
Is There a Relationship Between TILs and Regression in Melanoma?

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Recurrence of Melanoma After a Negative Sentinel Node Biopsy: Predictors and Impact of Recurrence Site on Survival.

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Loss of antigenicity with tissue age in breast cancer.

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Religiosity, Acculturation, and Preterm Birth in Mexican-Origin Women: A Pilot Study.

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Influence of age-related versus non-age-related renal dysfunction on survival in patients with left ventricular dysfunction.

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Indications for axillary ultrasound use in breast cancer patients.

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Prospective multi-institutional evaluation of pathologist assessment of PD-L1 assays for patient selection in triple negative breast cancer.

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Factors associated with higher hemoglobin A1c and type 2 diabetes-related costs: Secondary data analysis of adults 18 to 64 in Texas with commercial insurance.

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High grade prostate intraepithelial neoplasia (PIN) is a PSA-independent risk factor for prostate cancer in African American men: results from a pilot study.

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Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity.

# publications[].label
Data augmentation based on waterfall plots to increase value of response data generated by small single arm Phase II trials.

# publications[].label
A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non-Small Cell Lung Cancer.

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Abstract 3879: Patient preferences for disclosure of incidental genetic information discovered through high-throughput sequencing

# publications[].publisher
American Association for Cancer Research (AACR)

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Clinicopathologic predictors of survival in patients with desmoplastic melanoma.

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Review of Hybrid Bayesian Inference and Its Applications

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Malignancy in giant cell tumor of bone in the extremities.

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Measurement of phospholipids may improve diagnostic accuracy in ovarian cancer.

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Measurement of spatial and antibody-based PD-L1 heterogeneity in non-small cell lung cancer.

# publications[].publisher
American Society of Clinical Oncology (ASCO)

# publications[].label
Comparing Two Exponential Distributions Using the Exact Likelihood Ratio Test.

# publications[].label
Randomized phase II trial of fulvestrant alone or in combination with bortezomib in hormone receptor-positive metastatic breast cancer resistant to aromatase inhibitors: a New York Cancer Consortium trial.

# publications[].label
Ethnicity and age disparities in Ewing sarcoma outcome.

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Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma.

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Prospective multi-institutional evaluation of pathologist assessment of PD-L1 assays in triple negative breast cancer

# publications[].publisher
American Association for Cancer Research (AACR)

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Differential gene expression in liposarcoma: A biologic basis for clinically aggressive behavior?

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"Interchangeability" of PD-L1 immunohistochemistry assays: a meta-analysis of diagnostic accuracy.

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Consequences of axillary ultrasound in patients with T2 or greater invasive breast cancers.

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Bayesian-Frequentist Hybrid Inference in Applications with Small Sample Sizes

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Regression in thin melanoma is associated with nodal recurrence after a negative sentinel node biopsy.

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Prediction for Computer Experiments Having Quantitative and Qualitative Input Variables

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Effectiveness of a Lifestyle Intervention on Social Support, Self-Efficacy, and Physical Activity among Older Adults: Evaluation of Texercise Select.

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Age-Associated Dysregulation of Integrin Function in Vascular Smooth Muscle.

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Abstract P3-11-02: Predictors of complete pathological response to neoadjuvant chemotherapy for breast cancer: 19,310 cases from the national cancer database treated in 2010 and 2011

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Is the Presence of Tumor Infiltrating Lymphocytes Prognostic in Melanoma Patients?

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Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT): A Single Center Experience.

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Bidirectional Text Messaging to Monitor Endocrine Therapy Adherence and Patient-Reported Outcomes in Breast Cancer.

# publications[].publisher
American Society of Clinical Oncology (ASCO)

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Relapse-free survival in patients with nonmetastatic, surgically resected pancreatic neuroendocrine tumors: an analysis of the AJCC and ENETS staging classifications.

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Intake of tryptophan-enriched whey protein acutely enhances recall of positive loaded words in patients with multiple sclerosis.

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Impact of Diabetes Self-Management Education on Psychological Distress and Health Outcomes Among African Americans and Hispanics/Latinos With Diabetes.

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Variation in performance of kidney injury biomarkers due to cause of acute kidney injury.

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Is the presence of tumor-infiltrating lymphocytes predictive of outcomes in patients with melanoma?

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Sentinel Lymph Node Biopsy Is Prognostic in Thickest Melanoma Cases and Should Be Performed for Thick Melanomas.

# publications[].label
Hybrid Bayesian inference on HIV viral dynamic models

# publications[].label
Onset of side effects and adherence to endocrine therapy in the Breast Cancer Endocrine Therapy Adherence (BETA) pilot study

# publications[].publisher
American Society of Clinical Oncology (ASCO)

# publications[].label
Simulating the contribution of a biospecimen and clinical data repository in a phase II clinical trial: A value of information analysis.

# publications[].label
Abstract 3644: Variation in transmembrane transport genes influence epithelial ovarian cancer risk and histopathologic subtype.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Predictors for Use of Sentinel Node Biopsy and the Survival Impact of Performing Nodal Staging in Melanoma Patients

# publications[].label
Validation of Fluorescence in situ Hybridization Testing of USP6 Gene Rearrangement for Diagnosis of Primary Aneurysmal Bone Cyst.

# publications[].label
Bayesian hypothesis testing for selected regression coefficients

# publications[].label
ER splice variant expression in four large cohorts of human breast cancer patient tumors.

# publications[].label
EE116 Predicting High-Cost Diabetes Patients: An Analysis of Commercially-Insured Population

# publications[].label
Differential gene expression in liposarcoma: Insight into pathways for dedifferentiation?

# publications[].publisher
American Society of Clinical Oncology (ASCO)

# publications[].label
A phase II study of RO4929097 in metastatic colorectal cancer.

# publications[].label
The Prognostic Significance of Sentinel Lymph Node Status for Patients with Thick Melanoma.

# publications[].label
Biopsy Based Proteomic Assay Predicts Risk of Biochemical Recurrence after Radical Prostatectomy.

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Relationship of patient age to tumor factors and outcomes among patients undergoing sentinel node biopsy for melanoma.

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Clinical and Dosimetric Predictors of Radiation Pneumonitis (RP) in a Large Series of Patients Treated With Stereotactic Radiation Therapy (SBRT) to the Lung

# publications[].label
Abstract 4850: Variation in circadian rhythm genes influence epithelial ovarian cancer risk and invasiveness.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Contractility and adhesion to the matrix is impaired in vascular smooth muscle from Acta2 R149C mice

# publications[].label
Determination of the number of observers needed to evaluate a subjective test and its application in two PD-L1 studies.

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Improved survival modeling in cancer research using a reduced piecewise exponential approach.

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A Quantitative Evaluation of Electric Sit-Stand Desk Usage: 3-Month In-Situ Workplace Study

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Predictors for Use of Sentinel Node Biopsy and the Association with Improved Survival in Melanoma Patients Who Have Nodal Staging.

# publications[].label
Prognostic validity of a novel American Joint Committee on Cancer Staging Classification for pancreatic neuroendocrine tumors.

# publications[].publisher
American Society of Clinical Oncology (ASCO)

# publications[].label
Sit-Stand Desk Software Can Now Monitor and Prompt Office Workers to Change Health Behaviors.

# publications[].label
Predictors for Melanoma Recurrence and the Impact of Local Recurrence on Outcomes After a Negative Sentinel Node Biopsy

# publications[].label
Development and application of a novel metric to assess effectiveness of biomedical data.

# publications[].label
Physical activity and associated medical cost savings among at-risk older adults participating a community-based health & wellness program.

# publications[].label
Analysis of overdispersed count data: application to the Human Papillomavirus Infection in Men (HIM) Study.

# publications[].label
Role of axillary staging in women diagnosed with ductal carcinoma in situ with microinvasion.

# publications[].publisher
American Society of Clinical Oncology (ASCO)

# publications[].label
FACTORS ASSOCIATED WITH UPTAKE OF PRENATAL GENETIC TESTING IN HISPANIC WOMEN: AN EXPLORATORY STUDY

# publications[].label
Distance to Anopheles sundaicus larval habitats dominant among risk factors for parasitemia in meso-endemic Southwest Sumba, Indonesia.

# publications[].label
Discovery and disclosure of incidental genetic information obtained through high throughput sequencing.

# publications[].publisher
American Society of Clinical Oncology (ASCO)

# publications[].label
Group-based trajectory analysis identifies varying diabetes-related cost trajectories among type 2 diabetes patients in Texas: an empirical study using commercial insurance.

# publications[].label
Metastatic breast cancer alliance's patient education and access to trials: Perceptions and actions

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Reanalysis of the NCCN PD-L1 companion diagnostic assay study for lung cancer in the context of PD-L1 expression findings in triple-negative breast cancer.

# publications[].label
Utility of a 31-gene expression profile for predicting outcomes in patients with primary cutaneous melanoma referred for sentinel node biopsy.

# publications[].label
Factors predicting survival in thick melanoma: Do all thick melanomas have the same prognosis?

# publications[].label
Prediagnostic body weight and survival in high grade glioma.

# publications[].label
Regression is significantly associated with outcomes for patients with melanoma.

# publications[].label
TECHNOLOGY INNOVATIONS IN DEMENTIA CARE: IMPROVEMENTS IN FUNCTIONAL ASSESSMENTS THROUGH BACKGROUND SENSING

# publications[].label
Smart Software Can Increase Sit-Stand Desk Transitions During Active Computer Use.

# publications[].label
Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma?

# publications[].label
Abstract 3592: Risk factors of prostate cancer in African American men

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
PREDICTING HIGH-COST DIABETES PATIENTS: AN ANALYSIS OF COMMERCIALLY-INSURED POPULATION

# publications[].label
The unique clinical characteristics of melanoma diagnosed in children.

# publications[].label
Regression in Melanoma Predicts Lower Recurrence Rates and Better Recurrence-Free Survival

# publications[].label
Designing historical control studies with survival endpoints using exact statistical inference.

# publications[].label
Sentinel Lymph Node Biopsy is Prognostic in the Thickest Melanoma Cases and Should Be Performed for Thick Melanomas

# publications[].label
Glutathione S-transferase iso-enzymes in perfusate from pumped kidneys are associated with delayed graft function.

# publications[].label
Host genetic diversity drives variable central nervous system lesion distribution in chronic phase of Theiler's Murine Encephalomyelitis Virus (TMEV) infection.

# publications[].label
Acral Lentiginous Melanoma: Do Surgical Approach and Sentinel Lymph Node Biopsy Matter?

# publications[].label
Simultaneous Determination of Tuning and Calibration Parameters for Computer Experiments.

# researcherOn[].label
Optogenetic Toolkit for Remote Control of Voltage-Gated Calcium Channels

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# researcherOn[].label
Texas A&M Center for Environmental Health Research

# researcherOn[].awardedBy.label
National Institute of Environmental Health Sciences - (Durham, North Carolina, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Environmental Health Sciences

# streetAddress
Texas A&M Health Science Center; Epidemiology & Biostatistics; 1266 TAMUS