# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
My primary interests include Cancer; Oncogenes; Tumor Suppressor; Genes Programmed Cell Death (apoptosis); Chemoresistance, and Angiogenesis. My laboratory studies mechanisms of evolution of chemoresistance in diffuse large B-cell lymphoma (DLBCL).  One current primary objective is to conduct a Phase I study that (1) confirms RTI-79 safety in platinum-resistant/refractory ovarian cancer patients, and (2) demonstrates signals of efficacy in humans (ex: time-to-disease progression and changes in CA125 biomarker). A second objective is to better define the RTI-79 mechanism of action (MOA) by (1) determining how RTI-79 causes a rapid burst in superoxides, and (2) elucidating the basis of Nrf-2 pathway downregulation.

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Intracellular Signaling Peptides And Proteins

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Reverse Transcriptase Polymerase Chain Reaction

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Reverse Transcriptase Polymerase Chain Reaction

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3201 Cardiovascular Medicine And Haematology

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
Abilene Christian University - (Abilene, Texas, United States)

# educationAndTraining[].organization.label
The University of Texas Health Science Center at Houston - (Houston, Texas, United States)

# educationAndTraining[].organization.label
Baylor College of Medicine - (Houston, Texas, United States)

# educationAndTraining[].organization.label
The University of Texas MD Anderson Cancer Center - (Houston, Texas, United States)

# educationAndTraining[].organization.label
The University of Texas Health Science Center at Houston - (Houston, Texas, United States)

# educationAndTraining[].organization.label
Abilene Christian University - (Abilene, Texas, United States)

# publications[].label
Non-Hodgkin's B-cell lymphoma: advances in molecular strategies targeting drug resistance.

# publications[].label
Compositions and methods for drug-sensitization or inhibition of a cancer cell

# publications[].label
Akt, 14-3-3, and vimentin mediate a drug-resistant invasive phenotype in diffuse large B-cell lymphoma.

# publications[].label
Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation.

# publications[].label
Synthesis and binding of lactose-specific lectin by isolated lung cells.

# publications[].label
Binding of cellular proteins to a conformational domain of tumor suppressor protein p53.

# publications[].label
P85GAG-MOS ENCODED BY TS110 MOLONEY MURINE SARCOMA-VIRUS HAS AN ASSOCIATED PROTEIN-KINASE ACTIVITY

# publications[].label
Identification of p53 Proteins and Targets

# publications[].label
Epithelial cancers of the aerodigestive tract: biology, prevention, and therapy.

# publications[].label
Posttranslational regulation of p53 tumor suppressor protein function.

# publications[].label
Cell-type-specific regulation of p53 expression in nonsmall cell lung-carcinoma cells.

# publications[].label
Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity.

# publications[].label
Epidermal growth factor receptor protein-tyrosine kinase activity in human cell lines established from squamous carcinomas of the head and neck.

# publications[].label
Development of novel, non-toxic rifamycins that reverse drug resistance

# publications[].label
Serine kinase activity associated with Maloney murine sarcoma virus-124-encoded p37mos.

# publications[].label
In vitro proteolytic cleavage of Gazdar murine sarcoma virus p65gag.

# publications[].label
Two-dimensional gel analysis of apoptosis-specific p53 isoforms induced by 2-methoxyestradiol in human lung cancer cells.

# publications[].label
Proline oxidase induces apoptosis in tumor cells, and its expression is frequently absent or reduced in renal carcinomas.

# publications[].label
Matrix metalloproteinase-1 and -9 activation by plasmin regulates a novel endothelial cell-mediated mechanism of collagen gel contraction and capillary tube regression in three-dimensional collagen matrices.

# publications[].label
RACK1 and vimentin complex to regulate FAK during endothelial invasion.

# publications[].label
Gene expression profiling of p53-sensitive and -resistant tumor cells using DNA microarray.

# publications[].label
CELLULAR PROTEINS MODULATE NONSPECIFIC AND SEQUENCE-SPECIFIC DNA-BINDING OF A CONFORMATIONAL DOMAIN OF P53

# publications[].label
Cyclin A1 is a p53-induced gene that mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells.

# publications[].label
Retinoblastoma protein in non-small cell lung carcinoma, cells arrested for growth by retinoic acid

# publications[].label
Transient stabilization of p53 in non-small cell lung carcinoma cultures arrested for growth by retinoic acid.

# publications[].label
ANALYSIS OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND ASSOCIATED GLYCOPROTEIN ON HUMAN GLIOMA-CELLS INVITRO

# publications[].label
Two-dimensional gel analysis of p53-mediated changes in protein expression.

# publications[].label
Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling.

# publications[].label
SV40 T-ANTIGEN AS A DUAL ONCOGENE - STRUCTURE AND FUNCTION OF THE PLASMA MEMBRANE-ASSOCIATED POPULATION

# publications[].label
Synthesis and binding of lactose-specific lectin by isolated lung cells

# publications[].label
Use of site-specific antipeptide antibodies to perturb the serine kinase catalytic activity of p37mos.

# publications[].label
P85gag-mos encoded by ts110 Moloney murine sarcoma virus has an associated protein kinase activity.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Molecular regulation of capillary morphogenesis and regression in three-dimensional extracellular matrix environments.

# publications[].label
Potassium inhibition of transforming protein P85gag-mos and reversal of the transformed phenotype in 6m2 cells.

# publications[].label
Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma.

# publications[].label
Analysis of P210bcr-abl tyrosine protein kinase activity in various subtypes of Philadelphia chromosome-positive cells from chronic myelogenous leukemia patients.

# publications[].label
Recognition of mos-related proteins with an antiserum to a peptide of the v-mos gene product

# publications[].label
A cellular protein activates the sequence-specific DNA-binding of p53 by interacting with the central conserved region.

# publications[].label
Compositions and methods for drug-sensitization or inhibition of a cancer cell

# publications[].label
Compositions and methods for drug-sensitization or inhibition of a cancer cell

# publications[].label
The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway.

# publications[].label
Sorting mechanisms regulating membrane protein traffic in the apical transcytotic pathway of polarized MDCK cells.

# publications[].label
EXPRESSION AND ACTIVITY OF EGF RECEPTOR IN HEAD AND NECK SQUAMOUS CARCINOMA CELL-LINES

# publications[].label
Identification of a p53-response element in the promoter of the proline oxidase gene.

# publications[].label
14-3-3zeta mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen.

# publications[].label
A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis.

# publications[].label
Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK).

# publications[].label
Tumor suppressor activities of proline oxidase

# publications[].label
Sequence-specific interaction of a conformational domain of p53 with DNA.

# publications[].label
Expression of epidermal growth factor receptor and associated glycoprotein on cultured human brain tumor cells.

# publications[].label
Guiding Preclinical Medical Students in Finding, Synthesizing, and Communicating Translational Basic Research Literature: Roles for Basic Science Research Mentors.

# publications[].label
Retinoblastoma protein in non-small cell lung carcinoma, cells arrested for growth by retinoic acid.

# publications[].label
Further characterization of the in vitro products generated by proteolytic cleavage of Gazdar murine sarcoma virus p65gag.

# publications[].label
Solubilization of SV40 plasma-membrane-associated large tumor antigen using single-phase concentrations of 1-butanol.

# publications[].label
Simian virus 40 large T antigen and p53 are microtubule-associated proteins in transformed cells.

# publications[].label
2-DIMENSIONAL GEL ANALYSIS OF P53-MEDIATED CHANGES IN PROTEIN EXPRESSION

# publications[].label
A cAMP-independent serine/threonine kinase activity is associated with the mos sequences of ts110 Moloney murine sarcoma virus-encoded P85gag-mos.

# publications[].label
Head and neck squamous cell carcinoma cell lines as a model system for the study of oncogene expression during tumor progression and metastasis.

# publications[].label
The gag-mos hybrid protein of ts110 Moloney murine sarcoma virus: variation of gene expression with temperature.

# publications[].label
Analysis of phosphorylated isoforms of the p53 tumor suppressor protein in human lung carcinoma cells undergoing apoptosis.

# publications[].label
Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Induction and alternative splicing of the Bax gene mediated by p53 in a transformed endothelial cell line.

# publications[].label
Telomerase activity in immortalized endothelial cells undergoing p53-mediated apoptosis.

# publications[].label
Drug resistance and invasion in diffuse large B-cell lymphoma are mediated by Akt, 14-3-3 zeta, and Vimentin

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Biological and molecular characterization of an ECV-304-derived cell line resistant to p53-mediated apoptosis.

# publications[].label
EXPRESSION AND ACTIVITIES OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND ASSOCIATED GLYCOPROTEIN ON CULTURED HUMAN GLIOMA-CELLS

# publications[].label
Selective compartmentalization of different mdm2 proteins within the nucleus.

# publications[].label
Induction of p53 DNA-binding activity by tumor necrosis factor-alpha.

# publications[].label
Comparative gene expression profiling in p53-mediated apoptosis-resistant and sensitive endothelial cell lines.

# publications[].label
Two-dimensional gel analysis of p53-mediated changes in protein expression

# publications[].label
Further characterization of the P85gag-mos -associated protein kinase activity.

# publications[].label
ADAM17 mediates endothelial invasion in three-dimensional collagen matrices

# publications[].label
In polarized MDCK cells basolateral vesicles arise from clathrin-gamma-adaptin-coated domains on endosomal tubules.

# publications[].label
Selective compartmentalization of different mdm2 proteins within the nucleus

# publications[].label
A novel NF-kappa B p65 spliced transcript lacking exons 6 and 7 in a non-small cell lung carcinoma cell line.

# publications[].label
Posttranscriptional regulation of epidermal growth-factor receptor expression by retinoic Acid in a human lung epithelial-cell line.

# publications[].label
Recognition of mos-related proteins with an antiserum to a peptide of the v-mos gene product.

# publications[].label
Postnatal development of alveoli. Regulation and evidence for a critical period in rats.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Expression of Bax, Bcl-2, Waf-1, and PCNA gene products in an immortalized human endothelial cell line undergoing p53-mediated apoptosis.

# publications[].label
SV40 T-antigen as a dual oncogene: structure and function of the plasma membrane-associated population.

# publications[].label
Cell type-specific induction and alternative splicing of the Bax gene mediated by p53.

# publications[].label
14-3-3 mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen.

# streetAddress
Texas A&M Health Science Center; Molecular And Cellular Medicine; 1114 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine