# positions[].organizations[].parent[].label
School of Veterinary Medicine and Biomedical Sciences

# overview
My research revolves around understanding how aging affects regeneration. I have addressed this question by investigating mesenchymal stem cell aging in humans and progeroid mice. In my current position as Research Assistant Professor, I am exploring the effects of aging and progeria on a new in vivo model for regeneration, the mouse digit tip, which involves regeneration of bone, nail, skin and vasculature, and requires not only stem cells, but also various other cell types to interact in a well-balanced and timely manner. I have recently established that aging delays bone regeneration in this model by attenuating both osteoclast and osteoprogenitor activity, and will now examine which specific aging processes impair osteoclast and osteoprogenitor recruitment, proliferation and differentiation, with the long term goal to improve fracture healing in the elderly.

# keywords[]
Mechanistic Target Of Rapamycin Complex 1

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
Innsbruck Medical University - (Innsbruck, Austria)

# educationAndTraining[].organization.label
Buck Institute for Research on Aging - (Novato, California, United States)

# educationAndTraining[].organization.label
University of Salzburg - (Salzburg, Austria)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
University of Salzburg - (Salzburg, Austria)

# publications[].label
A novel rapamycin analog is highly selective for mTORC1 in vivo.

# publications[].label
Beer and its non-alcoholic compounds in health and disease.

# publications[].label
Identification of evolutionarily conserved genetic regulators of cellular aging.

# publications[].label
The bone marrow environment maintains polyfunctional memory T cells during human aging

# publications[].publisher
The American Association of Immunologists

# publications[].label
Isolation and Engineering of Rat Mesenchymal Stem Cells for Tendonndon Regeneration

# publications[].label
Mouse digit bone regeneration: A new model to study cell-specific effects of aging on bone repair

# publications[].label
Age-associated functional changes of human mesenchymal stem cells

# publications[].label
Mouse digit bone regeneration: A new model to study cell-specific effects of aging on bone repair

# publications[].label
Epimorphic regeneration of the mouse digit tip is finite.

# publications[].label
Sirtuin 3 deficiency does not impede digit regeneration in mice.

# publications[].label
Controversial issue: is it safe to employ mesenchymal stem cells in cell-based therapies?

# publications[].label
Digit specific denervation does not inhibit mouse digit tip regeneration.

# publications[].label
Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan.

# publications[].label
Induced regeneration of articular cartilage: Identification of a dormant regeneration program for a non-regenerative tissue.

# publications[].label
Changes of the Functional Capacity of Mesenchymal Stem Cells due to Aging or Age-Associated Disease - Implications for Clinical Applications and Donor Recruitment.

# publications[].label
Aging Delays Epimorphic Regeneration in Mice.

# publications[].label
Human bone marrow hosts polyfunctional memory CD4+ and CD8+ T cells with close contact to IL-15-producing cells.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Hyaline cartilage differentiation of fibroblasts in regeneration and regenerative medicine.

# publications[].label
Mouse digit regeneration: a new model to study age-related regenerative decline.

# publications[].label
Factors associated with healthy aging in septuagenarian and nonagenarian Mexican adults.

# publications[].label
Education and employment have a sex-dependent effect on healthy aging in Mexico.

# publications[].label
Isolation of mesenchymal stem cells from human bone and long-term cultivation under physiologic oxygen conditions.

# publications[].label
Mesenchymal stem cells show radioresistance in vivo.

# publications[].label
Stem Cell Models: A Guide to Understand and Mitigate Aging?

# publications[].label
Human bone marrow hosts polyfunctional memory CD4 and CD8 T cells with close contact to IL-15-producing stromal cells

# publications[].label
lin-Sca-1+ cells and age-dependent changes of their proliferation potential are reliant on mesenchymal stromal cells and are leukemia inhibitory factor dependent.

# publications[].label
Proliferation and differentiation of human bone-derived mesenchymal stem cells are affected by NADPH oxidase 4-produced ROS

# publications[].label
Leptin receptor/CD295 is upregulated on primary human mesenchymal stem cells of advancing biological age and distinctly marks the subpopulation of dying cells.

# publications[].label
Mouse Digit Tip Regeneration Is Mechanical Load Dependent.

# publications[].label
Aging delays epimorphic regeneration in mice

# publications[].label
Age-specific changes of mesenchymal stem cells are paralleled by upregulation of CD106 expression as a response to an inflammatory environment.

# publications[].label
Techniques in gerontology: cell lines as standards for telomere length and telomerase activity assessment.

# publications[].label
Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification.

# publications[].label
Sugar-Sweetened Beverages and Cancer Risk: A Narrative Review.

# publications[].label
Vanillic acid improves stress resistance and substantially extends lifespan in Caenorhabditis elegans.

# publications[].label
Proximal digit tip amputation initiates simultaneous blastema and transient fibrosis formation and results in partial regeneration.

# publications[].label
The Impact of Aging on Mechanisms of Mammalian Epimorphic Regeneration.

# publications[].label
The role of oxygen termination of nanocrystalline diamond on immobilisation of BMP-2 and subsequent bone formation.

# publications[].label
The suppressive effect of mesenchymal stromal cells on T cell proliferation is conserved in old age.

# publications[].label
Microcomputed tomography staging of bone histolysis in the regenerating mouse digit.

# publications[].label
The impact of aging on memory T cell phenotype and function in the human bone marrow.

# publications[].label
Medicine. Progeria accelerates adult stem cell aging.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# streetAddress
Texas A&M University; Vet Med - Physiology & Pharmacology; 4466 TAMU

# schools[]
School of Veterinary Medicine and Biomedical Sciences