# overview
The dynamic interaction of cancer cells with the tumor microenvironment (TME) is crucial to stimulate the heterogeneity of cancer cells, and to increase multidrug resistance ending in cancer cell progression and metastasis. Understanding the underlying molecular & cellular mechanisms governing these interactions can be used as a novel strategy to disrupt cancer cell-TME interaction and contribute to the development of efficient therapeutic strategies. By integrating cutting-edge cellular and molecular biology, bioinformatics, and bioengineering approaches, our lab is investigating the complexity of TME.

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Fanconi Anemia Complementation Group D2 Protein

# educationAndTraining[].organization.label
Purdue University - (West Lafayette, Indiana, United States)

# publications[].label
Circadian Gene Selection for Time-to-event Phenotype by Integrating CNV and RNAseq Data.

# publications[].label
The tumor suppressor C/EBP delta (CEBPD) promotes metastasis of MMTV-Neu mouse mammary tumors and augments mTOR/AKT/HIF-1 activity through inhibition of FBXW7 expression

# publications[].label
FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Multiple Omics Data Integration to Identify Long Noncoding RNA Responsible for Breast Cancer-Related Mortality.

# publications[].label
Carcinoma cells that have undergone an epithelial-mesenchymal transition differentiate into endothelial cells and contribute to tumor growth.

# publications[].label
Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth.

# publications[].label
Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance.

# publications[].label
The role of effective energy restriction on metastatic tumor growth

# publications[].label
Cancer-associated fibroblasts: The chief architect in the tumor microenvironment.

# publications[].label
C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
PER2 regulation of mammary gland development.

# publications[].label
Photothermal modulation of human stem cells using light-responsive 2D nanomaterials.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Cloning, expression and characterization of a putative flavonoid glucosyltransferase from grapefruit (citrus paradisi) leaves

# publications[].label
Bayesian structural equation modeling in multiple omics data with application to circadian genes.

# publications[].label
CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition.

# publications[].label
Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBP expression and contributes to transformation of breast tumor cells.

# publications[].label
2D Nanosilicate for additive manufacturing: Rheological modifier, sacrificial ink and support bath

# publications[].label
The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition.

# publications[].label
CEBPD (C/EBP) acts as a tumor suppressor in hormone receptor positive breast cancer cells and may serve as biomarker to predict the need for adjuvant therapy

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer.

# publications[].label
Identification, Recombinant Expression, and Biochemical Analysis of Putative Secondary Product Glucosyltransferases from Citrus paradisi.

# publications[].label
GSK3 regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer.

# publications[].label
Multifaceted entrancing role of glucose and its analogue, 2-deoxy-D-glucose in cancer cell proliferation, inflammation, and virus infection.

# publications[].label
A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Dietary Intakes of Amino Acids and Other Nutrients by Adult Humans

# publications[].label
Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT.

# publications[].label
The Cytotoxicity of Carbon Nanotubes and Hydroxyapatite, and Graphene and Hydroxyapatite Nanocomposites against Breast Cancer Cells.

# publications[].label
Carboxyl-coated magnetic nanoparticles for mRNA isolation and extraction of supercoiled plasmid DNA.

# publications[].label
Bayesian Structural Equation Modeling in Multiple Omics Data Integration with Application to Circadian Genes

# publications[].label
GD2 and GD3 synthase: novel drug targets for cancer therapy.

# streetAddress
Texas A & M University; 525 Lubbock St; Butler Hall, 3258