# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
are interested both in how lymphatic functions are impacted by disease and in how manipulating lymphatic biology or lymphangiogenesis may prevent or reduce tissue pathologies. Our research approach incorporates a vast array of tools from protein analysis and lipidomics to tissue engineering and transgenic mouse model generation. Current projects are focused on the pathophysiology of chronic inflammatory diseases such as obesity, lymphedema, lipedema, hypertension, and kidney disease.

# hrJobTitle
Associate Professor and Director of the Division of Lymphatic Biology

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Hypoxia-Inducible Factor 1, Alpha Subunit

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# educationAndTraining[].organization.label
ecole Polytechnique Federale de Lausanne - (Lausanne, Switzerland)

# educationAndTraining[].organization.label
Northwestern University - (Evanston, Illinois, United States)

# educationAndTraining[].organization.label
The University of Texas Southwestern Medical Center - (Dallas, Texas, United States)

# educationAndTraining[].organization.label
Pennsylvania State University - (State College, Pennsylvania, United States)

# publications[].label
Genetically inducing renal lymphangiogenesis attenuates hypertension in mice.

# publications[].label
Time course of histomorphological changes in adipose tissue upon acute lipoatrophy.

# publications[].label
Genetically Induced Renal Lymphangiogenesis Prevents the Development of L-NAME Hypertension in Mice.

# publications[].label
Claudin-4, a core component of the tight-junctional complex along the collecting system, is induced in nephrotic syndrome

# publications[].label
Characterization of Lymphangiogenesis in Adipose Tissue Upon Local, Induced VEGFD Overexpression

# publications[].label
Characterization of lymphangiogenesis in a model of adult skin regeneration.

# publications[].label
Fixing lymphatics improves glucose metabolism.

# publications[].label
Metabolomic Study To Identify Common Metabolites In Two Different Mouse Models Of Hypertension

# publications[].label
Hypercholesterolemic mice exhibit lymphatic vessel dysfunction and degeneration.

# publications[].label
Increased adipose tissue lymphatic vessel density inhibits thermogenesis through elevated neurotensin levels.

# publications[].label
An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State.

# publications[].label
Therapeutically-Induced Lymphangiogenesis is Ineffective in Resolving Established Kidney Disease in Mice.

# publications[].label
Abstract 098: Augmenting Renal Lymphatic Vessel Density Prevents Salt-sensitive Hypertension in Mice

# publications[].label
Therapeutic Induction of Renal Lymphatic Expansion Attenuates Blood Pressure in Mice With L-NAME Hypertension

# publications[].label
Lymphangiogenesis in the ovary: importance in follicle maturation and murine pregnancy

# publications[].label
Lack of "immunological fitness" during fasting in metabolically challenged animals.

# publications[].label
Impact of High Fat Diet and Bolus Feeding on Chyle Accumulation in a Mouse Model of Generalized Lymphatic Anomaly.

# publications[].label
Impact of Dietary Fatty Acids on Chylous Effusion in a Mouse Model of Generalized Lymphatic Anomaly

# publications[].label
Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease.

# publications[].label
A Novel Mouse Model of Inducible Lymphangiogenesis Through Controlled Local Expression of VEGF-D

# publications[].label
The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia.

# publications[].label
The role of hypoxia-inducible factor asparaginyl hydroxylase (FIH) in chronic kidney disease

# publications[].label
VEGFR-3 neutralization inhibits ovarian lymphangiogenesis, follicle maturation, and murine pregnancy.

# publications[].label
Augmenting Renal Lymphatic Vessel Density Prevents Salt-sensitive Hypertension in Mice.

# publications[].label
Adipose Tissue VEGF-D Overexpression Increases Lymphatic Vessel Density and Protects Against Inflammation and Insulin Resistance in Obesity

# publications[].label
Development of an assay for ozone-specific antioxidant capacity.

# publications[].label
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.

# publications[].label
Identification of Cyr61 and Tfgbi as Hypertensive Renal LEC Genes.

# publications[].label
Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads.

# publications[].label
Normal dendritic cell mobilization to lymph nodes under conditions of severe lymphatic hypoplasia.

# publications[].label
Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations.

# publications[].label
Adiponectin alters renal calcium and phosphate excretion through regulation of klotho expression.

# publications[].label
Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress.

# publications[].label
Hyperplasia, de novo lymphangiogenesis, and lymphatic regression in mice with tissue-specific, inducible overexpression of murine VEGF-D.

# publications[].label
Abstract 143: Enhancing Renal Lymphatic Vessel Density Blunts Both Salt-Sensitive and Angiotensin II-Dependent Hypertension in Mice

# publications[].label
Active response of the lymphatic endothelium to acute inflammation vs. chronic lymphedema: in vivo and in vitro studies

# publications[].label
Time-course of sodium transport along the nephron in nephrotic syndrome: The role of potassium.

# publications[].label
VEGF-C promotes the development of lymphatics in bone and bone loss.

# publications[].label
Abstract 024: Genetically Inducing Renal Lymphangiogenesis Prevents Angiotensin II-Induced Hypertension in Mice

# publications[].label
Reduced lymphatic function contributes to age-related disease.

# publications[].label
Mechanisms of obesity and related pathologies: the macro- and microcirculation of adipose tissue.

# publications[].label
Renal inflammation and injury are associated with lymphangiogenesis in hypertension.

# publications[].label
Proteinuria Increases Plasma Phosphate by Altering Its Tubular Handling.

# publications[].label
Abstract P132: A Kidney-Targeted Nanoparticle To Augment Renal Lymphatic Density Decreases Blood Pressure In Mice With L-NAME- And Angiotensin II-Induced Hypertension

# publications[].label
Tissular glucocorticoid reactivating enzyme 11-HSD1 drives pathogenic myofibroblast differentiation in chronic kidney disease

# publications[].label
ACTIVE REGULATION OF LIPID TRANSPORT AND METABOLISM BY LYMPHATICS: COMPLIMENTARY IN VIVO AND IN VITRO STUDIES

# publications[].label
Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage.

# publications[].label
Common Metabolites in Two Different Hypertensive Mouse Models: A Serum and Urine Metabolome Study.

# publications[].label
VEGFR-3 signaling in macrophages: friend or foe in disease?

# publications[].label
Inflammatory Alterations to Renal Lymphatic Endothelial Cell Gene Expression in Mouse Models of Hypertension.

# publications[].label
Current Mechanistic Understandings of Lymphedema and Lipedema: Tales of Fluid, Fat, and Fibrosis.

# publications[].label
Endotrophin neutralization through targeted antibody treatment protects from renal fibrosis in a podocyte ablation model.

# publications[].label
Pathological Type-2 Immune Response, Enhanced Tumor Growth, and Glucose Intolerance in Retnl (RELM) Null Mice: A Model of Intestinal Immune System Dysfunction in Disease Susceptibility.

# publications[].label
Augmenting Renal Lymphatic Density Prevents Angiotensin II-Induced Hypertension in Male and Female Mice.

# publications[].label
Emerging roles for lymphatics in acute kidney injury: Beneficial or maleficent?

# publications[].label
Regulation of lymphatic capillary regeneration by interstitial flow in skin.

# publications[].label
Enhancing Renal Lymphatic Vessel Density Blunts Both Salt-Sensitive and Angiotensin II-Dependent Hypertension in Mice

# publications[].label
Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization.

# publications[].label
A Kidney-Targeted Nanoparticle to Augment Renal Lymphatic Density Decreases Blood Pressure in Hypertensive Mice.

# publications[].label
Enhancing Renal Lymphatic Expansion Prevents Hypertension in Mice.

# publications[].label
Abstract P110: Differential Gene Expression Associated With Ccn1-positive Renal Cells In Murine Hypertensive Models

# publications[].label
Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells via VEGFR-3 regulation of VE-Cadherin.

# publications[].label
Spatiotemporal Landscape of Kidney Tubular Responses to Glomerular Proteinuria.

# publications[].label
Comparison of ozone-specific (OZAC) and oxygen radical (ORAC) antioxidant capacity assays for use with nasal lavage fluid.

# publications[].label
Dichotomous effects on lymphatic transport with loss of caveolae in mice.

# publications[].label
Isolation and quantitation of adiponectin higher order complexes.

# publications[].label
Expanded renal lymphatics improve recovery following kidney injury.

# publications[].label
Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk.

# publications[].label
Inducible Adipose Tissue VEGFD Drives Lymphatic Expansion and Improves Systemic Insulin Sensitivity in Obesity

# publications[].label
Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

# publications[].label
Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9.

# publications[].label
Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice.

# publications[].label
Transmural flow modulates cell and fluid transport functions of lymphatic endothelium.

# publications[].label
Loss of Caveolin-1 Increases Macromolecule Transport Across Lymphatic Endothelium

# publications[].label
Genetically Inducing Renal Lymphangiogenesis Prevents Angiotensin II-Induced Hypertension in Mice

# publications[].label
Immune cell trafficking, lymphatics and hypertension.

# publications[].label
Adiponectin promotes functional recovery after podocyte ablation.

# publications[].label
DHT Differentially Regulates T Helper Cell Related Cytokines and MicroRNAs In Visceral and Subcutaneous Adipose Tissue of Female Mice

# publications[].label
Molecular and biophysical regulators of lymphatic transport

# publications[].label
Abstract P3020: Therapeutic Induction of Renal Lymphatic Expansion Attenuates Blood Pressure in Mice With L-NAME Hypertension

# publications[].label
Abstract P339: Genetically Induced Renal Lymphangiogenesis Prevents the Development of L-NAME Hypertension in Mice

# publications[].label
Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury.

# publications[].publisher
Ovid Technologies (Wolters Kluwer Health)

# publications[].label
Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis.

# publications[].label
Impact of lymphangiogenesis on renal phosphate handling following kidney injury

# publications[].label
Tissue-Engineered Therapeutics for Lymphatic Regeneration: Solutions for Myocardial Infarction and Secondary Lymphedema.

# publications[].label
Microbiome-associated Metabolites Are Altered In Mouse Models Of Hypertension

# publications[].label
Transendothelial Transport May Determine Adiponectin Oligomer Functions

# publications[].label
Sodium, Interstitium, Lymphatics and Hypertension-A Tale of Hydraulics.

# publications[].label
Intravital quantification of tissue fluid balance changes in Lymphedema

# publications[].label
Evaluation of the Cardiometabolic Disorders after Spinal Cord Injury in Mice.

# publications[].label
Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages.

# publications[].label
A driving force for change: interstitial flow as a morphoregulator.

# publications[].label
Indications of Peripheral Pain, Dermal Hypersensitivity, and Neurogenic Inflammation in Patients with Lipedema.

# publications[].label
Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease.

# publications[].label
PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells.

# publications[].label
Evolution of hypoxia and hypoxia-inducible factor asparaginyl hydroxylase regulation in chronic kidney disease.

# publications[].label
Increased severity of chronic kidney disease in response to high potassium intake is dependent on mineralocorticoid receptor activation

# publications[].label
Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D.

# publications[].label
Vascular Endothelial Growth Factor-D(VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity.

# publications[].label
Nav1.8 neurons are involved in limiting acute phase responses to dietary fat.

# publications[].label
An endothelial-to-adipocyte extracellular vesicle axis governed by metabolic state

# publications[].label
Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen.

# publications[].label
Lymphangiogenesis: fuel, smoke, or extinguisher of inflammation's fire?

# publications[].tags
16 Peace, Justice and Strong Institutions

# publications[].label
Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress.

# publications[].label
Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema.

# researcherOn[].label
Adipose tissue lymphatic vessel functions in obesity

# researcherOn[].awardedBy.label
American Heart Association - (New York, New York, United States)

# researcherOn[].label
Lymphatics and lymphangiogenesis in kidney function and inflammation

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Diabetes and Digestive and Kidney Disorders

# researcherOn[].label
Role of renal lymphatics in blood pressure regulation

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M Health Science Center; Medical Physiology 1114 TAMUS; 8447 John Sharp Parkway

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine

# inTheNews[].label
Texas A&M Assistant Professor speaks on the importance of American Heart Association funding