{
"id" : "nf27056c4",
"class" : "Person",
"name" : "Hardin, Paul",
"primaryEmail" : "phardin1@tamu.edu",
"phone" : "1 979 458 4478",
"preferredTitle" : "Distinguished Professor",
"positions" : [ {
"id" : "n9dc5ba23",
"label" : "Distinguished Professor",
"type" : "FacultyPosition",
"organizations" : [ {
"id" : "ne1d4c4ac",
"label" : "Biology",
"parent" : [ {
"id" : "nfa5c5352",
"label" : "College of Arts and Sciences"
} ]
} ]
} ],
"overview" : "A diverse array of organisms including prokaryotic and eukaryotic microbes, plants, and animals display daily rhythms in physiology, metabolism and/or behavior. These rhythms are not passively driven by environmental cycles of light and temperature, but are actively controlled by endogenous circadian clocks that are set by environmental cycles, keep time in the absence of environmental cues, and activate overt physiological, metabolic and behavioral rhythms at the appropriate time of day. This remarkable conservation of circadian clock function through evolution suggests that maintaining synchrony with the environment is of fundamental importance. Our understanding of the circadian clock is particularly important for human health and well-being. The clearest examples of circadian clock dysfunction are those that result in abnormal sleep-wake cycles, but clock disturbances are also associated with other ailments including epilepsy, cerebrovascular disease, depression, and seasonal affective disorder. The realization that disorders of the sleep-wake cycle such as Familial Advanced Sleep Phase Syndrome can result from alterations in clock gene function underscores the clinical importance of understanding the molecular organization of the circadian system.
Work in my laboratory focuses on defining the molecular mechanisms that drive circadian clock function in the fruit fly, Drosophila melanogaster. We previously found that the core timekeeping mechanism is based on core and interlocked transcriptional feedback loops. Our studies currently focus on (1) defining post-translational regulatory mechanisms that operate in the core loop to set the 24 hour period, (2) determining whether interlocked loops are important for circadian timekeeping and/or output, (3) understanding how circadian oscillator cells are determined during development, and (4) defining mechanisms that control rhythms in olfactory and gustatory physiology and behavior.",
"hrJobTitle" : "Distinguished Professor",
"keywords" : [ "Animals", "Drosophila Melanogaster", "CLOCK Proteins", "Gene Expression Regulation, Developmental", "Alanine", "Circadian Rhythm", "RNA, Messenger", "Mutation", "Drosophila Proteins", "Phosphorylation", "Troponin", "Sea Urchins", "Troponin C", "Calcium-Binding Proteins", "Morphogenesis", "Cell Differentiation", "Calmodulin", "Animals", "RNA, Messenger", "Drosophila Melanogaster", "Light", "Drosophila", "Peripheral Tissues", "Passive Membrane Properties", "Cryptochrome", "Green Fluorescent Proteins", "Eye Proteins", "Animals", "Circadian Clocks", "Malpighian Tubules", "Photoreceptor", "Potassium Channels", "Larval Salivary Gland", "Gene Expression Profiling", "Larva", "Cryptochromes", "Transgenes", "Circadian Clock", "Drosophila Proteins", "Neuropeptides", "Male", "Clock Genes", "Gene Expression Regulation, Developmental", "Receptor-like Protein Tyrosine Phosphatases", "Animals", "Darkness", "Mutation", "Drosophila", "RNA Interference", "Animals, Genetically Modified", "Embryo, Nonmammalian", "Pacemaker Neurons", "Neurons", "Motor Activity", "Larva", "Circadian Rhythm", "Locomotor Activity", "Brain", "Circadian Rhythms", "Drosophila Proteins", "DNA, Antisense", "Phosphatase", "Biological Clocks", "DNA-Binding Proteins", "Molecular Sequence Data", "RNA, Messenger", "Trans-Activators", "Immunohistochemistry", "Blotting, Western", "Animals", "Transcription Factors", "Binding Sites", "Feedback", "Circadian Rhythm", "Animals, Genetically Modified", "CLOCK Proteins", "Drosophila", "Drosophila Proteins", "Nuclease Protection Assays", "Photoreceptor Cells, Invertebrate", "Hot Temperature", "G-box Binding Factors", "Electrophoretic Mobility Shift Assay", "Period Circadian Proteins", "Transcription, Genetic", "ARNTL Transcription Factors", "Drosophila Proteins", "E-Box Elements", "Drosophila Melanogaster", "Animals", "Circadian Rhythm", "Repressor Proteins", "CLOCK Proteins", "Gene Expression Regulation", "Circadian Rhythm", "Beta-Galactosidase", "Fluorescent 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"Ubiquitin-Protein Ligases", "Drosophila Melanogaster", "Receptors, Odorant", "Olfactory Receptor Neurons", "Smell", "GTP-Binding Protein Alpha Subunits, Gi-Go", "Animals", "Olfactory Pathways", "Electrophysiology", "Pertussis Toxin", "Animals, Genetically Modified", "Odorants", "Analysis Of Variance", "Signal Transduction", "Nucleic Acid Hybridization", "DNA", "Animals", "RNA, Messenger", "Genes", "Cloning, Molecular", "Troponin C", "Molecular Sequence Data", "Troponin", "Sea Urchins", "Base Sequence", "Protein Biosynthesis", "G-protein-coupled Receptor Kinase 2", "Drosophila Melanogaster", "Receptors, Cell Surface", "Behavior, Animal", "Circadian Rhythm", "Drosophila Proteins", "Feeding Behavior", "Taste", "Animals", "Drosophila", "Oscillometry", "Gene Expression Regulation", "Circadian Rhythm", "Animals", "Phosphorylation", "Mice", "Trans-Activators", "Time Factors", "Transcription, Genetic", "Models, Biological", "Humans", "Biological Clocks", "Biological Clocks", "Cryptochromes", "Transcription Factors", "Receptors, G-Protein-Coupled", "Eye Proteins", "CLOCK Proteins", "Protein Biosynthesis", "Basic Helix-Loop-Helix Transcription Factors", "Transcription, Genetic", "Photoreceptor Cells, Invertebrate", "RNA, Messenger", "Circadian Rhythm", "Mice", "Animals", "Models, Biological", "Drosophila Proteins", "ARNTL Transcription Factors", "Flavoproteins", "Drosophila Melanogaster", "Cell Cycle Proteins", "Cell Membrane", "Proteolipids", "Docosahexaenoic Acids", "Drosophila", "Eicosapentaenoic Acid", "Proto-Oncogene Proteins P21(ras)", "Fatty Acids, Omega-3", "Phospholipids", "Cells, Cultured", "Diet", "Animals", "Cholesterol", "Fish Oils", "Mice", "Cell Proliferation", "Drosophila", "Histone Acetyltransferases", "Animals", "Gene Expression", "RNA Interference", "Protein Binding", "CLOCK Proteins", "Circadian Rhythm", "Circadian Clocks", "Drosophila Proteins", "Transcription, Genetic", "Proteomics", "Transcription Factors", "Photoperiod", "Drosophila Melanogaster", "Feedback", "Drosophila Proteins", "Behavior, Animal", "Animals", "Light", "RNA, Messenger", "Period Circadian Proteins", "Nuclear Proteins", "Gene Expression Regulation", "Motor Activity", "Circadian Rhythm", "Phosphorylation", "Circadian Rhythm", "Drosophila Proteins", "CLOCK Proteins", "Period Circadian Proteins", "Circadian Clock", "ARNTL Transcription Factors", "Feedback Loop", "Drosophila Melanogaster", "Behavioral Rhythms", "PROTEIN PHOSPHORYLATION", "Drosophila Genetics", "Animals", "Clock Protein", "Mass Spectrometry (ms)", "Transcription Regulation", "Period Circadian Proteins", "Drosophila", "Gene Expression Regulation", "Circadian Rhythm", "RNA Interference", "ARNTL Transcription Factors", "Animals", "Drosophila Proteins", "CLOCK Proteins", "Phosphorylation", "Mitogen-Activated Protein Kinases", "Biological Clocks", "Sleep Research", "Generic Health Relevance", "Neurosciences", "Genetics", "Behavioral And Social Science", "Amino Acid Sequence", "Circadian Rhythm", "Heat 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"Animals", "DNA", "Telemetry", "Oligonucleotide Array Sequence Analysis", "Heart Rate", "Myocardium", "Photoreceptor Cells, Invertebrate", "Male", "Transcription Factors", "Animals", "Transcriptional Activation", "Repressor Proteins", "RNA, Messenger", "CLOCK Proteins", "Biological Clocks", "Drosophila Proteins", "Behavior, Animal", "Drosophila Melanogaster", "Circadian Rhythm", "Mutation", "Basic-Leucine Zipper Transcription Factors", "Female", "Feedback", "DNA", "Mutation", "Models, Theoretical", "Animals", "Temperature", "Transcription Factors", "Computer Simulation", "Feedback, Physiological", "Phosphorylation", "Heterozygote", "Protein Binding", "Protein Structure, Tertiary", "Kinetics", "Dose-Response Relationship, Drug", "Circadian Rhythm", "Oscillometry", "Histones", "Transcriptional Activation", "Drosophila", "Drosophila Proteins", "Time Factors", "Transgenes", "Basic-Leucine Zipper Transcription Factors", "Light", "Models, Biological", "Gene Expression Regulation", "DNA-Directed RNA Polymerases", "Acetylation", "CLOCK Proteins", "Transcription, Genetic", "Olfactory Receptor Neurons", "Animals", "Gene Expression Regulation", "DNA, Complementary", "Hot Temperature", "Olfactory Bulb", "Arrestin", "Sense Organs", "Electrophysiology", "Homozygote", "Phenotype", "Drosophila Melanogaster", "Drosophila Proteins", "Receptors, Odorant", "Smell", "Period Circadian Proteins", "Drosophila", "Motor Activity", "Nuclear Proteins", "Brain", "Animals, Genetically Modified", "Biological Clocks", "Male", "Animals", "Sexual Behavior, Animal", "Courtship", "Circadian Rhythm", "Drosophila Proteins", "Female", "Luciferases, Firefly", "Drosophila Melanogaster", "Tissue Culture Techniques", "Genes, Reporter", "Animals, Genetically Modified", "Recombinant Proteins", "Circadian Rhythm", "Animals", "Gene Expression", "Phosphorylation", "Period Circadian Proteins", "Protein Binding", "Transcription, Genetic", "CLOCK Proteins", "Drosophila", "Circadian Rhythm", "Animals", "Casein Kinase 1 Epsilon", "Transcription Factors", "Nuclear Proteins", "Drosophila Proteins", "Green Fluorescent Proteins", "Period Circadian Proteins", "Transcription Factors", "DNA-Binding Proteins", "Motor Activity", "Optic Lobe, Nonmammalian", "Tetanus Toxin", "Fluorescent Dyes", "Gene Expression Regulation", "Enhancer Elements, Genetic", "Brain", "Animals", "Drosophila Proteins", "Luminescent Proteins", "Circadian Rhythm", "Gene Targeting", "Mutation", "Drosophila", "Immunohistochemistry", "Xanthenes", "Neurons", "Gene Deletion", "Indicators And Reagents", "Neuropeptides", "Photoreceptor Cells, Invertebrate", "Nuclear Proteins", "Molting", "Gene Expression Regulation", "Myocytes, Cardiac", "Male", "Rats", "Circadian Rhythm", "Triglycerides", "Fatty Acids", "Cells, Cultured", "Fasting", "Heart", "Animals", "Rats, Wistar", "Circadian Clocks", "ARNTL Transcription Factors", "Drosophila Melanogaster", "CLOCK Proteins", "Drosophila Proteins", "Animals", "Gene Expression Regulation", "Drosophila Melanogaster", "Drosophila Proteins", "RNA, Messenger", "Alternative Splicing", "Period Circadian Proteins", "Insect Proteins", "Introns", "Seasons", "Motor Activity", "Circadian Rhythm", "Animals", "Photoperiod", "Temperature", "Nuclear Proteins", "Adaptation, Physiological", "Molecular Clocks", "Feedback Loops", "Post-translational Regulation", "Transcriptional Control", "Drosophila Melanogaster", "Genetic Testing", "Activity Rhythms", "Amino Acid Sequence", "Drosophila Melanogaster", "Drosophila", "Circadian Clocks", "Protein Phosphatases", "Circadian Rhythm", "Animals, Genetically Modified", "Gene Expression Regulation", "Phosphoprotein Phosphatases", "RNA Interference", "Male", "Gene Knockdown Techniques", "Drosophila Proteins", "Animals", "Mutation", "Transcription, Genetic", "Circadian Rhythm", "Circadian Clocks", "Drosophila Proteins", "Drosophila Melanogaster", "Protein Stability", "Cells, Cultured", "Drosophila", "Cycle", "Circadian Clock", "Animals", "Cryptochromes", "Neurons", "Cryptochrome", "ARNTL Transcription Factors", "CLOCK Proteins", "Animals, Genetically Modified", "Period Circadian Proteins", "Base Sequence", "RNA, Messenger", "Nuclear Proteins", "Animals", "Drosophila Melanogaster", "Circadian Rhythm", "Motor Activity", "Drosophila Proteins", "Gene Expression Regulation, Developmental", "Tissue Distribution", "Recombinant Fusion Proteins", "Nuclear Proteins", "Gene Expression Regulation", "Period Circadian Proteins", "Homeostasis", "Brain", "Rhodopsin", "Circadian Rhythm", "Eye Proteins", "Drosophila Proteins", "RNA, Messenger", "Genes, Insect", "Behavior, Animal", "Drosophila Melanogaster", "Animals", "Male", "Animals, Genetically Modified", "Photoreceptor Cells, Invertebrate", "Promoter Regions, Genetic", "Rats", "DNA-Binding Proteins", "Transcription Factors", "Periodicity", "Period Circadian Proteins", "Nuclear Proteins", "Animals", "Nuclear Receptor Subfamily 1, Group D, Member 1", "Carrier Proteins", "Glucose", "Gene Expression Regulation", "Receptors, Cytoplasmic And Nuclear", "Norepinephrine", "Protein Kinases", "Cells, Cultured", "Male", "Basic Helix-Loop-Helix Transcription Factors", "Sympathomimetics", "Mitochondrial Proteins", "Myocytes, Cardiac", "Circadian Rhythm", "Ion Channels", "Cell Cycle Proteins", "ARNTL Transcription Factors", "Uncoupling Protein 3", "Age Factors", "Rats, Wistar", "Drosophila", "Animals", "Neurons, Afferent", "Biological Clocks", "Drosophila Proteins", "Circadian Rhythm", "Receptors, Odorant", "Action Potentials", "Dendrites", "G-protein-coupled Receptor Kinase 2", "Fluorescent Antibody Technique", "Animals", "Chemoreceptor Cells", "Receptors, Cell Surface", "Blotting, Western", "Taste", "Circadian Rhythm", "Appetitive Behavior", "G-protein-coupled Receptor Kinase 2", "Drosophila Melanogaster", "Basic-Leucine Zipper Transcription Factors", "Analysis Of Variance", "Drosophila Proteins", "Electrophysiology", "Circadian Rhythm", "Drosophila", "CLOCK Proteins", "DNA Primers", "Transcription, Genetic", "Phosphorylation", "Base Sequence", "Cells, Cultured", "Animals", "Transcription Factors", "Polymerase Chain Reaction", "Drosophila Proteins", "Mutation", "Circadian Rhythm", "Biological Clocks", "Animals", "Periodicity", "Drosophila Melanogaster", "Models, Biological", "Locomotion", "Behavior, Animal", "Activity Cycles", "RNA, Messenger", "Light", "Binding Sites", "Calmodulin", "Parvalbumins", "Animals", "Troponin C", "Nucleic Acid Hybridization", "DNA", "Oligodeoxyribonucleotides", "Troponin", "Cloning, Molecular", "Calcium-Binding Proteins", "Base Sequence", "Chickens", "Amino Acid Sequence", "Calcium", "Sea Urchins", "Protein Binding", "Circadian Rhythm", "Transcriptional Activation", "Biological Clocks", "Trans-Activators", "Animals", "Humans", "Basic Helix-Loop-Helix Transcription Factors", "Drosophila Proteins", "Histone Acetyltransferases", "Repressor Proteins", "ARNTL Transcription Factors", "CLOCK Proteins", "Transcription Factors", "Histones", "Feedback", "CLOCK Proteins", "Circadian Rhythm", "Drosophila", "Drosophila Proteins", "Animals", "Transcription, Genetic", "Circadian Rhythm", "CLOCK Proteins", "Feedback, Physiological", "Models, Animal", "Neural Pathways", "Animals", "Humans", "Drosophila Proteins", "Brain", "Biological Clocks", "Period Circadian Proteins", "Transcription Factors", "Nuclear Proteins", "Circadian Clocks", "Circadian Rhythm", "Animals", "Nuclear Proteins", "Transcription, Genetic", "RNA Splicing", "Drosophila Melanogaster", "Drosophila Proteins", "Alternative Splicing", "RNA, Messenger", "Motor Activity", "Animals", "Behavior, Animal", "Circadian Rhythm", "Period Circadian Proteins", "Animals, Genetically Modified", "Ribonucleases", "Sensory Receptor Cells", "Electrophysiology", "Drosophila Melanogaster", "Smell", "Biological Clocks", "Suprachiasmatic Nucleus", "Circadian Rhythm", "Animals", "Female", "Repressor Proteins", "Cells, Cultured", "Genome, Insect", "Circadian Rhythm", "Transcription Factors", "Genomics", "E-Box Elements", "Base Sequence", "Transcription, Genetic", "Drosophila Melanogaster", "Biological Clocks", "Sequence Homology, Amino Acid", "Amino Acid Sequence", "Drosophila Proteins", "Basic Helix-Loop-Helix Transcription Factors", "Models, Biological", "CLOCK Proteins", "Gene Expression Regulation", "Neurons", "Animals", "Molecular Sequence Data", "Animals, Genetically Modified", "Memory Formation", "Light/dark", "Circadian", "Sleep", "Drosophila", "Biological Clocks", "Flavoproteins", "Repressor Proteins", "CLOCK Proteins", "Receptors, G-Protein-Coupled", "Suprachiasmatic Nucleus", "Period Circadian Proteins", "Darkness", "Animals", "Mice", "ARNTL Transcription Factors", "Eye Proteins", "Photoreceptor Cells, Invertebrate", "Transcription Factors", "Circadian Rhythm", "Drosophila", "Nuclear Proteins", "Gene Expression Regulation", "Mice, Knockout", "Promoter Regions, Genetic", "Trans-Activators", "Transcription, Genetic", "Basic Helix-Loop-Helix Transcription Factors", "Cell Cycle Proteins", "Light", "Drosophila Proteins", "Feedback", "Cryptochromes", "Mutagenesis, Site-Directed", "Trans-Activators", "Animals, Genetically Modified", "Nuclear Proteins", "Circadian Rhythm", "Base Sequence", "Transcription Factors", "Transcriptional Activation", "ARNTL Transcription Factors", "Basic Helix-Loop-Helix Transcription Factors", "Molecular Sequence Data", "Insect Proteins", "Regulatory Sequences, Nucleic Acid", "Beta-Galactosidase", "Animals", "Genes, Reporter", "Gene Expression Regulation", "Helix-loop-helix Motifs", "Drosophila Proteins", "Drosophila", "Period Circadian Proteins", "CLOCK Proteins", "Circadian Clock", "Circadian Rhythm", "Cryptochrome 2", "Drosophila Proteins", "Bmal1 C Terminus", "Amino Acid Sequence", "Transcription, Genetic", "Period Circadian Proteins", "Butterflies", "Clock", "CRISPR", "Vertebrates", "CLOCK Proteins", "Drosophila", "Cells, Cultured", "Animals", "Mice", "Cryptochromes", "ARNTL 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Factors", "Oscillometry", "Brain", "Immunohistochemistry", "Microscopy, Fluorescence", "Cell Nucleus", "Nuclear Proteins", "Drosophila", "Visual System", "Drosophila Melanogaster", "Light", "Neurons", "Posterior Dorsal Neurons 1", "Morning And Evening Oscillators", "Pigment-dispersing Factor", "Oscillator Coupling", "Circadian Rhythm", "Hormone Receptor-like In 38", "Animals", "Male", "Circadian Clocks", "Rest-activity Rhythms", "Drosophila", "Brain", "Circadian Clock", "Drosophila Melanogaster", "Female", "Cell Nucleus", "Male", "Ovary", "Period Circadian Proteins", "Cytoplasm", "Feedback", "RNA, Messenger", "Light", "Tissue Distribution", "Nuclear Proteins", "Animals", "Circadian Rhythm", "Drosophila Proteins", "Darkness", "Gene Expression", "Molecular Sequence Data", "Sequence Analysis, DNA", "Gene Expression Profiling", "Aging", "Gene Expression Regulation", "Darkness", "Cloning, Molecular", "Humans", "Light", "Genome", "Genes, Insect", "Drosophila Melanogaster", "Genomics", "DNA, 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"Circadian Rhythm", "Tissue Distribution", "Motor Activity", "Nervous System Physiological Phenomena", "Promoter Regions, Genetic", "Receptors, Odorant", "Terminology As Topic", "Drosophila", "Insect Proteins", "Animals", "Immunohistochemistry", "Animals", "Circadian Rhythm", "Insect Proteins", "Biological Clocks", "Nuclear Proteins", "Synaptic Transmission", "Promoter Regions, Genetic", "Neurons", "Neuropeptides", "Cell Cycle", "Drosophila Proteins", "Behavior, Animal", "Tetanus Toxin", "Motor Activity", "Drosophila", "Period Circadian Proteins", "Time Factors", "Metalloendopeptidases", "Brain", "Transcription Factors", "Period Circadian Proteins", "Transcription, Genetic", "Nuclear Proteins", "CLOCK Proteins", "Gene Expression Regulation", "Drosophila", "Models, Biological", "Genes, Insect", "Animals", "Feedback, Physiological", "Drosophila Proteins", "Circadian Rhythm", "Tissue Distribution", "Basic-Leucine Zipper Transcription Factors", "Fungi", "Eukaryota", "Biological Clocks", "Models, Biological", "Neurospora Crassa", "Circadian Rhythm", "Animals", "Humans", "Biological Clocks", "Gene Expression Profiling", "Models, Biological", "Circadian Rhythm", "Signal Transduction", "Animals", "RNA, Messenger", "Darkness", "Smell", "Photoreceptor Cells, Invertebrate", "Drosophila Melanogaster", "Genes, Reporter", "Mutation", "Animals", "Light", "Flavoproteins", "Biological Clocks", "Drosophila Proteins", "Phenotype", "Brain", "Receptors, G-Protein-Coupled", "Temperature", "Photic Stimulation", "Neurons", "Eye Proteins", "Gene Expression Regulation", "Circadian Rhythm", "Cryptochromes", "Extremities", "Time Factors", "Biological Clocks", "Gene Expression Regulation", "Basic Helix-Loop-Helix Transcription Factors", "Rats, Wistar", "CLOCK Proteins", "Cell Hypoxia", "Male", "Animals", "Rats", "Trans-Activators", "Myocardium", "Myocardial Reperfusion Injury", "Circadian Rhythm", "Transgenes", "Nuclear Proteins", "Gene Expression", "Drosophila Melanogaster", "Rhodopsin", "Darkness", "Animals", "Promoter Regions, Genetic", "Circadian Rhythm", "Photoreceptor Cells, Invertebrate", "Drosophila Proteins", "Light", "Period Circadian Proteins", "RNA, Messenger", "Electrophysiology", "Drosophila Melanogaster", "Smell", "Odorants", "Animals, Genetically Modified", "Circadian Rhythm", "Animals", "Female", "Photoreceptor Cells, Invertebrate", "Central Nervous System", "Drosophila Proteins", "Neurons", "Drosophila", "Biological Clocks", "Eye Proteins", "Receptors, G-Protein-Coupled", "Cytoplasm", "Fluorescent Antibody Technique, Direct", "Cell Nucleus", "Cryptochromes", "Animals", "Gene Deletion", "Animals, Genetically Modified", "Circadian Rhythm", "Proteins", "Mutation", "Feedback", "Ribonucleases", "Drosophila Melanogaster", "Period Circadian Proteins", "Gene Expression Regulation", "RNA, Messenger", "Motor Activity", "Drosophila Proteins", "Animals", "Nuclear Proteins", "Proteins", "Animals", "RNA, Messenger", "Genes, Insect", "Nuclear Proteins", "Nucleic Acid Precursors", "Promoter Regions, Genetic", "Gene Expression Regulation", "Feedback", "Circadian Rhythm", "Drosophila Melanogaster", "Drosophila Proteins", "Transcription, Genetic", "Period Circadian Proteins", "Genes, Insect", "Period Circadian Proteins", "Molecular Sequence Data", "Animals", "Feedback", "Nuclear Proteins", "Gene Expression Regulation", "Promoter Regions, Genetic", "RNA, Messenger", "Transcription, Genetic", "Drosophila Proteins", "Drosophila Melanogaster", "Circadian Rhythm", "Enhancer Elements, Genetic", "Base Sequence", "Regulatory Sequences, Nucleic Acid", "Drosophila Proteins", "Mutation", "Circadian Rhythm", "Nuclear Proteins", "CLOCK Proteins", "Insect Proteins", "Gene Expression", "Basic Helix-Loop-Helix Transcription Factors", "Transcription Factors", "ARNTL Transcription Factors", "Drosophila Melanogaster", "Transcription, Genetic", "Feedback", "Period Circadian Proteins", "Nervous System", "Animals", "Trans-Activators", "Analysis Of Variance", "Drosophila", "Smell", "Luciferases", "Biological Clocks", "DNA Primers", "Basic Helix-Loop-Helix Transcription Factors", "Neurons, Afferent", "Circadian Rhythm", "Motor Activity", "Animals", "CLOCK Proteins", "Odorants", "Transcription Factors", "Plasmids", "Transgenes", "ARNTL Transcription Factors", "RNA, Messenger", "Feedback", "Gene Expression Regulation", "Drosophila Proteins", "Electrophysiology", "Animals, Genetically Modified", "Central Pacemaker", "Drosophila Clock", "Twin-of-eyeless", "Circadian Oscillator", "Period Circadian Proteins", "Models, Biological", "Conserved Sequence", "Drosophila Proteins", "Animals", "Mammals", "Feedback, Physiological", "CLOCK Proteins", "Transcription Factors", "Nuclear Proteins", "Circadian Rhythm", "Drosophila", "Biological Clocks", "Behavior, Animal", "Photoperiod", "Light", "Neuropeptides", "Drosophila Melanogaster", "CLOCK Proteins", "Circadian Rhythm", "Neurons", "Animals, Genetically Modified", "Period Circadian Proteins", "Drosophila Proteins", 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