{
"id" : "nf41f3898",
"class" : "Person",
"name" : "Gomer, Richard",
"primaryEmail" : "rgomer@tamu.edu",
"phone" : "1 979 458 5745",
"preferredTitle" : "Distinguished Professor",
"positions" : [ {
"id" : "nbe81a5bb",
"label" : "Distinguished Professor",
"type" : "FacultyPosition",
"organizations" : [ {
"id" : "ne1d4c4ac",
"label" : "Biology",
"parent" : [ {
"id" : "nfa5c5352",
"label" : "College of Arts and Sciences"
} ]
} ]
} ],
"overview" : "Our laboratory is working on three areas of biomedicine, trying to move observations from basic research into the clinic. First, we are studying how the sizes of tissues and tumors are regulated, and how this can be manipulated for therapeutic purposes. As a model system, we are using the simple eukaryote Dictyostelium discoideum, which allows us to combine techniques such as biochemistry, genetics, computer modeling, and cell biology to study tissue size regulation. We have found that a secreted protein as well as the unusual molecule polyphosphate are signals in negative feedback loops that inhibit Dictyostelium cell proliferation, and we are studying the signal transduction pathway to understand similar mechanisms in humans.
Second, we are studying how some secreted proteins can make cells move away from the source of the signal. We found such a signal (called a chemorepellent) in Dictyostelium, and then found a similar signal in humans. We are working to understand the signal transduction pathway for both. The human signal repels neutrophils, and we found that this can be used therapeutically in mouse models of neutrophil-driven diseases such as rheumatoid arthritis and acute respiratory distress syndrome.
Third, we have found that a human blood protein called Serum Amyloid P (SAP) regulates a key step in the formation of scar tissue as well as the formation of the scar-like lesions in fibrosing diseases such as congestive heart failure and pulmonary fibrosis. We are studying this mechanism, and a biotech company (Promedior, now sold to Roche) we co-founded is testing SAP as a therapy for fibrosis in patients in a Phase 3 trials.",
"hrJobTitle" : "Professor",
"keywords" : [ "Protozoan Proteins", "Dictyostelium", "Movement", "Computer Simulation", "Cell Adhesion", "Animals", "Male", "Cells, Cultured", "Dppiv", "Tryptases", "Female", "Trypsin", "Ards", "Acute Respiratory Distress Syndrome", "Lung", "Par", "Disease Models, Animal", "Mice", "Mice, Knockout", "Respiratory Distress Syndrome", "Neutrophils", "Receptor, Par-2", "Mice, Inbred C57BL", "Dipeptidyl Peptidase 4", "Chemotaxis, Leukocyte", "Chemotaxis", "Animals", "Antibodies", "Genes", "RNA, Messenger", "Fluorescent Antibody Technique", "Dictyostelium", "Cloning, Molecular", "Fungal Proteins", "Base Sequence", "Genes, Fungal", "Transcription, Genetic", "Hepatitis", "Animals", "Diet, High-Fat", "Adipose Tissue", "Male", "Neuraminidase", "Inflammation", "Mice", "Panniculitis", "Mice, Inbred C57BL", "Fatty Liver", "Dictyostelium", "Chromosome Inversion", "RNA, Messenger", "Lectins", "Gene Expression Regulation", "Cell Movement", "Discoidins", "Transformation, Genetic", "Phenotype", "DNA, Recombinant", "Fungal Proteins", "Protozoan Proteins", "Rna, Fungal", "Inflammatory And Immune System", "5 Development Of Treatments And Therapeutic Interventions", "5.1 Pharmaceuticals", "Clinical Research", "Protein Binding", "Protease", "Dppiv", "Dictyostelium", "Functional Similarity", "Structure Similarity", "Apra", "Chemorepellent", "Protozoan Proteins", "Fibronectins", "Dipeptidyl Peptidase 4", "Structural Homology, Protein", "Humans", "Cell Adhesion Molecules", "Phosphotransferases", "Protozoan Proteins", "Protein Structure, Tertiary", "Receptors, G-Protein-Coupled", "Animals", "Signal Transduction", "Dictyostelium", "GTP-Binding Protein Alpha Subunits", "Gene Expression Regulation", "Lipid Metabolism", "Models, Biological", "Endosomes", "Autocrine Communication", "Culture Media, Conditioned", "Protozoan Proteins", "Dictyostelium", "Chemotaxis", "Signal Transduction", "Cell Division", "Nerve Tissue Proteins", "Male", "Cell Differentiation", "Monocytes", "C-reactive Protein", "Mice", "Animals", "Humans", "Pulmonary Fibrosis", "Fibroblasts", "Female", "Serum Amyloid P-component", "Lung", "Receptors, IgG", "Interphase", "Cell Aggregation", "Dictyostelium", "Cyclic AMP", "Spores, Fungal", "Cell Cycle", "Morphogenesis", "Cell Differentiation", "Cell Division", "Cell Adhesion Molecules", "Protozoan Proteins", "Dictyostelium", "Cyclic AMP", "Signal Transduction", "Gene Expression Regulation", "Promoter Regions, Genetic", "Animals", "Chromatography", "Cell Fractionation", "Yeasts", "Fungal Proteins", "Peptides", "Electrophoresis, Polyacrylamide Gel", "Protein Conformation", "Antibodies", "Recombination, Genetic", "Amino Acid Sequence", "Models, Genetic", "Base Sequence", "Escherichia Coli", "Protozoan Proteins", "Mutation", "Molecular Sequence Data", "Blotting, Northern", "Animals", "Gene Library", "Gene Deletion", "Glycogen", "Genetic Complementation Test", "Cell Division", "Dictyostelium", "Cell Survival", "Mutagenesis, Site-Directed", "Cellulose", "Cloning, Molecular", "Cell Differentiation", "Time Factors", "Lysine", "Phylogeny", "Phenotype", "Utp-glucose-1-phosphate Uridylyltransferase", "Recombinant Proteins", "Mice", "Humans", "Fibroblasts", "Serum Amyloid P-component", "Cell Differentiation", "Macrophage Colony-stimulating Factor", "RNA, Small Interfering", "Receptors, IgG", "Interleukin-13", "Monocytes", "HEK293 Cells", "Mice, Inbred C57BL", "Animals", "Oscillometry", "Expressed Sequence Tags", "Oligonucleotide Array Sequence Analysis", "Light", "Time Factors", "Neurospora Crassa", "Mutation", "Circadian Rhythm", "RNA, Messenger", "Monocytes", "Cattle", "Cells, Cultured", "Serum Albumin", "Humans", "Trypsin", "Cell Differentiation", "Animals", "Dose-Response Relationship, Drug", "Wound Healing", "Fibroblasts", "Drug Synergism", "Serum Albumin, Bovine", "Cattle", "Cytoskeletal Proteins", "Fluorescent Antibody Technique", "Cytoskeleton", "Animals", "Mitochondria, Heart", "Immunoblotting", "Autoantigens", "Myocardium", "Electrophoresis, Polyacrylamide Gel", "Animals", "Disease Models, Animal", "Cell Line", "Fibroblasts", "Mice, Inbred C57BL", "Pulmonary Fibrosis", "Cell Movement", "Serum Amyloid P-component", "Male", "Cell Count", "Rats, Sprague-Dawley", "Mice", "Leukocytes", "Injections, Intraperitoneal", "Time Factors", "Intubation, Intratracheal", "Humans", "Bleomycin", "Drug Administration Schedule", "Rats", "Time Factors", "Galactosidases", "Genes", "Escherichia Coli", "Kinetics", "Promoter Regions, Genetic", "Transcription, Genetic", "DNA Restriction Enzymes", "Genes, Bacterial", "Genes, Fungal", "Genes, Regulator", "Dictyostelium", "Beta-Galactosidase", "Dictyostelium", "Cyclic AMP", "Animals", "Cell Adhesion", "Computer Simulation", "Glucose", "Cell Movement", "Protozoan Proteins", "Blotting, Western", "Signal Transduction", "Cyclic GMP", "Myosins", "Cells, Cultured", "Recombinant Proteins", "Kinetics", "Time Factors", "Cell Aggregation", "Calcium", "Second Messenger Systems", "Signal Transduction", "Cyclic AMP", "Protozoan Proteins", "Radioligand Assay", "Cells, Cultured", "Cell Adhesion Molecules", "Cell Size", "Animals", "Dictyostelium", "Life Cycle Stages", "Dictyostelium", "Genomics", "Cytoskeleton", "Animals", "Cyclin-dependent Kinase 5", "Protein Serine-threonine Kinases", "Endocytosis", "Cell Differentiation", "Animals", "Dictyostelium", "Protozoan Proteins", "Cyclin-Dependent Kinases", "Signal Transduction", "Cells, Cultured", "Hydroxymethylglutaryl-CoA Reductase Inhibitors", "Scleroderma, Systemic", "Fibroblasts", "Endothelium, Vascular", "Immunosuppressive Agents", "Stem Cell Transplantation", "Humans", "Hematopoietic Stem Cells", "Cyclophosphamide", "Stem Cells", "Biological Factors", "Amino Acid Sequence", "Dictyostelium", "Animals", "Protozoan Proteins", "Cell Proliferation", "Molecular Sequence Data", "Sequence Alignment", "Humans", "Sequence Homology, Amino Acid", "Spores, Protozoan", "Cell Nucleus", "Protein Binding", "Gene Expression Regulation, Developmental", "Cytokines", "Tissue Culture Techniques", "Peritoneal Fibrosis", "Dialysis Solutions", "Time Factors", "Fibroblasts", "Lactate", "Kidney Failure, Chronic", "Fibrosis", "Peritoneal Dialysis", "Cell Differentiation", "Humans", "Serum Amyloid P-component", "Fibrocytes", "Leukocytes, Mononuclear", "Adult", "Genes, Fungal", "Protozoan Proteins", "Genes", "Kinetics", "Actins", "Spores, Fungal", "Fungal Proteins", "Discoidins", "Gene Expression Regulation", "Lectins", "Dictyostelium", "Fungal Proteins", "Biological Clocks", "Neurospora Crassa", "Circadian Rhythm", "DNA-Binding Proteins", "Transcription Factors", "Temperature", "Reference Standards", "Protein Binding", "Proteins", "Cell Line", "Phosphates", "Humans", "Aptamers, Nucleotide", "RNA", "Kinetics", "Thermodynamics", "Models, Molecular", "Serum", "RNA Stability", "Vascular Endothelial Growth Factor A", "Limit Of Detection", "Nucleic Acid Conformation", "Culture Media, Conditioned", "Protozoan Proteins", "Dictyostelium", "Cell Proliferation", "Protein Binding", "Animals", "Aged, 80 And Over", "Alzheimer Disease", "Serum Amyloid P-component", "Female", "Humans", "Biomarkers", "Middle Aged", "Brain", "Adult", "Aged", "Male", "Dementia", "5101 Astronomical Sciences", "51 Physical Sciences", "Reverse Transcriptase Polymerase Chain Reaction", "RNA, Messenger", "Dictyostelium", "Subcellular Fractions", "Recombination, Genetic", "Cell Movement", "Cell Adhesion", "Recombinant Proteins", "Glucose", "Blotting, Northern", "Aldehyde Reductase", "Glyceraldehyde", "Cyclic AMP", "Blotting, Western", "DNA", "Amino Acid Sequence", "Protozoan Proteins", "Sorbitol", "Signal Transduction", "Animals", "Computer Simulation", "Cell Line", "Gas Chromatography-Mass Spectrometry", "Cell Aggregation", "NADP", "Molecular Sequence Data", "Time Factors", "Transforming Growth Factor Beta1", "A549 Cells", "Cells, Cultured", "Neuraminidase", "Disease Models, Animal", "Humans", "Enzyme Inhibitors", "Cell Differentiation", "Pulmonary Fibrosis", "Leukocytes, Mononuclear", "Serum Amyloid P-component", "Animals", "Lung", "Fibroblasts", "Mice", "Dictyostelium", "Microsomes", "Hot Temperature", "Cytosol", "Glucose-6-Phosphatase", "Detergents", "Kinetics", "Signal Transduction", "Dose-Response Relationship, Drug", "Liver", "Animals", "Models, Biological", "P21-Activated Kinases", "Signal Transduction", "Cell Proliferation", "Actins", "Protozoan Proteins", "Green Fluorescent Proteins", "Chemotaxis", "Dictyostelium", "Cell Nucleus", "Transgenes", "Gene Expression Regulation", "Pseudopodia", "Pyruvate", "Size Regulation", "ATP", "Lactate", "Dictyostelium Discoideum", "Oxygen Consumption", "Scleroderma, Systemic", "Serum Amyloid P-component", "Fibrosis", "Disease Progression", "Mice, Knockout", "Mice, Inbred C57BL", "Mice", "Animals", "Humans", "Cell Size", "Mutagenesis", "Cell Aggregation", "Dictyostelium", "Movement", "Signal Transduction", "Animals", "Dictyostelium", "Base Sequence", "Cell Adhesion Molecules", "RNA, Messenger", "DNA, Fungal", "Amino Acid Sequence", "Transformation, Genetic", "Protozoan Proteins", "Animals", "Rna, Fungal", "Molecular Sequence Data", "Cell Aggregation", "Blotting, Southern", "Nucleic Acid Hybridization", "Genes, Fungal", "Blotting, Northern", "Glycoproteins", "Gene Expression Profiling", "Endocytosis", "Hydrogen-Ion Concentration", "Mutagenesis", "Animals", "Amino Acid Sequence", "Endosomes", "Base Sequence", "DNA, Protozoan", "Molecular Sequence Data", "Dictyostelium", "Protozoan Proteins", "ATP-Binding Cassette Transporters", "Subcellular Fractions", "Sequence Homology, Amino Acid", "Serum Amyloid P-component", "Obesity", "Mice", "Adipose Tissue", "Lectins, C-Type", "Male", "Hepatitis", "Fatty Liver", "Insulin Resistance", "Animals", "Receptors, Cell Surface", "Mice, Knockout", "Mice, Inbred C57BL", "Diet, High-Fat", "Cell Adhesion Molecules", "Antisense Elements (Genetics)", "Dictyostelium", "Genetic Techniques", "Gene Expression Regulation, Fungal", "Fungal Proteins", "Animals", "Cells, Cultured", "Neuraminidase", "Mice", "HEK293 Cells", "Pulmonary Fibrosis", "Humans", "Sialic Acids", "Transforming Growth Factor Beta", "Mice, Inbred C57BL", "Animals", "Male", "Enzyme Inhibitors", "Up-Regulation", "Macrophages", "Antitubercular Agents", "Fc Receptor", "Receptors, IgG", "Humans", "Serum Amyloid P-component", "M. Smegmatis", "Sap", "Tuberculosis", "Mycobacterium Tuberculosis", "Mycobacterium Smegmatis", "M. Tuberculosis", "M1/m2", "Drug Evaluation, Preclinical", "Glucose", "Phosphofructokinase-1", "Cell Line", "Glucose-6-Phosphatase", "Time Factors", "Animals", "Dictyostelium", "Recombinant Proteins", "Glycolysis", "Kinetics", "Glycogen Phosphorylase", "Signal Transduction", "Dose-Response Relationship, Drug", "Glucokinase", "Models, Biological", "Fructose-bisphosphatase", "Cells, Cultured", "Glycogen", "Cell Culture Techniques", "Interleukin-13", "Spleen", "Wound Healing", "Serum Amyloid P-component", "Animals", "Mice", "Fibroblasts", "Monocytes", "Immunoglobulin G", "Female", "Adult", "Humans", "Male", "Cell Differentiation", "Macrophage Colony-stimulating Factor", "Culture Media, Serum-Free", "Fibrosis", "Dictyostelium", "Models, Biological", "Cyclic GMP", "Protozoan Proteins", "Signal Transduction", "Movement", "Computer Simulation", "Animals", "Cyclic AMP", "Cell Adhesion", "Spectrometry, Mass, Secondary Ion", "Dictyostelium", "Lipids", "Microfilament Proteins", "Myocardium", "Contractile Proteins", "Muscles", "Time Factors", "Chick Embryo", "Myofibrils", "Molecular Weight", "Animals", "Phosphorylation", "Heart", "Filamins", "Gene Expression Regulation", "Protein Processing, Post-Translational", "Muscle Proteins", "Chickens", "Mice, Inbred C57BL", "Mice", "Animals", "Male", "Inflammation", "Sugars", "Macrophage", "Humans", "Bleomycin", "Lung", "Bronchoalveolar Lavage Fluid", "Fibrosis", "Sialidase", "Neuraminidase", "Pulmonary Fibrosis", "Glycosylation", "Neu3", "Cathepsins", "Immunologic Techniques", "Cell Differentiation", "Fungal Proteins", "Cell Compartmentation", "Antibodies, Monoclonal", "Dictyostelium", "Protozoan Proteins", "Cyclic AMP", "Spores, Fungal", "Gene Expression Regulation", "Fungal Proteins", "Animals", "RNA, Messenger", "Base Sequence", "Oncogenes", "Cloning, Molecular", "Dictyostelium", "Genes", "Ras Proteins", "Cyclic AMP", "Amino Acid Sequence", "Transforming Growth Factor Beta1", "Pulmonary Fibrosis", "Translation", "Epithelial Cells", "A549 Cells", "Humans", "Neuraminidase", "Sialidase", "Degradation", "Tgf-β1", "Idiopathic Pulmonary Fibrosis", "Serum Amyloid P-component", "Gastrointestinal Tract", "Diagnosis, Differential", "Macrophages", "Lung", "Animals", "Humans", "Cell Nucleus", "Basic-Leucine Zipper Transcription Factors", "Green Fluorescent Proteins", "Culture Media, Conditioned", "Cell Count", "Spores, Protozoan", "Autocrine Communication", "Cells, Cultured", "Protozoan Proteins", "Signal Transduction", "Dictyostelium", "Protein Transport", "Cell Survival", "Recombinant Fusion Proteins", "Cell Proliferation", "Time Factors", "Cell Adhesion Molecules", "Cell Communication", "Protozoan Proteins", "Dictyostelium", "Cell Count", "Fungal Proteins", "Diffusion", "Cell Differentiation", "Animals", "Disease Models, Animal", "Wounds And Injuries", "Keratins", "Female", "Collagen Type I", "Swine", "Serum Amyloid P-component", "Biopsy", "Skin", "Immunohistochemistry", "Treatment Outcome", "Hydrogel, Polyethylene Glycol Dimethacrylate", "Follow-Up Studies", "Animals", "Wound Healing", "Administration, Topical", "Humans", "Carrier Proteins", "Sialylation", "Pentraxin", "Transforming Growth Factor", "Serum Amyloid P", "Desialylation", "Animals", "Cytokines", "Glycoconjugates", "Humans", "Pulmonary Fibrosis", "Mice", "Biomarker", "Neuraminidase", "N-acetylneuraminic Acid", "Idiopathic Pulmonary Fibrosis", "Mitogens", "Dictyostelium", "DNA Primers", "Recombinant Proteins", "Proteins", "Signal Transduction", "Binding Sites", "Animals", "Base Sequence", "Receptors, Cell Surface", "N-acetylneuraminic Acid", "Choline Deficiency", "Non-alcoholic Fatty Liver Disease", "Neuraminidase", "Cell Adhesion Molecules", "Liver", "Lectins, C-Type", "Macrophages", "Adipose Tissue", "Diabetes Mellitus, Type 2", "Animals", "Fatty Liver", "Mice", "Disease Models, Animal", "Inflammation", "Protein Binding", "Cells, Cultured", "Syndecan-4", "Signal Transduction", "Axon Guidance", "Phosphatidylinositol Phosphates", "Nerve Tissue Proteins", "Chemotaxis", "Actin Cytoskeleton", "Cell Adhesion", "Intercellular Signaling Peptides And Proteins", "Neutrophils", "Protein Isoforms", "Humans", "Antibodies, Blocking", "Pseudopodia", "Cdc42 GTP-Binding Protein", "Ras Proteins", "Amyloidosis", "Wound Healing", "Tuberculosis", "Pentraxin", "Pulmonary Fbrosis", "Clinical Trials As Topic", "Signal Transduction", "Macrophage", "Macrophages", "Fibroblasts", "Neutrophils", "Humans", "Multigene Family", "Fibrocyte", "Fibrosis", "Immunomodulation", "Animals", "Serum Amyloid P-component", "Serum Amyloid P Component (sap)", "Fungal Proteins", "Transcription Factors", "DNA-Binding Proteins", "Neurospora Crassa", "Light", "Molecular Sequence Data", "Gene Expression Regulation, Fungal", "Signal Transduction", "Genes, Fungal", "Circadian Rhythm", "Protozoan Proteins", "Signal Transduction", "Guanosine Triphosphate", "Cell Adhesion Molecules", "Dictyostelium", "Hydrolysis", "Protein Conformation", "Chemokines", "Cyclic AMP", "Animals", "GTP-Binding Proteins", "Middle Aged", "Plasma", "Immunophenotyping", "Stem Cells", "Growth Inhibitors", "Cell Differentiation", "Female", "Male", "Humans", "Serum", "Fibroblasts", "Serum Amyloid P-component", "Cells, Cultured", "Monocytes", "Adult", "Aged", "Cell Density Sensing", "Microbial", "Chemorepulsion", "Review", "Quorum Sensing", "Theory", "Monte Carlo", "Dictyostelium", "Diffusion", "Microscopy, Electron", "Protozoan Proteins", "Serine", "Cytosol", "Dictyostelium", "Base Sequence", "Hydrogen-Ion Concentration", "Animals", "Organelles", "DNA Primers", "Cell Cycle Proteins", "Cell Cycle", "Membrane Fusion", "Catalysis", "Neutral Red", "Spores, Protozoan", "Staining And Labeling", "Starvation", "Dictyostelium", "Cell Cycle", "Gene Expression Profiling", "Cell Differentiation", "Animals", "Lung", "Pulmonary Fibrosis", "Mice, Knockout", "Bleomycin", "Animals", "Mice, Inbred C57BL", "Mice", "Serum Amyloid P-component", "Cell Differentiation", "Pneumonia", "Serum Amyloid P-component", "Fibrosis", "Cells, Cultured", "Th2 Cells", "Monocytes", "Humans", "Th1 Cells", "Cytokines", "Fibroblasts", "Cell Proliferation", "Cell Differentiation", "Animals", "Molecular Sequence Data", "DNA, Complementary", "Cell Differentiation", "Protozoan Proteins", "Amino Acid Sequence", "Dictyostelium", "Recombinant Fusion Proteins", "Molecular Weight", "Base Sequence", "Cell Movement", "Cell Aggregation", "Receptors, Cell Surface", "Cell Line, Tumor", "Galectin 3", "Lectins, C-Type", "Female", "Cell Adhesion Molecules", "Glycoproteins", "Cell Differentiation", "Animals", "Galectin 1", "Antigens, Neoplasm", "RNA, Messenger", "Carrier Proteins", "Culture Media, Conditioned", "Humans", "Recombinant Proteins", "Breast Neoplasms", "Mice", "Biomarkers, Tumor", "Monocytes", "Protozoan Proteins", "Cell Aggregation", "Dictyostelium", "Cyclic AMP", "Models, Biological", "Cell Movement", "Computer Simulation", "Signal Transduction", "Animals", "DNA, Fungal", "Genes, Fungal", "Gene Targeting", "Genes, Protozoan", "Genetic Vectors", "Mutagenesis", "DNA, Antisense", "Molecular Sequence Data", "DNA, Complementary", "Dictyostelium", "Animals", "Transformation, Genetic", "Phenotype", "Cloning, Molecular", "DNA, Protozoan", "Base Sequence", "Mutation", "Receptors, Cyclic AMP", "Caffeine", "Dictyostelium", "Cyclic AMP", "Cell Differentiation", "Gene Expression Regulation", "RNA, Messenger", "Animals", "Lung", "Pneumonia", "Covid-19 Drug Treatment", "Mice, Inbred C57BL", "Male", "Humans", "Mice", "Covid-19", "Female", "Disease Models, Animal", "Cytokine Release Syndrome", "Serum Amyloid P-component", "Muscle Proteins", "Chick Embryo", "Peptide Fragments", "Contractile Proteins", "Cell Differentiation", "Gene Expression Regulation", "Animals", "Muscles", "Microfilament Proteins", "Filamins", "DNA, Antisense", "Cdna Normalization", "Shotgun Antisense", "Genetic Screen", "DNA, Protozoan", "Mutagenesis", "Dictyostelium", "DNA, Complementary", "Sequence Analysis, DNA", "Leukocytes, Mononuclear", "Cell Differentiation", "Female", "Fibroblasts", "Magnetic Resonance Imaging", "Humans", "Cells, Cultured", "Male", "Dose-Response Relationship, Drug", "Gadolinium Dtpa", "Adult", "Young Adult", "Middle Aged", "Nephrogenic Fibrosing Dermopathy", "Microscopy, Confocal", "Dc-sign", "Blotting, Western", "Receptors, IgG", "Thiazoles", "C-reactive Protein", "Serum Amyloid P-component", "Fibrosis", "Serum Amyloid P", "Cell Adhesion Molecules", "Humans", "Neutrophils", "Pentraxin", "Animals", "HEK293 Cells", "Pulmonary Fibrosis", "Mice, Knockout", "Mice, Inbred C57BL", "Immunity, Innate", "Cells, Cultured", "Protein Binding", "IL-10", "Lung", "Receptors, Cell Surface", "Lectins, C-Type", "Interleukin-10", "Macrophages", "Injections, Intradermal", "Dermis", "Serum Amyloid P-component", "Actins", "Immunohistochemistry", "Wound Healing", "Mice, Inbred C57BL", "Mice", "Animals", "Drugs, Investigational", "Pulmonary Fibrosis", "Anti-Inflammatory Agents, Non-Steroidal", "Pyridones", "Drug Design", "Animals", "Humans", "Polyphosphates", "Dictyostelium", "Cell Membrane", "Receptors, G-Protein-Coupled", "Signal Transduction", "Bacillus Subtilis", "Extracellular Space", "Colony Count, Microbial", "Signal Transduction", "Arginase", "Protozoan Proteins", "Cell Movement", "Membrane Proteins", "Animals", "Fungal Proteins", "Cell Communication", "Receptors, Cell Surface", "Receptors, Cyclic AMP", "Cell Adhesion Molecules", "Cyclic AMP", "Cell Count", "Signal Transduction", "Gene Expression Regulation, Developmental", "Dictyostelium", "Neutrophil (pmn)", "Acute Respiratory Disease Syndrome", "Par2", "Dppiv", "Chemorepulsion", "Dictyostelium Discoideum", "Development", "Dictyostelium", "Polyphosphate", "Signal Transduction", "Proteomics", "Humans", "Proteasome", "Ras Proteins", "Polyphosphates", "Proto-Oncogene Proteins C-akt", "Akt", "Ras", "5101 Astronomical Sciences", "Bioengineering", "51 Physical Sciences", "Receptors, Prostaglandin E, Ep2 Subtype", "RNA, Messenger", "Protein Kinase Inhibitors", "Mice, Inbred C57BL", "Mice, Knockout", "Receptors, Prostaglandin E", "Dinoprostone", "Oocytes", "Mice", "Female", "Cells, Cultured", "Follicle Stimulating Hormone", "Enzyme Inhibitors", "Signal Transduction", "Animals", "Ovarian Follicle", "Cell Adhesion Molecules", "Dictyostelium", "Cloning, Molecular", "Animals", "Protozoan Proteins", "Mutation", "Signal Transduction", "Cell Aggregation", "Molecular Weight", "Base Sequence", "Culture Media, Conditioned", "Sequence Analysis", "Phenotype", "RNA, Messenger", "Protein Sorting Signals", "Molecular Sequence Data", "Cell Count", "Amino Acid Sequence", "Protozoan Proteins", "Electrophoresis, Polyacrylamide Gel", "Recombinant Proteins", "Phosphoric Diester Hydrolases", "Molecular Sequence Data", "Cyclic AMP", "Movement", "Base Sequence", "Dextrans", "Fluorescent Antibody Technique", "Blotting, Northern", "Fungal Proteins", "Culture Media, Conditioned", "Transformation, Genetic", "Gene Expression Regulation, Fungal", "DNA, Antisense", "Cell Adhesion Molecules", "Blotting, Western", "Fluorescein-5-isothiocyanate", "Animals", "Exocytosis", "Amino Acid Sequence", "Mutation", "Dictyostelium", "Cell Cycle", "Proteome", "Protozoan Proteins", "Dictyostelium", "Proteomics", "Animals", "Macrophages", "Neutrophils", "Fibrocyte Differentiation", "Fcγ Receptors", "Serum Amyloid P-component", "Humans", "Cell Differentiation", "Phagocytosis", "Immunity, Innate", "Mice", "Immunomodulation", "Fibrosis", "Neutrophil Adhesion", "Monocytes", "Macrophage Polarization", "Molecular Weight", "Cell Adhesion Molecules", "Molecular Sequence Data", "Kinetics", "Time Factors", "Recombinant Proteins", "Animals", "Protein Binding", "Base Sequence", "DNA Primers", "Receptors, Cell Surface", "Genes, Fungal", "Structure-Activity Relationship", "Dictyostelium", "Cell Aggregation", "Fungal Proteins", "Protozoan Proteins", "Chalones", "Spores, Protozoan", "Protozoan Proteins", "Dictyostelium", "Cell Proliferation", "Cells, Cultured", "Animals", "Flow Cytometry", "Fibroblasts", "Humans", "Biomarkers", "Calgranulin B", "Macrophages", "Monocytes", "Blood", "Receptors, Complement", "Cytokines", "Leukocyte Common Antigens", "Immunohistochemistry", "Membrane Glycoproteins", "Cell Separation", "Calgranulin A", "Gene Expression Regulation", "Flow Cytometry", "Cell Differentiation", "Protozoan Proteins", "G2 Phase", "DNA, Protozoan", "Animals", "Cell Cycle Proteins", "S Phase", "Calcium", "Dictyostelium", "Spores", "Cell Aggregation", "Feedback", "Body Constitution", "Cell Count", "Models, Biological", "Cell Movement", "Cell Adhesion", "Cell Division", "Animals", "Humans", "Hyaluronoglucosaminidase", "Monocytes", "Molecular Weight", "Cells, Cultured", "Endocytosis", "Serum Amyloid P-component", "Interleukin-4", "Leukocytes, Mononuclear", "Antibodies", "Humans", "Cell Differentiation", "Cell Survival", "Interleukin-13", "Adult", "Fibroblasts", "Cell Separation", "Hyaluronan Receptors", "Hyaluronic Acid", "Fibroblasts", "Mice, Knockout", "Monocyte", "Immunoglobulin G", "Animals", "Signal Transduction", "Pentraxin", "Immunologic Capping", "Receptors, IgG", "Cd64", "Fcrγ", "Mice", "Sap", "Cell Differentiation", "Dictyostelium", "Cyclic AMP", "Culture Media", "Cell Count", "Cell Differentiation", "Cells, Cultured", "Animals", "Gene Expression", "Interleukin-1beta", "Animals", "Rare Diseases", "Mice, Inbred C57BL", "Disease Models, Animal", "Lung", "Neuraminidase", "32 Biomedical And Clinical Sciences", "Cytokines", "Up-Regulation", "Inflammation", "Pulmonary Fibrosis", "Bronchoalveolar Lavage Fluid", "Mice", "Male", "Female", "Bleomycin", "Respiratory", "Sialic Acids", "Leukocytes, Mononuclear", "Transforming Growth Factor Beta1", "Mice, Knockout", "Cell Line", "2 Aetiology", "2.1 Biological And Endogenous Factors", "3208 Medical Physiology", "3201 Cardiovascular Medicine And Haematology", "Intercellular Signaling Peptides And Proteins", "Cell Differentiation", "Fibroblast", "Mice, Inbred C57BL", "Humans", "Slit2", "Nerve Tissue Proteins", "Lung", "Animals", "Bleomycin", "Mice", "Inflammation", "Fibrocyte", "Fibrosis", "Fibroblasts", "Cell Line", "Pulmonary Fibrosis", "Signal Transduction", "Cyclic AMP", "Glucose", "Animals", "Amino Acid Sequence", "RNA, Small Interfering", "Mutation", "Suppression, Genetic", "Protozoan Proteins", "Dictyostelium", "Molecular Sequence Data", "Cell Differentiation", "Cells, Cultured", "Animals", "Culture Media, Serum-Free", "Monocytes", "Mice", "Humans", "Fibroblasts", "Lipopolysaccharide Receptors", "Heparin", "Cell Differentiation", "Edetic Acid", "Cell Culture Techniques", "Anticoagulants", "Macrophages", "Severity Of Illness Index", "Cell Count", "Animals", "Treatment Outcome", "Inflammation", "Arthritis, Experimental", "Injections, Intra-Articular", "Neutrophils", "Disease Models, Animal", "Mice, Inbred DBA", "Mice", "Dipeptidyl Peptidase 4", "Dipeptidyl-peptidases And Tripeptidyl-peptidases", "Dictyostelium", "Mutation", "Tpp1", "Time Factors", "Aminopeptidases", "Protein Transport", "Batten Disease", "Humans", "Lysosomes", "Tripeptidyl Peptidase 1", "Suppression, Genetic", "Tripeptidyl-peptidase 1", "Proteolysis", "Neuronal Ceroid-lipofuscinoses", "Neuronal Ceroid Lipofuscinosis", "Genes, Suppressor", "Animals", "Spores", "Autophagy", "Serine Proteases", "FLUORESCENCE", "Primary Cell Culture", "Bacteria", "Exopolyphosphatase", "Saccharomyces Cerevisiae Proteins", "Humans", "Recombinant Proteins", "Polyphosphate Kinase", "Lysosomes", "Phagocytosis", "Cells, Cultured", "Acid Anhydride Hydrolases", "Burkholderia", "Hydrogen-Ion Concentration", "Macrophages", "Polyphosphate", "Mycobacterium Tuberculosis", "Phagosomes", "Polyphosphates", "Healthy Volunteers", "Dictyostelium", "Cysteine Endopeptidases", "Genes, Protozoan", "Cell Aggregation", "Dictyostelium", "Gene Expression Regulation, Developmental", "Cell Differentiation", "Animals", "Base Sequence", "Molecular Sequence Data", "Arsenic", "Animals", "Cells, Cultured", "Hot Temperature", "Chickens", "Cricetinae", "Arsenites", "Swine", "Methylation", "Kidney", "Isoelectric Point", "Muscles", "Heat-Shock Proteins", "Molecular Weight", "Proteins", "Cytokines", "Fungal Proteins", "Sap", "Candida Albicans", "Macrophage Polarization", "Phagocytosis", "Candidiasis", "Humans", "Serum Amyloid P-component", "Cells, Cultured", "Innate Immunity", "Macrophages", "Functional Amyloid", "Transformation, Genetic", "Proto-Oncogenes", "Gene Expression Regulation", "GTP Phosphohydrolases", "Receptors, Cyclic AMP", "GTP-Binding Proteins", "Cell Differentiation", "RNA, Messenger", "Mutation", "Dictyostelium", "Genes", "Adenylyl Cyclases", "Amino Acid Sequence", "Promoter Regions, Genetic", "Fluorescent Antibody Technique, Indirect", "Animals", "RNA, Messenger", "Base Sequence", "Culture Media, Conditioned", "Discoidins", "Cysteine", "Escherichia Coli", "Genes, Protozoan", "Luciferases", "Dictyostelium", "Lectins", "Protein Structure, Tertiary", "Phosphoric Diester Hydrolases", "Sequence Analysis, Protein", "Recombinant Proteins", "Genes, Reporter", "Molecular Weight", "Protozoan Proteins", "Gene Expression Regulation, Developmental", "Monocytes", "Protein-Tyrosine Kinases", "Immunoglobulin A", "Intracellular Signaling Peptides And Proteins", "Immunoglobulin M", "Receptors, IgG", "Protein Processing, Post-Translational", "Cell Differentiation", "Fibroblasts", "Antibodies, Monoclonal", "Cells, Cultured", "Immunoglobulin E", "Src-Family Kinases", "Biopolymers", "Humans", "Serum Amyloid P-component", "Immunoglobulin Fc Fragments", "Immunoglobulin G", "Phosphorylation", "Syk Kinase", "Immunohistochemistry", "Disease Models, Animal", "Male", "Neutrophil Infiltration", "Respiratory Distress Syndrome", "Humans", "Dipeptidyl Peptidase 4", "Chemotaxis, Leukocyte", "Mice", "Animals", "Protein Structure, Quaternary", "Mice, Inbred C57BL", "Neutrophils", "Muscles", "Binding Sites", "Amino Acid Sequence", "Mice", "Cell Adhesion Molecules", "Cells, Cultured", "Sequence Homology, Amino Acid", "Base Sequence", "Connectin", "Molecular Sequence Data", "DNA, Complementary", "Cricetinae", "Animals", "Intermediate Filament Proteins", "Cytoskeletal Proteins", "Muscle Proteins", "RNA, Messenger", "RNA-Directed DNA Polymerase", "Poly A", "Dictyostelium", "DNA", "Cloning, Molecular", "DNA-Directed DNA Polymerase", "Rna, Fungal", "Polymerase Chain Reaction", "Genes, Fungal", "Animals", "RNA, Messenger", "Dictyostelium", "Inositol 1,4,5-Trisphosphate", "Plc/ip3/ca2+", "Cell Density Sensing", "Cell Proliferation", "Quorum Sensing", "Polyphosphate", "Inositol Trisphosphate", "Calcium Signaling", "Calcium", "Signal Transduction", "Polyphosphates", "GTP-Binding Proteins", "Protozoan Proteins", "Pulmonary Fibrosis", "Sodium Chloride, Dietary", "Salt", "Mice", "Animals", "Bleomycin", "Bronchoalveolar Lavage Fluid", "NaCl", "Fibrocytes", "Inflammation", "Diet, Sodium-restricted", "Pseudopodia", "Receptors, G-Protein-Coupled", "Dictyostelium", "Chemotaxis", "Cell Migration Inhibition", "Cell Movement", "Protozoan Proteins", "Signal Transduction", "P21-Activated Kinases", "Extracellular Signal-Regulated MAP Kinases", "Ras Proteins", "Cell Proliferation", "Genes, Regulator", "Oncogenes", "Dictyostelium", "Genetic Vectors", "Genes", "Animals", "RNA, Messenger", "Retinoblastoma-like Protein P107", "Chalones", "Protozoan Proteins", "Dictyostelium", "Cell Cycle", "Cell Proliferation", "Bleomycin", "Fibrosis", "Tumor Necrosis Factor-alpha", "Fibrocyte", "Fibroblasts", "Culture Media, Conditioned", "Nerve Tissue Proteins", "Lung", "Keratan Sulfate", "Cell Differentiation", "Decorin", "Chondroitin Sulfate Proteoglycans", "Pulmonary Fibrosis", "Trypsin", "Inflammation", "Disease Models, Animal", "Chemical Fractionation", "Antibodies, Blocking", "Lumican", "Peptides", "Integrin Alpha2", "Cell Polarity", "Animals", "Intercellular Signaling Peptides And Proteins", "Macrophages", "Humans", "Ards", "Serum Amyloid P", "Acute Respiratory Distress Syndrome", "Adhesion", "Ali", "Neutrophil", "Cell Communication", "Type C Phospholipases", "Protozoan Proteins", "Animals", "Dictyostelium", "GTP-Binding Proteins", "Cell Count", "Membrane Proteins", "Guanosine 5'-O-(3-Thiotriphosphate)", "Fungal Proteins", "Cell Adhesion Molecules", "Cyclic AMP", "Signal Transduction", "Arginase", "Culture Media, Conditioned", "Cell Nucleus", "Cell Count", "Protozoan Proteins", "Gene Expression Regulation", "PTEN Phosphohydrolase", "Dictyostelium", "Signal Transduction", "Chemotaxis", "Spores, Protozoan", "Cell Proliferation", "Recombinant Fusion Proteins", "Dictyostelium", "Recombinant Fusion Proteins", "Animals", "Mutation", "Phenotype", "Ubiquitin-Protein Ligases", "Spores", "Molecular Sequence Data", "Genes, Protozoan", "Gene Expression", "Amino Acid Sequence", "Fibrosis", "Cicatrix", "Leukocytes, Mononuclear", "Cells, Cultured", "Trypsin", "Lactones", "Signal Transduction", "Receptor, Par-1", "Fibroblasts", "Interferon-gamma", "Monocytes", "Wound Healing", "Quinazolines", "Pyridines", "Thrombin", "Cell Movement", "Pyrroles", "Receptor, Par-2", "Serum Amyloid P-component", "Humans", "Albumins", "Tryptases", "Cell Differentiation", "Culture Media, Serum-Free", "Monocytes", "Animals", "Mice", "Serum Amyloid P-component", "Humans", "Cell Differentiation", "Rats", "Swine", "Cell Separation", "Fibroblasts", "Leukocytes, Mononuclear", "Cell Differentiation", "Cell Proliferation", "Wound Healing", "Blood Coagulation", "Macrophages", "Monocytes", "Leukocytes", "Polyphosphates", "Humans", "Fibroblasts", "Proteasome Endopeptidase Complex", "Neutrophils", "Luminescent Proteins", "Cell Aggregation", "Green Fluorescent Proteins", "Computer Simulation", "Myosins", "Movement", "Genes, Reporter", "Dictyostelium", "Cell Count", "Animals, Genetically Modified", "Actins", "Cell Adhesion", "Cytochalasin D", "Myosin-Light-Chain Kinase", "Cytoskeleton", "Animals", "Morphogenesis", "Phosphorylation", "Fluorescent Antibody Technique", "Microfilament Proteins", "Carrier Proteins", "Desmin", "Muscle Proteins", "Actinin", "Animals", "Actins", "Gelsolin", "Chick Embryo", "Intermediate Filament Proteins", "Filamins", "Contractile Proteins", "Peptide Fragments", "Muscles", "Sialidase Neu3", "Female", "Interleukin-1beta", "Male", "Pulmonary Fibrosis", "Idiopathic Pulmonary Fibrosis", "Mice", "Cell Line", "Bleomycin", "Therapeutics", "Animals", "Lung", "Inflammation", "Mice, Inbred C57BL", "Bleomycin Mouse Model", "Up-Regulation", "Cytokines", "Sialic Acids", "Transforming Growth Factor Beta1", "Leukocytes, Mononuclear", "Bronchoalveolar Lavage Fluid", "Neuraminidase", "Disease Models, Animal", "Mice, Knockout", "Feedback, Physiological", "Genes, Fungal", "Fungal Proteins", "Models, Biological", "Neurospora Crassa", "Circadian Rhythm", "DNA-Binding Proteins", "Signal Transduction", "Transcription Factors", "Pirfenidone", "Clinical Trials", "Fibrosis", "Receptors, Cyclic AMP", "Cyclic GMP", "Animals", "Protozoan Proteins", "3',5'-cyclic-amp Phosphodiesterases", "GTP-Binding Proteins", "Biological Factors", "Signal Transduction", "Dictyostelium", "Cyclic AMP", "Protozoan Proteins", "Autocrine Communication", "Dictyostelium", "Inositol Hexakisphosphate Kinase", "Cell Proliferation", "Phosphotransferases (phosphate Group Acceptor)", "Polyphosphates", "Cell Growth", "Polyphosphate", "Cell Biology", "Polyphosphate Kinase", "Stress", "Electrophoresis, Polyacrylamide Gel", "Cells, Cultured", "Animals", "Glycopeptides", "Molecular Weight", "Glycosylation", "Cell Membrane", "Glycoproteins", "Chromatography, High Pressure Liquid", "Dictyostelium", "Proteins", "Cell Differentiation", "Gene Expression Regulation", "Chromatography, Gel", "Cell Count", "Cell Movement", "PTEN Phosphohydrolase", "Dictyostelium", "Signal Transduction", "Oncogene Protein V-akt", "Sequence Alignment", "Phosphatidylinositol 3-Kinases", "Amino Acid Sequence", "Cyclic AMP", "Cell Size", "Protozoan Proteins", "Molecular Sequence Data", "Animals", "Morphogenesis", "Mutagenesis, Insertional", "Base Sequence", "Animals", "Cell Cycle Proteins", "Cloning, Molecular", "Amino Acid Sequence", "Video Recording", "Cell Differentiation", "Molecular Sequence Data", "Genes, Fungal", "Protozoan Proteins", "Dictyostelium", "RNA, Messenger", "Cell Cycle", "Cells, Cultured", "Cyclic AMP", "Dose-Response Relationship, Drug", "Time Factors", "Ultracentrifugation", "Signal Transduction", "Dictyostelium", "Recombinant Proteins", "Animals", "Cell Movement", "Receptors, Cyclic AMP", "Mitogen-Activated Protein Kinase 1", "Cyclic GMP", "Kinetics", "Protein Binding", "Protozoan Proteins", "Cell Movement", "Phosphodiesterase Inhibitors", "Dictyostelium Discoideum", "Dictyostelium", "Cyclic AMP", "Dispersal", "Chemotaxis", "FLUORESCENCE", "Cell Aggregation", "Phosphoric Diester Hydrolases", "Repulsion", "Computer Simulation", "Chemotactic Factors", "Signal Transduction", "Polyubiquitin", "Molecular Sequence Data", "DNA Primers", "Base Sequence", "Endopeptidases", "Gene Expression Regulation", "Cysteine Endopeptidases", "Animals", "Multienzyme Complexes", "Dictyostelium", "Cyclic AMP", "Biopolymers", "Amino Acid Sequence", "Ubiquitins", "Protozoan Proteins", "Proteasome Endopeptidase Complex", "Signal Transduction", "Base Sequence", "Dictyostelium", "Animals", "DNA, Fungal", "Alpha-mannosidase", "Enzyme Induction", "Lysosomes", "Sequence Deletion", "Mannosidases", "Cycloheximide", "Molecular Sequence Data", "Restriction Mapping", "Transformation, Genetic", "Gene Expression Regulation, Enzymologic", "Gene Expression Regulation, Fungal", "Transcription, Genetic", "Promoter Regions, Genetic", "Body Constitution", "Cell Count", "Animals", "Humans", "Galectin 3", "Antigens, Neoplasm", "Fibroblasts", "Carrier Proteins", "Glycoproteins", "Coculture Techniques", "Trypsin", "Leukocytes, Mononuclear", "Monocytes", "Thrombin", "Cell Differentiation", "Biomarkers, Tumor", "Receptor, Par-2", "Receptor, Par-1", "Humans", "Macrophages", "Phenotype", "Tryptases", "Autocrine Communication", "Animals", "Microscopy, Fluorescence", "Signal Transduction", "Protein Kinases", "Dictyostelium", "Microscopy, Video", "Cell Proliferation", "Green Fluorescent Proteins", "Recombinant Proteins", "Intercellular Signaling Peptides And Proteins", "Protozoan Proteins", "Protozoan Proteins", "RNA, Messenger", "Amino Acid Sequence", "Molecular Sequence Data", "Cell Adhesion", "Acid Phosphatase", "Blotting, Northern", "Gene Expression", "Mutation", "Dictyostelium", "DNA, Antisense", "Animals", "Recombinant Proteins", "Cell Movement", "Pulmonary Fibrosis", "Glycosylation", "Humans", "Neuraminidase", "Fibrosis", "Bleomycin", "Sialic Acids", "Lung", "Mice", "Macrophage", "Sialidase", "Male", "Mammals", "Inflammation", "Animals", "Female", "Receptors, Immunologic", "Leukemia, Myeloid, Acute", "Serum Amyloid P-component", "Leukemia", "Cell Survival", "Signal Transduction", "Apoptosis", "Cell Line, Tumor", "Receptors, Fc", "Antigens, CD", "Gene Expression Regulation", "Humans", "Pentraxin", "Cells, Cultured", "C Reactive Protein", "Phosphoinositide-3 Kinase Inhibitors", "Cell Proliferation", "Leukocytes, Mononuclear", "Phosphatidylinositol 3-kinase", "Cell Cycle", "Inhibitory Concentration 50", "Receptors, IgG", "C-reactive Protein", "S Phase", "Cell Aggregation", "Dictyostelium", "Cell Cycle", "Cell Differentiation", "DNA", "Animals", "Cloning, Molecular", "Genes, Lethal", "Oligonucleotides, Antisense", "Mutagenesis", "Plasmids", "Transformation, Genetic", "Animals", "Genetic Techniques", "DNA, Complementary", "Sequence Analysis, DNA", "Dictyostelium", "Dimerization", "Animals", "Time Factors", "Chromatography, Gel", "Cytoskeleton", "Recombinant Proteins", "Cloning, Molecular", "Protein Binding", "Cell Adhesion", "Dictyostelium", "Kinetics", "Iodine", "Cell Movement", "Signal Transduction", "Phosphorylation", "Protozoan Proteins", "Ultracentrifugation", "Myosins", "Dose-Response Relationship, Drug", "Cyclic AMP", "DNA, Complementary", "Actins", "Binding Sites", "CRP", "Interleukin-10", "Granulocyte-Macrophage Colony-Stimulating Factor", "Serum Amyloid P-component", "Cells, Cultured", "Pentraxins", "Factor H", "Sialic Acid Binding Ig-like Lectin 1", "Complement Factor H", "Sap", "Antigens, CD", "Humans", "Antigens, Differentiation, Myelomonocytic", "Inflammation", "Mannose Binding Lectin", "C1q", "Cell Differentiation", "Macrophage Activation", "Receptors, Cell Surface", "Ptx3", "Mbl", "C-reactive Protein", "Monocyte", "N-acetylneuraminic Acid", "Mannose-Binding Lectins", "Macrophage", "Macrophages", "Monocytes", "Glycoproteins", "Cell Aggregation", "Dictyostelium", "Culture Media", "Food Deprivation", "Animals", "Fibrosis", "Receptors, IgG", "Immunoglobulin G", "Humans", "Neutrophils", "Protein Isoforms", "Phagocytosis", "Macrophages", "Amino Acid Sequence", "Inflammation", "Cells, Cultured", "Fibroblasts", "Monocytes", "HEK293 Cells", "Antibodies, Blocking", "Serum Amyloid P-component", "Cell Adhesion", "Cell Differentiation", "Binding Sites, Antibody", "Protozoan Proteins", "GTP-Binding Protein Alpha Subunits", "Fimbriae Proteins", "Chalones", "Guanosine 5'-O-(3-Thiotriphosphate)", "Animals", "Cell Enlargement", "Colony Count, Microbial", "Cell Proliferation", "Recombinant Proteins", "Gtp-binding Protein Beta Subunits", "Guanosine Triphosphate", "Dictyostelium", "Signal Transduction", "Spores, Protozoan", "GTP-Binding Proteins", "Cell Membrane", "Cell Polarity", "Receptors, G-Protein-Coupled", "Pseudopodia", "Models, Biological", "Myosin Type Ii", "Chemotaxis", "Dictyostelium", "Protozoan Proteins", "Ras Proteins", "Phospholipases", "Cytoskeleton", "Protein Kinase C", "Guanylate Cyclase", "Signal Transduction", "Actins", "Protein Transport", "Phosphatidylinositol 3-Kinases", "Cyclic AMP", "Calcium Channels", "Extracellular Signal-Regulated MAP Kinases", "Mutation", "Recombinant Fusion Proteins", "Cell Membrane", "Cyclic AMP", "Protozoan Proteins", "Dictyostelium", "Animals", "Genes, Protozoan", "Proto-Oncogene Proteins", "Protein Serine-threonine Kinases", "Proto-Oncogene Proteins C-akt", "Green Fluorescent Proteins", "Quorum Sensing", "Cell Size", "Protozoan Proteins", "Dictyostelium", "Cyclic AMP", "Cell Count", "Cell Proliferation", "Signal Transduction", "Animals", "Inositol 1,4,5-Trisphosphate", "Cell Adhesion Molecules", "GTP-Binding Proteins", "Protozoan Proteins", "Receptors, Cell Surface", "Glutathione Transferase", "Amino Acid Sequence", "Mutation", "Protein Binding", "Trypsin", "Sequence Homology, Amino Acid", "Cyclic AMP", "Sequence Analysis, DNA", "Gene Expression Regulation", "Base Sequence", "Recombinant Fusion Proteins", "Molecular Sequence Data", "Dictyostelium", "Signal Transduction", "DNA, Complementary", "Cell Adhesion", "Membrane Proteins", "Adenosine Triphosphate", "Polyketides", "Chemotactic Factors", "Polyphosphates", "Cell Communication", "Cyclic AMP", "Adenine", "Ammonia", "Culture Media, Conditioned", "Morphogenesis", "Dictyostelium", "Animals", "Vimentin", "Filamins", "Actinin", "Sarcoplasmic Reticulum", "Chick Embryo", "Muscle Proteins", "Microfilament Proteins", "Muscles", "Myofibrils", "Cells, Cultured", "Cell Differentiation", "Desmin", "Contractile Proteins", "Recombinant Proteins", "Dictyostelium", "Animals", "Molecular Sequence Data", "Amino Acid Sequence", "Protozoan Proteins", "Cell Differentiation", "Protein Subunits", "Muramidase", "Cell Adhesion", "Macromolecular Substances", "Circular Dichroism", "Cell Movement", "Base Sequence", "Dictyostelium", "Sex Characteristics", "Chemotaxis", "Actins", "Neutrophils", "Female", "Male", "Humans", "Monocyte", "Microenvironment", "Benign", "Metastasis", "Stroma", "Fibroblasts", "Neoplasms", "Malignant", "Tumor", "Fibrosis", "Humans", "Wound", "Cancer", "Wound Healing", "Fibroblast", "Tumor Microenvironment", "Myofibroblast", "Scar", "Fibrocyte", "Gluconates", "Nitrates", "Serum Amyloid P-component", "Sodium Chloride", "Monocytes", "Cell Differentiation", "Humans", "Epithelial-Mesenchymal Transition", "Disease", "Stromal Cells", "Cell Lineage", "Organ Specificity", "Animals", "Humans", "Myxococcus Xanthus", "Protozoan Proteins", "Fungal Proteins", "Biological Factors", "Dictyostelium", "Peptides", "Animals", "Bacillus Subtilis", "Growth Substances", "Cell Adhesion Molecules", "Vibrio", "Amino Acids", "Transformation, Bacterial", "4-butyrolactone", "Receptors, Cell Surface", "Fibrosis", "Cell Differentiation", "Disease Models, Animal", "Cells, Cultured", "Myocardial Ischemia", "Fibroblasts", "Cardiomyopathies", "Chimera", "RNA, Messenger", "Cell Proliferation", "Mice", "Bone Marrow Cells", "Antigens, CD34", "Amyloid", "Leukocyte Common Antigens", "Animals", "Female", "Neuraminidase", "Sugars", "Activation", "Humans", "Fibrosis", "N-acetylneuraminic Acid", "Adhesion", "Aggregation", "Male", "Priming", "Neu3", "Neu4", "Sialidase", "Inflammation", "Sialic Acid", "Neu2", "Desialylation", "Glycoconjugate", "Neutrophil", "Neutrophils", "Neu1" ],
"educationAndTraining" : [ {
"id" : "nf41f3898_c5b34542-b399-11e9-adb7-00155d9b610c_add0f983",
"label" : "EducationalProcess",
"name" : "B.A. Bachelor of Arts",
"organization" : {
"id" : "nc5b34542-b399-11e9-adb7-00155d9b610c",
"label" : "Pomona College - (Claremont, California, United States)"
},
"field" : "Physics",
"abbreviation" : "B.A.",
"endDate" : "1977-01-01T00:00:00",
"isDateSuppressed" : "display_education_year"
}, {
"id" : "nf41f3898_5007d50e-b399-11e9-adb7-00155d9b610c_730827c3",
"label" : "EducationalProcess",
"name" : "Ph.D. Doctor of Philosophy",
"organization" : {
"id" : "n5007d50e-b399-11e9-adb7-00155d9b610c",
"label" : "California Institute of Technology - (Pasadena, California, United States)"
},
"field" : "Biology",
"abbreviation" : "Ph.D.",
"endDate" : "1983-01-01T00:00:00",
"isDateSuppressed" : "display_education_year"
}, {
"id" : "nf41f3898_e6451fbc-b399-11e9-adb7-00155d9b610c_37a38db5",
"label" : "PostdoctoralTraining",
"info" : "Postdoctoral Training",
"organization" : {
"id" : "ne6451fbc-b399-11e9-adb7-00155d9b610c",
"label" : "University of California, San Diego - (San Diego, California, United States)"
},
"endDate" : "1988-01-01T00:00:00"
} ],
"awardsAndHonors" : [ {
"id" : "n25ab1d7d-a41b-11ea-8785-005056bb4fb7",
"label" : "Association of Former Students University-Level Distinguished Achievement Award, The"
}, {
"id" : "nbbcfabae-c441-11e9-89ab-005056bb4fb7",
"label" : "Investigator/Alumni Investigator"
}, {
"id" : "nae77de1b-a837-11e9-bf6d-00155d562649",
"label" : "American Academy of Microbiology Fellow"
}, {
"id" : "n5b8aef3f-a964-11ed-aca7-005056bb4fb7",
"label" : "AAAS Fellow"
}, {
"id" : "na6041879-a5ac-11ea-8785-005056bb4fb7",
"label" : "Thomas Powell Chair in Sciences"
} ],
"publications" : [ {
"id" : "n133647SE",
"label" : "A precise group size in Dictyostelium is generated by a cell-counting factor modulating cell-cell adhesion.",
"type" : "AcademicArticle",
"publicationDate" : "2000-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n509810SE",
"label" : "Complexity of the Neurospora crassa Circadian Clock System: Multiple Loops and Oscillators",
"type" : "ConferencePaper",
"publicationDate" : "2007-01-01T11:11:11",
"venue" : { }
}, {
"id" : "n336823SE",
"label" : "Protease activated-receptor 2 is necessary for neutrophil chemorepulsion induced by trypsin, tryptase, or dipeptidyl peptidase IV.",
"type" : "AcademicArticle",
"publicationDate" : "2018-01-15T00:00:00",
"publisher" : "Oxford University Press (OUP)"
}, {
"id" : "n133624SE",
"label" : "A strategy to study development and pattern formation: use of antibodies against products of cloned genes.",
"type" : "AcademicArticle",
"publicationDate" : "1987-01-01T00:00:00",
"publisher" : "Elsevier"
}, {
"id" : "n546601SE",
"label" : "High-Fat Diet-Induced Adipose Tissue and Liver Inflammation and Steatosis in Mice Are Reduced by Inhibiting Sialidases.",
"type" : "AcademicArticle",
"publicationDate" : "2021-01-01T00:00:00",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133618SE",
"label" : "Fibrocytes and Collagen-Producing Cells of the Peripheral Blood",
"type" : "Chapter",
"publicationDate" : "2011-12-01T00:00:00",
"publisher" : "World Scientific Publishing"
}, {
"id" : "n133653SE",
"label" : "Phenocopy of discoidin I-minus mutants by antisense transformation in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1985-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133630SE",
"label" : "Toll-like receptor 2 agonists inhibit human fibrocyte differentiation.",
"type" : "AcademicArticle",
"publicationDate" : "2010-11-01T00:00:00",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133596SE",
"label" : "Functional similarities between the dictyostelium protein AprA and the human protein dipeptidyl-peptidase IV.",
"type" : "AcademicArticle",
"publicationDate" : "2017-03-01T00:00:00",
"publisher" : "Wiley",
"venue" : { }
}, {
"id" : "n133704SE",
"label" : "A G protein-coupled receptor with a lipid kinase domain is involved in cell-density sensing.",
"type" : "AcademicArticle",
"publicationDate" : "2007-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133599SE",
"label" : "A secreted protein is an endogenous chemorepellant in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2012-07-01T00:00:00",
"publisher" : "Proceedings of the National Academy of Sciences",
"venue" : { }
}, {
"id" : "n133610SE",
"label" : "The long pentraxin PTX3 promotes fibrocyte differentiation.",
"type" : "AcademicArticle",
"publicationDate" : "2015-03-16T00:00:00",
"publisher" : "Public Library of Science (PLoS)",
"venue" : { }
}, {
"id" : "n133656SE",
"label" : "Cell-autonomous determination of cell-type choice in Dictyostelium development by cell-cycle phase.",
"type" : "AcademicArticle",
"publicationDate" : "1987-08-01T00:00:00",
"publisher" : "American Association for the Advancement of Science (AAAS)",
"venue" : { }
}, {
"id" : "n133633SE",
"label" : "PSF and CMF, autocrine factors that regulate gene expression during growth and early development of Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1995-12-18T00:00:00",
"publisher" : "Springer Nature"
}, {
"id" : "n133682SE",
"label" : "Paralog chromatography.",
"type" : "AcademicArticle",
"publicationDate" : "1990-02-01T00:00:00",
"venue" : { }
}, {
"id" : "n133679SE",
"label" : "A second UDP-glucose pyrophosphorylase is required for differentiation and development in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2002-09-06T00:00:00",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133604SE",
"label" : "FcRI mediates serum amyloid P inhibition of fibrocyte differentiation.",
"type" : "AcademicArticle",
"publicationDate" : "2012-01-01T11:11:11",
"publisher" : "Oxford University Press (OUP)"
}, {
"id" : "n42512SE",
"label" : "Multiple oscillators regulate circadian gene expression in Neurospora.",
"type" : "AcademicArticle",
"publicationDate" : "2003-11-01T00:00:00",
"publisher" : "Proceedings of the National Academy of Sciences",
"venue" : { }
}, {
"id" : "n133587SE",
"label" : "Trypsin potentiates human fibrocyte differentiation.",
"type" : "AcademicArticle",
"publicationDate" : "2013-08-01T00:00:00",
"publisher" : "Public Library of Science (PLoS)",
"venue" : { }
}, {
"id" : "n133713SE",
"label" : "Mitoskelin: a mitochondrial protein found in cytoskeletal preparations.",
"type" : "AcademicArticle",
"publicationDate" : "1989-01-01T00:00:00",
"publisher" : "Wiley",
"venue" : { }
}, {
"id" : "n133694SE",
"label" : "Reduction of bleomycin-induced pulmonary fibrosis by serum amyloid P.",
"type" : "AcademicArticle",
"publicationDate" : "2007-09-01T00:00:00",
"publisher" : "The American Association of Immunologists",
"venue" : { }
}, {
"id" : "n133644SE",
"label" : "Spatial and temporal regulation of a foreign gene by a prestalk-specific promoter in transformed Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "1986-03-01T00:00:00",
"publisher" : "Taylor & Francis",
"venue" : { }
}, {
"id" : "n133627SE",
"label" : "A secreted cell number counting factor represses intracellular glucose levels to regulate group size in dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "2002-10-18T00:00:00",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133673SE",
"label" : "A density-sensing factor regulates signal transduction in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1995-06-01T00:00:00",
"publisher" : "Rockefeller University Press",
"venue" : { }
}, {
"id" : "n133665SE",
"label" : "The versatile Dictyostelium discoideum. Meeting report: International Dictyostelium Conference 2002.",
"type" : "ConferencePaper",
"publicationDate" : "2003-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133701SE",
"label" : "The cdk5 homologue, crp, regulates endocytosis and secretion in dictyostelium and is necessary for optimum growth and differentiation.",
"type" : "AcademicArticle",
"publicationDate" : "2002-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133709SE",
"label" : "Circulating progenitor cells and scleroderma.",
"type" : "AcademicArticle",
"publicationDate" : "2008-01-01T11:11:11",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133722SE",
"label" : "A secreted factor represses cell proliferation in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "2005-10-01T00:00:00",
"publisher" : "The Company of Biologists",
"venue" : { }
}, {
"id" : "n133591SE",
"label" : "Peritoneal Dialysis Fluid and Some of Its Components Potentiate Fibrocyte Differentiation.",
"type" : "AcademicArticle",
"publicationDate" : "2016-07-01T00:00:00",
"publisher" : "Sage Publications",
"venue" : { }
}, {
"id" : "n133659SE",
"label" : "Regulation of cell-type-specific gene expression in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1985-01-01T00:00:00",
"publisher" : "Cold Spring Harbor Laboratory",
"venue" : { }
}, {
"id" : "n42506SE",
"label" : "Two circadian timing circuits in Neurospora crassa cells share components and regulate distinct rhythmic processes.",
"type" : "AcademicArticle",
"publicationDate" : "2006-06-01T00:00:00",
"publisher" : "Sage Publications",
"venue" : { }
}, {
"id" : "n133613SE",
"label" : "Evoking picomolar binding in RNA by a single phosphorodithioate linkage.",
"type" : "AcademicArticle",
"publicationDate" : "2016-09-01T00:00:00",
"publisher" : "Oxford University Press (OUP)",
"venue" : { }
}, {
"id" : "n133638SE",
"label" : "Dictyostelium cells bind a secreted autocrine factor that represses cell proliferation.",
"type" : "AcademicArticle",
"publicationDate" : "2009-01-01T11:11:11",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133607SE",
"label" : "Brain serum amyloid P levels are reduced in individuals that lack dementia while having Alzheimer's disease neuropathology.",
"type" : "AcademicArticle",
"publicationDate" : "2012-01-01T11:11:11",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133662SE",
"label" : "Highspeed Keck spectroscopy of flares and oscillations in AE Aquarii",
"type" : "AcademicArticle",
"publicationDate" : "2003-02-01T00:00:00",
"publisher" : "Oxford University Press (OUP)",
"venue" : { }
}, {
"id" : "n133641SE",
"label" : "The discovery and broadband follow-up of the transient afterglow of GRB 980703",
"type" : "AcademicArticle",
"publicationDate" : "1998-01-01T00:00:00",
"venue" : { }
}, {
"id" : "n133676SE",
"label" : "Disruption of aldehyde reductase increases group size in dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "2004-01-09T00:00:00",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n326194SE",
"label" : "Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model.",
"type" : "AcademicArticle",
"publicationDate" : "2017-01-01T11:11:11",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133716SE",
"label" : "A protein in crude cytosol regulates glucose-6-phosphatase activity in crude microsomes to regulate group size in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "2006-06-16T00:00:00",
"publisher" : "Elsevier"
}, {
"id" : "n133584SE",
"label" : "The p21-activated kinase (PAK) family member PakD is required for chemorepulsion and proliferation inhibition by autocrine signals in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2014-05-01T00:00:00",
"publisher" : "Public Library of Science (PLoS)",
"venue" : { }
}, {
"id" : "n133706SE",
"label" : "A cell number counting factor alters cell metabolism.",
"type" : "AcademicArticle",
"publicationDate" : "2009-01-01T11:11:11",
"publisher" : "Taylor & Francis",
"venue" : { }
}, {
"id" : "n133693SE",
"label" : "Serum amyloid P and fibrosis in systemic sclerosis: comment on the article by Tennent et al.",
"type" : "AcademicArticle",
"publicationDate" : "2007-12-01T00:00:00",
"publisher" : "Wiley",
"venue" : { }
}, {
"id" : "n133668SE",
"label" : "Cell motility mediates tissue size regulation in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "2002-01-01T11:11:11",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133651SE",
"label" : "Doppler signatures of H flares in AE Aquarii",
"type" : "AcademicArticle",
"publicationDate" : "1998-07-01T00:00:00",
"publisher" : "Oxford University Press (OUP)",
"venue" : { }
}, {
"id" : "n133626SE",
"label" : "A density-sensing factor controls development in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1992-03-01T00:00:00",
"publisher" : "Cold Spring Harbor Laboratory",
"venue" : { }
}, {
"id" : "n133649SE",
"label" : "ABC transporters required for endocytosis and endosomal pH regulation in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "2001-11-01T00:00:00",
"publisher" : "The Company of Biologists",
"venue" : { }
}, {
"id" : "n415763SE",
"label" : "Serum Amyloid P and a Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin Ligand Inhibit High-Fat Diet-Induced Adipose Tissue and Liver Inflammation and Steatosis in Mice.",
"type" : "AcademicArticle",
"publicationDate" : "2019-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133674SE",
"label" : "Antisense: a key tool for cell and developmental studies in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1998-01-01T00:00:00",
"publisher" : "Springer US",
"venue" : { }
}, {
"id" : "n546603SE",
"label" : "Inhibiting Sialidase-Induced TGF-1 Activation Attenuates Pulmonary Fibrosis in Mice.",
"type" : "AcademicArticle",
"publicationDate" : "2021-01-01T00:00:00",
"publisher" : "American Society for Pharmacology & Experimental Therapeutics (ASPET)",
"venue" : { }
}, {
"id" : "n294500SE",
"label" : "Identification of compounds that decrease numbers of Mycobacteria in human macrophages in the presence of serum amyloid P.",
"type" : "AcademicArticle",
"publicationDate" : "2017-09-02T00:00:00",
"publisher" : "Oxford University Press (OUP)",
"tags" : "3 Good Health and Well-Being"
}, {
"id" : "n133725SE",
"label" : "Exposure of cells to a cell number-counting factor decreases the activity of glucose-6-phosphatase to decrease intracellular glucose levels in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2005-01-01T00:00:00",
"publisher" : "American Society for Microbiology"
}, {
"id" : "n133594SE",
"label" : "Improved serum-free culture conditions for spleen-derived murine fibrocytes.",
"type" : "AcademicArticle",
"publicationDate" : "2010-12-01T00:00:00",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133635SE",
"label" : "Emissionline oscillations in the dwarf nova V2051 Ophiuchi",
"type" : "AcademicArticle",
"publicationDate" : "2001-01-01T11:11:11",
"publisher" : "Oxford University Press (OUP)",
"venue" : { }
}, {
"id" : "n133719SE",
"label" : "Combining experiments and modelling to understand size regulation in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2008-01-01T11:11:11",
"publisher" : "The Royal Society",
"venue" : { }
}, {
"id" : "n133612SE",
"label" : "Secondary ion mass spectrometry imaging of Dictyostelium discoideum aggregation streams.",
"type" : "AcademicArticle",
"publicationDate" : "2014-06-01T00:00:00",
"publisher" : "Public Library of Science (PLoS)",
"venue" : { }
}, {
"id" : "n133680SE",
"label" : "Different temporal patterns of expression result in the same type, amount, and distribution of filamin (ABP) in cardiac and skeletal myofibrils.",
"type" : "AcademicArticle",
"publicationDate" : "1994-01-01T00:00:00",
"publisher" : "Wiley",
"venue" : { }
}, {
"id" : "n659426SE",
"label" : "The sialidase NEU3 promotes pulmonary fibrosis in mice.",
"type" : "AcademicArticle",
"publicationDate" : "2022-01-01T11:11:11",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133654SE",
"label" : "Cellular and subcellular distribution of a cAMP-regulated prestalk protein and prespore protein in Dictyostelium discoideum: a study on the ontogeny of prestalk and prespore cells.",
"type" : "AcademicArticle",
"publicationDate" : "1986-11-01T00:00:00",
"publisher" : "Rockefeller University Press",
"venue" : { }
}, {
"id" : "n133629SE",
"label" : "Developmental regulation of a Dictyostelium gene encoding a protein homologous to mammalian ras protein.",
"type" : "AcademicArticle",
"publicationDate" : "1984-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n419266SE",
"label" : "TGF-1 increases sialidase 3 expression in human lung epithelial cells by decreasing its degradation and upregulating its translation.",
"type" : "AcademicArticle",
"publicationDate" : "2020-04-20T00:00:00",
"publisher" : "Taylor & Francis",
"venue" : { }
}, {
"id" : "n133581SE",
"label" : "New approaches to modulating idiopathic pulmonary fibrosis.",
"type" : "AcademicArticle",
"publicationDate" : "2013-01-01T11:11:11",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133606SE",
"label" : "The putative bZIP transcription factor BzpN slows proliferation and functions in the regulation of cell density by autocrine signals in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "2011-07-01T00:00:00",
"publisher" : "Public Library of Science (PLoS)",
"venue" : { }
}, {
"id" : "n133677SE",
"label" : "Cell density-sensing in Dictyostelium by means of the accumulation rate, diffusion coefficient and activity threshold of a protein secreted by starved cells.",
"type" : "AcademicArticle",
"publicationDate" : "1994-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133711SE",
"label" : "A serum amyloid P-binding hydrogel speeds healing of partial thickness wounds in pigs.",
"type" : "AcademicArticle",
"publicationDate" : "2009-05-01T00:00:00",
"publisher" : "Wiley",
"venue" : { }
}, {
"id" : "n693024SE",
"label" : "Inhibitors of the Sialidase NEU3 as Potential Therapeutics for Fibrosis.",
"type" : "AcademicArticle",
"publicationDate" : "2022-12-23T00:00:00",
"publisher" : "MDPI"
}, {
"id" : "n133696SE",
"label" : "A single cell density-sensing factor stimulates distinct signal transduction pathways through two different receptors.",
"type" : "AcademicArticle",
"publicationDate" : "2002-08-30T00:00:00",
"publisher" : "Elsevier"
}, {
"id" : "n546600SE",
"label" : "A CD209 ligand and a sialidase inhibitor differentially modulate adipose tissue and liver macrophage populations and steatosis in mice on the Methionine and Choline-Deficient (MCD) diet.",
"type" : "AcademicArticle",
"publicationDate" : "2020-01-01T00:00:00",
"publisher" : "Public Library of Science (PLoS)",
"venue" : { }
}, {
"id" : "n386694SE",
"label" : "Different Isoforms of the Neuronal Guidance Molecule Slit2 Directly Cause Chemoattraction or Chemorepulsion of Human Neutrophils.",
"type" : "AcademicArticle",
"publicationDate" : "2019-01-01T00:00:00",
"publisher" : "The American Association of Immunologists",
"venue" : { }
}, {
"id" : "n382150SE",
"label" : "The Development of Serum Amyloid P as a Possible Therapeutic.",
"type" : "AcademicArticle",
"publicationDate" : "2018-01-01T11:11:11",
"publisher" : "Frontiers",
"venue" : { },
"tags" : "3 Good Health and Well-Being"
}, {
"id" : "n133621SE",
"label" : "Regulatory Pathways for Fibrocyte Differentiation",
"type" : "Chapter",
"publicationDate" : "2007-01-01T11:11:11",
"publisher" : "World Scientific Publishing"
}, {
"id" : "n42518SE",
"label" : "Overexpression of White Collar-1 (WC-1) activates circadian clock-associated genes, but is not sufficient to induce most light-regulated gene expression in Neurospora crassa.",
"type" : "AcademicArticle",
"publicationDate" : "2002-08-01T00:00:00",
"publisher" : "Wiley",
"venue" : { }
}, {
"id" : "n133671SE",
"label" : "A cell-density sensing factor regulates the lifetime of a chemoattractant-induced G alpha-GTP conformation.",
"type" : "AcademicArticle",
"publicationDate" : "1997-03-01T00:00:00",
"publisher" : "Wiley",
"venue" : { }
}, {
"id" : "n133646SE",
"label" : "Inhibition of fibrocyte differentiation by serum amyloid P.",
"type" : "AcademicArticle",
"publicationDate" : "2003-11-01T00:00:00",
"publisher" : "The American Association of Immunologists",
"venue" : { }
}, {
"id" : "n402582SE",
"label" : "The Use of Diffusion Calculations and Monte Carlo Simulations to Understand the Behavior of Cells in Dictyostelium Communities.",
"type" : "AcademicArticle",
"publicationDate" : "2019-01-01T00:00:00",
"publisher" : "Elsevier"
}, {
"id" : "n133688SE",
"label" : "A protein containing a serine-rich domain with vesicle fusing properties mediates cell cycle-dependent cytosolic pH regulation.",
"type" : "AcademicArticle",
"publicationDate" : "2000-06-23T00:00:00",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133615SE",
"label" : "Initial cell type choice in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "2011-02-01T00:00:00",
"publisher" : "American Society for Microbiology"
}, {
"id" : "n133597SE",
"label" : "Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice.",
"type" : "AcademicArticle",
"publicationDate" : "2014-04-02T00:00:00",
"publisher" : "Public Library of Science (PLoS)",
"venue" : { }
}, {
"id" : "n133703SE",
"label" : "Rapid keck spectroscopy of cataclysmic variables",
"type" : "ConferencePaper",
"publicationDate" : "2004-12-01T00:00:00",
"venue" : { }
}, {
"id" : "n133720SE",
"label" : "Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation.",
"type" : "AcademicArticle",
"publicationDate" : "2008-01-01T11:11:11",
"publisher" : "Oxford University Press (OUP)"
}, {
"id" : "n133660SE",
"label" : "CF45-1, a secreted protein which participates in Dictyostelium group size regulation.",
"type" : "AcademicArticle",
"publicationDate" : "2003-08-01T00:00:00",
"publisher" : "American Society for Microbiology",
"venue" : { }
}, {
"id" : "n133609SE",
"label" : "Galectin-3 Binding Protein Secreted by Breast Cancer Cells Inhibits Monocyte-Derived Fibrocyte Differentiation.",
"type" : "AcademicArticle",
"publicationDate" : "2015-08-01T00:00:00",
"publisher" : "The American Association of Immunologists",
"venue" : { }
}, {
"id" : "n133685SE",
"label" : "Mathematically modelling the effects of counting factor in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2006-03-01T00:00:00",
"publisher" : "Oxford University Press (OUP)",
"venue" : { }
}, {
"id" : "n133632SE",
"label" : "Mutagenesis and gene identification in Dictyostelium by shotgun antisense.",
"type" : "AcademicArticle",
"publicationDate" : "1996-05-01T00:00:00",
"publisher" : "Proceedings of the National Academy of Sciences",
"venue" : { }
}, {
"id" : "n133657SE",
"label" : "cAMP induction of prespore and prestalk gene expression in Dictyostelium is mediated by the cell-surface cAMP receptor.",
"type" : "AcademicArticle",
"publicationDate" : "1986-11-01T00:00:00",
"publisher" : "Proceedings of the National Academy of Sciences",
"venue" : { }
}, {
"id" : "n546599SE",
"label" : "Serum Amyloid P inhibits single stranded RNA-induced lung inflammation, lung damage, and cytokine storm in mice.",
"type" : "AcademicArticle",
"publicationDate" : "2021-01-01T00:00:00",
"publisher" : "Public Library of Science (PLoS)",
"venue" : { }
}, {
"id" : "n133691SE",
"label" : "Switching of filamin polypeptides during myogenesis in vitro.",
"type" : "AcademicArticle",
"publicationDate" : "1983-02-01T00:00:00",
"publisher" : "Rockefeller University Press",
"venue" : { }
}, {
"id" : "n421607SE",
"label" : "An improved shotgun antisense method for mutagenesis and gene identification.",
"type" : "AcademicArticle",
"publicationDate" : "2020-01-01T11:11:11",
"publisher" : "Future Science Group",
"venue" : { }
}, {
"id" : "n133699SE",
"label" : "Gadolinium-containing magnetic resonance image contrast agent promotes fibrocyte differentiation.",
"type" : "ConferencePaper",
"publicationDate" : "2009-12-01T00:00:00",
"publisher" : "Wiley",
"venue" : { }
}, {
"id" : "n133601SE",
"label" : "DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice.",
"type" : "AcademicArticle",
"publicationDate" : "2015-07-07T00:00:00",
"publisher" : "Proceedings of the National Academy of Sciences",
"venue" : { }
}, {
"id" : "n133714SE",
"label" : "Serum amyloid P inhibits dermal wound healing.",
"type" : "AcademicArticle",
"publicationDate" : "2008-03-01T00:00:00",
"publisher" : "Wiley",
"venue" : { }
}, {
"id" : "n133586SE",
"label" : "Investigational approaches to therapies for idiopathic pulmonary fibrosis.",
"type" : "AcademicArticle",
"publicationDate" : "2010-01-01T11:11:11",
"publisher" : "Taylor & Francis",
"venue" : { },
"tags" : "3 Good Health and Well-Being"
}, {
"id" : "n396865SE",
"label" : "The putative G protein-coupled receptor GrlD mediates extracellular polyphosphate sensing in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2019-04-15T00:00:00",
"publisher" : "American Society for Cell Biology (ASCB)",
"venue" : { }
}, {
"id" : "n133672SE",
"label" : "Cell-density sensing: come on inside and tell us about it.",
"type" : "AcademicArticle",
"publicationDate" : "1997-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133695SE",
"label" : "The cell density factor CMF regulates the chemoattractant receptor cAR1 in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1996-09-01T00:00:00",
"publisher" : "Rockefeller University Press",
"venue" : { }
}, {
"id" : "n554273SE",
"label" : "Using Dictyostelium to Develop Therapeutics for Acute Respiratory Distress Syndrome.",
"type" : "AcademicArticle",
"publicationDate" : "2021-01-01T00:00:00",
"publisher" : "Frontiers",
"venue" : { }
}, {
"id" : "n294502SE",
"label" : "Extracellular polyphosphate signals through Ras and Akt to prime Dictyostelium discoideum cells for development.",
"type" : "AcademicArticle",
"publicationDate" : "2017-07-01T00:00:00",
"publisher" : "The Company of Biologists",
"venue" : { }
}, {
"id" : "n133643SE",
"label" : "Highspeed Keck II and RXTE spectroscopy of Cygnus X2 I. Three Xray components revealed by correlated variability",
"type" : "AcademicArticle",
"publicationDate" : "2004-05-11T00:00:00",
"publisher" : "Oxford University Press (OUP)"
}, {
"id" : "n133628SE",
"label" : "Disrupted function of tumor necrosis factor-alpha-stimulated gene 6 blocks cumulus cell-oocyte complex expansion.",
"type" : "AcademicArticle",
"publicationDate" : "2003-10-01T00:00:00",
"publisher" : "The Endocrine Society",
"venue" : { }
}, {
"id" : "n133666SE",
"label" : "A cell-counting factor regulating structure size in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1999-08-01T00:00:00",
"publisher" : "Cold Spring Harbor Laboratory",
"venue" : { }
}, {
"id" : "n133689SE",
"label" : "A Dictystelium mutant with defective aggregate size determination.",
"type" : "AcademicArticle",
"publicationDate" : "1996-09-01T00:00:00",
"publisher" : "The Company of Biologists",
"venue" : { }
}, {
"id" : "n133700SE",
"label" : "The secreted proteome profile of developing Dictyostelium discoideum cells.",
"type" : "AcademicArticle",
"publicationDate" : "2010-07-01T00:00:00",
"publisher" : "Wiley",
"venue" : { }
}, {
"id" : "n133592SE",
"label" : "Serum amyloid P: a systemic regulator of the innate immune response.",
"type" : "AcademicArticle",
"publicationDate" : "2014-11-07T00:00:00",
"publisher" : "Oxford University Press (OUP)"
}, {
"id" : "n133708SE",
"label" : "A developmentally regulated cell surface receptor for a density-sensing factor in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1994-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133723SE",
"label" : "The secreted Dictyostelium protein CfaD is a chalone.",
"type" : "AcademicArticle",
"publicationDate" : "2008-08-01T00:00:00",
"publisher" : "The Company of Biologists",
"venue" : { }
}, {
"id" : "n133717SE",
"label" : "Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts.",
"type" : "AcademicArticle",
"publicationDate" : "2009-10-01T00:00:00",
"publisher" : "Public Library of Science (PLoS)",
"venue" : { }
}, {
"id" : "n133686SE",
"label" : "Cell cycle phase, cellular Ca2+ and development in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2001-04-01T00:00:00",
"venue" : { }
}, {
"id" : "n133663SE",
"label" : "Not being the wrong size.",
"type" : "AcademicArticle",
"publicationDate" : "2001-01-01T11:11:11",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133614SE",
"label" : "High and low molecular weight hyaluronic acid differentially regulate human fibrocyte differentiation.",
"type" : "AcademicArticle",
"publicationDate" : "2011-10-01T00:00:00",
"publisher" : "Public Library of Science (PLoS)",
"venue" : { }
}, {
"id" : "n133608SE",
"label" : "Inhibition of murine fibrocyte differentiation by cross-linked IgG is dependent on FcRI.",
"type" : "AcademicArticle",
"publicationDate" : "2014-08-21T00:00:00",
"publisher" : "Oxford University Press (OUP)"
}, {
"id" : "n133637SE",
"label" : "A secreted 80 x 10(3) Mr protein mediates sensing of cell density and the onset of development in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1991-05-01T00:00:00",
"publisher" : "The Company of Biologists",
"venue" : { }
}, {
"id" : "n401048SE",
"label" : "Attenuated Pulmonary Fibrosis in Sialidase-3 Knockout (Neu3(-/-)) Mice",
"type" : "ConferencePaper",
"publicationDate" : "2019-01-01T00:00:00",
"publisher" : "American Physiological Society",
"venue" : { }
}, {
"id" : "n133583SE",
"label" : "Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis.",
"type" : "AcademicArticle",
"publicationDate" : "2014-12-01T00:00:00",
"publisher" : "Proceedings of the National Academy of Sciences",
"venue" : { }
}, {
"id" : "n133692SE",
"label" : "A cell number-counting factor regulates levels of a novel protein, SslA, as part of a group size regulation mechanism in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "2007-09-01T00:00:00",
"publisher" : "American Society for Microbiology",
"venue" : { }
}, {
"id" : "n133640SE",
"label" : "Taking the Pulse of DQ Herculis",
"type" : "AcademicArticle",
"publicationDate" : "1995-07-01T00:00:00",
"publisher" : "American Astronomical Society",
"venue" : { }
}, {
"id" : "n133698SE",
"label" : "Improved serum-free culture conditions for the differentiation of human and murine fibrocytes.",
"type" : "AcademicArticle",
"publicationDate" : "2009-12-30T00:00:00",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133600SE",
"label" : "Role of the neutrophil chemorepellent soluble dipeptidyl peptidase IV in decreasing inflammation in a murine model of arthritis.",
"type" : "AcademicArticle",
"publicationDate" : "2015-10-01T00:00:00",
"publisher" : "Wiley",
"venue" : { }
}, {
"id" : "n133589SE",
"label" : "Partial genetic suppression of a loss-of-function mutant of the neuronal ceroid lipofuscinosis-associated protease TPP1 in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2015-02-01T00:00:00",
"publisher" : "The Company of Biologists",
"venue" : { }
}, {
"id" : "n133669SE",
"label" : "Keck II spectroscopy of mHz quasiperiodic oscillations in Hercules X1",
"type" : "AcademicArticle",
"publicationDate" : "2001-01-01T11:11:11",
"publisher" : "Oxford University Press (OUP)",
"venue" : { }
}, {
"id" : "n546602SE",
"label" : "Polyphosphate is an extracellular signal that can facilitate bacterial survival in eukaryotic cells.",
"type" : "AcademicArticle",
"publicationDate" : "2020-01-01T11:11:11",
"publisher" : "Proceedings of the National Academy of Sciences",
"venue" : { },
"tags" : "3 Good Health and Well-Being"
}, {
"id" : "n133652SE",
"label" : "Initial cell-type choice in a simple eukaryote: cell-autonomous or morphogen-gradient dependent?",
"type" : "AcademicArticle",
"publicationDate" : "1995-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133648SE",
"label" : "Heat shock proteins are methylated in avian and mammalian cells.",
"type" : "AcademicArticle",
"publicationDate" : "1981-06-01T00:00:00",
"publisher" : "Proceedings of the National Academy of Sciences",
"venue" : { }
}, {
"id" : "n393355SE",
"label" : "Serum Amyloid P Component Binds Fungal Surface Amyloid and Decreases Human Macrophage Phagocytosis and Secretion of Inflammatory Cytokines.",
"type" : "AcademicArticle",
"publicationDate" : "2019-03-12T00:00:00",
"publisher" : "American Society for Microbiology",
"venue" : { }
}, {
"id" : "n133617SE",
"label" : "A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases.",
"type" : "AcademicArticle",
"publicationDate" : "2016-10-01T00:00:00",
"publisher" : "AME Publishing Company",
"venue" : { }
}, {
"id" : "n133631SE",
"label" : "Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants.",
"type" : "AcademicArticle",
"publicationDate" : "1986-01-01T11:11:11",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133726SE",
"label" : "A cysteine-rich extracellular protein containing a PA14 domain mediates quorum sensing in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2005-06-01T00:00:00",
"publisher" : "American Society for Microbiology"
}, {
"id" : "n133705SE",
"label" : "Aggregated IgG inhibits the differentiation of human fibrocytes.",
"type" : "AcademicArticle",
"publicationDate" : "2006-01-01T11:11:11",
"publisher" : "Oxford University Press (OUP)"
}, {
"id" : "n133595SE",
"label" : "Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent.",
"type" : "AcademicArticle",
"publicationDate" : "2013-06-01T00:00:00",
"publisher" : "The American Association of Immunologists",
"venue" : { }
}, {
"id" : "n133634SE",
"label" : "Skelemin, a cytoskeletal M-disc periphery protein, contains motifs of adhesion/recognition and intermediate filament proteins.",
"type" : "AcademicArticle",
"publicationDate" : "1993-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133683SE",
"label" : "Increasing specificity from the PCR-RACE technique.",
"type" : "AcademicArticle",
"publicationDate" : "1992-01-01T00:00:00",
"venue" : { }
}, {
"id" : "n568755SE",
"label" : "An Autocrine Negative Feedback Loop Inhibits Dictyostelium discoideum Proliferation through Pathways Including IP3/Ca2.",
"type" : "AcademicArticle",
"publicationDate" : "2021-06-29T00:00:00",
"publisher" : "American Society for Microbiology",
"venue" : { }
}, {
"id" : "n331664SE",
"label" : "Dietary NaCl affects bleomycin-induced lung fibrosis in mice.",
"type" : "AcademicArticle",
"publicationDate" : "2017-01-01T11:11:11",
"publisher" : "Taylor & Francis",
"venue" : { }
}, {
"id" : "n604622SE",
"label" : "A chemorepellent inhibits local Ras activation to inhibit pseudopod formation to bias cell movement away from the chemorepellent.",
"type" : "AcademicArticle",
"publicationDate" : "2022-01-01T00:00:00",
"publisher" : "American Society for Cell Biology (ASCB)",
"venue" : { }
}, {
"id" : "n133655SE",
"label" : "Regulation of the Dictyostelium ras gene during development and in transformants.",
"type" : "AcademicArticle",
"publicationDate" : "1986-01-01T00:00:00",
"venue" : { }
}, {
"id" : "n133603SE",
"label" : "A retinoblastoma orthologue is required for the sensing of a chalone in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2014-03-01T00:00:00",
"publisher" : "American Society for Microbiology"
}, {
"id" : "n133580SE",
"label" : "TNF--stimulated fibroblasts secrete lumican to promote fibrocyte differentiation.",
"type" : "AcademicArticle",
"publicationDate" : "2015-09-01T00:00:00",
"publisher" : "Proceedings of the National Academy of Sciences",
"venue" : { }
}, {
"id" : "n133620SE",
"label" : "Serum amyloid P inhibits granulocyte adhesion.",
"type" : "AcademicArticle",
"publicationDate" : "2013-01-01T11:11:11",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133712SE",
"label" : "Cell density sensing mediated by a G protein-coupled receptor activating phospholipase C.",
"type" : "AcademicArticle",
"publicationDate" : "1998-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133588SE",
"label" : "A Dictyostelium secreted factor requires a PTEN-like phosphatase to slow proliferation and induce chemorepulsion.",
"type" : "AcademicArticle",
"publicationDate" : "2013-03-12T00:00:00",
"publisher" : "Public Library of Science (PLoS)",
"venue" : { }
}, {
"id" : "n133697SE",
"label" : "A putative Ariadne-like ubiquitin ligase is required for Dictyostelium discoideum development.",
"type" : "AcademicArticle",
"publicationDate" : "2006-10-01T00:00:00",
"publisher" : "American Society for Microbiology"
}, {
"id" : "n133590SE",
"label" : "A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.",
"type" : "AcademicArticle",
"publicationDate" : "2015-01-01T00:00:00",
"publisher" : "The American Association of Immunologists",
"venue" : { }
}, {
"id" : "n133622SE",
"label" : "Differentiation of circulating monocytes into fibroblast-like cells.",
"type" : "AcademicArticle",
"publicationDate" : "2012-12-01T00:00:00",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n404854SE",
"label" : "Extracellular Polyphosphate Promotes Macrophage and Fibrocyte Differentiation, Inhibits Leukocyte Proliferation, and Acts as a Chemotactic Agent for Neutrophils.",
"type" : "AcademicArticle",
"publicationDate" : "2019-07-01T00:00:00",
"publisher" : "The American Association of Immunologists",
"venue" : { }
}, {
"id" : "n133670SE",
"label" : "A cell number-counting factor regulates the cytoskeleton and cell motility in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "2002-02-01T00:00:00",
"publisher" : "Proceedings of the National Academy of Sciences",
"venue" : { }
}, {
"id" : "n133645SE",
"label" : "Highly homologous filamin polypeptides have different distributions in avian slow and fast muscle fibers.",
"type" : "AcademicArticle",
"publicationDate" : "1983-09-01T00:00:00",
"publisher" : "Rockefeller University Press",
"venue" : { }
}, {
"id" : "n417860SE",
"label" : "Attenuated pulmonary fibrosis in sialidase-3 knockout (Neu3-/-) mice.",
"type" : "AcademicArticle",
"publicationDate" : "2020-01-01T00:00:00",
"publisher" : "American Physiological Society",
"venue" : { }
}, {
"id" : "n42500SE",
"label" : "Complexity of the Neurospora crassa circadian clock system: multiple loops and oscillators.",
"type" : "AcademicArticle",
"publicationDate" : "2007-01-01T00:00:00",
"publisher" : "Cold Spring Harbor Laboratory",
"venue" : { }
}, {
"id" : "n133616SE",
"label" : "Pirfenidone treatment of idiopathic pulmonary fibrosis.",
"type" : "AcademicArticle",
"publicationDate" : "2011-02-08T00:00:00",
"publisher" : "Taylor & Francis",
"tags" : "3 Good Health and Well-Being"
}, {
"id" : "n133687SE",
"label" : "A cell number-counting factor regulates group size in Dictyostelium by differentially modulating cAMP-induced cAMP and cGMP pulse sizes.",
"type" : "AcademicArticle",
"publicationDate" : "2001-07-20T00:00:00",
"publisher" : "Elsevier"
}, {
"id" : "n133598SE",
"label" : "Extracellular Polyphosphate Inhibits Proliferation in an Autocrine Negative Feedback Loop in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2016-09-16T00:00:00",
"publisher" : "Elsevier"
}, {
"id" : "n133702SE",
"label" : "Regulation and processing of a secreted protein that mediates sensing of cell density in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1991-12-01T00:00:00",
"publisher" : "The Company of Biologists",
"venue" : { }
}, {
"id" : "n133721SE",
"label" : "A protein with similarity to PTEN regulates aggregation territory size by decreasing cyclic AMP pulse size during Dictyostelium discoideum development.",
"type" : "AcademicArticle",
"publicationDate" : "2008-10-01T00:00:00",
"publisher" : "American Society for Microbiology"
}, {
"id" : "n133684SE",
"label" : "RtoA links initial cell type choice to the cell cycle in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1996-11-01T00:00:00",
"publisher" : "The Company of Biologists",
"venue" : { }
}, {
"id" : "n133658SE",
"label" : "Two components of a secreted cell number-counting factor bind to cells and have opposing effects on cAMP signal transduction in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "2003-12-26T00:00:00",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n546598SE",
"label" : "Cell dispersal by localized degradation of a chemoattractant.",
"type" : "AcademicArticle",
"publicationDate" : "2021-02-01T00:00:00",
"publisher" : "Proceedings of the National Academy of Sciences",
"venue" : { }
}, {
"id" : "n133661SE",
"label" : "A deubiquitinating enzyme that disassembles free polyubiquitin chains is required for development but not growth in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1998-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133639SE",
"label" : "On the location of the oscillations in AE Aquarii",
"type" : "AcademicArticle",
"publicationDate" : "1993-01-01T11:11:11",
"publisher" : "American Astronomical Society",
"venue" : { }
}, {
"id" : "n133690SE",
"label" : "Characterization of the signal transduction pathways and cis-acting DNA sequence responsible for the transcriptional induction during growth and development of the lysosomal alpha-mannosidase gene in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "1993-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133642SE",
"label" : "[How to reach the right size?].",
"type" : "AcademicArticle",
"publicationDate" : "2004-02-01T00:00:00",
"publisher" : "EDP sciences",
"venue" : { }
}, {
"id" : "n133602SE",
"label" : "Trypsin, Tryptase, and Thrombin Polarize Macrophages towards a Pro-Fibrotic M2a Phenotype.",
"type" : "AcademicArticle",
"publicationDate" : "2015-09-01T00:00:00",
"publisher" : "Public Library of Science (PLoS)",
"venue" : { }
}, {
"id" : "n133585SE",
"label" : "The ROCO kinase QkgA is necessary for proliferation inhibition by autocrine signals in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2010-10-01T00:00:00",
"publisher" : "American Society for Microbiology",
"venue" : { }
}, {
"id" : "n133715SE",
"label" : "A 60-kilodalton protein component of the counting factor complex regulates group size in Dictyostelium discoideum.",
"type" : "AcademicArticle",
"publicationDate" : "2006-09-01T00:00:00",
"publisher" : "American Society for Microbiology",
"venue" : { }
}, {
"id" : "n679644SE",
"label" : "Changes in lung sialidases in male and female mice after bleomycin aspiration.",
"type" : "AcademicArticle",
"publicationDate" : "2022-11-16T00:00:00",
"publisher" : "Taylor & Francis",
"venue" : { }
}, {
"id" : "n330678SE",
"label" : "C-reactive protein (CRP) but not the related pentraxins serum amyloid P and PTX3 inhibits the proliferation and induces apoptosis of the leukemia cell line Mono Mac 6.",
"type" : "AcademicArticle",
"publicationDate" : "2017-01-01T11:11:11",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133619SE",
"label" : "Regulatory Pathways of Fibrocyte Development",
"type" : "Chapter",
"publicationDate" : "2011-12-01T00:00:00",
"publisher" : "World Scientific Publishing"
}, {
"id" : "n133675SE",
"label" : "A cell-cycle phase-associated cell-type choice mechanism monitors the cell cycle rather than using an independent timer.",
"type" : "AcademicArticle",
"publicationDate" : "1996-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133650SE",
"label" : "Gene identification by shotgun antisense.",
"type" : "AcademicArticle",
"publicationDate" : "1999-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133625SE",
"label" : "Cells respond to and bind countin, a component of a multisubunit cell number counting factor.",
"type" : "AcademicArticle",
"publicationDate" : "2002-09-06T00:00:00",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n294501SE",
"label" : "Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands.",
"type" : "AcademicArticle",
"publicationDate" : "2017-01-01T11:11:11",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133724SE",
"label" : "The secreted Dictyostelium protein CfaD is a chalone",
"type" : "AcademicArticle",
"publicationDate" : "2008-01-01T11:11:11",
"publisher" : "The Company of Biologists",
"venue" : { }
}, {
"id" : "n133667SE",
"label" : "Growing and starving Dictyostelium cells produce distinct density-sensing factors.",
"type" : "AcademicArticle",
"publicationDate" : "1992-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133593SE",
"label" : "Distinct Fc receptors mediate the effect of serum amyloid p on neutrophil adhesion and fibrocyte differentiation.",
"type" : "AcademicArticle",
"publicationDate" : "2014-08-15T00:00:00",
"publisher" : "The American Association of Immunologists",
"venue" : { }
}, {
"id" : "n133707SE",
"label" : "A Dictyostelium chalone uses G proteins to regulate proliferation.",
"type" : "AcademicArticle",
"publicationDate" : "2009-01-01T11:11:11",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n387656SE",
"label" : "An endogenous chemorepellent directs cell movement by inhibiting pseudopods at one side of cells.",
"type" : "AcademicArticle",
"publicationDate" : "2019-01-15T00:00:00",
"publisher" : "American Society for Cell Biology (ASCB)"
}, {
"id" : "n133718SE",
"label" : "A cell number counting factor regulates Akt/protein kinase B to regulate Dictyostelium discoideum group size.",
"type" : "AcademicArticle",
"publicationDate" : "2004-10-01T00:00:00",
"publisher" : "American Society for Microbiology"
}, {
"id" : "n133611SE",
"label" : "Cell density sensing and size determination.",
"type" : "AcademicArticle",
"publicationDate" : "2011-05-01T00:00:00",
"publisher" : "Wiley"
}, {
"id" : "n133681SE",
"label" : "A putative receptor mediating cell-density sensing in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "1999-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n416563SE",
"label" : "Extracellular signaling in Dictyostelium.",
"type" : "AcademicArticle",
"publicationDate" : "2019-01-01T00:00:00",
"publisher" : "UPV/EHU Press",
"venue" : { }
}, {
"id" : "n133664SE",
"label" : "The synthesis and deployment of filamin in chicken skeletal muscle.",
"type" : "AcademicArticle",
"publicationDate" : "1981-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133636SE",
"label" : "The different components of a multisubunit cell number-counting factor have both unique and overlapping functions.",
"type" : "AcademicArticle",
"publicationDate" : "2002-08-01T00:00:00",
"publisher" : "The Company of Biologists",
"venue" : { }
}, {
"id" : "n659427SE",
"label" : "Sex-Based Differences in Human Neutrophil Chemorepulsion.",
"type" : "AcademicArticle",
"publicationDate" : "2022-01-01T11:11:11",
"publisher" : "The American Association of Immunologists",
"venue" : { }
}, {
"id" : "n468226SE",
"label" : "Fibrocytes in the Tumor Microenvironment.",
"type" : "Chapter",
"publicationDate" : "2020-01-01T00:00:00",
"publisher" : "Springer Nature",
"venue" : { }
}, {
"id" : "n133582SE",
"label" : "NaCl potentiates human fibrocyte differentiation.",
"type" : "AcademicArticle",
"publicationDate" : "2012-09-01T00:00:00",
"publisher" : "Public Library of Science (PLoS)",
"venue" : { }
}, {
"id" : "n133605SE",
"label" : "Alternative origins of stroma in normal organs and disease.",
"type" : "AcademicArticle",
"publicationDate" : "2012-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133678SE",
"label" : "Intercellular signalling. Knowing that you're among friends.",
"type" : "AcademicArticle",
"publicationDate" : "1994-01-01T11:11:11",
"publisher" : "Elsevier",
"venue" : { }
}, {
"id" : "n133710SE",
"label" : "Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice.",
"type" : "AcademicArticle",
"publicationDate" : "2006-11-01T00:00:00",
"publisher" : "Proceedings of the National Academy of Sciences",
"venue" : { }
}, {
"id" : "n652351SE",
"label" : "The extracellular sialidase NEU3 primes neutrophils.",
"type" : "AcademicArticle",
"publicationDate" : "2022-12-25T00:00:00",
"publisher" : "Oxford University Press (OUP)"
}, {
"id" : "n384858SE",
"label" : "Sialidase Inhibitors Attenuate Pulmonary Fibrosis in a Mouse Model",
"type" : "ConferencePaper",
"publicationDate" : "2018-01-01T11:11:11",
"venue" : { }
} ],
"creativeWorks" : [ {
"id" : "n4d8bf5a9",
"label" : "BIOL492 Biomedical Therapeutics Devl"
}, {
"id" : "n120fff86",
"label" : "BIOL291 Research"
}, {
"id" : "n120fff86",
"label" : "BIOL291 Hnr-research"
}, {
"id" : "n4feed0ee",
"label" : "GENE691 Research"
}, {
"id" : "ncaade509",
"label" : "BIOL691 Research: In_ab"
}, {
"id" : "ncaade509",
"label" : "BIOL691 Research:in-ab"
}, {
"id" : "ncaade509",
"label" : "BIOL691 Research: In-ab"
}, {
"id" : "ncaade509",
"label" : "BIOL691 Research"
}, {
"id" : "nd5cf467b",
"label" : "BIOL686 Biomedical Therapeutics Dev"
}, {
"id" : "n5ea5678d",
"label" : "BIOL685 Directed Studies"
}, {
"id" : "n82163b8f",
"label" : "BIOL491 Hnr-research"
}, {
"id" : "n82163b8f",
"label" : "BIOL491 Research"
}, {
"id" : "n000b84de",
"label" : "BIOL696 Ethics And Resp Research"
}, {
"id" : "n94d45e21",
"label" : "BIOL291 Research"
}, {
"id" : "n782273ba",
"label" : "BIOL689 Sptp: Biomed Therapeutics Dev"
}, {
"id" : "n4b6d6782",
"label" : "BIOL681 Sem: Ethics And Resp Research"
}, {
"id" : "n8492ea20",
"label" : "BIOL213 Hnr-molecular Cell Biol"
}, {
"id" : "n8492ea20",
"label" : "BIOL213 Molecular Cell Biol"
}, {
"id" : "n40d440d2",
"label" : "BIOL489 Sptp:ethics In Biological Res"
}, {
"id" : "n6aaf106c",
"label" : "BIOL496 Ethics In Biological Research"
}, {
"id" : "na7196494",
"label" : "BICH491 Hnr-research"
}, {
"id" : "na7196494",
"label" : "BICH491 Research"
} ],
"researcherOn" : [ {
"id" : "nfd166e49-e865-11ea-a81a-005056bb4fb7",
"label" : "Genetic Suppression of Loss of TPP1",
"awardedBy" : {
"id" : "n8022b2fb-a812-11e9-bf6d-00155d562649",
"label" : "National Institutes of Health - (Bethesda, Maryland, United States)",
"preferredLabel" : "DHHS-NIH-National Institute of Neurological Disorders and Stroke"
},
"role" : "PrincipalInvestigatorRole",
"startDate" : "2017-01-01T00:00:00",
"endDate" : "2020-01-01T00:00:00"
}, {
"id" : "nf85661ab-e865-11ea-a81a-005056bb4fb7",
"label" : "Elucidation of a Eukaryotic Chemorepulsion Mechanism",
"awardedBy" : {
"id" : "n8022b2fb-a812-11e9-bf6d-00155d562649",
"label" : "National Institutes of Health - (Bethesda, Maryland, United States)",
"preferredLabel" : "DHHS-NIH-National Institute of General Medical Science"
},
"role" : "PrincipalInvestigatorRole",
"startDate" : "2016-01-01T00:00:00",
"endDate" : "2020-01-01T00:00:00"
}, {
"id" : "ndee2494f-e865-11ea-a81a-005056bb4fb7",
"label" : "Breaking a Novel Feedback Loop to Inhibit Fibrosis",
"awardedBy" : {
"id" : "n8022b2fb-a812-11e9-bf6d-00155d562649",
"label" : "National Institutes of Health - (Bethesda, Maryland, United States)",
"preferredLabel" : "DHHS-NIH-National Heart, Lung, and Blood Institute"
},
"role" : "PrincipalInvestigatorRole",
"startDate" : "2018-01-01T00:00:00",
"endDate" : "2022-01-01T00:00:00"
}, {
"id" : "n50e8b682-e866-11ea-a81a-005056bb4fb7",
"label" : "Pentraxin regulation of macrophage differentiation",
"awardedBy" : {
"id" : "n8022b2fb-a812-11e9-bf6d-00155d562649",
"label" : "National Institutes of Health - (Bethesda, Maryland, United States)",
"preferredLabel" : "National Institutes of Health"
},
"role" : "PrincipalInvestigatorRole",
"startDate" : "2014-01-01T00:00:00",
"endDate" : "2019-01-01T00:00:00"
}, {
"id" : "n5c53b479-e866-11ea-a81a-005056bb4fb7",
"label" : "Elucidation of a Dictyostelium chalone",
"awardedBy" : {
"id" : "n8022b2fb-a812-11e9-bf6d-00155d562649",
"label" : "National Institutes of Health - (Bethesda, Maryland, United States)",
"preferredLabel" : "National Institutes of Health"
},
"role" : "PrincipalInvestigatorRole",
"startDate" : "2012-01-01T00:00:00",
"endDate" : "2018-01-01T00:00:00"
} ],
"teachingActivities" : [ {
"id" : "n4d8bf5a9",
"label" : "BIOL492 Biomedical Therapeutics Devl",
"role" : "Instructor"
}, {
"id" : "n120fff86",
"label" : "BIOL291 Research",
"role" : "Instructor"
}, {
"id" : "n120fff86",
"label" : "BIOL291 Hnr-research",
"role" : "Instructor"
}, {
"id" : "n4feed0ee",
"label" : "GENE691 Research",
"role" : "Instructor"
}, {
"id" : "ncaade509",
"label" : "BIOL691 Research: In_ab",
"role" : "Instructor"
}, {
"id" : "ncaade509",
"label" : "BIOL691 Research:in-ab",
"role" : "Instructor"
}, {
"id" : "ncaade509",
"label" : "BIOL691 Research: In-ab",
"role" : "Instructor"
}, {
"id" : "ncaade509",
"label" : "BIOL691 Research",
"role" : "Instructor"
}, {
"id" : "nd5cf467b",
"label" : "BIOL686 Biomedical Therapeutics Dev",
"role" : "Instructor"
}, {
"id" : "n5ea5678d",
"label" : "BIOL685 Directed Studies",
"role" : "Instructor"
}, {
"id" : "n82163b8f",
"label" : "BIOL491 Hnr-research",
"role" : "Instructor"
}, {
"id" : "n82163b8f",
"label" : "BIOL491 Research",
"role" : "Instructor"
}, {
"id" : "n000b84de",
"label" : "BIOL696 Ethics And Resp Research",
"role" : "Instructor"
}, {
"id" : "n94d45e21",
"label" : "BIOL291 Research",
"role" : "Instructor"
}, {
"id" : "n782273ba",
"label" : "BIOL689 Sptp: Biomed Therapeutics Dev",
"role" : "Instructor"
}, {
"id" : "n4b6d6782",
"label" : "BIOL681 Sem: Ethics And Resp Research",
"role" : "Instructor"
}, {
"id" : "n8492ea20",
"label" : "BIOL213 Hnr-molecular Cell Biol",
"role" : "Instructor"
}, {
"id" : "n8492ea20",
"label" : "BIOL213 Molecular Cell Biol",
"role" : "Instructor"
}, {
"id" : "n40d440d2",
"label" : "BIOL489 Sptp:ethics In Biological Res",
"role" : "Instructor"
}, {
"id" : "n6aaf106c",
"label" : "BIOL496 Ethics In Biological Research",
"role" : "Instructor"
}, {
"id" : "na7196494",
"label" : "BICH491 Hnr-research",
"role" : "Instructor"
}, {
"id" : "na7196494",
"label" : "BICH491 Research",
"role" : "Instructor"
} ],
"email" : "rgomer@tamu.edu",
"firstName" : "Richard",
"lastName" : "Gomer",
"streetAddress" : "Texas A&M University; Biology; 301 Old Main Drive",
"locality" : "College Station",
"region" : "TX",
"postalCode" : "77843-3474",
"country" : "USA",
"organizations" : [ "Biology" ],
"schools" : [ "College of Arts and Sciences" ],
"netid" : "richard47",
"uid" : "786202fb4a0922e4889ceefd14c2cd89",
"inTheNews" : [ {
"id" : "n0b5ed425-09cb-11eb-89f9-005056bb4fb7",
"label" : "Seven Texas A&M Faculty Members Awarded With University Distinguished Professorships"
} ],
"etdChairOf" : [ {
"id" : "n39886161",
"label" : "Xiang, Wang (2018-08). Inhibiting Serum Amyloid P - Fc?R1 Interactions on Human Macrophages Decreases Numbers of Intracellular Mycobacteria. Master's Thesis.",
"url" : "http://hdl.handle.net/1969.1/173954",
"publicationDate" : "2018-08-01T00:00:00"
}, {
"id" : "n01ba83b8",
"label" : "White, Michael (2015-06). Linking Fibrosis and Cancer through the Differentiation of Fibrocytes. Doctoral Dissertation.",
"url" : "http://hdl.handle.net/1969.1/155167",
"publicationDate" : "2015-06-01T00:00:00"
}, {
"id" : "nd19776b7",
"label" : "Suess, Patrick Michael (2018-05). Insight into an Ancient and Enigmatic Molecule Using Dictyostelium discoideum. Doctoral Dissertation.",
"url" : "http://hdl.handle.net/1969.1/173518"
}, {
"id" : "nc62cd856",
"label" : "Cox, Nehemiah (2015-05). Regulation of Innate Immune Responses and Fibrosis by Serum Amyloid P. Doctoral Dissertation.",
"url" : "http://hdl.handle.net/1969.1/161252",
"publicationDate" : "2015-05-01T00:00:00"
}, {
"id" : "n6ec1e708",
"label" : "Herlihy, Sarah E (2014-06). Linking Two Seemingly Unrelated Diseases, Cancer and Acute Respiratory Distress Syndrome, Through a Dictyostelium Secreted Protein. Doctoral Dissertation.",
"url" : "http://hdl.handle.net/1969.1/153282",
"publicationDate" : "2014-08-01T00:00:00"
} ],
"featuredProfileDisplay" : "true",
"publicationToInterfolio" : "true",
"image" : "https://vivo.library.tamu.edu/vivo/file/n6655/richard47.jpg",
"thumbnail" : "https://vivo.library.tamu.edu/vivo/file/n2835/thumbnail_richard47.jpg",
"websites" : [ {
"id" : "nd8b334bf_url",
"label" : "Lab website",
"url" : "https://www.bio.tamu.edu/lab-website-richard-gomer/"
} ],
"modTime" : "Sun Mar 24 22:14:37 UTC 2024",
"type" : [ "FacultyMember" ],
"_links" : {
"self" : {
"href" : "https://api.library.tamu.edu/scholars-discovery/individual/nf41f3898"
},
"individual" : {
"href" : "https://api.library.tamu.edu/scholars-discovery/individual/nf41f3898"
}
}
}