# positions[].organizations[].label
Center for Genomic and Precision Medicine

# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Heart failure (impaired ventricular pump function) is an eventual outcome for diverse cardiovascular disorders and the leading cause of combined morbidity and mortality in the United States and other developed industrial nations. The focus of my lab is to understand the molecular and cellular mechanisms that initiate and mediate the pathogenesis of maladaptive cardiac remodeling, such as cardiac hypertrophy and fibrosis as result of various pathological scenarios such as myocardial infarction, hypertension, obesity, diabetes, aging and post-traumatic stress disorder. The overall approach consists of generation and analysis of clinically-relevant genetic mouse models including a tool mouse enabling tracking endogenous cardiac exosomes, and conduct mechanistic studies using cutting-edge technology. The ultimate goal of our efforts is to provide clinical translation for the prevention and treatment of pathological cardiac remodeling from our mechanistic studies.

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Hypoxia-Inducible Factor 1, Alpha Subunit

# educationAndTraining[].organization.label
Baylor College of Medicine - (Houston, Texas, United States)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
The University of Texas Health Science Center at Houston - (Houston, Texas, United States)

# awardsAndHonors[].label
Enhancing Development and Generating Excellence in Scholarship (EDGES) Fellow

# publications[].label
Active ROCK-1 is generated by caspase 3Cleavage in human and mouse heart failure and disruption of ROCK-1 attenuates myocyte apoptosis

# publications[].label
Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2.

# publications[].label
Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells.

# publications[].label
Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac function.

# publications[].label
Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis.

# publications[].label
Communication between Cardiomyocytes and Cardiac Fibroblasts: Mechanistic Role of ROCK1 in Fibrotic Cardiac Remodeling

# publications[].label
Downregulation of RND3/RhoE in glioblastoma patients promotes tumorigenesis through augmentation of notch transcriptional complex activity.

# publications[].label
Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance.

# publications[].label
Spatial and temporal tracking of cardiac exosomes in mouse using a nano-luciferase-CD63 fusion protein.

# publications[].label
Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy

# publications[].label
Activation of heat-shock factor by stretch-activated channels in rat hearts.

# publications[].label
Protein tyrosine phosphatase-like A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway.

# publications[].label
Activation of HSF and selective increase in heat-shock proteins by acute dexamethasone treatment.

# publications[].label
Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling.

# publications[].label
Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1.

# publications[].label
HSF activation and increased expression of HSP72 is mediated by stretch-activated channels in the isolated perfused rat heart

# publications[].label
Activation of heat shock factor by decreases in intracellular ATP and pH in isolated rat hearts

# publications[].label
Genetic deletion of Rnd3 results in aqueductal stenosis leading to hydrocephalus through up-regulation of Notch signaling.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis.

# publications[].label
Dissecting the Mechanisms of Doxorubicin and Oxidative Stress-Induced Cytotoxicity: The Involvement of Actin Cytoskeleton and ROCK1.

# publications[].label
Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction

# publications[].label
LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment.

# publications[].label
Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure.

# publications[].label
Rho kinase signaling and cardiac physiology.

# publications[].label
NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repression.

# publications[].label
Identification and characterization of a new isoform of small GTPase RhoE.

# publications[].label
RND3 promotes Snail 1 protein degradation and inhibits glioblastoma cell migration and invasion.

# publications[].label
ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency.

# publications[].label
Rnd3/RhoE Plays an Essential Role in the Transition of Heart to Failure

# publications[].label
Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.

# publications[].label
Histone methyltransferase Setd2 is critical for the proliferation and differentiation of myoblasts.

# publications[].label
Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1 and Regulates Responsive Cardiac Angiogenesis.

# publications[].label
Activation of the heat shock response: relationship to energy metabolites. A (31)P NMR study in rat hearts.

# publications[].label
Expression of heat shock proteins in turtle and mammalian hearts: Relationship to anoxia tolerance

# publications[].label
Double-inducible gene activation system for caspase 3 and 9 in epidermis.

# publications[].label
RhoE Fine-Tunes Inflammatory Response in Myocardial Infarction.

# publications[].label
Targeted expression of Cre recombinase provokes placental-specific DNA recombination in transgenic mice.

# publications[].label
Involvement of activated SUMO-2 conjugation in cardiomyopathy

# researcherOn[].label
Mechanism of Srf-N-Mediated Cardiac Suppression

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Mechanistic Role of Rnd3 in Response to Cardiac Stress

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Rho signaling in the development and treatment of myocardial infarction complication

# researcherOn[].awardedBy.label
American Heart Association - (New York, New York, United States)

# researcherOn[].label
RhoE-mediated Sterile Inflammation Regulation in Acute Myocardial Infarction

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Heart, Lung, and Blood Institute

# researcherOn[].label
Epigenetic signaling, pathological cardiac hypertrophy and Western diet

# researcherOn[].awardedBy.label
National Heart Lung and Blood Institute - (Bethesda, Maryland, United States)

# researcherOn[].label
Fibrogenic Role of Rock Delta1 and Mechanism In Cardiac Remodeling

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Heart, Lung, and Blood Institute

# researcherOn[].label
Establishment of an endogenous cardiac exosome tracking system

# researcherOn[].awardedBy.label
American Heart Association - (New York, New York, United States)

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Heart, Lung, and Blood Institute

# streetAddress
Ibt Center For Translational Cancer Research; Texas A&M College of Medicine; 1201 TAMUS

# organizations[]
Center for Genomic and Precision Medicine

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine

# inTheNews[].label
Texas A&M University Announces 2020 EDGES Fellows