# overview
I study how protein levels are regulated in cells, with a particular focus on how translation is rapidly

reprogrammed in response to environmental stresses and viral infection. I use an integrative approach,

combining biophysical, biochemical and cell biological tools to gain a deep understanding of how translational

specificity is modulated, from the fluctuating dynamics of macromolecular machines to the dramatic

reorganization of the cytoplasm by biomolecular condensation.

# keywords[]
1.1 Normal Biological Development And Functioning

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1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

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1.1 Normal Biological Development And Functioning

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1.1 Normal Biological Development And Functioning

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35 Commerce, Management, Tourism And Services

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Atpases Associated With Diverse Cellular Activities

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
University of California, Berkeley - (Berkeley, California, United States)

# educationAndTraining[].organization.label
Yale University - (New Haven, Connecticut, United States)

# educationAndTraining[].organization.label
University of Chicago - (Chicago, Illinois, United States)

# publications[].label
Illuminating the Proteasome: Fluorescence Assays for Investigating the Kinetics of Proteasome Substrate Processing

# publications[].label
The 26S Proteasome Utilizes a Kinetic Gateway to Prioritize Substrate Degradation.

# publications[].label
No Granules, No Problem: Stress Granules Are Not Required For mRNA Condensation Or Translational Regulation During Stress

# publications[].label
Ubiquitin modulates 26S proteasome conformational dynamics and promotes substrate degradation

# publications[].label
Bounded flexibility in dayson and daysoff scheduling

# publications[].label
Direct Observation of Protein Translocation by the 26S Proteasome

# publications[].label
Recombinant Expression, Unnatural Amino Acid Incorporation, and Site-Specific Labeling of 26S Proteasomal Subcomplexes.

# publications[].label
Structure and Function of the 26S Proteasome.

# publications[].label
Deconvolution of substrate processing by the 26S proteasome reveals a selective kinetic gateway to degradation

# publications[].label
Preservation of orphan ribosomal proteins during stress in chaperone-stirred condensates

# publications[].label
Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response.

# publications[].label
Adaptive preservation of orphan ribosomal proteins in chaperone-dispersed condensates.

# publications[].label
Chaperone regulation of biomolecular condensates

# publications[].label
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs.

# publications[].label
Track: Protein Phase Separation in Biomolecular Condensates The functional and molecular determinants of stress-induced mRNA condensation

# publications[].label
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs.

# publications[].label
An adaptive biomolecular condensation response is conserved across environmentally divergent species.

# publications[].label
An adaptive biomolecular condensation response is conserved across environmentally divergent species.

# publications[].label
The functional and molecular determinants of stress-induced mRNA condensation

# publications[].label
Ubiquitin modulates 26S proteasome conformational dynamics and promotes substrate degradation.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Adaptive preservation of orphan ribosomal proteins in chaperone-stirred condensates

# publications[].label
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules.

# publications[].label
The functional and molecular determinants of stress-induced mRNA condensation

# publications[].label
BPS2025-Function and composition of RNA granules during chikungunya virus infection

# researcherOn[].awardedBy.label
Helen Hay Whitney Foundation - (New City, New York, United States)