# keywords[]
National Heart, Lung, And Blood Institute (U.S.)

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Single-Strand Specific DNA And RNA Endonucleases

# keywords[]
Single-Strand Specific DNA And RNA Endonucleases

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Single-Strand Specific DNA And RNA Endonucleases

# keywords[]
CENTRAL NERVOUS SYSTEM/effect Of Drugs On

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
NLR Family, Pyrin Domain-Containing 3 Protein

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Vpr Gene Products, Human Immunodeficiency Virus

# keywords[]
Single-Strand Specific DNA And RNA Endonucleases

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
University of Oxford - (Oxford, Oxfordshire, United Kingdom)

# educationAndTraining[].organization.label
Polytechnic of Medimurje in Cakovec - (Čakovec, Croatia)

# educationAndTraining[].organization.label
Haverford College - (Philadelphia, Pennsylvania, United States)

# educationAndTraining[].organization.label
George Washington University - (Washington D.C., District of Columbia, United States)

# educationAndTraining[].organization.label
University of Pennsylvania - (Philadelphia, Pennsylvania, United States)

# awardsAndHonors[].label
Lee C. Howley Sr. Prize for Arthritis Scientific Research

# publications[].label
Stem Cells in the Face: Tooth Regeneration and Beyond

# publications[].label
One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Enhanced in situ detection of beta-glucuronidase activity in murine tissue.

# publications[].label
Bone fragility in transgenic mice expressing a mutated gene for type I procollagen (COL1A1) parallels the age-dependent phenotype of human osteogenesis imperfecta.

# publications[].label
Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase. Effect of chain length, helical conformation and amino acid sequence in the substrate.

# publications[].label
Mass spectrometric gene diagnosis of one-base substitution from polymerase chain reaction amplified human DNA.

# publications[].label
Further characterization of embryonic tendon fibroblasts and the use of immunoferritin techniques to study collagen biosynthesis.

# publications[].label
First-stage autosomal genome screen in extended pedigrees suggests genes predisposing to low bone mineral density on chromosomes 1p, 2p and 4q.

# publications[].label
Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis.

# publications[].label
PUROMYCIN INHIBITION OF COLLAGEN SYNTHESIS AS EVIDENCE FOR A RIBOSOMAT

# publications[].label
A subtle disease and a dilemma: can cells secrete collagen that does not contain a sugar-tag?

# publications[].label
A 1.9-Kb 5' fragment from the human COL1A1 gene drives inappropriate expression of the human COL2A1 gene in tissues of transgenic mice that normally express only the COL1A1 gene.

# publications[].label
Self-assembly into fibrils of collagen II by enzymic cleavage of recombinant procollagen II. Lag period, critical concentration, and morphology of fibrils differ from collagen I.

# publications[].label
High levels of expression of a minigene version of the human pro alpha 1 (I) collagen gene in stably transfected mouse fibroblasts. Effects of deleting putative regulatory sequences in the first intron.

# publications[].label
How does a skin fibroblast make type I collagen fibers?

# publications[].label
Partial characterization of protocollagen from embryonic cartilage.

# publications[].label
A mutation in the pro alpha 2(I) gene (COL1A2) for type I procollagen in Ehlers-Danlos syndrome type VII: evidence suggesting that skipping of exon 6 in RNA splicing may be a common cause of the phenotype.

# publications[].label
Structure of a full-length cDNA clone for the prepro alpha 2(I) chain of human type I procollagen. Comparison with the chicken gene confirms unusual patterns of gene conservation.

# publications[].label
Stop codon in the procollagen II gene (COL2A1) in a family with the Stickler syndrome (arthro-ophthalmopathy).

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases.

# publications[].label
Efficient DNA sequencing on microtiter plates using dried reagents and Bst DNA polymerase.

# publications[].label
Significance of urinary hydroxyproline in man.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Use of a proline analogue to prevent lung injury following oxygen toxicity in rats

# publications[].label
Analysis of the COL1A1 and COL1A2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COL1A1 mutations in 15 patients with osteogenesis imperfecta type I: identification of common sequences of null-allele mutations.

# publications[].label
Procollagen-a precursor form of collagen.

# publications[].label
Electronmicroscopic Localization of Deletions in the Human Pro2(I) Collagen Genea

# publications[].label
The synthetic polytripeptides (Pro-Pro-Gly)10 and (Pro-Pro-Gly)20 form micro-crystalline structures similar to segmental structures formed by collagen.

# publications[].label
Catabolism and excretion of free hydroxyproline in infancy.

# publications[].label
Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies.

# publications[].label
Segment-long-spacing aggregates and isolation of COOH-terminal peptides from type I procollagen.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Copolymerization of normal type I collagen with three mutated type I collagens containing substitutions of cysteine at different glycine positions in the alpha 1 (I) chain.

# publications[].label
Hydroxylation of proline after the release of proline-rich polypeptides from ribosomal complexes during uninhibited collagen biosynthesis.

# publications[].label
Genetic trail of osteoporosis: candidate genes versus genome Screens? small families versus large families?

# publications[].label
Cloning a cDNA for the pro-alpha 2 chain of human type I collagen.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Rat adult stem cells (marrow stromal cells) engraft and differentiate in chick embryos without evidence of cell fusion.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A long-awaited discovery: hypoxia prevents mouse cells from undergoing spontaneous p53-dependent transformation.

# publications[].label
Isotopic studies on urinary hydroxyproline as evidence for rapidly catabolized forms of collagen in the young rat.

# publications[].label
Arg519-Cys mutation in COL2A1: evidence for multiple founders.

# publications[].label
A second mutation in the type II procollagen gene (COL2AI) causing stickler syndrome (arthro-ophthalmopathy) is also a premature termination codon.

# publications[].label
Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. I. Arrest of collagen accumulation in growing chick embryos.

# publications[].label
Intraduodenal hydrolysis of gelatin as a measure of protein digestion in normal subjects and in patients with malabsorption syndromes.

# publications[].label
Further hydroxylation of lysyl residues in collagen by protocollagen lysyl hydroxylase in vitro.

# publications[].label
Hardly Tendentious--Repairing Like with Like.

# publications[].label
Conformation sensitive gel electrophoresis for simple and accurate detection of mutations: comparison with denaturing gradient gel electrophoresis and nucleotide sequencing.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Single base mutation in the pro alpha 2(I) collagen gene that causes efficient splicing of RNA from exon 27 to exon 29 and synthesis of a shortened but in-frame pro alpha 2(I) chain.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Transgenic mice that express a mini-gene version of the human gene for type I procollagen (COL1A1) develop a phenotype resembling a lethal form of osteogenesis imperfecta.

# publications[].label
Assembly of type I collagen fibrils de novo. Between 37 and 41 degrees C the process is limited by micro-unfolding of monomers.

# publications[].label
Unique characteristics of human mesenchymal stromal/progenitor cells pre-activated in 3-dimensional cultures under different conditions.

# publications[].label
EFFECTS OF HYDROCORTISONE ON THE SYNTHESIS OF SULPHATED MUCOPOLYSACCHARIDES AND COLLAGEN IN CHICK EMBRYOS.

# publications[].label
Single Base Mutation in the Type III Procollagen Gene That Converts the Codon for Glycine 883 to Aspartate in a Proband with Mild Symptoms of EhlersDanlos Syndrome IVa

# publications[].label
Assignment of the human pro alpha 2(I) collagen structural gene (COLIA2) to chromosome 7 by molecular hybridization.

# publications[].label
Why should mesenchymal stem cells (MSCs) cure autoimmune diseases?

# publications[].label
The intracellular biosynthesis of collagen. Some possible implications for diseases of bone and other connective tissues.

# publications[].label
The gene for the alpha 1(IV) chain of human type IV procollagen: the exon structures do not coincide with the two structural subdomains in the globular carboxy-terminus of the protein.

# publications[].label
In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP.

# publications[].label
Substitution of serine for alpha 1(I)-glycine 844 in a severe variant of osteogenesis imperfecta minimally destabilizes the triple helix of type I procollagen. The effects of glycine substitutions on thermal stability are either position of amino acid specific.

# publications[].label
Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs).

# publications[].label
Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility.

# publications[].label
Hopkins Memorial Medal lecture. Pleasant surprises en route from the biochemistry of collagen to attempts at gene therapy.

# publications[].label
A single base mutation that converts glycine 907 of the alpha 2(I) chain of type I procollagen to aspartate in a lethal variant of osteogenesis imperfecta. The single amino acid substitution near the carboxyl terminus destabilizes the whole triple helix.

# publications[].label
Is newly-secreted elastin cleaved to a smaller molecule before being incorporated into crosslinked elastin fibers?

# publications[].label
Administration of TSG-6 improves memory after traumatic brain injury in mice.

# publications[].label
Detection of mismatched bases in double stranded DNA by gel electrophoresis.

# publications[].label
Internal deletion in a collagen gene in a perinatal lethal form of osteogenesis imperfecta.

# publications[].label
Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Regeneration after nerve transection: effect of inhibition of collagen synthesis.

# publications[].label
Expression of human COL1A1 gene in stably transfected HT1080 cells: the production of a thermostable homotrimer of type I collagen in a recombinant system.

# publications[].label
A STUDY OF URINARY AND SERUM LYSOZYME IN PATIENTS WITH RENAL DISEASE.

# publications[].label
Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline.

# publications[].label
SYNTHESIS OF HYDROXYPROLINE IN VITRO BY THE HYDROXYLATION OF PROLINE IN A PRECURSOR OF COLLAGEN.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Location of xylosyltransferase in the cisternae of the rough endoplasmic reticulum of embryonic cartilage cells.

# publications[].label
Cleavage of type I procollagen by C- and N-proteinases is more rapid if the substrate is aggregated with dextran sulfate or polyethylene glycol.

# publications[].label
Review: ex vivo engineering of living tissues with adult stem cells.

# publications[].label
Kinetic patterns of protocollagen hydroxylase and further studies on the polypeptide substrate.

# publications[].label
Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs).

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Two cysteine substitutions in procollagen I: a glycine replacement near the N-terminus of alpha 1(I) chain causes lethal osteogenesis imperfecta and a glycine replacement in the alpha 2(I) chain markedly destabilizes the triple helix.

# publications[].label
Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Mutations in collagen genes. Consequences for rare and common diseases.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
The thermal transition of a non-hydroxylated form of collagen. Evidence for a role for hydroxyproline in stabilizing the triple-helix of collagen.

# publications[].label
Anticonvulsant properties of monoamine oxidase inhibitors.

# publications[].label
Separation of human pro alpha 1 (I) and pro alpha 2 (I) procollagen chains by reverse phase high performance liquid chromatography.

# publications[].label
Stem cells and cell therapies in lung biology and lung diseases.

# publications[].label
NH2-terminal extensions on skin collagen from sheep with a genetic defect in conversion of procollagen into collagen.

# publications[].label
Mitochondrial transfer between cells can rescue aerobic respiration.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Mutations that alter the primary structure of type I collagen. The perils of a system for generating large structures by the principle of nucleated growth.

# publications[].label
INCORPORATION OF SULFATE AND THE SYNTHESIS OF COLLAGEN BY CULTURES OF EMBRYONIC CHONDROCYTES.

# publications[].label
Oxygen-18 studies on the conversion of proline to collagen hydroxyproline.

# publications[].label
The exciting prospects of new therapies with mesenchymal stromal cells.

# publications[].label
The biosynthesis of collagen and its disorders (second of two parts).

# publications[].label
Effect of polymer size on the inhibition of protocollagen proline hydroxylase by polyproline II.

# publications[].label
Assessment of small polymorphisms in defined human collagen gene segments.

# publications[].label
The biosynthesis of basement membrane collagen in embryonic chick lens. II. Synthesis of a precursor form by matrix-free cells and a time-dependent conversion to chains in intact lens.

# publications[].label
A rapid and simple PCR-based method for isolation of cDNAs from differentially expressed genes.

# publications[].label
Stem cells in the face: tooth regeneration and beyond.

# publications[].label
A sequence polymorphism in the 3'-nontranslated region of the pro alpha 1 chain of type I procollagen.

# publications[].label
Inhibition of type i collagen expression by antisense oligonucleotides in keloid fibroblast cultures

# publications[].label
Human stem/progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor  and Notch signaling.

# publications[].label
Characterization of recombinant human collagen II with Arg519-to-Cys substitution.

# publications[].label
An allele of COL9A2 associated with intervertebral disc disease.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype.

# publications[].label
Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor--induced protein 6.

# publications[].label
Nucleotide sequences of complementary deoxyribonucleic acids for the pro alpha 1 chain of human type I procollagen. Statistical evaluation of structures that are conserved during evolution.

# publications[].label
Aggregation of a type I collagen precursor containing N-terminal propeptides.

# publications[].label
A fourth example suggests that premature termination codons in the COL2A1 gene are a common cause of the Stickler syndrome: analysis of the COL2A1 gene by denaturing gradient gel electrophoresis.

# publications[].label
Collagen II containing a Cys substitution for arg-alpha1-519. Homotrimeric monomers containing the mutation do not assemble into fibrils but alter the self-assembly of the normal protein.

# publications[].label
Heterozygous glycine substitution in the COL11A2 gene in the original patient with the Weissenbacher-Zweymller syndrome demonstrates its identity with heterozygous OSMED (nonocular Stickler syndrome).

# publications[].label
Two improved methods for preparing ferritin-protein conjugates for electron microscopy.

# publications[].label
A lethal variant of osteogenesis imperfecta has a single base mutation that substitutes cysteine for glycine 904 of the alpha 1(I) chain of type I procollagen. The asymptomatic mother has an unidentified mutation producing an overmodified and unstable type I procollagen.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
A specific method for the analysis of hydroxyproline in tissues and urine.

# publications[].label
C to T polymorphism in exon 33 of the COL3A1 gene.

# publications[].label
Prevention of collagen deposition following pulmonary oxygen toxicity in the rat by cis-4-hydroxy-L-proline.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Modifications of a specific assay for hydroxyproline in urine.

# publications[].label
Modified procedure for the assay of H-3-or C-14-labeled hydroxyproline.

# publications[].label
Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. II. Morphological and physical properties of collagen containing the analogue.

# publications[].label
Proline analogues inhibit the formation of helical collagen

# publications[].label
Osteogenesis imperfecta. A model for genetic causes of osteoporosis and perhaps several other common diseases of connective tissue.

# publications[].label
Influence of cortisol on the synthesis of sulfated mucopolysaccharides and collagen in chick embryos.

# publications[].label
The human COL11A2 gene structure indicates that the gene has not evolved with the genes for the major fibrillar collagens.

# publications[].label
The biosynthesis of basement membrane collagen in embryonic chick lens. I. Delay between the synthesis of polypeptide chains and the secretion of collagen by matrix-free cells.

# publications[].label
Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen.

# publications[].label
ISOTOPIC STUDIES ON COLLAGEN DEGRADATION AND THE URINE EXCRETION OF HYDROXYPROLINE.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Incorporation of cis-hydroxyproline into collagen by tendon cells. Failure of the intracellular collagen to assume a triple-helical conformation.

# publications[].label
cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Tissue- and development-specific expression in transgenic mice of a type I procollagen (COL1A1) minigene construct with 2.3 kb of the promoter region and 2 kb of the 3'-flanking region. Specificity is independent of the putative regulatory sequences in the first intron.

# publications[].label
Lack of a phenotype in transgenic mice aberrantly expressing COL2A1 mRNA because of highly selective post-transcriptional down-regulation.

# publications[].label
Should publications on mesenchymal stem/progenitor cells include in-process data on the preparation of the cells?

# publications[].label
Addition of mannose to both the amino- and carboxy-terminal properties of type II procollagen occurs without formation of a triple helix.

# publications[].label
Isolation of a highly clonogenic and multipotential subfraction of adult stem cells from bone marrow stroma.

# publications[].label
Adult bone marrow stem/progenitor cells (MSCs) are preconditioned by microenvironmental "niches" in culture: a two-stage hypothesis for regulation of MSC fate.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment.

# publications[].label
Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels

# publications[].label
A type I collagen with substitution of a cysteine for glycine-748 in the alpha 1(I) chain copolymerizes with normal type I collagen and can generate fractallike structures.

# publications[].label
A new epidermal growth factor-like domain in the human core protein for the large cartilage-specific proteoglycan. Evidence for alternative splicing of the domain.

# publications[].label
Precursors of the hydroxyproline and ketoproline in actinomycin.

# publications[].label
Sequential hydroxylation of lysine and glycosylation of hydroxylysine during the biosynthesis of collagen in isolated cartilage.

# publications[].label
Use of a natural modulator of inflammation (TSG-6) for the therapy of traumatic brain injury

# publications[].label
Sequential cleavage of type I procollagen by procollagen N-proteinase. An intermediate containing an uncleaved pro alpha 1(I) chain.

# publications[].label
Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response.

# publications[].label
Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A recombinant homotrimer of type I procollagen that lacks the central two D-periods. The thermal stability of the triple helix is decreased by 2 to 4 degrees C.

# publications[].label
Biosynthesis of cartilage procollagen. Influence of chain association and hydroxylation of prolyl residues on the folding of the polypeptides into the triple-helical conformation.

# publications[].label
In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Dkk-1-derived synthetic peptides and lithium chloride for the control and recovery of adult stem cells from bone marrow.

# publications[].label
The hydroxylation of proline to hydroxyproline during the synthesis of collagen in chick embryos.

# publications[].label
An inbred line of transgenic mice expressing an internally deleted gene for type II procollagen (COL2A1). Young mice have a variable phenotype of a chondrodysplasia and older mice have osteoarthritic changes in joints.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
An ultrastructural, microanalytical, and spectroscopic study of bone from a transgenic mouse with a COL1.A1 pro-alpha-1 mutation.

# publications[].label
Mutations that alter the primary structure of type I procollagen have long-range effects on its cleavage by procollagen N-proteinase.

# publications[].label
Recombinant procollagen II: Deletion of D period segments identifies sequences that are required for helix stabilization and generates a temperature-sensitive N-proteinase cleavage site.

# publications[].label
Sequential steps in the synthesis of hydroxylysine and the glycosylation of hydroxylysine during the biosynthesis of collagen.

# publications[].label
Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Phase-directed therapy: TSG-6 targeted to early inflammation improves bleomycin-injured lungs.

# publications[].label
More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running exercise.

# publications[].label
The biosynthesis of basement membrane collagen in embryonic chick lens. 3. Intracellular formation of the triple helix and the formation of aggregates through disulfide bonds.

# publications[].label
A Single Base Mutation in Type III Procollagen That Converts the Codon for Glycine 619 to Arginine in a Family with Familial Aneurysms and Mild Bleeding Tendenciesa

# publications[].label
Characterization of type I procollagen N-proteinase from fetal bovine tendon and skin. Purification of the 500-kilodalton form of the enzyme from bovine tendon.

# publications[].label
TNF-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Formation of collagen fibrils in vitro by cleavage of procollagen with procollagen proteinases.

# publications[].label
Defining the probability that a cell therapy will produce a malignancy.

# publications[].label
A-2-->G transition at the 3' acceptor splice site of IVS17 characterizes the COL2A1 gene mutation in the original Stickler syndrome kindred.

# publications[].label
Synthesis of an elastin component of molecular weight about 70,000 by polysomes from chick embryo aortas.

# publications[].label
Soliciting strategies for developing cell-based reference materials to advance mesenchymal stromal cell research and clinical translation.

# publications[].label
Hydroxylation of prolyl residues in type II procollagen in vitro and in cellulo. Lack of preferential hydroxylation of specific regions of the protein.

# publications[].label
Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven process.

# publications[].label
Drosha regulates hMSCs cell cycle progression through a miRNA independent mechanism.

# publications[].label
Defects in the processing of procollagen to collagen are demonstrable in cultured fibroblasts from patients with the Ehlers-Danlos and osteogenesis imperfecta syndromes.

# publications[].label
Quantitative assay for hydroxylysine in protein hydrolyzates.

# publications[].label
Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells.

# publications[].label
Effect of cycloheximide on collagen biosynthesis as evidence for a post-ribosomal site for the hydroxylation of proline.

# publications[].label
Detection and location of single-base mutations in large DNA fragments by immunomicroscopy.

# publications[].label
Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility

# publications[].label
Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality.

# publications[].label
SOURCE OF THE ELEVATED SERUM ALKALINE PHOSPHATASE ACTIVITY IN BILIARY OBSTRUCTION: STUDIES UTILIZING ISOLATED LIVER PERFUSION.

# publications[].label
Nuclease S1 mapping of a homozygous mutation in the carboxyl-propeptide-coding region of the pro alpha 2(I) collagen gene in a patient with osteogenesis imperfecta.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Tissue-specific expression of the gene for type I procollagen (COL1A1) in transgenic mice. Only 476 base pairs of the promoter are required if collagen genes are used as reporters.

# publications[].label
Detection of single-base mutations by reaction of DNA heteroduplexes with a water-soluble carbodiimide followed by primer extension: application to products from the polymerase chain reaction.

# publications[].label
Copolymerization of pNcollagen III and collagen I. pNcollagen III decreases the rate of incorporation of collagen I into fibrils, the amount of collagen I incorporated, and the diameter of the fibrils formed.

# publications[].label
Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: evidence for solvent-induced bends in DNA heteroduplexes.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Characterization of recombinant type II collagen: arthritogenicity and tolerogenicity in DBA/1 mice.

# publications[].label
An interpretation of the action of psychotropic drugs.

# publications[].label
Collagen synthesis: localization of prolyl hydroxylase in tendon cells detected with ferritin-labeled antibodies.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Widely distributed mutations in the COL2A1 gene produce achondrogenesis type II/hypochondrogenesis.

# publications[].label
Inhibition of collagen synthesis by the proline analogue cis-4-hydroxyproline.

# publications[].label
Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1).

# publications[].label
A defect in the structure of type I procollagen in a patient who had osteogenesis imperfecta: excess mannose in the COOH-terminal propeptide.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Molecular basis of osteogenesis imperfecta and related disorders of bone.

# publications[].label
Procollagen N-proteinase and procollagen C-proteinase. Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling.

# publications[].label
BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells.

# publications[].label
Cleavage of type I and type II procollagens by type I/II procollagen N-proteinase. Correlation of kinetic constants with the predicted conformations of procollagen substrates.

# publications[].label
Structure of the organic matrix: collagen structure (chemical).

# publications[].label
A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice.

# publications[].label
Restriction fragment length polymorphism associated with the pro alpha 2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Large introns in the 3' end of the gene for the pro alpha 1 (IV) chain of human basement membrane collagen.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Oxygen-18 studies on the conversion of proline to hydroxyproline.

# publications[].label
Substitution of cysteine for glycine-alpha 1-691 in the pro alpha 1(I) chain of type I procollagen in a proband with lethal osteogenesis imperfecta destabilizes the triple helix at a site C-terminal to the substitution.

# publications[].label
Structure of the human type IV collagen genes.

# publications[].label
A rapid assay for 14C-labeled hydroxylysine in collagen and related materials.

# publications[].label
Temperature sensitivity of aberrant RNA splicing with a mutation in the G+5 position of intron 37 of the gene for type III procollagen from a patient with Ehlers-Danlos syndrome type IV.

# publications[].label
Influence of scurvy and lathyrism (odoratism) on hydroxyproline excretion.

# publications[].label
Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo.

# publications[].label
Integrated microfluidic system for the processing of membrane proteins isolated from stem cells

# publications[].label
Self-assembly of collagen I from a proband homozygous for a mutation that substituted serine for glycine at position 661 in the alpha 2(I) chain. Possible relationship between the effects of mutations on critical concentration and the severity of the phenotype.

# publications[].label
Heritable osteoarthritis. Diagnosis and possible modes of cell and gene therapy.

# publications[].label
Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration.

# publications[].label
A 19-base pair deletion in the pro-alpha 2(I) gene of type I procollagen that causes in-frame RNA splicing from exon 10 to exon 12 in a proband with atypical osteogenesis imperfecta and in his asymptomatic mother.

# publications[].label
Partial purification of a procollagen C-proteinase. Inhibition by synthetic peptides and sequential cleavage of type I procollagen.

# publications[].label
Type II collagen and avascular necrosis of the femoral head.

# publications[].label
Perspectives on the synthesis and application of triple-helical, collagen-model peptides.

# publications[].label
Presence of translatable mRNA for pro alpha 2(I) chains in fibroblasts from a patient with osteogenesis imperfecta whose type I collagen does not contain alpha 2(I) chains.

# publications[].label
Effect of iproniazid on brain levels of norepinephrine and serotonin.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Strategies for improving animal models for regenerative medicine.

# publications[].label
Purification of (14C) protocollagen and its hydroxylation by prolyl-hydroxylase.

# publications[].label
Studies on the intracellular localization of collagen synthesis in the intact chick embryo.

# publications[].label
Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma.

# publications[].label
Data against a Common Assumption: Xenogeneic Mouse Models Can Be Used to Assay Suppression of Immunity by Human MSCs.

# publications[].label
The Gordon Wilson lecture. Mutations in type I procollagen genes. An explanation for brittle bones and a paradigm for other diseases of connective tissue.

# publications[].label
Complete structure of the human COL11A2 gene: the exon sizes and other features indicate the gene has not evolved with genes for other fibriller collagens.

# publications[].label
Mutations in collagen genes as a cause of rare and perhaps common diseases of connective tissue.

# publications[].label
Type I procollagen N-proteinase from whole chick embryos. Cleavage of a homotrimer of pro-alpha 1(I) chains and the requirement for procollagen with a triple-helical conformation.

# publications[].label
Human multipotent stromal cells (MSCs) increase neurogenesis and decrease atrophy of the striatum in a transgenic mouse model for Huntington's disease.

# publications[].label
Expression of a human cartilage procollagen gene (COL2A1) in mouse 3T3 cells.

# publications[].label
Kinetics for the secretion of procollagen by freshly isolated tendon cells.

# publications[].label
Role of iron in the synthesis of collagen in connective tissue.

# publications[].label
InVitro Macrophage Assay Predicts the InVivo Anti-inflammatory Potential of Exosomes from Human Mesenchymal Stromal Cells.

# publications[].label
Comparison of poly-L-proline I and II as inhibitors of protocollagen hydroxylase.

# publications[].label
Stem cells and cell therapies in lung biology and lung diseases.

# publications[].label
Isolation and partial characterization of the carboxy-terminal propeptide of type II procollagen from chick embryos

# publications[].label
Identification of the HSPB4/TLR2/NF-B axis in macrophage as a therapeutic target for sterile inflammation of the cornea.

# publications[].label
Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Correction for Munoz et al., Human steprogenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Identical G+1 to A mutations in three different introns of the type III procollagen gene (COL3A1) produce different patterns of RNA splicing in three variants of Ehlers-Danlos syndrome. IV. An explanation for exon skipping some mutations and not others.

# publications[].label
Characterization of human type II procollagen and collagen-specific antibodies and their application to the study of human type II collagen processing and ultrastructure.

# publications[].label
Interchain disulfide bonds at the COOH-terminal end of procollagen synthesized by matrix-free cells from chick embryonic tendon and cartilage.

# publications[].label
Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Partial purification and characterization of protocollagen lysine hydroxylase from chick embryos.

# publications[].label
Type I procollagen: the gene-protein system that harbors most of the mutations causing osteogenesis imperfecta and probably more common heritable disorders of connective tissue.

# publications[].label
Transfer of puromycin-containing polypeptides through the plasma membrane of cartilage cells synthesizing collagen.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
The zipper-like folding of collagen triple helices and the effects of mutations that disrupt the zipper.

# publications[].label
Hydroxylation of peptide-bound proline and lysine before and after chain completion of the polypeptide chains of procollagen.

# publications[].label
MSCs: Changing Hypotheses, Paradigms, and Controversies on Mechanisms of Action in Repairing Tissues

# publications[].label
Myelin synthesis in peripheral nerve in vitro: sulphatide incorporation requires a transport lipoprotein.

# publications[].label
Complete sequence of the 23-kilobase human COL9A3 gene. Detection of Gly-X-Y triplet deletions that represent neutral variants.

# publications[].label
Completion of the last half of the structure of the human gene for the Pro alpha 1 (I) chain of type I procollagen (COL1A1).

# publications[].label
HYDROXYLATION OF PROLINE IN PARTICULATE FRACTIONS FROM CARTILAGE.

# publications[].label
Intracellular pool of unhydroxylated polypeptide precursors of collagen.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Mutations in human procollagen genes. Consequences of the mutations in man and in transgenic mice.

# publications[].label
Abnormal response to physical activity in femurs after heterozygous inactivation of one allele of the Col2a1 gene for type II collagen in mice.

# publications[].label
Deletion of a large domain in recombinant human procollagen II does not alter the thermal stability of the triple helix.

# publications[].label
The biosynthesis of collagen and its disorders (first of two parts).

# publications[].label
Retention of nonhelical procollagen containing cis-hydroxyproline in rough endoplasmic reticulum.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies.

# publications[].label
Can mutated genes cause common osteoarthritis?

# publications[].label
Concanavalin A binds of purified prolyl hydroxylase and partially inhibits its enzymic activity.

# publications[].label
A human COL2A1 gene with an Arg519Cys mutation causes osteochondrodysplasia in transgenic mice.

# publications[].label
Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Structure of a full-length cDNA clone for the prepro alpha 1(I) chain of human type I procollagen.

# publications[].label
Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions.

# publications[].label
Mutation analysis of coding sequences for type I procollagen in individuals with low bone density.

# publications[].label
A simple technique for measuring the specific activity of labeled hydroxyproline in biological materials.

# publications[].label
Stem cells and cell therapies in lung biology and diseases: conference report.

# publications[].label
A point mutation in a type I procollagen gene converts glycine 748 of the alpha 1 chain to cysteine and destabilizes the triple helix in a lethal variant of osteogenesis imperfecta.

# publications[].label
Substitutions for glycine alpha 1-637 and glycine alpha 2-694 of type I procollagen in lethal osteogenesis imperfecta. The conformational strain on the triple helix introduced by a glycine substitution can be transmitted along the helix.

# publications[].label
Incorporation of cis-hydroxyproline into protocollagen and collagen. Collagen containing cis-hydroxyproline in place of proline and trans-hydroxyproline is not extruded at a normal rate.

# publications[].label
Human type I procollagen genes are located on different chromosomes

# publications[].label
Isolation and characterization of rapidly self-renewing stem cells from cultures of human marrow stromal cells.

# publications[].label
Structure of cDNA clones coding for the entire prepro alpha 1 (III) chain of human type III procollagen. Differences in protein structure from type I procollagen and conservation of codon preferences.

# publications[].label
Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs).

# publications[].label
Studies on the synthesis and intracellular accumulation of protocollagen in organ culture of embryonic cartilage.

# publications[].label
Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model.

# publications[].label
Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone.

# publications[].label
Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension.

# publications[].label
Hydroxylation of lysine in a polypeptide precursor of collagen.

# publications[].label
Collagens: molecular biology, diseases, and potentials for therapy.

# publications[].label
Mild Traumatic Brain Injury Induced Through an Exposure to Blast Shock Waves Causes Lasting Hippocampus-Dependent and Hippocampus-Independent Memory Dysfunction and Depression

# publications[].label
Steady-state levels of mRNAs coding for the type IV collagen and laminin polypeptide chains of basement membranes exhibit marked tissue-specific stoichiometric variations in the rat.

# publications[].label
Adult rat and human bone marrow stromal cells differentiate into neurons.

# publications[].label
Further proof for an unpopular concept: a single cell from bone marrow can serve as a stem cell for both hematopoiesis and osteogenesis.

# publications[].label
Evidence for a structural mutation of procollagen type I in a patient with the Ehlers-Danlos syndrome type VII.

# publications[].label
Procollagen N-proteinase. Properties of the enzyme purified from chick embryo tendons.

# publications[].label
Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells.

# publications[].label
How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow.

# publications[].label
Stanniocalcin-1 regulates extracellular ATP-induced calcium waves in human epithelial cancer cells by stimulating ATP release from bystander cells.

# publications[].label
Assembly in vitro of thin and thick fibrils of collagen II from recombinant procollagen II. The monomers in the tips of thick fibrils have the opposite orientation from monomers in the growing tips of collagen I fibrils.

# publications[].label
Rat marrow stromal cells are more sensitive to plating density and expand more rapidly from single-cell-derived colonies than human marrow stromal cells.

# publications[].label
Collagen diseases and the biosynthesis of collagen.

# publications[].label
Transcription of human type I collagen genes. Variation in the relative rates of transcription of the pro alpha 1 and pro alpha 2 genes.

# publications[].label
Genetic linkage analysis of hereditary arthro-ophthalmopathy (Stickler syndrome) and the type II procollagen gene.

# publications[].label
Multipotent mesenchymal stromal cells attenuate chronic inflammation and injury-induced sensitivity to mechanical stimuli in experimental spinal cord injury.

# publications[].label
Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Nonviral gene delivery of erythropoietin by mesenchymal stromal cells.

# publications[].label
Three new point mutations in type II procollagen (COL2A1) and identification of a fourth family with the COL2A1 Arg519-->Cys base substitution using conformation sensitive gel electrophoresis.

# publications[].label
Marrow stromal cells as stem cells for nonhematopoietic tissues.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Mutations that substitute serine for glycine alpha 1-598 and glycine alpha 1-631 in type I procollagen. The effects on thermal unfolding of the triple helix are position-specific and demonstrate that the protein unfolds through a series of cooperative blocks.

# publications[].label
Further evidence for a transport form of collagen. Its extrusion and extracellular conversion to tropocollagen in embryonic tendon.

# publications[].label
Kinetics for the secretion of nonhelical procollagen by freshly isolated tendon cells.

# publications[].label
Recombinant DNA and collagen research. Is amino acid sequencing obsolete? Can we study diseases involving collagen by analysis of the genes?

# publications[].label
Osteogenesis imperfecta calls for caution.

# publications[].label
Protocollagen proline hydroxylase in normal liver and in hepatic fibrosis.

# publications[].label
Hydroxylation of proline in synthetic polypeptides with purified protocollagen hydroxylase.

# publications[].label
The synthesis of type I collagen fibers and potential inhibitors of the process.

# publications[].label
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels.

# publications[].label
Use of an automated workstation to facilitate PCR amplification, loading agarose gels and sequencing of DNA templates.

# publications[].label
Mutation in the COL2A1 gene in a patient with hypochondrogenesis. Expression of mutated COL2A1 gene is accompanied by expression of genes for type I procollagen in chondrocytes.

# publications[].label
Concise review: two negative feedback loops place mesenchymal stem/stromal cells at the center of early regulators of inflammation.

# publications[].label
Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene.

# publications[].label
Isolation and partial characterization of the amino-terminal propeptide of type II procollagen from chick embryos.

# publications[].label
ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice.

# publications[].label
Spondyloepiphyseal dysplasia and precocious osteoarthritis in a family with an Arg75-->Cys mutation in the procollagen type II gene (COL2A1).

# publications[].label
Marrow stromal cells as stem cells for continual renewal of nonhematopoietic tissues and as potential vectors for gene therapy.

# publications[].label
Molecular heterogeneity in the mild autosomal dominant forms of osteogenesis imperfecta.

# publications[].label
Hepatic fibrosis in rats produced by carbon tetrachloride and dimethylnitrosamine: observations suggesting immunoassays of serum for the 7S fragment of type IV collagen are a more sensitive index of liver damage than immunoassays for the NH2-terminal propeptide of type III procollagen.

# publications[].label
Increase in blood serotonin levels induced by iproniazid in man and rabbits

# publications[].label
Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: potential therapy for cystic fibrosis.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans.

# publications[].label
Mutations in type I procollagen genes that cause osteogenesis imperfecta.

# publications[].label
Phenotypic heterogeneity in osteogenesis imperfecta: the mildly affected mother of a proband with a lethal variant has the same mutation substituting cysteine for alpha 1-glycine 904 in a type I procollagen gene (COL1A1).

# publications[].label
Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization.

# publications[].label
Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation.

# publications[].label
Complete primary structure of the alpha 1-chain of human basement membrane (type IV) collagen.

# publications[].label
G to A polymorphism in exon 45 of the COL1A1 gene.

# publications[].label
Biosynthesis of abnormal collagens with amino acid analogues. II. Inability of cartilage cells to extrude collagen polypeptides containing L-azetidine-2-carboxylic acid or cis-4-fluoro-L-proline.

# publications[].label
Temperature-induced post-translational over-modification of type I procollagen. Effects of over-modification of the protein on the rate of cleavage by procollagen N-proteinase and on self-assembly of collagen into fibrils.

# publications[].label
A Substitution of Cysteine for Glycine 904 in COL1A1 in a Proband with Lethal Osteogenesis Imperfecta and in Her Asymptomatic Mother

# publications[].label
A heterozygous defect for structurally altered pro-alpha 2 chain of type I procollagen in a mild variant of osteogenesis imperfecta. The altered structure decreases the thermal stability of procollagen and makes it resistant to procollagen N-proteinase.

# publications[].label
Migratory response of mesenchymal stem cells to macrophage migration inhibitory factor and its antagonist as a function of colony-forming efficiency.

# publications[].label
Structure of cDNA clones coding for human type II procollagen. The alpha 1(II) chain is more similar to the alpha 1(I) chain than two other alpha chains of fibrillar collagens.

# publications[].label
Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Substitution of arginine for glycine at position 154 of the 1 chain of type I collagen in a variant of osteogenesis imperfecta: Comparison to previous cases with the same mutation

# publications[].label
Use of glutaraldehyde-fixed Escherichia coli cells as a convenient support for radioimmune assays.

# publications[].label
Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1).

# publications[].label
Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes.

# publications[].label
Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Identification and cloning of integration site of DNA by PCR.

# publications[].label
PUROMYCIN INHIBITION OF COLLAGEN SYNTHESIS AS EVIDENCE FOR A RIBOSOMAT OR POST-RIBOSOMAL SITE FOR THE HYDROXYLATION OF PROLINE.

# publications[].label
Enzymatic synthesis of hydroxyproline by the hydroxylation of poly(L-propyl-glycyl-L-prolyl).

# publications[].label
Demonstration by immunofluorescence that the same cells from chick embryo aortas synthesize elastin and collagen types I and III.

# publications[].label
Structural organization of the gene for the alpha 1 chain of human type IV collagen.

# publications[].label
Correction of a mineralization defect by overexpression of a wild-type cDNA for COL1A1 in marrow stromal cells (MSCs) from a patient with osteogenesis imperfecta: a strategy for rescuing mutations that produce dominant-negative protein defects.

# publications[].label
Connective tissue biochemistry of neurofibromas.

# publications[].label
The clinical features of homozygous alpha 2(I) collagen deficient osteogenesis imperfecta.

# publications[].label
Synthesis of elastin and procallagen by cells from embryonic aorta. Differences in the role of hydroxyproline and the effects of proline analogs on the secretion of the two proteins.

# publications[].label
Refinement of the chromosome 5p locus for familial calcium pyrophosphate dihydrate deposition disease.

# publications[].label
Synthesis of (Pro-Hyp-Gly) n of defined molecular weights. Evidence for the stabilization of collagen triple helix by hydroxypyroline.

# publications[].label
Growing tips of type I collagen fibrils formed in vitro are near-paraboloidal in shape, implying a reciprocal relationship between accretion and diameter.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A single base mutation in type I procollagen (COL1A1) that converts glycine alpha 1-541 to aspartate in a lethal variant of osteogenesis imperfecta: detection of the mutation with a carbodiimide reaction of DNA heteroduplexes and direct sequencing of products of the PCR.

# publications[].label
Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma.

# publications[].label
Rat marrow stromal cells rapidly transduced with a self-inactivating retrovirus synthesize L-DOPA in vitro.

# publications[].label
A HindIII polymorphism in the 3' end of the human alpha 1(IV) collagen gene.

# publications[].label
Mesenchymal stem/stromal cells inhibit the NLRP3 inflammasome by decreasing mitochondrial reactive oxygen species.

# publications[].label
Deletion of 19 base pairs in intron 13 of the gene for the pro alpha 2(I) chain of type-I procollagen (COL1A2) causes exon skipping in a proband with type-I osteogenesis imperfecta.

# publications[].label
Relative transcription rates and mRNA levels for the two chains of type I procollagen.

# publications[].label
Titration and melting curves of the collagen-like triple helices formed from (Pro-Pro-Gly) in aqueous solution.

# publications[].label
Human multipotent stromal cells undergo sharp transition from division to development in culture.

# publications[].label
Single base mutation in the type III procollagen gene that converts the codon for glycine 883 to aspartate in a mild variant of Ehlers-Danlos syndrome IV.

# publications[].label
Role of the first intron in the regulation of the COL 1A1 gene.

# publications[].label
Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential.

# publications[].label
Does bound water contribute to the stability of collagen?

# publications[].label
Characterization of the precursor forms of the 1 and 2 chains of collagen from matrix-free tendon cells.

# publications[].label
Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system.

# publications[].label
A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury.

# publications[].label
Assignment of the human collagen alpha 1 (XIII) chain gene (COL13A1) to the q22 region of chromosome 10.

# publications[].label
Affinity column purification of protocollagen proline hydroxylase from chick embryos and further characterization of the enzyme.

# publications[].label
DNA polymorphisms in collagen genes: potential use in the study of disease.

# publications[].label
Heterozygous mutation in the G+5 position of intron 33 of the pro-alpha 2(I) gene (COL1A2) that causes aberrant RNA splicing and lethal osteogenesis imperfecta. Use of carbodiimide methods that decrease the extent of DNA sequencing necessary to define an unusual mutation.

# publications[].label
Inheritance of an RNA splicing mutation (G+ 1 IVS20) in the type III procollagen gene (COL3A1) in a family having aortic aneurysms and easy bruisability: phenotypic overlap between familial arterial aneurysms and Ehlers-Danlos syndrome type IV.

# publications[].label
Radial packing, order, and disorder in collagen fibrils.

# publications[].label
Can proline analogues be used to prevent fibroblasts from overgrowing cultures of epithelial cells?

# publications[].label
Isolation of unhydroxylated type I procollagen folding of the protein in vitro.

# publications[].label
Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats--similarities to astrocyte grafts.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region.

# publications[].label
Antibodies to chick-tendon procollagen. Affinity purification with the isolated disulfide-linded NH2-terminal extensions and reactivity with a component in embryonic serum.

# publications[].label
Incorporation of proline analogues into collagen polypeptides Effects on the production of extracellular procollagen and on the stability of the triple-helical structure of the molecule

# publications[].label
Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.

# publications[].label
Bone turnover and type I collagen C-telopeptide isomerization in adult osteogenesis imperfecta: associations with collagen gene mutations.

# publications[].label
A Homozygous Frameshift Mutation in the Pro2(I) Collagen COOHPropeptide Results in Osteogenesis Imperfecta

# publications[].label
Fundamentals of Culture and Characterization of Mesenchymal Stem/Progenitor Cells (MSCs) from Bone Marrow Stroma

# publications[].label
Synthesis and processing of a type I procollagen containing shortened pro-alpha 1(I) chains by fibroblasts from a patient with osteogenesis imperfecta.

# publications[].label
Identification of COL2A1 gene mutations in patients with chondrodysplasias and familial osteoarthritis.

# publications[].label
Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations.

# publications[].label
Synthesis of an altered type III procollagen in a patient with type IV Ehlers-Danlos syndrome. A structural change in the alpha 1(III) chain which makes the protein more susceptible to proteinases.

# publications[].label
Synthesis and secretion of under-hydroxylated procollagen at various temperatures by cells subject to temporary anoxia.

# publications[].label
Cross-talk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPS-stimulated cocultures: the MSCs are activated to secrete prostaglandin E2.

# publications[].label
Mutations in type I procollagen genes: An explanation for brittle bones and a paradigm for other diseases of connective tissue

# publications[].label
Biosynthesis of abnormal collagens with amino acid analogues. I. Incorporation of L-azetidine-2-carboxylic acid and cis-4-fluoro-L-proline into protocollagen and collagen.

# publications[].label
Synthesis of recombinant human procollagen II in a stably transfected tumour cell line (HT1080).

# publications[].label
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6.

# publications[].label
A cDNA cassette system for the synthesis of recombinant procollagens. Variants of procollagen II lacking a D-period are secreted as triple-helical monomers.

# publications[].label
Amplification of coronary arteriogenic capacity of multipotent stromal cells by epidermal growth factor.

# publications[].label
Proteolytic enzymes as probes for the triple-helical conformation of procollagen.

# publications[].label
The molecular defect in a nonlethal variant of osteogenesis imperfecta. Synthesis of pro-alpha 2(I) chains which are not incorporated into trimers of type I procollagen.

# publications[].label
Gene structure for the alpha 1 chain of a human short-chain collagen (type XIII) with alternatively spliced transcripts and translation termination codon at the 5' end of the last exon.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Somatic cell mosaicism: another source of phenotypic heterogeneity in nuclear families with osteogenesis imperfecta.

# publications[].label
Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Hydroxylation of (Pro-Pro-Gly)5 and (Pro-Pro-Gly)10 by prolyl hydroxylase. Evidence for an asymmetric active site in the enzyme.

# publications[].label
Substitution of aspartate for glycine 1018 in the type III procollagen (COL3A1) gene causes type IV Ehlers-Danlos syndrome: the mutated allele is present in most blood leukocytes of the asymptomatic and mosaic mother.

# publications[].label
Partial rescue of a lethal phenotype of fragile bones in transgenic mice with a chimeric antisense gene directed against a mutated collagen gene.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
STUDIES WITH PROLINE-3,4,-H3 ON THE HYDROXYLATION OF PROLINE DURING COLLAGEN SYNTHESIS IN CHICK EMBRYOS.

# publications[].label
Substitution of arginine for glycine at position 154 of the alpha 1 chain of type I collagen in a variant of osteogenesis imperfecta: comparison to previous cases with the same mutation.

# publications[].label
Use of an antisense oligonucleotide to inhibit expression of a mutated human procollagen gene (COL1A1) in transfected mouse 3T3 cells.

# publications[].label
Potential use of marrow stromal cells as therapeutic vectors for diseases of the central nervous system.

# publications[].label
Variations in the glycosylation of the collagen synthesized by chick embryo cartilage. Effects of development and several hormones.

# publications[].label
Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: variations in yield, growth, and differentiation.

# publications[].label
Diphtheria toxin inhibits the synthesis of myelin proteolipid and basic proteins by peripheral nerve in vitro.

# publications[].label
Hydroxyprolinemia and increased excretion of free hydroxyproline in early infancy.

# publications[].label
Synthesis and conformational properties of a recombinant C-propeptide of human type III procollagen.

# publications[].label
Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Stanniocalcin-1 attenuates ischemic cardiac injury and response of differentiating monocytes/macrophages to inflammatory stimuli.

# publications[].label
The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice.

# publications[].label
Inhibition of collagen formation by proline analogues: degree of replacement and specificity of action

# publications[].label
Prolyl hydroxylase activity in L-929 fibroblasts incubated with and without ascorbate

# publications[].label
Inhibition of the self-assembly of collagen I into fibrils with synthetic peptides. Demonstration that assembly is driven by specific binding sites on the monomers.

# publications[].label
Purification and partial characterization of the enzyme for the hydroxylation of proline in protocollagen

# publications[].label
Are clinical trials with mesenchymal stem/progenitor cells too far ahead of the science? Lessons from experimental hematology.

# publications[].label
Completion of the intron-exon structure of the gene for human type II procollagen (COL2A1): variations in the nucleotide sequences of the alleles from three chromosomes.

# publications[].label
Ascorbate can increase hydroxyproline synthesis in cultured fibroblasts without activation of prolyl hydroxylase

# publications[].label
Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views.

# publications[].label
Detection of sequence variants in the gene for human type II procollagen (COL2A1) by direct sequencing of polymerase chain reaction-amplified genomic DNA.

# publications[].label
Formation of collagen fibrils by enzymic cleavage of precursors of type I collagen in vitro.

# publications[].label
Synthesis of a shortened pro-alpha 2(I) chain and decreased synthesis of pro-alpha 2(I) chains in a proband with osteogenesis imperfecta.

# publications[].label
Comparison of the anti-inflammatory effects of induced pluripotent stem cell-derived and bone marrow-derived mesenchymal stromal cells in a murine model of corneal injury.

# publications[].label
Mutations in type 1 procollagen that cause osteogenesis imperfecta: effects of the mutations on the assembly of collagen into fibrils, the basis of phenotypic variations, and potential antisense therapies.

# publications[].label
Ferritin-conjugated antibodies used for labeling of organelles involved in the cellular synthesis and transport of procollagen.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Time lag in the secretion of collagen by matrix-free tendon cells and inhibition of the secretory process by colchicine and vinblastine.

# publications[].label
Regulating migration of bone marrow stromal cells to injured bronchial epithelium

# publications[].label
Structure of protocollagen proline hydroxylase from chick embryos.

# publications[].label
A new 500-kDa form of type I procollagen N-proteinase from chick embryo tendons.

# publications[].label
Protein structure and the specific heat of water.

# publications[].label
Partial characterization of a low molecular weight human collagen that undergoes alternative splicing.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Sarcoma derived from cultured mesenchymal stem cells.

# publications[].label
Protocollagen proline hydroxylase from Ascaris lumbricoides.

# publications[].label
Effects of long-term diabetes and galactosaemia upon lens and retinal mRNA levels in the rat.

# publications[].label
Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-B signaling in resident macrophages.

# publications[].label
A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Rapidly self-renewing human multipotent marrow stromal cells (hMSC) express sialyl Lewis X and actively adhere to arterial endothelium in a chick embryo model system.

# publications[].label
Seminars in medicine of the Beth Israel Hospital, Boston. Mutations in collagen genes as a cause of connective-tissue diseases.

# publications[].label
Mutations in osteogenesis imperfecta leading to the synthesis of abnormal type I procollagens.

# publications[].label
A 1,064 bp fragment from the promoter region of the Col11a2 gene drives lacZ expression not only in cartilage but also in osteoblasts adjacent to regions undergoing both endochondral and intramembranous ossification in mouse embryos.

# publications[].label
Hydroxylation of proline and the intracellular accumulation of a polypeptide precursor of collagen.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
A transport form of collagen from embryonic tendon: electron microscopic demonstration of an NH 2 -terminal extension and evidence suggesting the presence of cystine in the molecule (chick embryo-tropocollagen-gel filtration).

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Intracellular hydroxylation of non-helical protocollagen to form triple-helical procollagen and subsequent secretion of the molecule.

# publications[].label
Increased protocollagen hydroxylase activity in the livers of rats with hepatic fibrosis.

# publications[].label
Synthesis and extrusion of collagen by freshly isolated cells from chick embryo tendon

# publications[].label
Altered helical structure of a homotrimer of alpha 1(I)chains synthesized by fibroblasts from a variant of osteogenesis imperfecta.

# publications[].label
The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow.

# publications[].label
Synthesis of elastin in aortas from chick embryos. Conversion of newly secreted elastin to cross-linked elastin without apparent proteolysis of the molecule.

# publications[].label
Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC1.

# publications[].label
Further proof of the plasticity of adult stem cells and their role in tissue repair.

# publications[].label
Self-assembly into fibrils of a homotrimer of type I collagen.

# publications[].label
Univariate and bivariate variance component linkage analysis of a whole-genome scan for loci contributing to bone mineral density.

# publications[].label
Exclusion of mutations in the gene for type III collagen (COL3A1) as a common cause of intracranial aneurysms or cervical artery dissections: results from sequence analysis of the coding sequences of type III collagen from 55 unrelated patients.

# publications[].label
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.

# publications[].label
Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1.

# publications[].label
Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Incorporation of proline analogs into procollagen. Assay for replacement of imino acids by cis-4-hydroxy-L-proline and cis-4-fluoro-L-proline.

# publications[].label
The A and B fragments of normal type I procollagen have a similar thermal stability to proteinase digestion but are selectively destabilized by structural mutations.

# publications[].label
Vitamin D receptor genotype is not associated with bone mineral density in three ethnic/regional groups.

# publications[].label
Gastrointestinal absorption and renal excretion of hydroxyproline peptides.

# publications[].label
Hydroxyprolinemia as an illustration of nonessential enzymes in man.

# publications[].label
Posttranslational enzymes in the biosynthesis of collagen: extracellular enzymes.

# publications[].label
Direct sequencing of PCR products derived from cDNAs for the pro alpha 1 and pro alpha 2 chains of type I procollagen as a screening method to detect mutations in patients with osteogenesis imperfecta.

# publications[].label
Sequence and genomic organization of the human G-protein Golfalpha gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia.

# publications[].label
Incorporation of 3,4-dehydroproline into protocollagen and collagen. Limited hydroxylation of proline and lysine in the same polypeptide.

# publications[].label
Kinetics of the incorporation of tropoelastin into elastic fibers in embryonic chick aorta.

# publications[].label
Serum deprivation of human marrow stromal cells (hMSCs) selects for a subpopulation of early progenitor cells with enhanced expression of OCT-4 and other embryonic genes.

# publications[].label
Dissociation of the synthesis of sulphated mucopolysaccharides and the synthesis of collagen in embryonic cartilage.

# publications[].label
The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Substitution of aspartic acid for glycine at position 310 in type II collagen produces achondrogenesis II, and substitution of serine at position 805 produces hypochondrogenesis: analysis of genotype-phenotype relationships.

# publications[].label
Inhibitors of procollagen N-protease. Synthetic peptides with sequences similar to the cleavage site in the pro alpha 1(I) chain.

# publications[].label
Asymmetry in the hydroxylation of (Pro-Pro-Gly) 5 by protocollagen proline hydroxylase.

# publications[].label
Triple-Helix Formation and Disulphide Bonding during the Biosynthesis of Lens Basement-Membrane Collagen

# publications[].label
Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Proline analogue removes fibroblasts from cultured mixed cell populations.

# publications[].label
iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers.

# publications[].label
Multipotential marrow stromal cells transduced to produce L-DOPA: engraftment in a rat model of Parkinson disease.

# publications[].label
Perspectives on the synthesis and application of triple-helical, collagen-model peptides

# publications[].label
Two new recurrent nucleotide mutations in the COL1A1 gene in four patients with osteogenesis imperfecta: about one-fifth are recurrent.

# publications[].label
Assembly of type I collagen fibrils de novo by the specific enzymic cleavage of pC collagen. The fibrils formed at about 37 degrees C are similar in diameter, roundness, and apparent flexibility to the collagen fibrils seen in connective tissue.

# publications[].label
Human COL9A1 and COL9A2 genes. Two genes of 90 and 15 kb code for similar polypeptides of the same collagen molecule.

# publications[].label
The mRNAs for the pro-alpha 1(I) and pro-alpha 2(I) chains of type I procollagen are translated at the same rate in normal human fibroblasts and in fibroblasts from two variants of osteogenesis imperfecta with altered steady state ratios of the two mRNAs.

# publications[].label
A method for the simultaneous measurement of the radioactivity of proline-C14 and hydroxyproline-C14 in biological materials.

# publications[].label
Modulation of procollagen gene expression by retinoids. Inhibition of collagen production by retinoic acid accompanied by reduced type I procollagen messenger ribonucleic acid levels in human skin fibroblast cultures.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Mutation in type II procollagen (COL2A1) that substitutes aspartate for glycine alpha 1-67 and that causes cataracts and retinal detachment: evidence for molecular heterogeneity in the Wagner syndrome and the Stickler syndrome (arthro-ophthalmopathy).

# publications[].label
Three Single Base Mutations in Type III Procollagen Gene That Prevent Correct RNA Splicing in Variants of EhlersDanlos Syndrome IVa

# publications[].label
Effect of cis-4-hydroxy-L-proline on lung mechanics and collagen content of bleomycin-treated hamsters.

# publications[].label
Adult stem cells, lung biology, and lung disease. NHLBI/Cystic Fibrosis Foundation Workshop.

# publications[].label
Histamine receptor H1 and dermatopontin: new downstream targets of the vitamin D receptor.

# publications[].label
Enzymatic Synthesis of Hydroxyproline by the Hydroxylation of Poly(L-prolyl-glycyl-L-prolyl)

# publications[].label
Relearning the lessons of genomic stability of human cells during expansion in culture: implications for clinical research.

# publications[].label
Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs).

# publications[].label
Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer.

# publications[].label
Prolyl 4-Hydroxylase from Human Placenta. Simultaneous Isolation of Immunoglobulin G which Binds to Ascaris Cuticle Collagen

# publications[].label
Prevention of bleomycin-induced pulmonary fibrosis in the hamster by Cis-4-hydroxy-L-proline

# publications[].label
Denatured collagen from the cuticle of Ascaris lumbricoides as a substrate for protocollagen proline hydroxylase.

# publications[].label
Targeted disruption of Col11a2 produces a mild cartilage phenotype in transgenic mice: comparison with the human disorder otospondylomegaepiphyseal dysplasia (OSMED).

# publications[].label
Collagen synthesis and collagenase activity in dermal fibroblasts from patients with diabetes and digital sclerosis.

# publications[].label
The complete cDNA coding sequence for the mouse pro alpha 1(I) chain of type I procollagen.

# publications[].label
Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy.

# publications[].label
Folding mechanism of the triple helix in type-III collagen and type-III pN-collagen. Role of disulfide bridges and peptide bond isomerization.

# publications[].label
Effects of the stereo-configuration of the hydroxyl group in 4-hydroxyproline on the triple-helical structures formed by homogenous peptides resembling collagen.

# publications[].label
Electron microscopy of protocollagen proline hydroxylase from chick embryos.

# publications[].label
Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases.

# publications[].label
Present and future research on collagen and genes for collagen.

# publications[].label
Genetic linkage of a polymorphism in the type II procollagen gene (COL2A1) to primary osteoarthritis associated with mild chondrodysplasia.

# publications[].label
Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms.

# publications[].label
Crystal induced inflammation in canine joints. 3. Evidence against bradykinin as a mediator of inflammation.

# publications[].label
Cadmium ions inhibit procollagen C-proteinase and cupric ions inhibit procollagen N-proteinase.

# publications[].label
Apoptosis of chondrocytes in transgenic mice lacking collagen II.

# publications[].label
Synthesis and physical properties of (hydroxyproline-proline-glycine)10: hydroxyproline in the X-position decreases the melting temperature of the collagen triple helix.

# publications[].label
Absence of Therapeutic Benefit of the Anti-Inflammatory Protein TSG-6 for Corneal Alkali Injury in a Rat Model.

# publications[].label
Efficient procedure for preparing cosmid libraries from microgram quantities of genomic DNA fragments size fractionated by gel electrophoresis.

# publications[].label
Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation.

# publications[].label
Erratum: Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: Evidence for solvent-induced bends in DNA heteroduplexes (Proceedings of the National Academy of Sciences of the United States of America (November 1, 1993) 90:21 (10325-10329))

# publications[].label
Review of the national arthritis advisory board symposium, molecular biology: its potential for advancing rheumatology research

# publications[].label
Effect of Cis-4- hydroxy-L-proline on lung mechanics and collagen content of bleomycin-treated hamsters

# publications[].label
PCR detection of a HindIII polymorphism in the human gene for type II procollagen (COL2A1).

# publications[].label
Use of conformation sensitive gel electrophoresis to detect single-base changes in the gene for COL10A1.

# publications[].label
Genetic diseases of connective tissues in animals.

# publications[].label
Partial purification and characterization of a neutral protease which cleaves the N-terminal propeptides from procollagen.

# publications[].label
Phenotypic variability and incomplete penetrance of spontaneous fractures in an inbred strain of transgenic mice expressing a mutated collagen gene (COL1A1).

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Hydroxylation of proline and lysine in protocollagen involves two separate enzymatic sites.

# publications[].label
Human type I procollagen genes are located on different chromosomes.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
An effect of puromycin on the synthesis of collagen by embryonic cartilage in vitro.

# publications[].label
GASTROINTESTINAL ABSORPTION AND RENAL EXCRETION OF HYDROXYPROLINE PEPTIDES

# publications[].label
Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Studies on protocollagen lysine hydroxylase. Hydroxylation of synthetic peptides and the stoichiometric decarboxylation of -ketoglutarate.

# publications[].label
Three new polymorphisms at the COL1A2 locus.

# publications[].label
Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It.

# publications[].label
Anti-inflammatory protein tumor necrosis factor--stimulated protein 6 (TSG-6) promotes early gingival wound healing: an in vivo study.

# publications[].label
Partial isodisomy for maternal chromosome 7 and short stature in an individual with a mutation at the COL1A2 locus.

# publications[].label
Aregenerative anemia associated with benign thymoma.

# publications[].label
Donor variation in the growth properties and osteogenic potential of human marrow stromal cells.

# publications[].label
"Stemness" does not explain the repair of many tissues by mesenchymal stem/multipotent stromal cells (MSCs).

# publications[].label
Osteogenesis imperfecta: cloning of a pro-alpha 2(I) collagen gene with a frameshift mutation.

# publications[].label
Synthesis of type I procollagen: formation of interchain disulfide bonds before complete hydroxylation of the protein.

# publications[].label
cDNA clones coding for the pro-alpha1(IV) chain of human type IV procollagen reveal an unusual homology of amino acid sequences in two halves of the carboxyl-terminal domain.

# publications[].label
Labeled antibodies to protocollagen proline hydroxylase from chick embryos for intracellular localization of the enzyme.

# publications[].label
Pleomorphism in type I collagen fibrils produced by persistence of the procollagen N-propeptide.

# publications[].label
Implantation of allogenic synovial stem cells promotes meniscal regeneration in a rabbit meniscal defect model.

# publications[].label
Iron-containing metallocenes as active site directed inhibitors of the proteinase that cleaves the NH2-terminal propeptides from type I procollagen.

# publications[].label
Targeting gene therapy for osteogenesis imperfecta.

# publications[].label
Meeting Report: Mesenchymal and nonhematopoietic stem cells: recent progress and current controversies

# publications[].label
Human immunodeficiency virus type 1 Vpr alters bone marrow cell function.

# publications[].label
Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1).

# publications[].label
Mutations in collagen genes: causes of rare and some common diseases in humans.

# publications[].label
A single base mutation that substitutes serine for glycine 790 of the alpha 1 (III) chain of type III procollagen exposes an arginine and causes Ehlers-Danlos syndrome IV.

# publications[].label
Rate of helix formation by intracellular procollagen and protocollagen. Evidence for a role for disulfide bonds.

# publications[].label
Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF- stimulated gene/protein 6.

# publications[].label
An anticonvulsant effect of monoamine oxidase inhibitors.

# publications[].label
Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6.

# publications[].label
Collagen II containing a Cys substitution for Arg-alpha1-519. Analysis by atomic force microscopy demonstrates that mutated monomers alter the topography of the surface of collagen II fibrils.

# publications[].label
An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction.

# publications[].label
Defining the risks of mesenchymal stromal cell therapy.

# publications[].label
Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides.

# publications[].label
Thermal stability of type I and type III procollagens from normal human fibroblasts and from a patient with osteogenesis imperfecta.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Oligopeptides with the sequences ala-pro-gly and gly-pro-gly as substrates or inhibitors for protocollagen proline hydroxylase.

# publications[].label
Nuclease S1 mapping of a homozygous mutation in the carboxyl-propeptide-coding region of the pro alpha 2(I) collagen gene in a patient with osteogenesis imperfecta.

# publications[].label
A simple and efficient enzymatic method for covalent attachment of DNA to cellulose. Application for hybridization-restriction analysis and for in vitro synthesis of DNA probes.

# publications[].label
Marrow stromal cells as stem cells for continual renewal of nonhematopoietic tissues and as potential vectors for gene therapy.

# publications[].label
A single base mutation in the type II procollagen gene (COL2A1) that converts glycine alpha 1-247 to serine in a family with late-onset spondyloepiphyseal dysplasia.

# publications[].label
Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Helical model of nucleation and propagation to account for the growth of type I collagen fibrils from symmetrical pointed tips: a special example of self-assembly of rod-like monomers.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Mutations in COL11A2 cause non-syndromic hearing loss (DFNA13).

# publications[].label
Structure of a cDNA for the pro alpha 2 chain of human type I procollagen. Comparison with chick cDNA for pro alpha 2(I) identifies structurally conserved features of the protein and the gene.

# publications[].label
Streptozotocin-diabetes but not galactose-feeding increases the serum concentration of type IV collagen antigens in rats.

# publications[].label
Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells.

# publications[].label
Embryonic Stem Cells Versus Adults Stem Cells

# publications[].label
Formation of interchain disulfide bonds and helical structure during biosynthesis of procollagen by embryonic tendon cells.

# publications[].label
Increased expression of the gene for the pro alpha 1(IV) chain of basement-membrane procollagen in cultured skin fibroblasts from two variants of osteogenesis imperfecta.

# publications[].label
Lag between incorporation of proline into protocollagen and synthesis of hydroxyproline during collagen biosynthesis in vitro and in vivo.

# publications[].label
The triple helix in equilibrium with coil conversion of collagen-like polytripeptides in aqueous and nonaqueous solvents. Comparison of the thermodynamic parameters and the binding of water to (L-Pro-L-Pro-Gly)n and (L-Pro-L-Hyp-Gly)n.

# publications[].label
Isotopic Studies on Collagen Degradation and the Urine Excretion of Hydroxyproline *

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Specific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides. The most effective target sites are clustered in double-stranded regions of the predicted secondary structure for the mRNA.

# publications[].label
The mouse col11a2 gene. Some transcripts from the adjacent rxr-beta gene extend into the col11a2 gene.

# publications[].label
Central-nervous-system effects of ingestin of L-tryptophan by normal subjects.

# publications[].label
Novel object recognition in Apoe(-/-) mice improved by neonatal implantation of wild-type multipotential stromal cells.

# publications[].label
Comparison of the NH2-Terminal sequences of chick Type I preprocollagen chains synthesized in an nRNA-dependent reticulocyte lysate.

# publications[].label
Identification of collagen in synovial fluid.

# publications[].label
Stable transfection of MSCs by electroporation.

# publications[].label
Genetic causes of aortic aneurysms. Unlearning at least part of what the textbooks say.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Inhibition of scar formation by the proline analog cis-hydroxyproline.

# publications[].label
Five families with arginine 519-cysteine mutation in COL2A1: evidence for three distinct founders.

# publications[].label
A 15 base-pair AT-rich variable number tandem repeat in the type III procollagen gene (COL3A1) as an informative marker for 2q31-2q32.3.

# publications[].label
Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta.

# publications[].label
Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis.

# publications[].label
MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner.

# publications[].label
Creation of a system for the assembly and expression of DNA constructs encoding novel recombinant human procollagen II.

# publications[].label
Recombinant DNA and collagen research. Is amino acid sequencing obsolete? Can we study diseases involving collagen by analysis of the genes?

# publications[].label
Preactivation of human MSCs with TNF- enhances tumor-suppressive activity.

# publications[].label
A substitution of cysteine for glycine 748 of the alpha 1 chain produces a kink at this site in the procollagen I molecule and an altered N-proteinase cleavage site over 225 nm away.

# publications[].label
Exclusion of COL1A1, COL1A2, and COL3A1 genes as candidate genes for Ehlers-Danlos syndrome type I in one large family.

# publications[].label
Polymerization of pNcollagen I and copolymerization of pNcollagen I with collagen I. A kinetic, thermodynamic, and morphologic study.

# publications[].label
Intracellular accumulation of protocollagen and extrusion of collagen by embryonic cartilage cells.

# publications[].label
Premature vertebral endplate ossification and mild disc degeneration in mice after inactivation of one allele belonging to the Col2a1 gene for Type II collagen.

# publications[].label
Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome.

# publications[].label
Use of differentiating adult stem cells (marrow stromal cells) to identify new downstream target genes for transcription factors.

# publications[].label
Thermal stability of the triple helix of type I procollagen and collagen. Precautions for minimizing ultraviolet damage to proteins during circular dichroism studies.

# publications[].label
Targeted insertions of two exogenous collagen genes into both alleles of their endogenous loci in cultured human cells: the insertions are directed by relatively short fragments containing the promoters and the 5' ends of the genes.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Purification and partial characterization of the type II procollagen synthesized by embryonic cartilage cells.

# publications[].label
Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels.

# publications[].label
A SIMPLE METHOD FOR DIFFERENTIAL ASSAY OF TRITIUM AND CARBON-14 IN WATER-SOLUBLE BIOLOGICAL MATERIALS.

# publications[].label
Osteopenia in 37 members of seven families: analysis based on a model of dominant inheritance.

# publications[].label
Formation of the triple helix of type I procollagen in cellulo. A kinetic model based on cis-trans isomerization of peptide bonds.

# publications[].label
Formation of enzyme-substrate complexes with protocollagen proline hydroxylase and large polypeptide substrates.

# publications[].label
Inhibitors of collagen biosynthesis as a means of controlling scar formation in tendon injury.

# publications[].label
Primary and secondary effects of ascorbate on procollagen synthesis and protein synthesis by primary cultures of tendon fibroblasts.

# publications[].label
Abstracts from the Second International Conference on Molecular Biology and Pathology of Matrix. Philadelphia, Pennsylvania, June 15-18, 1988.

# publications[].label
Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta.

# publications[].label
Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate.

# publications[].label
Enzymatic synthesis of hydroxyproline by the hydroxylation of poly(L-propyl-glycyl-L-prolyl).

# publications[].label
Pharmaceutical Induction of ApoE Secretion

# publications[].label
Increased steady-state levels of laminin B1 mRNA in kidneys of long-term streptozotocin-diabetic rats. No effect of an aldose reductase inhibitor.

# publications[].label
A model for the triple-helical structure of (Pro-Hyp-Gly)10 involving a cis peptide bond and inter-chain hydrogen-bonding to the hydroxyl group of hydroxyproline.

# publications[].label
The collagen fibril: the almost crystalline structure.

# publications[].label
G to A polymorphism in exon 31 of the COL3A1 gene.

# publications[].label
Sequencing of cDNA from 50 unrelated patients reveals that mutations in the triple-helical domain of type III procollagen are an infrequent cause of aortic aneurysms.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Human mesenchymal stromal cells (MSCs) reduce neointimal hyperplasia in a mouse model of flow-restriction by transient suppression of anti-inflammatory cytokines.

# publications[].label
TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Intraperitoneally infused human mesenchymal stem cells form aggregates with mouse immune cells and attach to peritoneal organs.

# publications[].label
Interchain Disulphide Bonding in Procollagen from Embryonic Chick Tendon Cells and the Formation of the Triple-Helical Structure

# publications[].label
Ascorbate increases the synthesis of procollagen hydroxyproline by cultured fibroblasts from chick embryo tendons without activation of prolyl hydroxyla.

# publications[].label
Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Osteogenesis imperfecta: phenotypic heterogeneity, protein suicide, short and long collagen.

# publications[].label
Collagen degradation and the response to parathyroid extract in the intact rhesus monkey.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.

# publications[].label
Collagen fibrils in vitro grow from pointed tips in the C- to N-terminal direction.

# publications[].label
Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression.

# publications[].publisher
Proceedings of the National Academy of Sciences

# researcherOn[].label
Preparation and Distribution of Adult Stem Cells

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.label
Central Texas Veterans Health Care System - (Waco, Texas, United States)

# researcherOn[].awardedBy.preferredLabel
Central Texas Veterans Health Care System

# researcherOn[].label
Mesenchymal Stem Cell Derived A1-Exosomes for Traumatic Brain Injury

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Neurological Disorders and Stroke

# researcherOn[].awardedBy.label
Central Texas Veterans Health Care System - (Waco, Texas, United States)

# researcherOn[].awardedBy.preferredLabel
Central Texas Veterans Health Care System

# streetAddress
Texas A&M Health Science Center; Molecular And Cellular Medicine; 1114 TAMUS