# positions[].label
Regents & Distinguished Professor and Director

# positions[].organizations[].label
Center for Infectious and Inflammatory Diseases

# overview
The primary interest of our laboratory is to try to understand the structural function of the extracellular matrix. Of particular interest is the study of the molecular mechanisms of microbial adhesion to host tissue. This process, which is believed to represent a critical initial step in the development of infections, involves specific cell-surface proteins that recognize and bind with a high affinity to components in the host tissue. Our goal is to decipher these events at a molecular level and, based on structural analysis of the interacting components, design new strategies to prevent and treat infections.

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
Cyclic AMP Response Element-Binding Protein

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
1.1 Normal Biological Development And Functioning

# publications[].label
Bioactive hydrogels with enhanced initial and sustained cell interactions.

# publications[].label
Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection.

# publications[].label
Heparan Sulfate: On the Structure and Function of the Cell Associated Proteoglycans

# publications[].label
Genome-wide analysis of in vivo CcpA binding with and without its key co-factor HPr in the major human pathogen group A Streptococcus

# publications[].label
Fibronectin binding determinants of the Staphylococcus aureus fibronectin receptor.

# publications[].label
Staphylococcal adhesion to collagen in intra-articular sepsis.

# publications[].label
The Synthesis of Collagen Peptides and Characterization of Their Inhibitory Effects on the Collagen Binding Activities of Integrins 11 and 21

# publications[].label
SdrG, a fibrinogen-binding bacterial adhesin of the microbial surface components recognizing adhesive matrix molecules subfamily from Staphylococcus epidermidis, targets the thrombin cleavage site in the Bbeta chain.

# publications[].label
A heparan sulfate-degrading endoglycosidase from rat liver tissue.

# publications[].label
Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMM) ClfA and Fbl with fibrinogen.

# publications[].label
Cloning and expression of the gene for a fibronectin-binding protein from Staphylococcus aureus.

# publications[].label
Demonstration of a platelet enzyme, degrading heparan sulphate.

# publications[].label
Influence of cyclic strain and decorin deficiency on 3D cellularized collagen matrices.

# publications[].label
The fibronectin-binding protein Fnm contributes to adherence to extracellular matrix components and virulence of Enterococcus faecium.

# publications[].label
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.

# publications[].label
Prokaryotic Collagen-Like Proteins as Novel Biomaterials.

# publications[].label
Clumping factor B (ClfB), a new surface-located fibrinogen-binding adhesin of Staphylococcus aureus.

# publications[].label
Binding of fibronectin to Staphylococcus strains.

# publications[].label
The tandem beta-zipper model defines high affinity fibronectin-binding repeats within Staphylococcus aureus FnBPA.

# publications[].label
Cell-surface heparan sulfate: an intercalated membrane proteoglycan.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Augmenting the articular cartilage-implant interface: Functionalizing with a collagen adhesion protein.

# publications[].label
Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM.

# publications[].label
Collagen-binding MSCRAMMS of Gram-positive bacteria inhibit complement activation via the classical pathway

# publications[].label
A family of putative MSCRAMMs from Enterococcus faecalis.

# publications[].label
Specific cell components of Bacteroides gingivalis mediate binding and degradation of human fibrinogen.

# publications[].label
Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense.

# publications[].label
Functions of proteoglycans at the cell surface.

# publications[].label
Binding of a peptide from a Streptococcus dysgalactiae MSCRAMM to the N-terminal F1 module pair of human fibronectin involves both modules.

# publications[].label
Isolation of a putative laminin binding protein from Streptococcus anginosus.

# publications[].label
Staphylococcal biofilm formation and development: Related diseases, host immune responses and therapy

# publications[].label
Surface protein adhesins of Staphylococcus aureus.

# publications[].label
Characterization of a dermatan sulfate proteoglycan synthesized by murine parietal yolk sac (PYS-2) cells.

# publications[].label
A second fibronectin-binding region is present in collagen alpha chains.

# publications[].label
Heparin-dependent fibroblast growth factor activities: effects of defined heparin oligosaccharides.

# publications[].label
Decorin-binding sites in the adhesin DbpA from Borrelia burgdorferi: a synthetic peptide approach.

# publications[].label
Coagulase and Efb of Staphylococcus aureus Have a Common Fibrinogen Binding Motif.

# publications[].label
Genome-wide analysis of in vivo CcpA binding with and without its key co-factor HPr in the major human pathogen group A Streptococcus.

# publications[].label
Binding of the proteoglycan decorin to collagen type VI.

# publications[].label
Distribution of sulphate and iduronic acid residues in heparin and heparan sulphate.

# publications[].label
Fibrinolysis inhibition and fibronectin in the blood in patients with the delayed microembolism syndrome.

# publications[].label
Attachment of rat hepatocytes to collagen and fibronectin; a study using antibodies directed against cell surface components.

# publications[].label
Biosynthesis of heparin. 3. Formation of iduronic acid residues.

# publications[].label
A family of fibrinogen-binding MSCRAMMs from Enterococcus faecalis.

# publications[].label
Substrate adhesion of rat hepatocytes: on the mechanism of attachment to fibronectin.

# publications[].label
Collagen-mimetic hydrogels promote human endothelial cell adhesion, migration and phenotypic maturation.

# publications[].label
Regulation of bone formation and remodeling by G-protein-coupled receptor 48.

# publications[].label
Role of fibronectin-binding MSCRAMMs in bacterial adherence and entry into mammalian cells.

# publications[].label
Streptococcal Scl1 and Scl2 proteins form collagen-like triple helices.

# publications[].label
Binding of Escherichia coli to fibronectin. A mechanism of tissue adherence.

# publications[].label
Fibronectin binding protein A of Staphylococcus aureus can mediate human T lymphocyte adhesion and coactivation.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Gene trap screening for cell surface and extracellular matrix molecules produced by chondrocytes.

# publications[].label
The role of MSCRAMMs in staphylococcal skeletal infections

# publications[].label
Assessment of prokaryotic collagen-like sequences derived from streptococcal Scl1 and Scl2 proteins as a source of recombinant GXY polymers.

# publications[].label
Identification and biochemical characterization of the ligand binding domain of the collagen adhesin from Staphylococcus aureus.

# publications[].label
Endothelial cell response to chemical, biological, and physical cues in bioactive hydrogels.

# publications[].label
Virulence potential of the staphylococcal adhesin CNA in experimental arthritis is determined by its affinity for collagen.

# publications[].label
The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
N-[3H]Acetyl-labeling, a convenient method for radiolabeling of glycosaminoglycans.

# publications[].label
Interaction of heparin with proteins. Demonstration of different binding sites for antithrombin and lipoprotein lipase.

# publications[].label
Multiple domains contribute to heparin/heparan sulfate binding by human HIP/L29.

# publications[].label
Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex.

# publications[].label
Fibronectin binding protein compositions and methods of use

# publications[].label
Multiple Binding Sites in Collagen Type I for the Integrins α1β1 and α2β1

# publications[].label
Identification of a Staphylococcus aureus extracellular matrix-binding protein with broad specificity.

# publications[].label
Collagen binding protein compositions and methods of use

# publications[].label
Binding of Microbial Pathogens to Connective Tissue Fibronectin: An Early Step in Localized and Invasive Infections

# publications[].label
Adherence of Staphylococcus aureus fibronectin binding protein A mutants: an investigation using optical tweezers.

# publications[].label
A Collagen Hug model for Staphylococcus aureus CNA binding to collagen

# publications[].label
Antibodies that block adherence of to fibronectin.

# publications[].label
Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Cell-surface heparan sulfate. Isolation and characterization of a proteoglycan from rat liver membranes.

# publications[].label
Characterization of the interaction between the Staphylococcus aureus clumping factor (ClfA) and fibrinogen.

# publications[].label
Measurement of adhesive forces between bacteria and protein-coated surfaces using optical tweezers

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Antibody response to fibronectin-binding adhesin FnbpA in patients with Staphylococcus aureus infections.

# publications[].label
Specific binding sites in collagen for integrins and use thereof

# publications[].label
Host-directed therapy in foals can enhance functional innate immunity and reduce severity of Rhodococcus equi pneumonia.

# publications[].label
Measurement of adhesive forces between individual Staphylococcus aureus MSCRAMMs and protein-coated surfaces by use of optical tweezers.

# publications[].label
Adherence of Borrelia burgdorferi to the proteoglycan decorin.

# publications[].label
Fibrinogen is a ligand for the Staphylococcus aureus microbial surface components recognizing adhesive matrix molecules (MSCRAMM) bone sialoprotein-binding protein (Bbp).

# publications[].label
Enterococcus faecalis adhesin, ace, mediates attachment to extracellular matrix proteins collagen type IV and laminin as well as collagen type I.

# publications[].label
Structure and metabolism of rat liver heparan sulphate.

# publications[].label
Biosynthesis of heparin. Assay and properties of the microsomal uronosyl C-5 epimerase.

# publications[].label
Binding of Streptococcus pyogenes to laminin.

# publications[].label
Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10.

# publications[].label
Sequence changes in the isoforms of staphylococcal MSCRAMMs Bbp/SdrE affect ligand specificity

# publications[].label
The evolution and maintenance of virulence in Staphylococcus aureus: a role for host-to-host transmission?

# publications[].label
Quantification of S. aureus binding to extracellular matrix molecules using optical tweezers.

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Treatment of Staphylococcus aureus infections utilizing antibodies that bind to fibronectin binding proteins

# publications[].label
Fibronectin receptors from gram-positive bacteria: comparison of active sites.

# publications[].label
Conformational changes in the fibronectin binding MSCRAMMs are induced by ligand binding.

# publications[].label
Endothelins produced by endothelial cells promote collagen gel contraction by fibroblasts.

# publications[].label
A Novel MSCRAMM Subfamily in Coagulase Negative Staphylococcal Species.

# publications[].label
Biosynthesis of dermatan sulfate. I. Formation of L-iduronic acid residues.

# publications[].label
A heparin-binding synthetic peptide of heparin/heparan sulfate-interacting protein modulates blood coagulation activities.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
vhp Is a Fibrinogen-Binding Protein Related to vWbp in Staphylococcus aureus.

# publications[].publisher
American Society for Cell Biology (ASCB)

# publications[].label
The antithrombin-binding sequence of heparin. Location of essential N-sulfate groups.

# publications[].label
Genomic and surface proteomic analysis of the canine pathogen Staphylococcus pseudintermedius reveals proteins that mediate adherence to the extracellular matrix.

# publications[].label
Reduced sulfation of liver heparan sulfate in experimentally diabetic rats.

# publications[].label
Matricellular hevin regulates decorin production and collagen assembly.

# publications[].label
Isolation of the pericellular matrix of human fibroblast cultures.

# publications[].label
A "dock, lock, and latch" structural model for a staphylococcal adhesin binding to fibrinogen.

# publications[].label
The fibrinogen-binding MSCRAMM (clumping factor) of Staphylococcus aureus has a Ca2+-dependent inhibitory site.

# publications[].label
Fibronectin fibril formation involves cell interactions with two fibronectin domains.

# publications[].label
Decorin binding protein compositions and methods of use

# publications[].label
Anticoagulant activity of heparin: separation of high-activity and low-activity heparin species by affinity chromatography on immobilized antithrombin.

# publications[].label
Evidence for the "dock, lock, and latch" ligand binding mechanism of the staphylococcal microbial surface component recognizing adhesive matrix molecules (MSCRAMM) SdrG.

# publications[].label
Collagen-Mimetic Proteins with Tunable Integrin Binding Sites for Vascular Graft Coatings.

# publications[].label
Differentiation of human trophoblast cells in vitro stimulated by extracellular matrix

# publications[].label
Decorin binding protein compositions and methods of use

# publications[].label
Composition for the attachment of implants to collagen or other components of biological tissue

# publications[].label
The anticoagulant effect of heparan sulfate and dermatan sulfate.

# publications[].label
Integrity of the pericellular fibronectin matrix of fibroblasts is independent of sulfated glycosaminoglycans.

# publications[].label
Fibronectin binding protein compositions and methods of use

# publications[].label
Structural and biochemical characterization of Staphylococcus aureus clumping factor B/ligand interactions.

# publications[].label
The Activity of Heparin Preparations Studied by Amidolytic and Clotting Methods

# publications[].label
The mutagenesis of the RGD sequence of recombinant osteopontin causes it to lose its cell adhesion ability.

# publications[].label
Inducible Epithelial Resistance against Coronavirus Pneumonia in Mice.

# publications[].label
Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper.

# publications[].label
Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia.

# publications[].label
Ace is a collagen-binding MSCRAMM from Enterococcus faecalis.

# publications[].label
Identification and phenotypic characterization of a second collagen adhesin, Scm, and genome-based identification and analysis of 13 other predicted MSCRAMMs, including four distinct pilus loci, in Enterococcus faecium.

# publications[].label
A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage.

# publications[].label
In vitro biosynthesis of cold insoluble globulin (fibronectin) by mouse peritoneal macrophages.

# publications[].label
Chondrogenic activity of the heparan sulfate proteoglycan perlecan maps to the N-terminal domain I.

# publications[].label
Procollagen C proteinase enhancer 1 genes are important determinants of the mechanical properties and geometry of bone and the ultrastructure of connective tissues.

# publications[].label
Biosynthesis of heparin. Solubilization and partial characterization of N- and O-sulphotransferases.

# publications[].label
Conditional adherence of Enterococcus faecalis to extracellular matrix proteins.

# publications[].label
Decorin proteoglycan inhibitor of fibrinogen blood clotting

# publications[].label
Thrombospondin modulates focal adhesions in endothelial cells.

# publications[].label
A 'Collagen Hug' model for Staphylococcus aureus CNA binding to collagen.

# publications[].label
Streptococcus anginosus adheres to vascular endothelium basement membrane and purified extracellular matrix proteins.

# publications[].label
Structure and interactions of proteoglycans in the extracellular matrix produced by cultured human fibroblasts.

# publications[].label
The Enterococcus faecalis MSCRAMM ACE binds its ligand by the Collagen Hug model.

# publications[].label
Interaction of lipoprotein lipase with native and modified heparin-like polysaccharides.

# publications[].label
Targeted protein engineering provides insights into binding mechanism and affinities of bacterial collagen adhesins.

# publications[].label
Cooperative binding and activation of fibronectin by a bacterial surface protein.

# publications[].label
Structural requirements for the interaction of heparin with antithrombin III.

# publications[].label
Adhesion, growth, and matrix production by fibroblasts on laminin substrates.

# publications[].label
The role of glycosylation in the secretion of proteoglycans.

# publications[].label
A Fibronectin Binding Protein from Staphylococcus Aureus and its Role in Bacterial Adherence

# publications[].label
Fibrinogen binding is affected by amino acid substitutions in C-terminal repeat region of fibronectin binding protein A.

# publications[].label
Identification and biochemical characterization of two novel collagen binding MSCRAMMs of Bacillus anthracis.

# publications[].label
Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby

# publications[].label
Erratum: Molecular characterization and expression of a gene encoding a Staphylococcus aureus collagen adhesin (Journal of Biological Chemistry (1992) 267 (4766-4772))

# publications[].label
Interactions of Bacteroides gingivalis with fibrinogen.

# publications[].label
Measurement of adhesive forces between S. epidermidis and fibronectin-coated surfaces using optical tweezers.

# publications[].label
The serine-aspartate repeat (Sdr) protein family in Staphylococcus epidermidis.

# publications[].label
Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A novel fibronectin binding motif in MSCRAMMs targets F3 modules.

# publications[].label
Vaccination with a recombinant fragment of collagen adhesin provides protection against Staphylococcus aureus-mediated septic death.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Monoclonal antibodies to CNA, a collagen-binding microbial surface component recognizing adhesive matrix molecules, detach Staphylococcus aureus from a collagen substrate.

# publications[].label
Peptide analogs to a fibronectin receptor inhibit attachment of Staphylococcus aureus to fibronectin-containing substrates.

# publications[].label
Physiologic Implications of the Interaction between Lipoprotein Lipase and Some Sulfated Glycosaminoglycans

# publications[].label
Regulation of cell substrate adhesion: effects of small galactosaminoglycan-containing proteoglycans.

# publications[].label
Domain structure of the Staphylococcus aureus collagen adhesin.

# publications[].label
Porphyromonas gingivalis surface components bind and degrade connective tissue proteins.

# publications[].label
Identification of N-sulphated disaccharide units in heparin-like polysaccharides.

# publications[].label
The identification and functional characterization of WxL proteins from Enterococcus faecium reveal surface proteins involved in extracellular matrix interactions.

# publications[].label
Bacteroides gingivalis and Bacteroides intermedius recognize different sites on human fibrinogen.

# publications[].label
Characterization of protease-resistant fragments of laminin mediating attachment and spreading of rat hepatocytes.

# publications[].label
Substrate adhesion of rat hepatocytes: a comparison of laminin and fibronectin as attachment proteins.

# publications[].label
Elucidation of Endothelial Cell Hemostatic Regulation with Integrin-Targeting Hydrogels.

# publications[].label
A newly identified enhancer element responsible for type II collagen gene expression.

# publications[].label
Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use

# publications[].label
Crystal structures of fibronectin-binding sites from Staphylococcus aureus FnBPA in complex with fibronectin domains.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility.

# publications[].label
Inhibition of Enterococcus faecium adherence to collagen by antibodies against high-affinity binding subdomains of Acm.

# publications[].label
Specific binding sites in collagen for integrins and use thereof

# publications[].label
Prokaryotic collagen-like proteins and uses thereof

# publications[].label
Invasion of eukaryotic cells by Borrelia burgdorferi requires (1) integrins and Src kinase activity.

# publications[].label
A heparin-degrading endoglycosidase from rat spleen.

# publications[].label
Peptide inhibitor of fibrinogen blood clotting

# publications[].label
Amino acid polymorphisms in the fibronectin-binding repeats of fibronectin-binding protein A affect bond strength and fibronectin conformation.

# publications[].label
Structure and biosynthesis of heparin-like polysaccharides.

# publications[].label
Adherence of Borrelia burgdorferi. Identification of critical lysine residues in DbpA required for decorin binding.

# publications[].label
Decorin binds fibrinogen in a Zn2+-dependent interaction.

# publications[].label
Binding of laminin to oral and endocarditis strains of viridans streptococci.

# publications[].label
Evaluation of late outgrowth endothelial progenitor cell and umbilical vein endothelial cell responses to thromboresistant collagen-mimetic hydrogels.

# publications[].label
Heterogeneity of lysosomes originating from rat liver parenchymal cells. Metabolic relationship of subpopulations separated by density-gradient centrifugation.

# publications[].label
Substrate adhesion of rat hepatocytes: mechanism of attachment to collagen substrates.

# publications[].label
A structural model of the Staphylococcus aureus ClfA-fibrinogen interaction opens new avenues for the design of anti-staphylococcal therapeutics.

# publications[].label
Is the GehD lipase from Staphylococcus epidermidis a collagen binding adhesin?

# publications[].label
Identification of Porphyromonas gingivalis components that mediate its interactions with fibronectin.

# publications[].label
Substrate adhesion of rat hepatocytes. On the role of fibronectin in cell spreading.

# publications[].label
Binding of heparan sulfate to type V collagen. A mechanism of cell-substrate adhesion.

# publications[].label
Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection.

# publications[].label
Complement evasion by Staphylococcus aureus Bbp and SdrE that act on the C3 convertase

# publications[].label
Fibronectin-binding protein A of Staphylococcus aureus has multiple, substituting, binding regions that mediate adherence to fibronectin and invasion of endothelial cells.

# publications[].label
Structure of the pericellular matrix: association of heparan and chondroitin sulfates with fibronectin-procollagen fibers.

# publications[].label
Biosynthesis of heparin. Loss of C-5 hydrogen during conversion of D-glucuronic to L-iduronic acid residues.

# publications[].label
Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi.

# publications[].label
Decorin binding protein essential peptides and methods of use

# publications[].label
Oligosaccharides generated by an endoglucuronidase are intermediates in the intracellular degradation of heparan sulfate proteoglycans.

# publications[].label
Adsorption of follicular dendritic cell-secreted protein (FDC-SP) onto mineral deposits. Application of a new stable gene expression system.

# publications[].label
Multilayer vascular grafts based on collagen-mimetic proteins.

# publications[].label
Characterization of Bacterial Adhesin Interactions with Extracellular Matrix Components Utilizing Biosensor Technology

# publications[].label
Relationship of heparan sulfate proteoglycans to the cytoskeleton and extracellular matrix of cultured fibroblasts.

# publications[].label
Isolation and characterization of heparin from human mastocytoma tissue.

# publications[].label
The Collagen Receptor Discoidin Domain Receptor 1b Enhances Integrin 1-Mediated Cell Migration by Interacting With Talin and Promoting Rac1 Activation.

# publications[].label
Characterization of epiphycan, a small proteoglycan with a leucine-rich repeat core protein.

# publications[].label
Biosynthesis of heparin. Concerted action of early polymer-modification reactions.

# publications[].label
KRAS Inhibitor that Simultaneously Inhibits Nucleotide Exchange Activity and Effector Engagement.

# publications[].label
Differential gene trap: A new strategy for identifying genes regulated during cartilage differentiation

# publications[].label
Three new members of the serine-aspartate repeat protein multigene family of Staphylococcus aureus.

# publications[].label
A novel binding site in collagen type III for integrins alpha1beta1 and alpha2beta1.

# publications[].label
Active and passive immunity against Borrelia burgdorferi decorin binding protein A (DbpA) protects against infection.

# publications[].label
Inhibition of complement activation by a secreted Staphylococcus aureus protein.

# publications[].label
Chronic Wound Dressings Based on Collagen-Mimetic Proteins.

# publications[].label
Staphylococcus epidermidis MSCRAMM SesJ Is Encoded in Composite Islands.

# publications[].label
Cold-insoluble globulin mediates the adhesion of rat liver cells to plastic Petri dishes.

# publications[].label
Binding of heparin and heparan sulphate to rat liver cells.

# publications[].label
Structure of the collagen-binding domain from a Staphylococcus aureus adhesin.

# publications[].label
Optical measurements of dynamic adhesive forces between bacteria and protein-coated surfaces

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Isolation and characterization of a heparan sulfate proteoglycan from rat liver plasma membranes

# publications[].label
Synthetic Peptides Mimic the Active Sites of Fibronectin Receptors from Gram-Positive Bacteria

# publications[].label
Molecular Basis of Adherence of Staphylococcus aureus to Biomaterials

# publications[].label
Crystallization and preliminary X-ray analysis of B-domain fragments of a Staphylococcus aureus collagen-binding protein.

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
Cloning and expression of two different genes from Streptococcus dysgalactiae encoding fibronectin receptors.

# publications[].label
Structural organization of the fibrinogen-binding region of the clumping factor B MSCRAMM of Staphylococcus aureus.

# publications[].label
Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi.

# publications[].label
Fibronectin binding to a Streptococcus pyogenes strain.

# publications[].label
Collagen Receptor of Staphylococcus aureus

# publications[].label
Is the sensitivity of cells for FGF-1 and FGF-2 regulated by cell surface heparan sulfate proteoglycans?

# publications[].label
Adhesion of glycosaminoglycan-deficient chinese hamster ovary cell mutants to fibronectin substrata.

# publications[].label
MSCRAMM-mediated adherence of microorganisms to host tissues.

# publications[].label
Crystallization of ClfA and ClfB fragments: the fibrinogen-binding surface proteins of Staphylococcus aureus.

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
A proteoglycan form of heparin and its degradation to single-chain molecules.

# publications[].label
A monoclonal antibody enhances ligand binding of fibronectin MSCRAMM (adhesin) from Streptococcus dysgalactiae.

# publications[].label
Heparin enhances the rate of binding of fibronectin to collagen.

# publications[].label
Allosteric Regulation of Fibronectin/51 Interaction by Fibronectin-Binding MSCRAMMs.

# publications[].label
Interactions between collagen IX and biglycan measured by atomic force microscopy.

# publications[].label
Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis.

# publications[].label
Heparan sulfate proteoglycans are concentrated on the sinusoidal plasmalemmal domain and in intracellular organelles of hepatocytes.

# publications[].label
Binding of Efb from Staphylococcus aureus to fibrinogen blocks neutrophil adherence.

# publications[].label
Screening for genes preferentially expressed in the early phase of chondrogenesis.

# publications[].label
Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin.

# publications[].label
Compositions And Use Of A Fibrinogen Binding Motif Present In EFB And COA For Therapeutics And Vaccines Against Staphylococcus Aureus

# publications[].label
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through 21 integrin

# publications[].label
Entry of Bacillus anthracis spores into epithelial cells is mediated by the spore surface protein BclA, integrin 21 and complement component C1q.

# publications[].label
Staphylococcus aureus expresses a major histocompatibility complex class II analog.

# publications[].label
Prokaryotic collagen-like proteins and uses thereof

# publications[].label
Isolation and characterization of a fibronectin receptor from Staphylococcus aureus.

# publications[].label
Bioactive hydrogels based on Designer Collagens.

# publications[].label
Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof

# publications[].label
Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion.

# publications[].label
Identification of residues in the Staphylococcus aureus fibrinogen-binding MSCRAMM clumping factor A (ClfA) that are important for ligand binding.

# publications[].label
Heparan sulfate proteoglycans of rat embryo fibroblasts. A hydrophobic form may link cytoskeleton and matrix components.

# publications[].label
An engineered alpha1 integrin-binding collagenous sequence.

# publications[].label
The activity of heparin preparations studied by amidolytic and clotting methods

# publications[].label
The Staphylococcus aureus collagen adhesin is a virulence determinant in experimental septic arthritis.

# publications[].label
Biosynthesis of heparin. Loss of C-5 hydrogen during conversion of d-glucuronic to l-iduronic acid residues

# publications[].label
Influence of collagen-based integrin 1 and 2 mediated signaling on human mesenchymal stem cell osteogenesis in three dimensional contexts.

# publications[].label
Biosynthesis of heparin. Studies on the microsomal sulfation process.

# publications[].label
Expression of the collagen adhesin ace by Enterococcus faecalis strain OG1RF is not repressed by Ers but requires the Ers box.

# publications[].label
Decorin core protein secretion is regulated by N-linked oligosaccharide and glycosaminoglycan additions.

# publications[].label
Decorin-transforming growth factor- interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices.

# publications[].label
Modulation of differentiation markers in human choriocarcinoma cells by extracellular matrix: on the role of a three-dimensional matrix structure.

# publications[].label
Multicomponent Lyme vaccine: three is not a crowd.

# publications[].label
Nucleotide and amino acid sequences of asporins

# publications[].label
Antibodies to Coagulase of Staphylococcus aureus crossreact to Efb and reveal different binding of shared Fibrinogen binding repeats

# publications[].label
Molecular mechanisms of microbial adhesion to host proteins

# publications[].label
Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody.

# publications[].label
Binding of heparin on the surface of cultured human endothelial cells.

# publications[].label
Biosynthesis of heparin. Assay and properties of the microsomal N-acetyl-D-glucosaminyl N-deacetylase.

# publications[].label
The collagen-binding adhesin is a virulence factor in Staphylococcus aureus keratitis.

# publications[].label
Expression and localization of PG-Lb/epiphycan during mouse development.

# publications[].label
Anticoagulant activity of heparin: assay of bovine, human and porcine preparations by amidolytic and clotting methods.

# publications[].label
Nucleotide sequence of the gene for a fibronectin-binding protein from Staphylococcus aureus: use of this peptide sequence in the synthesis of biologically active peptides.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface.

# publications[].label
The proteoglycan decorin binds C1q and inhibits the activity of the C1 complex.

# publications[].publisher
The American Association of Immunologists

# publications[].label
Isolation and characterization of a putative collagen receptor from Staphylococcus aureus strain Cowan 1.

# publications[].label
The BBA33 lipoprotein binds collagen and impacts Borrelia burgdorferi pathogenesis.

# publications[].label
Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of Gram-positive bacteria inhibit complement activation via the classical pathway.

# publications[].label
Multiple specificities of the staphylococcal and streptococcal fibronectin-binding microbial surface components recognizing adhesive matrix molecules.

# publications[].label
A Streptococcal Collagen-like Protein Interacts with the α2β1 Integrin and Induces Intracellular Signaling

# publications[].label
Scl1-dependent internalization of group A Streptococcus via direct interactions with the alpha2beta(1) integrin enhances pathogen survival and re-emergence.

# publications[].label
Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi.

# publications[].label
Borrelia burgdorferi binds fibronectin through a tandem beta-zipper, a common mechanism of fibronectin binding in staphylococci, streptococci, and spirochetes.

# publications[].label
Method and compositions for inhibiting thrombin-induced coagulation

# publications[].label
Fibronectin Binding Proteins from Staphylococcus aureus

# publications[].label
A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A.

# publications[].label
Corrigendum to Multilayer vascular grafts based on collagen-mimetic proteins [Acta Biomaterialia 8 (2012) 10101021]

# publications[].label
Structure and properties of an under-sulfated heparan sulfate proteoglycan synthesized by a rat hepatoma cell line.

# publications[].label
Biosynthesis of heparin: studies on the microsomal sulphation process

# publications[].label
Two different genes coding for fibronectin-binding proteins from Streptococcus dysgalactiae. The complete nucleotide sequences and characterization of the binding domains.

# publications[].label
Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, 11 integrin andStaphylococcus aureusCna MSCRAMM.

# publications[].label
Biosynthesis of heparin: solubilization and partial characterization of N and O sulphotransferases

# publications[].label
Microbes, hemostasis and vascular biology.

# publications[].label
Antibodies recognizing a highly expressed putative antigen of CA-MRSA and methods of use

# publications[].label
Abstract 582: Targeting the blood-brain barrier with a non-canonical iron-mimicry mechanism: A translational approach for the detection and treatment of human brain tumors

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Mapping the ligand-binding region of Borrelia burgdorferi fibronectin-binding protein BBK32.

# publications[].label
Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development.

# publications[].label
Novel fold and assembly of the repetitive B region of the Staphylococcus aureus collagen-binding surface protein.

# publications[].label
Protein kinase C phosphorylates two of the four known syndecan cytoplasmic domains in vitro.

# publications[].label
Quantification of S. aureus Adhesion to Fibronectin Using Optical Tweezers

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Molecular characterization and expression of a gene encoding a Staphylococcus aureus collagen adhesin.

# publications[].label
Glycosaminoglycans and their binding to biological macromolecules.

# publications[].label
Resistance to Lyme disease in decorin-deficient mice.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Endothelial cells secrete a factor that promotes fibroblast contraction of hydrated collagen gels.

# publications[].label
Interactions of Pathogenic Microorganisms with Fibronectin

# publications[].label
Binding of collagen to Staphylococcus aureus Cowan 1.

# publications[].label
A multifunctional streptococcal collagen-mimetic protein coating prevents bacterial adhesion and promotes osteoid formation on titanium.

# publications[].label
Anticoagulant activity of heparin: isolation of antithrombin-binding sites.

# publications[].label
Binding of fibronectin to the surface of group A, C, and G streptococci isolated from human infections.

# publications[].label
Collagen gel contraction by cells associated with proliferative vitreoretinopathy.

# publications[].label
Decorin modulates fibrin assembly and structure.

# publications[].label
Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family.

# publications[].label
Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity.

# publications[].label
Collagen Binding Proteins of Gram-Positive Pathogens.

# publications[].label
The role of adhesion molecules in the pathogenesis of Staphylococcus aureus keratitis

# publications[].label
High affinity streptococcal binding to human fibronectin requires specific recognition of sequential F1 modules.

# publications[].label
Structure of the antithrombin-binding site in heparin.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Decorin Deficient Cells Demonstrate Increased Proliferation and Altered Phenotypic Properties

# publications[].label
beta-Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC.

# publications[].label
Crystallization and preliminary X-ray crystallographic analysis of Ace: a collagen-binding MSCRAMM from Enterococcus faecalis.

# publications[].label
A role for decorin in cutaneous wound healing and angiogenesis.

# publications[].label
Fibronectin receptors from Streptococcus dysgalactiae and Staphylococcus aureus. Involvement of conserved residues in ligand binding.

# publications[].label
Editorial: Cell Surface Proteins of Gram-Positive Pathogenic Bacteria.

# publications[].label
Inhibition of Staphylococcus aureus adherence to collagen under dynamic conditions.

# publications[].label
Reduced sulfation of liver heparan sulfate in experimentally diabetic rats

# publications[].label
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus.

# publications[].label
The fibronectin-binding MSCRAMM FnbpA of Staphylococcus aureus is a bifunctional protein that also binds to fibrinogen.

# publications[].label
Prokaryotic collagen-like proteins and uses thereof

# publications[].label
SdrC induces staphylococcal biofilm formation through a homophilic interaction.

# publications[].label
A type VII secretion system of Streptococcus gallolyticus subsp. gallolyticus contributes to gut colonization and the development of colon tumors.

# publications[].label
Staphylococcus aureus isolates from patients with Kawasaki disease express high levels of protein A.

# publications[].label
The molecular-weight-dependence of the anti-coagulant activity of heparin.

# publications[].label
Erratum: Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, <inf>1</inf><inf>1</inf> integrin and Staphylococcus aureus Cna MSCRAMM (Journal of Biological Chemistry (1999) 274 (24906-24913))

# publications[].label
MSCRAMMS in staphylococcal Bone infections

# publications[].label
Characterization of human DSPG3, a small dermatan sulfate proteoglycan.

# publications[].label
Adhesion of rat hepatocytes to collagen.

# publications[].label
Heparin-binding peptides from thrombospondins 1 and 2 contain focal adhesion-labilizing activity.

# publications[].label
Interactions of bacteria with extracellular matrix proteins.

# publications[].label
Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them

# publications[].label
BBK32, a fibronectin binding MSCRAMM from Borrelia burgdorferi, contains a disordered region that undergoes a conformational change on ligand binding.

# publications[].label
Hevin regulates decorin production and collagen fibrillogenesis

# publications[].label
Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof

# publications[].label
Binding of the basement membrane protein laminin to Escherichia coli.

# publications[].label
Cellular invasion by Staphylococcus aureus involves a fibronectin bridge between the bacterial fibronectin-binding MSCRAMMs and host cell beta1 integrins.

# publications[].label
On the molecular weight dependence of the anticoagulant activity of heparin

# publications[].label
The molecular basis of fibronectin-mediated bacterial adherence to host cells.

# publications[].label
Src kinase has a central role in in vitro cellular internalization of Staphylococcus aureus.

# publications[].label
Critical residues in the ligand-binding site of the Staphylococcus aureus collagen-binding adhesin (MSCRAMM).

# publications[].label
Identification and characterization of the C3 binding domain of the Staphylococcus aureus extracellular fibrinogen-binding protein (Efb).

# publications[].label
Endocarditis and biofilm-associated pili of Enterococcus faecalis.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Prokaryotic collagen-like proteins and uses thereof

# publications[].label
A heparin binding synthetic peptide from human HIP / RPL29 fails to specifically differentiate between anticoagulantly active and inactive species of heparin.

# publications[].label
Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments.

# publications[].label
Characterization of the collagen-binding S-layer protein CbsA of Lactobacillus crispatus.

# publications[].label
Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma.

# publications[].publisher
American Society for Clinical Investigation

# researcherOn[].label
Analysis of Staphylococcus Aureus Host Interactions

# researcherOn[].awardedBy.label
National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
National Institute of Infectious Diseases

# researcherOn[].label
Multilayer Vascular Grafts Based on Collagen-Mimetic Hydrogels

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Analysis of Staphylococcus Aureus Host Interactions

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# researcherOn[].label
Collagen Binding as a Virulence Mechanism in Lyme Borreliosis

# researcherOn[].awardedBy.label
National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M Health Science Center; Ibt-Office Of The Director; 1201 TAMUS

# organizations[]
Center for Infectious and Inflammatory Diseases

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# etdChairOf[].label
Kang, Mingsong (2014-08). Complement Evasion by S. aureus Surface Proteins. Doctoral Dissertation.

# etdChairOf[].label
Francis, Mathew Prashanth (2015-04). Understanding the Structural Basis for Functional Differences in Staphylococcal MSCRAMMS SDRE1 and BBP/SDRE2 and Their Role in Species Tropism. Doctoral Dissertation.