First name,Last name,Preferred title,Overview,Position,Department,Individual
R. Stanley,Williams,Professor,,Professor,Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n00f3c2fd
Yuxiang,Sun,Professor,"Dr. Sun is an expert on ""hunger hormone"" ghrelin. She generated the first set of ghrelin and ghrelin receptor knockout mice, and discovered novel roles of ghrelin signaling in diabetes, thermogenesis, and inflammation. Her laboratory uses state-of-the-art tools to study ghrelin system in energy sensing, metabolism and immunity, and aging. Her work suggests that ghrelin signal might be a promising drug target for obesity, diabetes, inflammation, and Alzheimer's disease.",Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n0228c22e
Hongwei,Zhao,Professor,,Professor,Epidemiology and Biostatistics,https://scholars.library.tamu.edu/vivo/display/n0698bd50
Seth,Murray,Professor,"Dr. Murray's research interests focus on improving the productivity, sustainability (economic and environmental) and quality of agricultural production through scientific research and development; mostly in maize (corn). The approaches used to conduct this research include 1) high-throughput field phenotyping (UAVs/drones, ground vehicles, NIRS), 2) molecular quantitative genetic discovery (including QTL mapping, GWAS), 3) statistical modeling and novel analysis methods (including big data and metanalysis), 4) development of new breeding and genetics approaches (including use of computer simulations), and ultimately 5) applied maize (corn) field breeding (classical and molecular). Primary traits of interest for discovering genetic variation and improving in maize for are yield, southern adaptation, stress (aflatoxin resistance, drought tolerance), plant height, composition (colored grain, high grain antioxidants, low phosphorus), and perennialism. Graduate student training is deeply embedded in all of my research.",Eugene Butler Endowed Chair||Professor,College of Agriculture and Life Sciences||Soil and Crop Sciences,https://scholars.library.tamu.edu/vivo/display/n06b68456
Dorothy,Shippen,Professor,"We are taking biochemical, molecular genetic and cytological approaches to study the structure, function and maintenance of telomeres. Telomeres are higher order nucleoprotein complexes that cap the ends of eukaryotic chromosomes and play essential roles in conferring genome stability and cell proliferation capacity. The protective cap of the telomere is comprised of specific telomere binding proteins that regulate the length of telomeric DNA tract and allow the cell distinguish the chromosome terminus from a double-strand break. Telomeric DNA is synthesized by the action of telomerase, an unusual reverse transcriptase that replenishes telomeric DNA lost as a consequence of replication by conventional DNA polymerases. We have developed the genetically tractable flowering plant Arabidopsis thaliana as a model system for studying telomeres in higher eukaryotes. With its sequenced genome, abundant genetic and transgenic tools, and extraordinarily high tolerance to genome instability, Arabidopsis has proven to be an excellent model for investigating fundamental processes in telomere biology. Current studies focus on defining the function and molecular evolution of telomere capping proteins and components of the telomerase ribonucleoprotein complex.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n07e86cac
William,Murphy,Professor,"Mammalian comparative genomics, phylogeny, biogeography, and molecular evolution, with a specific emphasis on feline evolutionary genomics, including: gene mapping, sex chromosome genetics, speciation and mechanisms of male hybrid sterility.",Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n08093092
Peter,Rentzepis,Professor,My research interest include lasers and their application to science and technology.,Faculty Affiliate||Professor,Energy Institute||Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n08418952
Byung-Jun,Yoon,Professor,"Dr. Yoon's main theoretical interests include objective-based uncertainty quantification, optimal experimental design (OED), machine learning, and signal processing. Application areas of interest include bioinformatics, computational network biology, and AI-driven drug/materials discovery.",Professor,Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n08866781
Mark,Westhusin,Professor,My laboratory is interested in developing transgenic animal models of disease and novel platforms for the production of biopharmaceuticals. We are currently exploring methods to produce vaccines in the milk of transgenic animals.,Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n088680ea
James,Sanders,Professor,"Dr. Sanders teaches undergraduate and graduate courses in animal breeding and conducts research in beef cattle genetics and breeding. His research has included systems analysis of beef cattle production, comparisons of cattle breeds for birth, growth, carcass and cow productivity traits, evaluation of genetic change within cattle breeds, evaluation of hybrid vigor retention in Bos indicus/Bos taurus crossbred cattle, identification of genes with major effects on birth, growth, carcass, disposition, and cow productivity traits in beef cattle, and genetic history of the Brahman breed.",Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/n0b98a027
Bruce,Riley,Professor,"My lab studies inner ear development in zebrafish. A prominent feature of our research is to investigate how cell-cell signaling and downstream gene-interactions control development. One project in the lab focuses on how cell signaling regulates ectodermal patterning during gastrulation to establish the otic placode, the precursor of the inner ear. Our recent work shows that localized Fgf signaling is especially critical for inducing formation of the otic placode, and members of the Pax2/5/8 family of transcription factors are important mediators of Fgf signaling. During later stages of inner ear development, we are exploring how sensory hair cells and neurons are regulated. Our studies address how these cells initially form, how they are genetically maintained, and how they become specialized for hearing vs. balance. We are also investigating how zebrafish can replace dead and damaged hair cells, an ability that mammals have lost. The inability to regenerate hair cells explains why humans show progressive irreversible hearing loss as we age. It is hoped that activating or augmenting human homologs of genes shown to operate in zebrafish might help restore hearing and balance in humans.",Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n0dbb8253
Charles,Love,Professor,,Professor,Large Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/n0fc9f72c
Emily,Wilson,Professor,"The goals of my lab are to understand the role of mechanical forces in vascular growth and remodeling processes. Cells within the blood vessel wall are exposed to numerous mechanical forces including fluid shear stress, circumferential wall stress, and axial stress as part of their normal environment and alterations in these parameters plays important roles in the development and progression of vascular pathologies such as atherosclerosis, hypertension and aneurysms. Our experiments are focused on how understanding how vascular smooth muscle cells sense changes in the mechanical environment and how this leads to changes in gene expression and cellular phenotype.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n105bddf7
Michael,Criscitiello,Professor and Associate Dean for Research and Graduate Studies,"My Comparative Immunogenetics Laboratory studies immunology, molecular genetics and evolution. Most of our group's research focuses on the natural history and future application of the vertebrate adaptive immune system, with particular attention given to the genetics of lymphocyte antigen receptors. Particular expertise lies in the evolution of vertebrate immunoglobulin loci, T cell receptor loci and the major histocompatibility complex. Additionally, we are interested in the evolution of diversification mechanisms at work there (e.g., recombination activating genes (RAG), activation-induced cytidine deaminase (AID), and the high allelic polymorphism maintained by classical MHC genes). Most recently, we have been working on lymphocyte development in shark thymus that suggests plasticity across the B lymphocyte/T lymphocyte divide, immunoglobulin heavy and light chain isotype pairing in an amphibian system, immunogenetics in marine mammals of conservation importance, mucosal humoral immunity in diverse tetrapods and cattle antibodies with an unheralded domain extending for novel antigen binding possibilities.",Associate Dean for Research and Graduate Studies||Professor,School of Veterinary Medicine and Biomedical Sciences||Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n11e21ca8
Jorge,Cruz-Reyes,Professor,"We combine approaches in molecular genetics, structural biology, biochemistry, proteomics, and bioinformatics to study the amazing RNA biology of trypanosome parasites. One research line is on an RNA editing process by uridine insertion and deletion that creates amino acid coding triplets in most mRNAs. Yet a single error in the U-changes yields a frame-shift. Trypanosomes split from other eukaryotic lineages over a hundred million years ago, yet this editing has analogies with RNAi, CRISPR/Cas9, mRNA splicing and other systems directed by small non-coding RNAs (ncRNAs).",Professor||Professor,Texas A&M AgriLife Research||Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n147e77ee
Friedhelm,Schroeder,Professor,Intracellular lipid transfer proteins; lipid metabolism; multiphoton imaging of intracellular lipid transport and targeting in living cells and tissues of gene targeted animals.,Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n157063e2
Stratos,Pistikopoulos,Professor,"The objective of my research programme is to develop fundamental theory and optimization based methodologies and computational tools that enable process engineers to analyze, design and evaluate process manufacturing systems which are economically attractive, energy efficient and environmentally benign, while at the same time exhibit good performance characteristics like flexibility, controllability, robustness, reliability and safety.",Director||Professor,Energy Institute||Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/n1aaac28f
Charles,Long,Professor,"My laboratory is currently working on a number of projects involving genetic engineering in cattle, goats, sheep and horses. We use CRISPR/Cas gene editing to specifically alter the coding sequence of genes in sheep to produced biomedical models of human disease, specifically hypophosphatasia. My lab is actively working on projects to produce gene edited cattle that are resistant to respiratory disease. We have also successfully used gene editing to correct the glycogen branching enzyme deficiency mutation in horses. We are also interested in altering the carcass characteristics of beef cattle by genetic engineering genes specifically related to meat tenderness in Bos indicus cattle. Other projects in the lab involve the use of mesenchymal stem cell-based therapies for treatment of equine disease and in particular methods for using these cells to over express proteins that can modulate the inflammatory response. We also have interest in using livestock as bioreactors to produce biotherapeutics and vaccine antigens in their milk. I have extensive experience in using genetic engineering in combination with assisted reproductive technologies (including somatic cell nuclear transfer) to produce live animals.",Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n1dc326d5
Emile,Schweikert,Professor,"Our research explores the extreme limits of analytical chemistry: the characterization of atto to zeptomole quantities of molecules. The aim is to detect such amounts of analyte within nanometric surface volumes. The goal is chemical imaging of surfaces with exquisite spatial resolution. The first challenge is to conceive methods and instrumentation for the accurate identification of as little as a few thousand molecules. The second challenge is to convert a measurement into analytical information. A measurement by itself, even a spectacular one such as detection of a single atom or molecule, is not sufficient. Measurements must be related to the physico-chemical system sampled in terms of concentration and/or spatiotemporal localization.
Our experimental procedure is based on the desorption of atomic and molecular species when a solid is bombarded with energetic massive projectiles such as, for example, C60+ or Au4004+ . Their impact causes abundant emission of neutral and ionized atoms, molecules and molecular fragments. The desorbed ions are detected by time-of-flight mass spectrometry. The experimental procedure is that of secondary ion mass spectrometry with two innovations: the massive nature of the projectile and the mode of bombardment which is in a sequence of individual massive cluster impacts each isolated in time and space. Multiple ions can be ejected from a single impact. Given the size of the projectile (<= 3 nm in diameter), the co-ejected ions must originate from molecules colocated within nanometric dimensions.
The new capabilities for detecting, localizing and tracking small numbers of molecules (10-18 to 10-21 moles) are tested on surfaces, membranes, and nano-objects selected for their relevance in catalysis, microelectronics, environmental and biomedical research.",Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n233d0627
Yassin,,Distinguished Professor,,Professor||Professor and Head||Faculty Affiliate,Mechanical Engineering||Energy Institute||Nuclear Engineering,https://scholars.library.tamu.edu/vivo/display/n24b7e601
David,Russell,Professor,"My research focuses on proteomics, lipidomics, biophysical chemistry and application and development of mass spectrometry, such as ""label-free"" nano-particle based biosensors and novel peptide/protein isolation and purification strategies. We are also investigating the structure(s) of model peptides in an effort to better describe folding/unfolding and structure of membrane and intrinsically disordered (IDP) proteins. Peptides take on very different 2?, 3? and 4? structure, which determine or influence bio-activity. In the presence of lipid vesicles peptides can exist as solution-phase species, ""absorbed"" on lipid bilayers or ""inserted"" (as a monomer or multimer) in lipid bilayers. By what mechanism do peptides interact with lipid membranes to affect these structural changes, how do peptide-lipid interactions promote self-assembly to form intermediates that eventually yield aggregates, i.e., amyloid fibrils, or how does metal ion coordination affect the structure of metalloproteins? Mass spectrometry-based experiments, hydrogen/deuterium (H/D) exchange, chemical 'foot-printing' and gas-phase (ion-molecule and ion-ion reaction chemistry) and solution-phase chemical modifications, have expanded our abilities to address such questions, and new instrumental approaches, esp. ion mobility spectrometry (IMS) combined with enhanced molecular dynamics simulations (MDS), have become standard tools for structural-mass spectrometry studies. Over the past several years we have either acquired or developed novel, next-generation IM-MS instruments that are redefining cutting-edge structural-mass spectrometry research as well as cutting-edge computational tools essential to carry out these studies. Our new laboratories in the Interdisciplinary Life Sciences Building (ILSB) provides exciting opportunities for collaborative, interdisciplinary research with chemical-biologists, biochemists and other chemists.",Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n280e03e6
Virender,Sharma,Professor,"My research focuses on (1) chemistry and application of ferrates, (2) formation, fate, and toxicity of silver and gold engineered and natural nanoparticles in aquatic environment, (3) applications of ferrites to destroy toxins and pollutants under solar light, and apply carbon-based materials to remediate contaminated water",Faculty Affiliate||Professor,Energy Institute||Environmental and Occupational Health,https://scholars.library.tamu.edu/vivo/display/n28508dfb
Mariappan,Muthuchamy,Professor,"The main goal of our laboratory is to understand the molecular mechanisms of cardiac muscle dynamics in normal and diseased states. Particularly, our interests focus on the relationships between thin filament activation and crossbridge kinetics, and how the mechanotransduction signaling transmits to myofilament activation. We use multiple techniques, molecular, cellular, biochemistry, structural and biophysical, to obtain information on the fundamental regulatory mechanisms of cardiac muscle contraction.
Our lab group is also investigating the role of lymphatics in different tissue beds, including mesentery, skeletal muscle, and brain using various animal models.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n2877399b
Dana,Gaddy,Professor,"My laboratory has been engaged in multiple areas of NIH-funded musculoskeletal research since 1996. We were the first to identify the non-steroidal gonadal inhibin hormones in regulating the hypothalamic-pituitary-gonadal-skeletal axis in mice, and the role of changes in inhibins that signal the onset of menopause (reproductive aging) to the onset of increasing bone turnover. We also demonstrated the anabolic effect of continual Inhibin exposure in normal mice and in bone repair. Our cellular focus on Inhibins and the related factor, Activin A revealed that Activin A suppresses local bone resorption through suppression of osteoclast formation, motility and survival. Our ongoing work is in the area of specific inhibin/betaglycan receptor interactions that mediate the effects on bone cells. We are also greatly interested in improving the low bone mass that we were the first to identify in both humans with Down Syndrome (DS) and in mouse models of DS as a low bone turnover disease. Our current NIH-funded research is working to identify the mechanisms of reduced fracture healing and compromised bone regeneration in Down Syndrome. We have demonstrated the efficacy of both PTH and SclAb in DS, and are now actively testing nutriceuticals to increase bone mass in mouse models of Down Syndrome. The limitations of using mouse models to study bone disease led us to our most recent and exciting endeavors in collaboration with TAMU experts in reproduction and embryo transfer technologies to develop a large platform model of bone disease, using sheep. We have generated the first large animal model of hypophosphatasia (HPP) via high efficiency gene editing of a knock-in point mutation in the ALPL gene, whose musculoskeletal and dental phenotypes are consistent with human HPP. We are now using this model to determine the etiology of mineralization deficiencies, muscle weakness and premature tooth loss by analysis of longitudinal biopsies and analysis of muscle, bone and dental specimens using CT, microCT, mechanical testing, immunohistochemistry, histomorphometry and ex vivo bone marrow cultures.",Professor||Adjunct Professor,Veterinary Integrative Biosciences||Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n2dc10a1a
Shaodong,Guo,Professor and Presidential Impact Fellow,"The long-term goal of our research is to study the molecular mechanisms of insulin signal transduction, insulin resistance and associated cardiovascular dysfunction, aiming at nutritional and therapeutic intervention for control of metabolic and cardiovascular disorders. My laboratory is focused on the study of cellular signaling and gene transcriptional regulation of metabolic homeostasis that are governed by the PI3K->Akt->FoxO pathway, with the hope of understanding how dysregulation of this pathway in insulin/IGF-1 action causes liver damage, cardiovascular dysfunction, and pancreatic beta cell failure, resulting in diabetes, obesity, and organ failure.",Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n2ef8f395
Edward,Vargo,Professor,"We use molecular genetic tools, primarily microsatellite markers and mtDNA sequence data, to conduct basic and applied studies of termites and other insect pests of human structures. Our work on termites encompasses the breeding structure of colonies, colony and population genetic structure, invasion biology, foraging areas, colony densities and population dynamics. Research on other structural pests, mainly ants, cockroaches and bedbugs, focuses on population genetic structure, invasion biology, and dispersal.",Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/n3165cf9e
Pingwei,Li,Professor,"The research in my lab focuses on elucidating the structural basis of innate immune responses towards microbial nucleic acids. The cGAS/STING pathway plays a central role in innate immunity toward bacterial and viral DNA. cGAS is activated by dsDNA and catalyzes the synthesis of a cyclic dinucleotide cGAMP, which binds to the adaptor STING that mediates the recruitment and activation of protein kinase TBK1 and transcription factor IRF-3. Activated IRF-3 translocates to the nucleus and induces the expression of type I interferons (IFN), an important family of antiviral cytokine. To elucidate the mechanism of cGAS activation, we determined the structures of cGAS in isolation and in complex with DNA. The cGAS/DNA complex structure reveals that cGAS interacts with DNA through two binding sites. Enzyme assays and IFN-? reporter assays of cGAS mutants demonstrate that interactions at both DNA binding sites are essential for cGAS activation. To investigate how cGAMP activates STING, we determined the structures of STING in isolation and in complex with cGAMP. These structures reveal that STING forms a V-shaped dimer and binds cGAMP at the dimer interface. We have also determined the structures of TBK1 in complex with two inhibitors, which show that TBK1 exhibits an I?B kinase fold with distinct domain arrangement. To elucidate the mechanism of IRF-3 recruitment by STING, we determined the structure of a phosphorylated STING peptide bound to IRF-3. To understand how phosphorylation activates IRF-3, we solved the structure of an IRF-3 phosphomimetic mutant bound to CBP, which reveals how phosphorylation induces the dimerization and activation of IRF-3.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n31ebad17
Vladislav,Panin,Professor,"It has been long recognized that glycans play a wide spectrum of essential roles in metazoan organisms, while defects in glycosylation are involved in numerous human diseases and abnormalities, from cancer to brain malformation and defects of immune system. However, the complexity of glycosylation pathways and limitations of genetic and in vivo approaches available for studying glycosylation in higher animals significantly impede the research in mammals. We are using the advantages of Drosophila model system, including its decreased genetic redundancy, powerful arsenal of molecular genetic approaches, and comprehensively characterized development, to elucidate mechanisms underlying the function of glycosylation in development and physiology. We employ a multidisciplinary approach to study the roles of several novel glycosyltransferase genes at molecular, cellular, and organismal levels. Currently, our laboratory is involved in two main projects: one project focuses on studying the function of sialylation in the central nervous system, while another project is aimed at elucidation of molecular mechanisms of protein O-mannosylation.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n337aaa32
Paul,Samollow,Professor,"Comparative functional genomics and genome evolution in vertebrates; structural organization of genetic material and its relationship to patterns of gene regulation and expression within and among species. Epigenetics of meiotic recombination; patterns and epigenetic determinants of sexual dimorphism in meiotic recombination rates and chromosomal distributions. Population genomics: genetic and ecological processes that influence the distribution of genetic diversity within and among populations in nature; population structure, isolation, and speciation. QTL mapping: linkage mapping to detect genes that influence physiologic and health-related traits. Research in my laboratory focuses primarily on the genome of the gray, short-tailed opossum, Monodelphis domestica, the world's primary laboratory marsupial model for genomic, biomedical, and evolutionary research. We also study isolated desert populations of pupfishes of the genus Cyprinodon in west Texas.nature, and their roles in promoting population structuring, isolation, and speciation. QTL mapping: linkage mapping to detect genes that influence physiologic and health-related traits. Research in my laboratory focuses primarily on the genome of the gray, short-tailed opossum, Monodelphis domestica, the world's primary laboratory marsupial model for genomic, biomedical, and evolutionary research. We also study isolated desert populations of pupfishes of the genus Cyprinodon in west Texas.",Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n38c16b10
Lane,Baker,Professor,,Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n3b0176ae
Luc,Berghman,Professor,"The hallmark of my research career is the development of novel antibodies and applying them toward the development of new immuno-biotechnological tools. My lab has developed an antibody discovery platform in chickens that goes from in silico sequence to epitope-specific chicken IgG (IgY) in less than 3 weeks based on in vivo CD40-targeted immunogen delivery.
Research projects include the study of the immune response in the chicken, especially the function of CD40-positive antigen presenting cells (such as the dendritic cells) in activating the humoral immune response and the development of chicken egg yolk antibodies, monoclonal antibodies and recombinant antibodies for diagnostic, prophylactic and therapeutic purposes. a Dr. Berghman was the recipient of the 2016 Zoetis Fundamental Science Award.",Professor||Professor,Poultry Science||Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n3e016f20
Robert,Chapkin,Distinguished Professor,"Research in the Chapkin lab focuses on dietary/microbial modulators related to the prevention of cancer and chronic inflammatory diseases.
Our central goal is to (1) understand cancer chemoprevention at a fundamental level, and (2) to test pharmaceutical agents in combination with dietary/microbial (countermeasures to the Western diet) to more effectively improve gut health and reduce systemic chronic inflammation. Since diet influences gut microbiota composition and metabolite production, to unravel the interrelationships among gut health and the structure of the gut microbial ecosystem, we are in the process of evaluating (using transgenic mouse, Drosophila models and humans) how the gut microbiome modulates intestinal cells, innate immune cells and tumors. As part of this endeavor, we are modeling at the molecular level the dynamic relationship between diet and gut microbe-derived metabolites which modulate chronic inflammation and the hierarchical cellular organization of the intestine, e.g., stem cell niche.",Distinguished Professor||Professor,Biochemistry and Biophysics||Nutrition,https://scholars.library.tamu.edu/vivo/display/n3fbb59f8
Thomas,Mcdonald,Professor,"My research focuses on environmental chemistry, petroleum geochemistry, and general organic chemistry.",Professor,Environmental and Occupational Health,https://scholars.library.tamu.edu/vivo/display/n407d0459
Qinglei,Li,Professor,"My long-term research goal is to identify the cellular and molecular basis of pregnancy failure and uterine dysfunction, thereby contributing to a framework for developing novel diagnostic and therapeutic strategies to improve reproductive potential. To benefit human and animal health, research in my lab focuses on defining the mechanism underlying uterine development and the pathogenesis of gynecologic cancers. My laboratory has created mouse models that harbor genetic modifications of critical transforming growth factor ? (TGF?) signaling components using conditional loss-of-function and gain-of-function approaches in the uterus. These models have yielded new insights into the fundamental roles of TGF? signaling in reproductive tract development and function. We have also developed pre-clinical mouse models for ovarian granulosa cell tumor and endometrial cancer. These disease models may be harnessed to uncover new opportunities for cancer treatment.",Professor||Professor,The Texas A&M University System||Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n408645cd
Micky,Eubanks,Professor,,Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/n40f09614
Geoffrey,Kapler,Professor and Chair,"Dr. Kapler's broad research interests are concerned with the replication and transmission of eukaryotic chromosomes. The failure to completely replicate the genome during S phase or partially re-replicate chromosomes leads to genome instability- a hallmark of cancer cells. The central questions investigated in the laboratory are concerned with how replication initiation sites are established in chromosomes and how they are regulated during conventional (G1/S/G2/M) and alternative cell cycles, including endoreplication (gap-S-gap-S...) and locus-specific gene amplification. The current focus of the lab is to use high throughput (nascent strand) DNA sequencing to generate a comprehensive map of replication initiation sites under different physiological conditions.",Professor and Chair||Professor,Cell Biology and Genetics||Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n4128afa1
James,Batteas,Professor,"The research in our group is organized around three main projects: nanoscale materials and devices, biological surfaces and interfaces and nanotribology,
with the overarching goal of developing custom engineered surfaces and interfaces. This requires obtaining a fundamental (molecular level) understanding of the underlying chemistry and physics of the systems in question to afford rational approaches to test and develop new technologies. In much of our research we employ a range of scanned probe microscopies such as scanning tunneling microscopy (STM) and atomic force microscopy (AFM) to probe structure and to manipulate materials at the nanoscale.",Faculty Affiliate||Professor||Faculty Fellow||D. Wayne Goodman Professor of Chemistry,Center for Health Systems and Design||Energy Institute||Chemistry||Chemistry,https://scholars.library.tamu.edu/vivo/display/n413d1dff
Shannon,Glaser,Professor,"The long-term goal of my research program is to understand how activated (proliferating) cholangiocytes participate in the progression of cholestatic liver diseases and eventual development of cholangiocarcinoma. My research is focused on elucidating the factors (such as, mechanical stress) and intracellular signaling mechanisms that regulate cholangiocyte proliferation and biliary fibrosis during extrahepatic cholestasis.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n424a02f1
Loren,Skow,Professor,Comparative genomics of mammals with emphasis on organization and evolution of the mammalian genome; molecular analysis of the major histocompatibility complex of hoofed animals; genetic mechanisms of inherent resistance to infectious diseases.,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n4326eaa3
Sakhila,Banu,Professor,"My long-term goals are two-fold: 1) to understand the molecular mechanism of prenatal CrVI exposure on placental and fetal development, ovarian and uterine function, and pregnancy outcome, and; 2) to understand the protective effects of various natural and synthetic antioxidants (such as edaravone, glutathione, vitamin C and resveratrol) against the deleterious effects of heavy-metals, CrVI in particular. Current research in my lab is focused on the study of reproductive and developmental toxicity of CrVI. Drinking water contamination with CrVI in the United States is a growing problem due to increased usage of CrVI and improper disposal of Cr waste into the environment. Significant contamination with CrVI has been found in the drinking water sources of all the states in the U.S. Effects of Cr on reproductive health in women and development in children have received less attention. Epidemiological data document that women exposed to Cr in environmental or occupational settings suffer from infertility, gynecological problems, congenital malformation of fetuses, neonatal mortality, and premature abortions with increased levels of Cr in their blood, urine and placenta. Cr can bind directly to DNA and nuclear proteins, cause DNA strand breaks and mutations, alter the balance between reactive oxygen species (ROS) and antioxidants, and activate several cell signaling pathways. Therefore, my current research objective is to determine molecular pathways and identify target genes/proteins by which Cr alters prenatal development and organogenesis of female reproductive system in the offspring.",Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n4783d1f1
Van,Wilson,Professor,"My area of specialization is the molecular biology of papovaviruses, with a primary focus on how viral proteins modify the host cell environment. Recently, we determined that the viral replication proteins, E1 and E2, are post-translationally modified by addition of 1 or more SUMO moieties. Sumoylation is a widespread modification whose biological functions are only recently becoming understood. Studies are in progress to 1) determine the role of sumoylation in the viral life cycle, 2) evaluate the effect of sumoylation on the structure and activity of the E1 helicase, 3) understand the mechanism by which sumoylation influences E2 stability and transcriptional activity, and 4) determine how sumoylation is modulated by the viral E6 oncoprotein. In addition to the role of sumoylation in the viral life cycle, we are also exploring how sumoylation participates in normal keratinocyte differentiation. We have developed a keratinocyte cell line inducibly expressing a tagged SUMO moiety to facilitate proteomics studies of sumoylation changes and regulation during controlled differentiation.",Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n4837bbf9
Hong,Liang,Professor,,Faculty Affiliate||Professor||Affiliated faculty,Mechanical Engineering||Energy Institute||Materials Science and Engineering,https://scholars.library.tamu.edu/vivo/display/n4923e41d
Thomas,Kent,Professor,"Neurologist and clinician scientist with a basic, translational and clinical research program, focused mostly on stroke and other brain injuries. The laboratory utilizes a variety of cell free, tissue culture and in-vivo techniques to design and characterize a series of carbon nanomaterials that possess the ability to act as catalytic antioxidants as well as support key mitochondrial functions. This NIH-supported research is in collaboration with synthetic nano-chemists at Rice University (Tour Lab) and biochemists at University of Texas Health Science Center Houston (Tsai Lab). The group is testing a variety of engineered modifications of these versatile, non-toxic materials to address specific cell injury and death mechanisms including ferroptosis and interruption in electron transport and oxidative phosphorylation.
A major interest of ours is the role of diabetes in worsening outcome from stroke, a condition that affects minority and rural Texans disproportionally. With a range of research from molecular interactions to whole animal and clinical studies, the work in this lab is deeply translational, leveraging the group's clinical training and experience to insure that conclusions have direct relevance to the disease state, with the ultimate goal of facilitating the identification of new therapies for these major contributors to disability and mortality.",Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/n4acd1da6
Yinan,Wei,Professor,"We are interested in studying the interaction between microbes and host systems, in the context of antibiotic resistance, infection, and the innate immune response.",Professor,Pharmacy Practice,https://scholars.library.tamu.edu/vivo/display/n4bb89912
Cynthia,Meininger,Professor,"My research focuses primarily on the vascular complications of diabetes. Using animal models of human diabetes, we have demonstrated that an inability of endothelial cells to produce nitric oxide may be partly responsible for these vascular complications. We are developing a gene/drug therapy approach for treating cardiovascular disease associated with diabetes. Targeted nanoparticles will deliver either the gene for GTPCH or BH4 itself into endothelial cells oxidatively damaged by diabetes to correct endothelial GTPCH deficiency, increase tetrahydrobiopterin levels, restore nitric oxide production and reverse the vascular dysfunction seen in diabetes. Our endothelium-targeting nanoparticle approach will not only reverse the damage caused by disease but will increase antioxidant levels to protect the endothelial cells from future damage and/or dysfunction.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n531a623d
Jorge,Seminario,Professor,"Dr. Seminario's research covers several aspects of nanotechnology such as the analysis, design, and simulation of systems and materials of nanometer dimensions--especially those needed for development and systems for energy, nanosensors and nanoelectronics. Among his recent goals is the design of smaller, cleaner, more efficient and faster devices for energy production and storage as well as for detection of chemical, biological and nuclear agents. He has developed new scenarios for nanodevice architectures using a multiscale and multidisciplinary approach that progresses from the atomistic level to the final product, guided by first principles calculations.",Faculty Affiliate||Professor,Energy Institute||Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/n563c3880
Jean-Philippe,Pellois,Professor,"Our goal is to determine how proteins function in space and time in the context of complex cellular networks. We focus on chemistry-driven approaches to manipulate protein structure beyond what is feasible with standard genetics. In particular, we use semi-synthetic light-activatable proteins as biophysical probes to investigate protein mechanisms inside living cells. Areas of interest include the important but poorly understood process of protein S-acylation, signal transduction, and protein trafficking.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n5815f42d
Sonya,Gordon,Professor,,Professor,Small Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/n5ac1c075
Jaime,Alvarado-Bremer,Professor,,Associate Professor||Professor,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences||Marine Biology",https://scholars.library.tamu.edu/vivo/display/n5b437859
Jianxun,Song,Professor,T cell biology
T cell-based immunotherapy
Cell metabolism,Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n5b9879a8
Wenshe,Liu,Bovay Chair and Professor in Chemistry,"Our research interest is to design methods for the genetic incorporation of noncanonical amino acids into proteins in living cells and apply these methods in three major directions: deciphering functions of protein posttranslational modifications, small molecule sensing, and expanding chemical diversities of phage display libraries. To study protein posttranslational modifications, we have constructed methods for the site-specific installation of lysine acetylation and methylation in proteins and will apply them to study functional roles of these two modifications on p53, a tumor suppressor protein. We have also developed a strategy to site-specifically install two noncanonical amino acids into one protein in E. coli and are applying this approach to construct biosensors for small organic molecules and metal ions. Phage display is an efficient method to identify peptides for therapeutic interventions. However, a phage display peptide library has limited structure motifs and functional groups because only 20 natural amino acids can be used to generate a library. We plan to expand the chemical diversity of a phage display library by incorporating multiple noncanonical amino acids and chemically modifying them to extend functional diversities. Screening this unnatural phage display library against therapeutic targets such as c-Abl tyrosine kinase is expected to identify highly potent inhibitors.",Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n5d9506ea
Svetlana,Sukhishvili,Professor,"My research focuses on stimuli-responsive all-polymer and polymer nanocomposite assemblies for sensing, separation and biomedical applications; structure and dynamics of polyelectrolyte assemblies; materials with controllable optical, swelling and drug-release responses; remote manipulation of material shape; smart antibacterial materials; and surface modification for controlling wettability, adhesion and adsorption.",Professor,Materials Science and Engineering,https://scholars.library.tamu.edu/vivo/display/n616e513c
Ann,Kier,Professor Emerita,,Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n6c0ad160
Zixiang,Xiong,Professor,"My research interest include distributed source coding for sensor networks, data hiding, and network information theory Joint source-channel coding, networked multimedia and data compression Genomic signal processing Network traffic smoothing and modeling.",Professor,Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n6d2fe7ec
William,Park,Professor,"Most of our work in the last few years has focused on manipulating starch biosynthesis in plants. This has led to the identification of a number of specific DNA polymorphisms that have a profound impact on the structure and functional properties of starch granules. Interestingly, the effect of some of these polymorphisms is temperature sensitive. For example, a key G/T polymorphism at the 5' leader intron splice site of rice granule bound starch synthase has little phenotypic effect at 18 ?C, but at 25 ?C it activates an alternate splice site that results in a premature open reading frame. At 32 ?C, a third nonconsensus TT/GT splice site is activated. This type of temperature sensitivity is one of the key factors responsible for the complex genotype x environment relationships seen in starch structure and represents a good target for manipulation via biotechnology. We have also worked with an industrial partner and a breeder to develop the first commercial rice varieties specifically tailored to work with a new type of processing technology and to identify the genes responsible for optimal raw material/process interactions. Other work in the laboratory is focused on the identification and manipulation of DNA polymorphisms associated with disease resistance and with herbicide resistance in the wild relatives of crop plants.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n7012b9fe
Robert,Burghardt,Professor,"Research in the laboratory is focused on investigating mechanisms by which a variety of biological response modifiers ranging from mechanical signals, hormones and growth factors to environmental chemicals alter cellular signaling pathways and cellular homeostasis.","Professor||Director, Image Analysis Laboratory",School of Veterinary Medicine and Biomedical Sciences||Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n70a3d026
Keyan,Zhu Salzman,Professor,"Over millions of years of co-evolution with insects, plants have developed various defense machineries that can be activated in response to insect herbivory. Insects, in turn, have developed a variety of strategies to evade these plant defense mechanisms. An improved understanding of this complex plant defense and insect counter-defense relationship will facilitate development of better strategies to improve host plant defense. Currently, we are using Arabidopsis to study plant defense signal transduction pathways against insect pests. Meanwhile, since effectiveness of plant defense is also determined by the insect response, my laboratory is also investigating how insects adapt to the challenge of plant defense molecules, as well as to human imposed management strategies, and is working to identify new insect vulnerable systems.",Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/n716ece47
Larry,Johnson,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n72de4d00
Frances,Ligler,Professor,,Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/n74321a1f
Michael,Thomson,Professor,"My research expertise is in plant molecular breeding with an emphasis on rice genetics and genomics, international agriculture, and developing CRISPR-based gene editing approaches for efficient gene validation and trait development. My primary objective is to apply new genetics discoveries to rice improvement to help Texas producers and rice farmers around the world produce higher yields of superior quality rice in an environmentally sustainable manner. I am also leading the AgriLife Research Crop Genome Editing Lab to optimize high-throughput gene editing across a number of diverse crop species.",Professor,Soil and Crop Sciences,https://scholars.library.tamu.edu/vivo/display/n74c30954
Terry,Thomas,Professor,"My interests are evolutionarily broad and include animals, plants and fungi. A major focus of the lab is the genomic analysis of gene expression programs during plant gene expression programs, particularly during embryogenesis and seed development, and the underlying regulatory mechanisms required for the initiation and maintenance of these programs. This work has illustrated the combinatorial interactions of cis and trans -acting factors that result in specific gene regulatory events. We are also using genomics tools to study the interaction of the rice blast fungus, Magnaporthe grisea , with plant hosts; the circadian control of gene expression; and the development of the vertebrate retina. An additional focal area is the utilization of molecular and cellular approaches for crop improvement. As part of these research activities, we have developed or adapted high throughput genomics approaches to accelerate the gene discovery process and subsequent analysis of gene expression and function.",Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n79201ac5
Kung-Hui (Bella),Chu,Professor,"Our research interests are in enhancing our understanding of microbial-mediated processes in natural and engineered systems, and in application and development of biotechnology to address various environmental challenges in water, soils, and energy. The Chu lab applies molecular biology, isotopic techniques, chemical analysis, and phage biology to study environmental and biological systems, with focuses on (i) microbial ecology, fate and transport, biodegradation of environmental pollutants such as emerging contaminants and persistent organic pollutants, (ii) production of biofuels and bioproducts from renewable resources, and (iii) detection, tracking, and quantification of microorganisms that play roles in water quality, bioremediation, carbon sequestration and nitrogen cycle in the environment. Other research areas include development and application of novel sorbents and catalysts (bio and non-bio) for removing and/or monitoring emerging environmental pollutants.",Faculty Affiliate||Professor,Civil Engineering||Energy Institute,https://scholars.library.tamu.edu/vivo/display/n7a373eec
Gerard,Cote,Professor,,Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/n7bbfddf5
Francis,Rouquette,Professor,"Primary aspects of this plant-animal interface research program includes simultaneous quantifying of forage persistence and sustainability with animal responses to stocking strategies and grazing intensities. Component research areas include forage germplasm evaluations for team-released varieties; assessment of soil nutrient status under long-term nutrient cycling with fertilizer-stocking regimens; cow-calf and stocker performance on bermudagrass, small grains, ryegrass, and clover; and lifetime animal performance attributes from birth-to-pasture-to-feedlot-carcass with database archival on BeefSys.",Professor||Professor,Soil and Crop Sciences||Overton Research and Extension Center,https://scholars.library.tamu.edu/vivo/display/n82f8d1bd
Allison,Rice-Ficht,Senior Associate Vice President for Research,"Studies in the our lab are currently focused on the use of unique biomaterials for controlled release of live and subunit vaccines. Our focus is currently directed to the production of vaccines against human Brucellosisand Q fever, but will be applied to the storage and delivery of other vaccines. A study of specific immune mechanisms and potentiation through controlled releases is underway. Another focus is the study of alpha crystalline structure and function. These unique proteins protect against thermal insult and modulate folding and activity of other proteins",Professor||Senior Associate Vice President for Research,Cell Biology and Genetics||Division of Research,https://scholars.library.tamu.edu/vivo/display/n84a56c5b
Rosemary,Walzem,Professor,"Dr. Walzem's core research focus within the laboratory is directed towards understanding how the structure of triglyceride-rich lipoproteins influences their ability to carry out specific nutrient delivery tasks. Her studies include identification of mechanisms and regulatory processes that control the assembly of trigylceride-rich lipoproteins in issues, structural studies of lipoproteins themselves and physiological studies to determine substrate properties and metabolic fates of different types of lipoproteins. Diet can significantly alter lipoprotein physiology through multiple mechanisms, and studies of diet effects provides a significant sub-theme to the research program. A variety of species are used to address specific questions, however, avian and human lipoprotein metabolism as it relates to egg production and atherogenesis, respectively, are emphasized.",Professor,Poultry Science,https://scholars.library.tamu.edu/vivo/display/n85cd191f
Hongbin,Zhang,Professor,"My research is focused on genomics and systems biology in crop plants, particularly development of genomic and systems biological knowledge and new or advanced technologies for enhanced crop research and breeding. These include re-establishing of the molecular basis and mechanisms of genetics and biology; cloning and characterization of genes and quantitative trait loci (QTLs) controlling traits of agronomic importance; deciphering of the molecular mechanisms of biological phenomena or traits of importance such as quantitative genetics, epigenetics, crop yield, crop quality, heterosis and plant polyploidization; and development of molecular toolkits and associated pipelines for next-generation enhanced crop breeding such as gene-based breeding and crop production such as molecular precision agriculture.",Professor,Soil and Crop Sciences,https://scholars.library.tamu.edu/vivo/display/n8ad1df35
Michael,Polymenis,Professor,"The promise for the treatment of proliferative disorders, with incalculable potential benefits to human health, has driven basic research into the genetic control of cell division for decades. However, what determines when cells initiate their division remains mysterious. It is as if we are staring at a beautiful engine, with little knowledge about what turns it on. How cells are set off to a new round of cell division, remains as one of the most fundamental, unanswered questions. It is virtually unknown which cellular pathways affect initiation of division, which factors operate within each pathway, the extent of interactions between pathways, and how each pathway is molecularly linked to the machinery of cell division. Our studies aim to answer these questions using baker's yeast. This model organism has a machinery of cell division that is very similar to that of human cells, and it is suited for genetic and biochemical studies.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n8c9420b2
David,Threadgill,Professor,"Our laboratory uses the mouse as an experimental genetic model to investigate factors that contribute to inter-individual differences in health and disease. Ourcurrent research activities include the identification and functional characterization of alleles contributing to cancer susceptibility, the function of theErbbgenefamily in development and disease, and the role of genetic variation in response to environmental stimuli. To support these investigations, we also aredeveloping new genetic tools to support mammalian systems genetic approaches to phenotypes with complex genetic and environmental etiologies.",Director||Professor||Professor||Professor,Cell Biology and Genetics||Institute of Genome Sciences and Society||Biochemistry and Biophysics||Nutrition,https://scholars.library.tamu.edu/vivo/display/n8ee0b54f
James,Sacchettini,Professor,"My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n90385563
Weston,Porter,Professor,y laboratory is interested in determining the role of factors in normal development and how disruption of these pathways results in associated pathologies.,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n90e6f6c0
Hisashi,Koiwa,Professor,,Professor,Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/n931bc4cc
Susan,Ayres,Professor,"My research focuses on the intersections between law, literature, and culture.",Professor,School of Law,https://scholars.library.tamu.edu/vivo/display/n939eb064
Timothy,Phillips,Professor,food safety; molecular toxicology; elucidation of fundamental chemical mechanisms of toxic action/interaction of food-borne carcinogens; mutagens; and developmental toxicants; and development of methods to detect and detoxify foodborne and environmental toxins.,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n94eef946
Terje,Raudsepp,Professor,"Comparative genomics and molecular cytogenetics of animals, birds and other vertebrates organization, function and evolution of sex chromosomes; equine genomics - genomics of genetic diseases and disorders of sexual development and reproduction; alpaca and camelid genomics.",Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n970d3a82
Nancy,Ing,Professor,"Dr. Ing's research interests focus on understanding how hormones regulate gene expression in animal tissues. Current research projects investigate the earliest days of pregnancy in the sheep uterus and the regulation of estrogen receptor gene expression, as well as stress hormone effects on gene expression in the stallion testes. Most recently, we have been studying the RNAs in sperm from stallions and honey bees in order to find a pattern consistent with high fertility.",Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/n98a4a111
Jeetain,Mittal,Professor,Dr. Mittal's research focuses on biomolecular self-assembly processes with a specialization in protein phase separation and nanoparticle superlattice design.,Professor,Artie Mcferrin Department of Chemical En,https://scholars.library.tamu.edu/vivo/display/n9c511486
Xiaohua,Liu,Professor,"As a bioengineer, I have a broad background in biomedical science and engineering, with specific training and expertise in novel biomaterials design/fabrication, controlled protein release, and the use of stem cells for bone, dental and other tissues repair and regeneration. Some of the our current research projects include:
1. Development of novel biomimetic materials/scaffolds for dental and craniofacial tissue regeneration.
2. Development of controlled drug/growth factor delivery system
3. Development of bio-inspired platform to explore cell-material interactions in three-dimension (3D).",Associate Professor||Professor,School of Dentistry||Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n9cd6704b
John,Stallone,Professor,"Research in my lab focuses on male-female differences in normal cardiovascular function, and in the development of various diseases, including hypertension, coronary artery disease, and stroke, and the roles of the sex hormones in these male-female differences in cardiovascular disease. A major topic of study in my lab is the so-called ""estrogen paradox"" which reveals protective effects of this female sex hormone in younger women and animals, but deleterious effects in older females.",Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n9dab7ff2
Jun,Kameoka,Professor,"My research focuses on Biosensor, chemical sensor, microfluidics.",Faculty Affiliate||Professor,Energy Institute||Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/na22e6ad9
Patrick,Stover,Vice Chancellor and Dean,,Professor||Vice Chancellor and Dean,College of Agriculture and Life Sciences||Nutrition,https://scholars.library.tamu.edu/vivo/display/na2e4838e
Samba,Reddy,Professor,"My major research goals are to understand the molecular pathophysiology and develop novel therapeutic strategies for epilepsy, with an emphasis on neurosteroids and GABA inhibition in the brain. Neurosteroids are steroids synthesized locally within the brain that rapidly change neural excitability by non-genomic mechanisms, principally via postsynaptic GABAA receptors that play critical role in epilepsy. Current work in his lab is focused on uncovering molecular mechanisms of neurosteroids in epilepsy and brain disorders, and testing the efficacy of mechanism-based, rationale therapeutic strategies for epilepsy and epileptogenesis. Reddy lab is utilizing multidisciplinary approaches such as pharmacological, molecular, electrophysiological (patch-clamp), mass spectrometry, and transgenic mouse models in research projects.",Professor,Neuroscience and Experimental Therapeutics,https://scholars.library.tamu.edu/vivo/display/na96b32aa
Srinath,Palakurthi,Professor,,Professor,Pharmacy Practice,https://scholars.library.tamu.edu/vivo/display/nafb53cb2
Christabel Jane,Welsh,Professor,Mechanisms of disease pathogenesis of neurotropic viruses. Immunological therapies for multiple sclerosis and epilepsy. Neuroimmunological changes in the injured CNS,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/nbb081247
Amanda,Macfarlane,Director Food and Nutrition Evidence Center,,Director Food and Nutrition Evidence Center||Professor,Texas A&M AgriLife Research||Nutrition,https://scholars.library.tamu.edu/vivo/display/nbd1502ad
David,Huston,Professor,The overall goal of my laboratory is to understand mechanisms regulating inflammation and thereby develop strategies for modulating immune responses. One project focuses on the role of the cytokine thymic stromal lymphopoietin (TSLP) as the master switch in the pathobiology of allergic inflammation and asthma. The role of allergens and respiratory viruses on the induction of TSLP transcription by mast cells and epithelial cells is being studied in vitro and in human subjects.,Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/nbd68089f
Clint,Magill,Professor,"The use of molecular probes is allowing us to gain new insights into fungal plant pathogens and to host responses to potential pathogens. We are currently developing real-time PCR primers for two downy mildews that are considered to be a threat to maize production if introduced into the US. We are also developing PCR-based tags genes for resistance to headsmut, anthracnose, downy mildew and grain mold in sorghum. These molecular tags will be useful for breeding cultivars with more durable resistance and for cloning specific resistance genes. We have also used PCR to clone segments of the cotton and sorghum equivalents of genes that function in known host defense pathways. These clones are being used to compare the rate and timing of induction of each gene in resistant and susceptible lines following inoculation with a pathogen. Genome wide association studies are being used to identify genes associated with disease response (susceptible or resistant) to several pathogens in sorghum.",Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/nc127cd28
Kevin,Burgess,Professor,"We use novel strategies Exploring Key Orientations (EKO) that feature datamining to compare simulated preferred conformers of chemotypes we design with key features at protein-protein interfaces. Many chemotype candidates can be screened against one PPI, or one chemotype can be screened against all the PPI interfaces in the PDB. Virtual hit chemotypes are prepared in my lab, then tested against protein-protein interactions of biomedicinal interest using an array of biophysical and cellular assays.
We also design small molecules to target cell surface receptors that are selectively overexpressed in cancer cells. Much or our work has been focused on the TrkC receptor that is particularly important to metastatic breast cancer and melanoma. Going forwards we are interested in expanding the targets to include cell surface receptors that are overexpressed when cancer cells undergo aberrant epithelial to mesenchymal transitions (EMT) to produce circulating tumor cells and cancer stem cells. Much of this work involves design and synthesis of the small molecules for this targeting.",Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/nc4a5cad4
Gary,Voelker,Professor,"I am an ornithologist/evolutionary biologist, and my lab focuses primarily on developing molecular phylogenies of avian lineages (and now a few mammals), and using these phylogenies to address questions posed by relationships within those lineages. To date, this research has focused on genera that are distributed on two or more continents (Anthus (pipits), Motacilla (wagtails), Cinclus (dippers) and Turdus (thrushes)). In addition to resolving species relationships and revising taxonomy, work in my lab has has dealt with reconstructing historical biogeography and examining the relative roles that dispersal and vicariance (e.g., mountain uplift) may have played in the development of modern day species distributions and assemblages.",Professor,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences",https://scholars.library.tamu.edu/vivo/display/nc63d7bcc
Jaan,Laane,Professor,Research efforts on a variety of projects concentrate on the use of fluorescence spectroscopy of jet-cooled molecules and Fourier transform infrared (FT-IR) and laser Raman spectroscopies. Computer methods for quantum mechanical calculations and on-line instrument control are also utilized and developed.,Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/nd19e1c2f
Fen,Wang,Professor,"The laboratory focuses on understanding the molecular basis of cell signaling, and how aberrant cell signaling leads to birth defects and causes cancers. Using in vitro cell culture systems and in vivo mouse models, we study how the fibroblast growth factor (FGF) activates its receptor (FF) tyrosine kinase, and how the activated FF transmits the signals to downstream targets and regulates proliferation, differentiation, homeostasis, and function of the cells, as well as in organogenesis and development, including prostate and cardiovascular system development. The laboratory also employs molecular biology, cell biology, and mouse genetic technologies to study how aberrant FGF signals promote tumor initiation, progression, and metastasis. In addition, how environmental factors contribute to tumorigenesis and congenital birth defects by modulating FGF signal intensity and specificity is also under the scope of our research interests.",Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/nd5ef47ba
Katrin,Hinrichs,Professor,,Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/nd851437e
Sarah,Hamer,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ndc2c4e3e
Qi,Zheng,Professor,,Professor,Epidemiology and Biostatistics,https://scholars.library.tamu.edu/vivo/display/ndebdc652
Julian,Leibowitz,Professor,We have two projects in my lab. The first project is focused on identifying evolutionarily conserved RNA secondary structures in the coronavirus RNA genome and functionally examining their role in viral replication through reverse genetic and biochemical approaches. We have previously done this for a number of RNA secondary structures contained within the 5? and 3? regions of the genome and shown that they function as cis-acting elements in replication. Studies in my laboratory have identified a structurally dynamic region of the 5'UTR that interacts with the 3'UTR to facilitate transcription.
A second project in my laboratory has been to develop a reverse genetic system for MHV-1. In collaboration with investigators in Toronto and Pennsylvania my laboratory has demonstrated that MHV-1 infection of susceptible mice provides a safe and convenient rodent model for severe coronavirus infections such as SARS and MERS. The development of a reverse genetic system will allow us to investigate the contributions of individual viral genes to the pathogenesis of the severe pulmonary disease caused by this virus.,Professor||Professor,Microbial Pathogenesis and Immunology||Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/ne2185aa0
Dickson,Varner,Professor,"Dr. Dickson Varner is a Diplomate of the American College of Theriogenologists. His special interests include equine theriogenology, fertility probes for stallions, in-vitro preservation of equine spermatozoa, capacitation of equine spermatozoa, assisted reproductive techniques, and subfertility in stallions.",Professor,Large Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/ne3339085
Cecilia,Tamborindeguy,Professor,"Our laboratory studies transmission of plant pathogens by insects. Research is aimed at understanding ecological and molecular aspects of plant-insect-pathogen interactions. We use Zebra Chip (ZC),an emergent disease affecting solanaceous plants, as model system. The causative agent, ""Candidatus Liberibacter solanacearum"", is an alpha-proteobacterium vectored y the potato/tomato psyllid Bactericera cockerelli. We currently use genetic and biochemical approaches to investigate different aspects of pathogen transmission and the biology of the vector insect.",Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/ne6e645ee
Victor,Ugaz,Professor,"I am the world's smallest plumber--my research involves manipulating fluid flow in tiny channels the size of a human hair. Harnessing microfluidic phenomena makes it possible to build pocket-sized systems that can perform sophisticated chemical and biochemical tests outside the confines of a conventional lab. But achieving precise control over the flow of liquids at these small size scales is extremely challenging. Therefore, we are working to understand fundamental transport phenomena in microfluidic systems, and how they can be exploited to enable innovative applications including:
Fast and inexpensive diagnosis of infection and disease.
Sensitive screening for early detection of cancer.
Biodegradable sponges for easy cleanup of oil spills.
Spontaneous organization of chemical building blocks to form long-chain molecules--a key unanswered question in the origin of life.",Professor,Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/ne76e71aa
Joe,Arosh,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ne8898820
Leif,Andersson,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ne8ae2a28
David,Caldwell,Professor and Head,,Professor||Professor and Head,"Poultry Science||Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences",https://scholars.library.tamu.edu/vivo/display/nea632206
Ryland,Young,Professor,"Most bacterial viruses (phages) cause lysis of their host cell to release the progeny virions. Large phages elaborate an enzyme (""endolysin"") to degrade the cell wall and also a small membrane protein (""holin""). The holin accumulates in the membrane and then, at a precisely scheduled time, suddenly forms a hole to allow release of endolysin through the cytoplasmic membrane to gain access to the wall. We use molecular genetics and biochemistry to study how this small protein is able to act as a molecular ""clock"" and punch holes in membranes. Small phages make single proteins which cause host lysis in a different way. This strategy is to target the host cell wall synthesis machinery; that is, the virus makes a ""protein antibiotic"" that causes lysis in the same way as antibiotics like penicillin by inhibiting an enzyme in the multi-step pathway of murein biosynthesis. Thus, when the infected cell tries to divide, it blows up, or lyses, because it can't make the new cell wall between the daughter cells. Remarkably, each of three different, small phages blocks a different step in the pathway. These small lysis proteins are models for a completely new class of antibacterial antibiotics. Also, the E. coli SlyD protein is required for this mode of lysis in one case. SlyD is a member of an ubiquitous family of proteins related to human ""immunophilins,"" the targets of immune-suppression drugs. We study SlyD to learn about the role of this class of proteins in biology.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/nea775348
Thomas,Welsh,Professor,"Areas of research for Dr. Welsh include developing endocrine-based biotechnologies to selectively and precisely regulate growth and reproduction in livestock; in vitro and in vivo methodologies used to identify mechanisms whereby specific hormones regulate the biosynthesis of pituitary, adrenal, gonadal and hypothalamic hormones; and correlative in vivo and in vitro studies conducted using bovine, equine, porcine and ovine animal models.",Professor||Professor,Animal Science||Texas A&M AgriLife Research,https://scholars.library.tamu.edu/vivo/display/neae2cac6
James,Derr,Professor,"Dr. Derr has directed worldwide research projects in wildlife and livestock conservation genetics for over 25 years. This body of work has produced more than 75 scientific publications reporting original research on many different species. For example, Dr. Derr has authored articles on bison, dolphins, domestic and wild cats, elk, pronghorn antelope, sheep, quail, white-tailed and mule deer, whales, domestic livestock and multiple fish species. All of this conservation genetics research has been funded through international, federal, state, NGO and private funding sources including the DSC and DSC Foundation. In addition, Dr. Derr is an impactful educator through his teaching efforts in undergraduate genetic courses to students interested in medicine (human and veterinary) and he has mentored over 100 graduate students in the fields of conservation / population genetics and animal health. One of Dr. Derr's most popular courses is ""Wildlife Conservation Medicine"". This course is designed for first- and second-year veterinary students to travel to South Africa and Botswana to learn how to chemically immobilize, treat and transport everything from African plains game to dangerous game. His efforts with these young veterinarians ensure they graduate with specialized knowledge and skills to handle health care and conservation issues with the tremendous number of exotic wildlife species here in the State of Texas on private ranches and preserves.",Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/nebe46b3d
Stephen,Smith,Professor,"Dr. Smith teaches meat science, nutrition and physiological nutrition courses. He also conducts research on the growth and development of adipose tissue, particularly in the bovine species. He has investigated the limitation of cattle to marble and has used his background in molecular biology to investigate lipid metabolism in the bovine muscle.",Professor||Professor,Animal Science||Nutrition,https://scholars.library.tamu.edu/vivo/display/nee8e5966
Roger,Smith,Professor,Application of flow cytometry to study of animal disease and clinical veterinary medicine; core flow cytometry laboratory.,Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/nefd6ee54
Clare,Gill,Professor,"Dr. Gill teaches an undergraduate senior seminar course and a graduate course in applied animal genomics. Her primary research interest is in development and application of efficient molecular tools for comparative genomics. She is also the principal investigator of the McGregor Genomics Project, which is a collaborative effort to map genes for production efficiency in cattle.",Professor||Executive Associate Dean and Associate Dean for Research,College of Agriculture and Life Sciences||Animal Science,https://scholars.library.tamu.edu/vivo/display/nf0375f36
David,Riley,Professor,"Dr. Riley teaches these 3 graduate courses: Quantitative Genetics, Genetic Prediction, and Advanced Quantitative Genetics. Research efforts include the association of genes, gene combinations, and other molecular variants with beef cattle production traits, especially those traits related to reproduction and efficiency. Research interests include the incorporation of genomic information in traditional animal breeding strategies and prediction of breeding values using such information. Other research efforts include the assessment and quantification of the epigenetic variation in livestock traits, and the expression of heterosis by crossbred animals for important traits.",Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/nf0ce11af
John,Mullet,Professor,"Functional genomics, bioinformatics, and DNA chip technology are fundamentally changing research on biological systems. Knowledge of complete genome sequences and high resolution genome technology provide an extraordinary opportunity to understand complex biological processes and to relate detailed understanding of protein structure and biochemical mechanism to the function of whole organisms and biological systems in nature.
Our research team is helping to build genome maps and DNA diagnostic microarrays/chips for analysis of global gene expression and biodiversity. This new technology is being used to explore the molecular basis of several fundamental plant responses: (1) light responsive genetic systems that help protect plants from damage by high intensity UV/blue light; (2) genetic systems that allow plants to adapt to the environment; (3) genes and signal transduction pathways that help protect plants from insects and disease; and (4) genes that regulate plant development (flowering time, fertility restoration, chloroplast development/number).",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/nf1c81fcb
Kate,Creevy,Professor,"Dr. Creevy is a board-certified small animal veterinary internist, with a primary research interest in longevity, healthspan, morbidity and mortality within and among dog breeds as well as secondary research interests in infectious disease, and pedagogical theory in science education. In 2007, she established a productive collaboration with Dr. Daniel Promislow, combining her expertise in veterinary research and clinical practice with his expertise in genetics, aging and statistical analysis. Initially, their work was focused on the analysis of existing veterinary medical datasets. With the addition of Dr. Matt Kaeberlein, in 2014, the trio founded the Dog Aging Project and began to create a community of dog owners interested in becoming involved in this citizen-science project. The Dog Aging Project's current longitudinal study ambitious undertaking is the largest prospective study of companion dogs ever performed, enrolling 10,000 dogs across the nation who will be followed for ten years.",Professor,Small Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/nf40f2eea
Joerg,Steiner,Professor,"My veterinary career has mainly focused on two aspects, patient care and clinically-relevant research. As a veterinary clinician and clinical teacher I am exposed to a wide variety of canine and feline patients with complex medical conditions. These patients serve as a constant source of new clinical problems that beckon to be studied further. Sometimes these studies are merely clinical, relating to characterization of an uncommon condition, diagnosis of a difficult-to-diagnose condition, or a novel therapeutic approach to a well-described condition. In other instances studies that are spurred by clinical cases are more basic-science based, utilizing state-of-the-art technologies to further evaluate the etiology or pathogenesis of a disease. In some instances, studies may provide comparative aspects related to experimental animals, such as rodents or primates, or even to human patients with similar conditions. I believe that my role as a mentor can be unique in that I can help graduate students bridge the gap between science and clinical aspects and between veterinary and human medical interests - giving us further opportunities to advance the concept of one-health.","Professor||Director, Gastrointestinal Laboratory",School of Veterinary Medicine and Biomedical Sciences||Small Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/nf4de66a0
Jiang,Chang,Professor,"Heart failure (impaired ventricular pump function) is an eventual outcome for diverse cardiovascular disorders and the leading cause of combined morbidity and mortality in the United States and other developed industrial nations. The focus of my lab is to understand the molecular and cellular mechanisms that initiate and mediate the pathogenesis of maladaptive cardiac remodeling, such as cardiac hypertrophy and fibrosis as result of various pathological scenarios such as myocardial infarction, hypertension, obesity, diabetes, aging and post-traumatic stress disorder. The overall approach consists of generation and analysis of clinically-relevant genetic mouse models including a tool mouse enabling tracking endogenous cardiac exosomes, and conduct mechanistic studies using cutting-edge technology. The ultimate goal of our efforts is to provide clinical translation for the prevention and treatment of pathological cardiac remodeling from our mechanistic studies.",Professor,Center for Genomic and Precision Medicine,https://scholars.library.tamu.edu/vivo/display/nf80a9dad
Uel,Mcmahan,Professor,"McMahan and his research group provide one of the cornerstones for Texas A&M's new Interdisciplinary Life Sciences Building and its related teaching and research efforts. His work focuses on how the nervous system's synapses form in the embryo and function in the adult in various animal species. It relies on high-resolution imaging, chemical characterization and experimental manipulation of specific macromolecules and organelles, which altogether provide insights unobtainable via any other approach. The findings bear directly on the problems of understanding the molecular basis of human brain diseases and restoring brain function after trauma.",Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nfc3672e7
J,Johnston,Professor,"I estimate genome size for sequencing projects for a very wide range of vertebrates, invertebrates and plants..
I work on genome size evolution, & genomics.
My other areas of research include cytological, ecological and population genetics of arthropods.",Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/nfc3f68fb
Darwin,Prockop,Professor,,Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/nfcfd0990
Craig,Nessler,Professor,,Adjunct Professor||Professor||Faculty Fellow,Center for Health Systems and Design||Soil and Crop Sciences||Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/nfe5a2ef4
Matthew,Sachs,Professor,"Understanding the mechanisms by which upstream open reading frames (uORFs) in mRNA transcripts control gene expression is currently the major focus of my laboratory. A substantial component of this work is focused on the uORF-encoded fungal arginine attenuator peptide (AAP). The major goal of this work is to understand the mechanism by which a nascent peptide encoded by this uORF controls the movement of ribosomes on mRNA and regulates gene expression. Control mechanisms mediated by uORFs and nascent peptides exist in mammals, fungi, plants, viruses, and bacteria, but relatively little is known of the molecular details of such control. The AAP is encoded by a uORF in the 5?-leader regions of mRNAs specifying the first enzyme in fungal arginine (Arg) biosynthesis. Synthesis of the AAP rapidly reduces gene expression in response to Arg. AAP-mediated regulation is observed in vivo in both Neurospora crassa and Saccharomyces cerevisiae and in vitro, using fungal, plant and animal extracts. The nascent AAP causes the ribosome to stall when the concentration of Arg is high.",Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nfe74574c
David,Stelly,Professor,"My scientific research, graduate and post-graduate programs employs multi-disciplinary approaches to conduct and study use of naturally occurring germplasm for crop improvement. Elements of the research include wild-species germplasm introgression, chromosome substitution, reproductive and ploidy manipulations, conventional cytogenetics and fluorescence in situ hybridization, genetic analysis, DNA marker and assay (SNP) development, marker assisted selection, reproductive cytology and genetics, and various types of genome mapping, sequencing, and their integration for genome sequencing and assembly. Most of my research aims to enhance the germplasm, knowledge, science and technologies for genetic improvement Upland cotton, e.g., economic yield and sustainability; some, however, is devoted to sorghum and peanut, especially wide hybridization and germplasm utilization.",Professor||Chair,Soil and Crop Sciences||Molecular and Environmental Plant Sciences,https://scholars.library.tamu.edu/vivo/display/nfec36db0