First name,Last name,Preferred title,Overview,Position,Department,Individual
James,Samuel,Regents Professor and Head,"Our laboratory works with the obligate intracellular bacterial pathogen, Coxiella burnetii, the etiologic agent of Q fever and a category B biothreat agent. The long-term goal of this research is to understand the molecular pathogenic mechanisms involved in the host-pathogen interaction. To accomplish this broad goal, project in the lab are designed to test the molecular mechanisms employed by both the host and pathogen. Current pathogen studies include 1) broad survey of proteins secreted via a type 4 secretion system (T4SS) followed by determination of essentiality of each substrate for virulence and detailed analysis of mechanism of host modulation 2) survey of essential virulence loci identified by specific mutant screens, and 3) definition of the relative virulence of phylogenetically distinct isolate groups.",Regents Professor and Head,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n01c3216f
Yuxiang,Sun,Professor,"Dr. Sun is an expert on ""hunger hormone"" ghrelin. She generated the first set of ghrelin and ghrelin receptor knockout mice, and discovered novel roles of ghrelin signaling in diabetes, thermogenesis, and inflammation. Her laboratory uses state-of-the-art tools to study ghrelin system in energy sensing, metabolism and immunity, and aging. Her work suggests that ghrelin signal might be a promising drug target for obesity, diabetes, inflammation, and Alzheimer's disease.",Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n0228c22e
Patricia,Pietrantonio,Professor and Texas AgriLife Research Fellow,"We work with important pests that are critical to Texas and the world focusing on public and animal health and on pests of cotton. We are interested in elucidating the functions of arthropod neuropeptides that signal through G protein-coupled receptors. Many of these neuropeptides are pleiotropic and many of their multiple functions are still unknown. We utilize loss-of-function experiments through RNAi, peptidomimetics, the discovery of antagonists through target-based high-throughput screening of small molecules on recombinant receptors expressed in mammalian cells, immunohistochemistry, and develop physiological in vitro and in vivo assays towards advancing arthropod endocrinology. The laboratory has pioneered the discovery of the first neuropeptide receptor in the Acari and the first insect prostaglandin receptor. The molecular and cell culture laboratories are BL2 and the Insect toxicology laboratory is BL1. We use state-of-the-art technologies and the lab is well equipped to do almost everything in-house.",Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/n0555af9d
Donald,Darensbourg,Distinguished Professor,"The fundamentally interesting and challenging chemistry associated with carbon dioxide, coupled with its high potential as a source of chemical carbon, provides adequate justification for comprehensive investigations in this area. In our research program we have attempted to establish a clearer mechanistic view of carbon-hydrogen, carbon-carbon, and carbon-oxygen bond forming processes resulting from carbon dioxide insertion into M-H, M-C, and M-O bonds.
Relevant to the latter process our research has addressed the utilization of carbon dioxide in the development of improved synthetic routes for the production of polycarbonates. The hazardous and expensive production process currently in place industrially for these materials involves the interfacial polycondensation of phosgene and diols, accentuates the need for these studies. Although we and others have made significant advances in the synthesis of these useful thermoplastics from carbon dioxide and epoxides much of the fundamental knowledge concerning the reaction kinetics of these processes is lacking, due in part to the practical challenges associated with sampling and analyzing systems at elevated temperatures and pressures. This information is needed for making this process applicable to the synthesis of a variety of copolymers possessing a range of properties and uses. Our studies are examining in detail the mechanistic aspects of metal catalyzed carbon dioxide/epoxide coupling reactions employing in situ spectroscopy methods. For this purpose Fourier-transform infrared attenuated total refluctance (FTIR/ATR) spectroscopy is being utilized. Other related investigations involve the development of structural and reactivity models for the industrially prevalent double metal cyanide catalysts(DMC) used in polyethers and polycarbonate synthesis from epoxides or CO2/epoxides, respectively.",Distinguished Professor||Faculty Affiliate,Energy Institute||Chemistry,https://scholars.library.tamu.edu/vivo/display/n06bf3bf8
Dorothy,Shippen,Professor,"We are taking biochemical, molecular genetic and cytological approaches to study the structure, function and maintenance of telomeres. Telomeres are higher order nucleoprotein complexes that cap the ends of eukaryotic chromosomes and play essential roles in conferring genome stability and cell proliferation capacity. The protective cap of the telomere is comprised of specific telomere binding proteins that regulate the length of telomeric DNA tract and allow the cell distinguish the chromosome terminus from a double-strand break. Telomeric DNA is synthesized by the action of telomerase, an unusual reverse transcriptase that replenishes telomeric DNA lost as a consequence of replication by conventional DNA polymerases. We have developed the genetically tractable flowering plant Arabidopsis thaliana as a model system for studying telomeres in higher eukaryotes. With its sequenced genome, abundant genetic and transgenic tools, and extraordinarily high tolerance to genome instability, Arabidopsis has proven to be an excellent model for investigating fundamental processes in telomere biology. Current studies focus on defining the function and molecular evolution of telomere capping proteins and components of the telomerase ribonucleoprotein complex.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n07e86cac
Peter,Rentzepis,Professor,My research interest include lasers and their application to science and technology.,Faculty Affiliate||Professor,Energy Institute||Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n08418952
James,Muir,Professor,"I teach graduate courses at Tarleton State University, Stephenville, TX 76401. I mentor MSc & PhD students at various universities around the world. My research program focuses on grassland ecology, mostly at the plant-animal interface, with special emphasis on legumes. Topics include grassland restoration, ecosystems services, native legume domestication and the role of condensed tannins in ruminant systems.
I have current cooperative research projects in Tanzania, Botswana and Brazil. In the past I have worked extensively in Kenya, Senegal, South Africa, Malawi, Argentina and Portugal.",Regents Professor||Regents Professor,"Texas A&M AgriLife Research||Tarleton State University - (Stephenville, Texas, United States)",https://scholars.library.tamu.edu/vivo/display/n08762c08
Mark,Westhusin,Professor,My laboratory is interested in developing transgenic animal models of disease and novel platforms for the production of biopharmaceuticals. We are currently exploring methods to produce vaccines in the milk of transgenic animals.,Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n088680ea
John,Jifon,Professor,"Dr. Jifon's research is focused on environmental stress physiology of plants -- the physiological, biochemical and molecular mechanisms and traits that confer tolerance to environmental stresses (especially to drought, radiation/temperature extremes, and nutrient imbalance). A key theme in his research is to use integrated measurements obtained at leaf, whole-plant, and stand levels to study factors that regulate photosynthetic efficiency, water/nutrient use efficiency, assimilate partitioning, yield and quality. The aim is to use the information gained in these studies to develop practical strategies to optimize productivity and quality by improving plant tolerance to environmental stresses.",Professor||Professor,Texas A&M AgriLife Research||Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/n0aa3912d
Carolyn,Cannon,Associate Professor,"Our goal is to develop novel, non-toxic antimicrobial formualtions with efficacy against gram-positive and gram-negative multi-drug resistant pathogens.",Associate Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n0b3870aa
Ethan,Grossman,"Professor, Michel T. Halbouty Chair","My research focuses on global change and paleoclimates, stable isotope geochemistry, coastal environments past and present, hypoxia, isotope hydrology, past and present, biogeochemistry and geomicrobiology of aquifer systems.","Faculty Affiliate||Professor, Michel T. Halbouty Chair||Director",Geology and Geophysics||Stable Isotope Geosciences Facility||Energy Institute,https://scholars.library.tamu.edu/vivo/display/n0c709094
Lawrence,Wolinsky,Dean,,Dean||Professor||Faculty Fellow,Periodontics||School of Dentistry||Center for Health Systems and Design,https://scholars.library.tamu.edu/vivo/display/n0d0247f9
James,Womack,Distinguished Professor,"Comparative mammalian genomics with emphasis on bovids and laboratory animals. Study of evolution of gene families and genomic variation underlying disease resistance. Investigation of genetic mechanisms in innate immunity with focus on livestock, select agents, and agricultural biosecurity.",Distinguished Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n0e1a49e2
Emily,Wilson,Professor,"The goals of my lab are to understand the role of mechanical forces in vascular growth and remodeling processes. Cells within the blood vessel wall are exposed to numerous mechanical forces including fluid shear stress, circumferential wall stress, and axial stress as part of their normal environment and alterations in these parameters plays important roles in the development and progression of vascular pathologies such as atherosclerosis, hypertension and aneurysms. Our experiments are focused on how understanding how vascular smooth muscle cells sense changes in the mechanical environment and how this leads to changes in gene expression and cellular phenotype.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n105bddf7
Timothy,Devarenne,Associate Professor,"We study the biochemical and molecular mechanisms underlying the control of programmed cell death (PCD) in plants and how PCD is manipulated during plant-pathogen interactions. Specifically we study the interaction between tomato and Pseudomonas syringae pv. tomato (Pst) the causative agent of bacterial spot disease. Resistance to this disease is conferred by the host Pto serine/threonine protein kinase which recognizes Pst strains expressing the type III effector protein AvrPto.
PCD is induced during both resistant and susceptible plant-pathogen interactions. In the case of a resistant interaction, PCD induced by the plant, known as the hypersensitive response (HR), and acts to limit the spread of the pathogen. In susceptible plant-pathogen interactions plant PCD is induced by the pathogen after infection leading to death of the host. Studies have indicated that the genes controlling host PCD during the HR are the same genes that are manipulated by the pathogen during susceptible interactions. The difference lies in the timing of controlling the activity of these genes; HR PCD occurs within 12 hours of pathogen recognition while pathogen-induced PCD occurs several days after infection.
Many of these genes that control plant PCD are serine/threonine (S/T) protein kinase. We are interested in studying a specific class of S/T protein kinases that control PCD in plants called AGC kinases and how they are regulated in both resistant and susceptible plant-pathogen interactions. Additionally, when plants are not attacked by pathogens, PCD is a process that requires constant control so that cell death does not occur. We are looking at the signaling mechanisms and pathways employed to keep PCD under check in non-pathogen challenged plants.",Faculty Affiliate||Associate Professor,Energy Institute||Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n11411275
Jorge,Cruz-Reyes,Professor,"We combine approaches in molecular genetics, structural biology, biochemistry, proteomics, and bioinformatics to study the amazing RNA biology of trypanosome parasites. One research line is on an RNA editing process by uridine insertion and deletion that creates amino acid coding triplets in most mRNAs. Yet a single error in the U-changes yields a frame-shift. Trypanosomes split from other eukaryotic lineages over a hundred million years ago, yet this editing has analogies with RNAi, CRISPR/Cas9, mRNA splicing and other systems directed by small non-coding RNAs (ncRNAs).",Professor||Professor,Texas A&M AgriLife Research||Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n147e77ee
Friedhelm,Schroeder,Professor,Intracellular lipid transfer proteins; lipid metabolism; multiphoton imaging of intracellular lipid transport and targeting in living cells and tissues of gene targeted animals.,Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n157063e2
Tatyana,Igumenova,,"My laboratory is broadly interested in understanding the structural basis of signal transduction events that occur at the membrane surface. These events are mediated by signaling proteins that reversibly associate with membranes in response to binding second messengers, such as Ca2+ ions, diacylglycerol, and phosphoinositides. One of the key kinases regulating these signal transduction pathways is the Protein Kinase C (PKC) family. Aberrant levels of PKC expression or activity have been implicated in a large number of human diseases, such as cancer, cardiac failure, Alzheimer's disease, and diabetes. Despite the significance of PKC in signal transduction and human health, the structural and dynamical basis of its activation upon binding to lipid membranes remains elusive.",Associate Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n1c6e6632
Charles,Long,Professor,"My laboratory is currently working on a number of projects involving genetic engineering in cattle, goats, sheep and horses. We use CRISPR/Cas gene editing to specifically alter the coding sequence of genes in sheep to produced biomedical models of human disease, specifically hypophosphatasia. My lab is actively working on projects to produce gene edited cattle that are resistant to respiratory disease. We have also successfully used gene editing to correct the glycogen branching enzyme deficiency mutation in horses. We are also interested in altering the carcass characteristics of beef cattle by genetic engineering genes specifically related to meat tenderness in Bos indicus cattle. Other projects in the lab involve the use of mesenchymal stem cell-based therapies for treatment of equine disease and in particular methods for using these cells to over express proteins that can modulate the inflammatory response. We also have interest in using livestock as bioreactors to produce biotherapeutics and vaccine antigens in their milk. I have extensive experience in using genetic engineering in combination with assisted reproductive technologies (including somatic cell nuclear transfer) to produce live animals.",Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n1dc326d5
Kayla,Bayless,Associate Professor,"My laboratory conducts research in two areas of molecular and cellular medicine: the mechanism through which primary human endothelial cells invade into 3D matrices, and communication between invading endothelial cells and their surrounding 3D collagen matrix.",Associate Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/n1dd3799c
Juan,Bustamante,Instructional Associate Professor,,Instructional Associate Professor,Irma Lerma Rangel School of Pharmacy,https://scholars.library.tamu.edu/vivo/display/n208ab557
Gregory,Johnson,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n22b3a445
Umesh,Bageshwar,Research Assistant Professor,Our current work focuses on identifying the interaction site(s) between the Tat precursor pre-SufI and the TatBC receptor complex based on chemical crosslinking and the complementation of the Escherichia coli Tat pathway by the Mycobacterium tuberculosis Tat pathway.,Research Assistant Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/n23071727
Blanca,Lupiani,Professor,"Research in my laboratory focuses on better understanding the molecular mechanisms of pathogenesis of Marek's disease virus, a chicken oncogenic alphaherpesvirus. We study gene function using biochemical techniques and by introducing mutations into the viral genome. The knowledge obtained from these studies is used to develop vaccines to control this critical poultry pathogen. In addition, we are investigating the use of Marek's disease vaccines as viral vectors to control other viral diseases of poultry.",Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n255741f6
Sanjay,Reddy,Professor,"The long-term goal of my laboratory is to understand the molecular basis of pathogenesis of Marek's disease virus (MDV), a potent oncogenic herpesvirus that causes T-cell tumors in chickens. MDV codes for a protein (Meq), which shares significant resemblance with the Jun/Fos family of transcriptional factors. We have shown that this gene plays a critical role in latency and transformation of T-lymphocytes. Understanding the basic mechanism of viral pathogenesis will aid in the development of improved vaccine. We are also interested in other important poultry disease like avian influenza.",Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n28054661
David,Russell,Professor,"My research focuses on proteomics, lipidomics, biophysical chemistry and application and development of mass spectrometry, such as ""label-free"" nano-particle based biosensors and novel peptide/protein isolation and purification strategies. We are also investigating the structure(s) of model peptides in an effort to better describe folding/unfolding and structure of membrane and intrinsically disordered (IDP) proteins. Peptides take on very different 2?, 3? and 4? structure, which determine or influence bio-activity. In the presence of lipid vesicles peptides can exist as solution-phase species, ""absorbed"" on lipid bilayers or ""inserted"" (as a monomer or multimer) in lipid bilayers. By what mechanism do peptides interact with lipid membranes to affect these structural changes, how do peptide-lipid interactions promote self-assembly to form intermediates that eventually yield aggregates, i.e., amyloid fibrils, or how does metal ion coordination affect the structure of metalloproteins? Mass spectrometry-based experiments, hydrogen/deuterium (H/D) exchange, chemical 'foot-printing' and gas-phase (ion-molecule and ion-ion reaction chemistry) and solution-phase chemical modifications, have expanded our abilities to address such questions, and new instrumental approaches, esp. ion mobility spectrometry (IMS) combined with enhanced molecular dynamics simulations (MDS), have become standard tools for structural-mass spectrometry studies. Over the past several years we have either acquired or developed novel, next-generation IM-MS instruments that are redefining cutting-edge structural-mass spectrometry research as well as cutting-edge computational tools essential to carry out these studies. Our new laboratories in the Interdisciplinary Life Sciences Building (ILSB) provides exciting opportunities for collaborative, interdisciplinary research with chemical-biologists, biochemists and other chemists.",Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n280e03e6
Mariappan,Muthuchamy,Professor,"The main goal of our laboratory is to understand the molecular mechanisms of cardiac muscle dynamics in normal and diseased states. Particularly, our interests focus on the relationships between thin filament activation and crossbridge kinetics, and how the mechanotransduction signaling transmits to myofilament activation. We use multiple techniques, molecular, cellular, biochemistry, structural and biophysical, to obtain information on the fundamental regulatory mechanisms of cardiac muscle contraction.
Our lab group is also investigating the role of lymphatics in different tissue beds, including mesentery, skeletal muscle, and brain using various animal models.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n2877399b
Merwyn,Kothmann,Professor and Associate Department Head,"Dr. Kothmann's research is focused on developing models for ranchers to utilize in planning, monitoring and evaluating grazing management. He is also exploring the use of Bayesian belief networks as probabilistic expert systems for decision analysis in natural resources management.",Professor and Associate Department Head,Ecology and Conservation Biology,https://scholars.library.tamu.edu/vivo/display/n2aa90cf3
Jian,Feng,Professor and Assistant Dean,,Assistant Dean for Research and Professor,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n2b3403fd
Herman,Scholthof,Professor,,Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/n2c6ec1cb
Luis,Cisneros-Zevallos,Professor,The mission of our research program at the Plant Bioactives & Bioprocessing Research Laboratory is to generate information that can benefit the agriculture and processing industry by adding value to crops through bioactive compound discovery and the design of appropriate methods to enhance their content in plants as well as extend their post-harvest shelf-life.,Professor,Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/n2e6bb4c1
Suresh,Pillai,Professor,"Dr. Pillai's research focuses on bacterial cell-to-cell signaling, the molecular ecology of pathogens in natural and man-made ecosystems and the use of novel technologies to concentrate, detect, and decontaminate pathogens. His research on molecular microbial ecology and cell-cell signaling is targeted at understanding the complex and hitherto poorly understood relationship between microbial communities and human behavior. His research is aimed at understanding the role that the GI tract-associated microbiome has on human behavior.",Professor,Poultry Science,https://scholars.library.tamu.edu/vivo/display/n3009b050
Duncan,Mackenzie,Associate Professor,"Hormones secreted by the thyroid gland are of primary importance in the regulation of such fundamental physiological processes as growth, nutrient utilization, and reproduction. In my laboratory we examine the regulation of the secretion of thyroid hormones and their actions in poikilothermic vertebrates in order to understand the evolution of thyroid function. We are presently focusing on the regulation on thyroid hormone secretion and the mechanisms of iodine transport in commercially-important fish species such as the red drum (Sciaenops ocellatus), the channel catfish (Ictalurus punctatus), and even the zebrafish (Danio rerio).
This research is aimed at providing new insights into the potentially ancient role of thyroid hormones in nutrient assimilation, as well as elucidating evolutionary trends in the regulation of thyroid function. These studies may serve identify ways in which the pituitary-thyroid axis may be manipulated to enhance aquaculture production or endangered species conservation.",Associate Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n33bd0e42
M,Castell-Perez,Professor,"Characterization of food and biological materials, biomass pretreatments for bioenergy, food rheology, smart packaging systems, food safety technologies including irradiation and active packaging.",Professor||Professor,Biological and Agricultural Engineering||Nutrition,https://scholars.library.tamu.edu/vivo/display/n34204884
Jennifer,Herman,Associate Professor,"The study of how bacteria organize important cellular processes and determining the functional/physiological implications of this organization for the cell is one of the most exciting areas of research in microbiology. In the Herman lab, we utilize the model organism Bacillus subtilis, a bacterium with superb molecular, genetic and cell biological tools, that that can also differentiate into a resting cell type called a spore. Our research goal is to elucidate how bacteria coordinate key biological processes, with their cellular architecture using molecular, biochemical, and cell biological techniques.",Associate Professor||Associate Professor,Texas A&M AgriLife Research||Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n359e91fd
Luis,Tedeschi,Professor,"Dr. Tedeschi conducts research on energy and nutrient requirements of grazing and feedlot animals, growth biology and bioenergetics, chemical composition and kinetics of fermentation of feeds, modeling and simulation of decision support systems, and evaluation of models (http://nutritionmodels.tamu.edu). He has collaborated with several researchers overseas to develop models for small ruminants (sheep and goats). He utilizes System Dynamics concepts applied to nutrition.",Associate Professor||Professor,Animal Science||Nutrition,https://scholars.library.tamu.edu/vivo/display/n387904d6
Luc,Berghman,Professor,"The hallmark of my research career is the development of novel antibodies and applying them toward the development of new immuno-biotechnological tools. My lab has developed an antibody discovery platform in chickens that goes from in silico sequence to epitope-specific chicken IgG (IgY) in less than 3 weeks based on in vivo CD40-targeted immunogen delivery.
Research projects include the study of the immune response in the chicken, especially the function of CD40-positive antigen presenting cells (such as the dendritic cells) in activating the humoral immune response and the development of chicken egg yolk antibodies, monoclonal antibodies and recombinant antibodies for diagnostic, prophylactic and therapeutic purposes. a Dr. Berghman was the recipient of the 2016 Zoetis Fundamental Science Award.",Professor||Professor,Poultry Science||Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n3e016f20
Karl,Aufderheide,Emeritus Associate Professor,"Cell/Developmental Biology. Developmental Genetics. Intracellular differentiation of eukaryotes, especially ciliates. General interests in: intracellular pattern formation and morphogenesis; molecular aspects of gene expression in ciliate protozoa; development of organelles, including intracellular motility and organelle localization. Specific interests in: signal transduction, regulation of cytoskeletal organization, and motility in the social amoeba Dictyostelium; organization, patterning and morphogenesis of surface-related cytoskeletal and membranous structures of ciliates, especially Paramecium; applications of laser optical force trap technology to developmental problems in Paramecium tetraurelia and Tetrahymena thermophila; 2 molecular aspects of serotype gene expression in P. tetraurelia; development of exocytotic organelles (the trichocysts) in P. tetraurelia. General approach involves use of classical and modern light and electron microscopic techniques, integrated with genetic, molecular, mechanical or physiological manipulations of the cells.",Associate Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n3ed65e09
Thomas,Mcdonald,Professor,"My research focuses on environmental chemistry, petroleum geochemistry, and general organic chemistry.",Professor,Environmental and Occupational Health,https://scholars.library.tamu.edu/vivo/display/n407d0459
Thomas,Meek,Professor,"Marketed drugs have been developed for representatives of all six classes of enzymes, and comprise essential therapies for the treatment of cancers, HIV/AIDS, hypercholesterolemia, and bacterial infections. The availability of known point mutations that are causative of human cancers , as well as the full genomic descriptions of many pathogens, such as parasitic protozoa and infectious bacteria, provides an emerging means to identify new or known enzymes that would constitute potential drug targets. Likewise, the availability of crystal structures of many of these enzymes or their analogues, provides a means to rationally design new inhibitors of enzyme drug targets via the use of molecular modelling and a full understanding of the chemical mechanism of the target enzymes, as an important adjuvant to inhibitor discovery via high-throughput screening.
Our laboratory will initially focus on the detailed study of the mechanisms of cysteine proteases such as cathepsin C, the isocitrate lyase of Mycobacterium tuberculosis, and human ATP-citrate lyase, by the use of pre-steady-state and steady-state kinetics, as well as by use of existing crystal structures of these enzymes, to inform the design of both covalent and other mechanism-based modes for the inactivation of these enzymes. We will design and synthesize candidate inhibitors, and test them against these and other enzyme targets, and determine their suitability as potential drug candidates.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n41081941
Geoffrey,Kapler,Professor and Chair,"Dr. Kapler's broad research interests are concerned with the replication and transmission of eukaryotic chromosomes. The failure to completely replicate the genome during S phase or partially re-replicate chromosomes leads to genome instability- a hallmark of cancer cells. The central questions investigated in the laboratory are concerned with how replication initiation sites are established in chromosomes and how they are regulated during conventional (G1/S/G2/M) and alternative cell cycles, including endoreplication (gap-S-gap-S...) and locus-specific gene amplification. The current focus of the lab is to use high throughput (nascent strand) DNA sequencing to generate a comprehensive map of replication initiation sites under different physiological conditions.",Professor and Chair||Professor,Cell Biology and Genetics||Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n4128afa1
James,Batteas,Professor,"The research in our group is organized around three main projects: nanoscale materials and devices, biological surfaces and interfaces and nanotribology,
with the overarching goal of developing custom engineered surfaces and interfaces. This requires obtaining a fundamental (molecular level) understanding of the underlying chemistry and physics of the systems in question to afford rational approaches to test and develop new technologies. In much of our research we employ a range of scanned probe microscopies such as scanning tunneling microscopy (STM) and atomic force microscopy (AFM) to probe structure and to manipulate materials at the nanoscale.",Faculty Affiliate||Professor||Faculty Fellow||D. Wayne Goodman Professor of Chemistry,Center for Health Systems and Design||Energy Institute||Chemistry||Chemistry,https://scholars.library.tamu.edu/vivo/display/n413d1dff
Shannon,Glaser,Professor,"The long-term goal of my research program is to understand how activated (proliferating) cholangiocytes participate in the progression of cholestatic liver diseases and eventual development of cholangiocarcinoma. My research is focused on elucidating the factors (such as, mechanical stress) and intracellular signaling mechanisms that regulate cholangiocyte proliferation and biliary fibrosis during extrahepatic cholestasis.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n424a02f1
Loren,Skow,Professor,Comparative genomics of mammals with emphasis on organization and evolution of the mammalian genome; molecular analysis of the major histocompatibility complex of hoofed animals; genetic mechanisms of inherent resistance to infectious diseases.,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n4326eaa3
Gonzalo,Rivera,Associate Professor,"My laboratory is interested in the role played by cytoskeletal remodeling in development and disease, particularly, angiogenesis and tumor progression and invasion. The long-term goal of our research is to understand how extracellular signals that alter tyrosine phosphorylation and the metabolism of inositol phospholipids modulate actin dynamics and cell motility. Areas of interest include the biogenesis of actin-based structures of invasion, intracellular trafficking, and three-dimensional tissue morphogenesis in vitro. Our research employs a combination of molecular genetics, cell biology, proteomics, and high-resolution optical imaging.",Associate Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n47ddea15
Van,Wilson,Professor,"My area of specialization is the molecular biology of papovaviruses, with a primary focus on how viral proteins modify the host cell environment. Recently, we determined that the viral replication proteins, E1 and E2, are post-translationally modified by addition of 1 or more SUMO moieties. Sumoylation is a widespread modification whose biological functions are only recently becoming understood. Studies are in progress to 1) determine the role of sumoylation in the viral life cycle, 2) evaluate the effect of sumoylation on the structure and activity of the E1 helicase, 3) understand the mechanism by which sumoylation influences E2 stability and transcriptional activity, and 4) determine how sumoylation is modulated by the viral E6 oncoprotein. In addition to the role of sumoylation in the viral life cycle, we are also exploring how sumoylation participates in normal keratinocyte differentiation. We have developed a keratinocyte cell line inducibly expressing a tagged SUMO moiety to facilitate proteomics studies of sumoylation changes and regulation during controlled differentiation.",Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n4837bbf9
Tadhg,Begley,Distinguished Professor,"The Begley Group is interested in the mechanistic chemistry and enzymology of complex organic transformations, particularly those found on the vitamin biosynthetic pathways. We are currently working on the biosynthesis of thiamin, molybdopterin, pyridoxal phosphate and menaquinone. Our research involves a combination of molecular biology, protein biochemistry, organic synthesis and structural studies and provides a strong training for students interested in understanding the organic chemistry of living systems and in pursuing careers in biotechnology, drug design or academia.
Thiamin pyrophosphate plays a key role in the stabilization of the acyl carbanion synthon in carbohydrate and amino acid metabolism. The biosyntheses of the thiamin pyrimidine and thiazole are complex and are different from any of the characterized chemical or biochemical routes to these heterocycles. We are particularly interested in cellular physiology and the mechanistic enzymology of thiamin biosynthesis. As an example of one of the complex transformations on this pathway, the figure below shows the structure of the pyrimidine synthase catalyzing the complex rearrangement of aminoimidazole ribotide (left) to the thiamin pyrimidine (right).",Distinguished Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n498aa35b
Yinan,Wei,Professor,"We are interested in studying the interaction between microbes and host systems, in the context of antibiotic resistance, infection, and the innate immune response.",Professor,Pharmacy Practice,https://scholars.library.tamu.edu/vivo/display/n4bb89912
Thomas,Diekwisch,Professor and Department Head,"Stem Cells and Tissue Engineering In previous studies we have generated and characterized stem cell populations in dental tissues. We have also developed novel extracellular matrix-based scaffold materials. Currently we are performing a number of studies to examine the use of stem cells and scaffolds to regenerate periodontal and other tissues.
Chromatin, Epigenetics, and microRNAs Twenty years ago, we discovered the cp27 chromatin factor in our laboratory. This factor is part of the large SRCAP chromatin complex that plays important roles in development and cell division. A second aspect of our epigenetics research is focused on the role of histone methylation in odontogenic tissue differentiation and disease.
Periodontics Our lab works on the development and differentiation of periodontal tissues as a means to generate new progenitor based approaches for the regeneration of periodontal tissues. More recently, we have conducted studies to understand how epigenetic changes affect periodontal tissue response to pathogens.
Enamel Formation and Evolution Our lab is interested in determining the mechanisms of enamel crystal formation. We are asking how mineral ions are transported toward the enamel layer and what factors govern the nucleation and elongation of enamel crystals. Using an evolutionary biology approach, we are studying the relationship between the amelogenin molecule and enamel mechanical properties.
Evolution and Development Our lab focuses on the evolution of jaws and teeth, especially tooth enamel and periodontal ligament. Specifically, we are interested in the effects of changes in the amelogenin protein on the evolution of the amazing physical properties of enamel. We are also trying to understand how the non-mineralized state of the periodontal ligament evolved in vertebrates.","Director, Center for Craniofacial Research and Diagnosis||Bernhard Gottlieb Endowed Chair for Craniofacial Research||Professor and Head, Department of Periodontics",School of Dentistry||School of Dentistry||School of Dentistry,https://scholars.library.tamu.edu/vivo/display/n52565fe6
Cynthia,Meininger,Professor,"My research focuses primarily on the vascular complications of diabetes. Using animal models of human diabetes, we have demonstrated that an inability of endothelial cells to produce nitric oxide may be partly responsible for these vascular complications. We are developing a gene/drug therapy approach for treating cardiovascular disease associated with diabetes. Targeted nanoparticles will deliver either the gene for GTPCH or BH4 itself into endothelial cells oxidatively damaged by diabetes to correct endothelial GTPCH deficiency, increase tetrahydrobiopterin levels, restore nitric oxide production and reverse the vascular dysfunction seen in diabetes. Our endothelium-targeting nanoparticle approach will not only reverse the damage caused by disease but will increase antioxidant levels to protect the endothelial cells from future damage and/or dysfunction.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n531a623d
Arthur,Laganowsky,Associate Professor,"A long-term research goal of our group is to determine the molecular basis behind protein-lipid interactions and how these interactions can modulate the structure and function of membrane proteins, including their interactions with signaling molecules. What determines the selectivity of membrane proteins towards lipids, and the coupling between lipid binding events and function remains a key knowledge gap in the field; one that if addressed will significantly advance our understanding of how lipids participate in both normal and pathophysiological processes of membrane proteins. Therefore, there is a critical need to expand our fundamental knowledge in this emerging field by applying and developing innovative approaches to elucidate how lipids modulate the structure function of membrane proteins. To this end, we are studying a number of ion channels, receptors and other types of membrane proteins.",Associate Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n542411e4
Phanourios,Tamamis,Assistant Professor,,Associate Professor,Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/n5673e0c8
Mark,Burow,Professor,"Goals of the program are, in collaboration with peanut breeding programs in College Station and Stephenville to
(1) release new cultivars for Texas growers, incorporating:
high yield
improved edible seed quality -early maturity, high oleic oil
resistance to water deficit, heat, and salt stress
resistance to disease and pests, especially leafspot, nematodes, and Sclerotinia blight
(2) Participate in the International Peanut Genome Initiative, and use genomics technology in cultivar
development
(3) Participate in international collaborations with scientists, especially in Ghana and Burkina Faso
through a Peanut and Mycotoxin Innovation Lab/ USAID project",Professor||Professor,Soil and Crop Sciences||Lubbock Research and Extension Center,https://scholars.library.tamu.edu/vivo/display/n57d1bc41
Glen,Laine,Regents Professor,,"Director , Michael E BeBakey Institute||Professor",Michael E. DeBakey Institute||Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n58440639
Thomas,Marek,Senior Research Engineer,,Senior Research Engineer,Amarillo Research and Extension Center,https://scholars.library.tamu.edu/vivo/display/n58f5e117
Winfried,Teizer,Professor,"I lead the NanoLab in the Physics Department of Texas A&M University, which is working on various projects in the general areas of biomolecular motility, molecular nanomagnets, spintronics, nanophysics and highly correlated systems. The goal is to further the understanding of physical properties at the size or temperature scale where quantum mechanics governs the dominant processes.",Professor,Physics and Astronomy,https://scholars.library.tamu.edu/vivo/display/n5ad8688a
Paul,de Figueiredo,Associate Professor,I have strong interests in elucidating the molecular mechanisms that mediate interactions between the intracellular bacterial pathogen Brucella spp. and host cells.,Associate Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n5e6f7b12
Gladys,Ko,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n5e930c1f
Svetlana,Sukhishvili,Professor,"My research focuses on stimuli-responsive all-polymer and polymer nanocomposite assemblies for sensing, separation and biomedical applications; structure and dynamics of polyelectrolyte assemblies; materials with controllable optical, swelling and drug-release responses; remote manipulation of material shape; smart antibacterial materials; and surface modification for controlling wettability, adhesion and adsorption.",Professor,Materials Science and Engineering,https://scholars.library.tamu.edu/vivo/display/n616e513c
Allen,Honeyman,Associate Professor,,Associate Professor,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n62788a8f
Jon,Skare,Regents Professor and Associate Head,"Jon Skare is Regents Professor and Associate Head of the Department of Microbial Pathogenesis and Immunology in the College of Medicine at Texas A&M University. He has been a faculty member at Texas A&M since 1996 and has led a research laboratory centered around the pathogenic mechanisms operative in Borrelia burgdorferi, the spirochetal bacterium that causes Lyme disease. He has published over 50 peer reviewed manuscript, reviews, and book chapters and been funded continuously by the NIH since 1999 with over $20 million dollars in total costs. Dr. Skare has trained ten graduate students, sixteen postdoctoral fellows, and numerous undergraduate students in his research group during his time at Texas A&M. The majority of his postdoctoral trainees and students have gone on to hold academic or industry positions in the medical sciences.
Research interests are focused on microbial pathogenesis with an emphasis in spirochetal infections, particularly Borrelia burgdorferi, the etiologic agent of Lyme disease. Broad training in the molecular biology, genetics, and biochemistry of prokaryotic systems is employed to answer research-related questions. Long-term interests in the lab are centered on understanding how B. burgdorferi promotes its pathogenic potential and persists in the disparate hosts it occupies in nature (e.g., both ticks and mammals). In this regard, the research program is aligned with: (i) regulatory pathways that contribute to the establishment of infection during the arthropod to mammalian transition; (ii) identifying and characterizing surface structures that contribute to the colonization and maintenance of infection via adherence mechanisms; and (iii) the ability of B. burgdorferi and relapsing fever Borrelia to persistently infect hosts in the face of a potent innate and adaptive immune response.",Professor and Associate Head,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n638ae603
Gary,Kunkel,Associate Professor,"An important step to control the amount of RNA or protein in particular types of cells is at the level of transcription of genes. Our lab studies a multifunctional vertebrate transcriptional activator protein known as SBF/Staf/ZNF143. This protein binds to SPH sites within promoters of many genes that produce small stable RNAs (e.g., snRNAs and others) PLUS probably over 2000 promoters of genes that produce mRNAs. Two separate activation domains in this protein direct its action at small RNA vs. mRNA gene promoters. We are using zebrafish as a vertebrate model organism to study the roles of SBF/Staf during development. In vivo studies are coupled with biochemical and molecular biology methods to decipher the mechanisms by which this protein stimulates transcription of various types of genes.",Associate Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n638b96b2
Lynne,Opperman,Regents Professor and Department Head,,Regents Professor and Head,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n6542ca2e
Ann,Kier,Professor Emerita,,Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n6c0ad160
Joshua,Wand,Professor and Department Head,"We are broadly interested in how the biophysical properties of proteins are manifested in their biological function. We are particularly engaged in trying to reveal the nature of internal protein motion and how this influences functions ranging from molecular recognition to allostery and catalysis. These basic ideas are being employed in a range of studies including protein engineering to optimize protein drugs, reverse micelle encapsulation to aid fragment-based drug discovery, understanding the regulation of Parkin, which is involved in mitophagy and early onset Parkinson's Disease, and the enzyme AKR1C3, which is central to resistant forms of prostate cancer.",Professor and Department Head,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n6caf5ddd
Guan,Zhu,Professor,"Our laboratory conducts translational research with an ultimate goal to discover new anti-parasitic therapeutics by targeting metabolic enzymes and other molecules critical or essential to the parasite infection, survival and development, such as those involved in the lipid and energy metabolisms and interacting with host cells in Cryptosporidium and other protozoan parasites. Other research areas include functional genomics and molecular evolution of apicomplexan parasites, and parasitic diseases important to the conservation of wild animals.",Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n6d62f33b
Robert,Burghardt,Professor,"Research in the laboratory is focused on investigating mechanisms by which a variety of biological response modifiers ranging from mechanical signals, hormones and growth factors to environmental chemicals alter cellular signaling pathways and cellular homeostasis.","Professor||Director, Image Analysis Laboratory",School of Veterinary Medicine and Biomedical Sciences||Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n70a3d026
Larry,Johnson,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n72de4d00
Frances,Ligler,Professor,,Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/n74321a1f
Michael,Thomson,Professor,"My research expertise is in plant molecular breeding with an emphasis on rice genetics and genomics, international agriculture, and developing CRISPR-based gene editing approaches for efficient gene validation and trait development. My primary objective is to apply new genetics discoveries to rice improvement to help Texas producers and rice farmers around the world produce higher yields of superior quality rice in an environmentally sustainable manner. I am also leading the AgriLife Research Crop Genome Editing Lab to optimize high-throughput gene editing across a number of diverse crop species.",Professor,Soil and Crop Sciences,https://scholars.library.tamu.edu/vivo/display/n74c30954
Elizabeth,Pishko,Lecturer,,Lecturer,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n75e85328
Leslie,Adams,Senior Professor,"My research is focused on the: 1) investigation of the comparative molecular pathogenesis of zoonotic intracellular bacterial pathogens in natural animal models, particularly brucellosis, salmonellosis, and mycobacterial diseases; 2) development of vaccines and host gene expression-based diagnostics for zoonotic and select agent caused diseases, and especially 3) development of in silico host:pathogen interactome predictive models based upon bi-directional in vivo host (bovine/murine) and Brucella spp., Mycobacterium spp.and Salmonella enterica Typhimurium interactions. We developed an in silico computational infection biology model based on actuall temporal in vivo bovine model microarray-based transcriptomic and proteomic profiling of the acute infectious process. We developed a systems biology analysis of both host and pathogen comprehensive transcriptomic and proteomic datasets derived from our in vivo biological model. We computationally fused the datasets based on actual Salmonella, Brucella and Mycobacterium data and computationally predicted bovine host structural proteins to identify maximum likelihoods of host and pathogen protein:protein interactions as the basis for our preliminary in silico interactome model to predict mechanistic genes and linked perturbed cellular pathways.",Senior Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n75fee121
Terry,Thomas,Professor,"My interests are evolutionarily broad and include animals, plants and fungi. A major focus of the lab is the genomic analysis of gene expression programs during plant gene expression programs, particularly during embryogenesis and seed development, and the underlying regulatory mechanisms required for the initiation and maintenance of these programs. This work has illustrated the combinatorial interactions of cis and trans -acting factors that result in specific gene regulatory events. We are also using genomics tools to study the interaction of the rice blast fungus, Magnaporthe grisea , with plant hosts; the circadian control of gene expression; and the development of the vertebrate retina. An additional focal area is the utilization of molecular and cellular approaches for crop improvement. As part of these research activities, we have developed or adapted high throughput genomics approaches to accelerate the gene discovery process and subsequent analysis of gene expression and function.",Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n79201ac5
Christine,Mullen,Senior Lecturer,,Senior Lecturer,Chemistry,https://scholars.library.tamu.edu/vivo/display/n79b0381c
Roderick,Dashwood,University Distinguished Professor,"Research integrates multiomic, genetic, epigenetic and immune approaches for precision oncology. Epigenetic readers, writers and erasers that reversibly regulate immune players in the antigen presentation pathway are of current mechanistic interest. Molecular and cell-based assays are combined with preclinical models coupled to polypectomy. Clinical specimens and organoids from patients undergoing colectomy provide for human translation. Supported by the NCI, NINDS/NIA, and the John S. Dunn Foundation.",John S. Dunn Chair in Disease Prevention||Distinguished Professor||Director,Institute of Biosciences and Technology||Center for Epigenetics and Disease Prevention||School of Medicine,https://scholars.library.tamu.edu/vivo/display/n7a63dbe7
Fuller,Bazer,Distinguished Professor,"Dr. Bazer's research in reproductive biology focuses on uterine biology and pregnancy, particularly pregnancy recognition signaling from the conceptus to the maternal uterus by interferon tau and estrogen from ruminant and pig conceptuses, respectively. The roles of uterine secretions as transport proteins, regulatory molecules, growth factors and enzymes and endocrine regulation of their secretion is another major research interest. The endocrinology of pregnancy, especially the roles of lactogenic and growth hormones in fetal-placental development and uterine functions are being studied. The mechanism(s) of action and potential therapeutic value of conceptus interferons and uterine-derived hematopoietic growth factors are areas of research with both pigs and sheep as models for human disease.",Distinguished Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/n7ad91d50
Ursula,Winzer-Serhan,Associate Professor,"I am interested in studying how gene environmental interactions shape the brain during development. In particular, I am interested in how early life exposure to psychoactive drugs, like nicotine and alcohol, permanently shape the brain which could result in long-term cognitive impairments, anxiety, and anti-social behavior. My lab is currently focused on the effects of nicotine. Nicotine interacts with nicotinic acetylcholine receptors (nAChR) which are ligand-gated, pentameric cation channels.",Associate Professor,Neuroscience and Experimental Therapeutics,https://scholars.library.tamu.edu/vivo/display/n7c166c20
Karen,Wooley,Distinguished Professor,"Our research activities combine organic syntheses, polymerization strategies and polymer modification reactions in creative ways to afford unique macromolecular structures, which have been designed as functional nanostructures, polymer systems having unique macromolecular architectures, and/or degradable polymers. The emphasis is upon the incorporation of functions and functionalities into selective regions of polymer frameworks. In some cases, the function is added at the small molecule, monomer, stage, prior to polymerization, whereas, in other cases, chemical modifications are performed upon polymers or at the nanostructure level; each requires a strategic balance of chemical reactivity and the ultimate composition and structure.",Distinguished Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n7d5d2fbd
Stephen,Crouse,Professor,"My research focus is in the general area of Exercise as Medicine. My specific health-related research aims have been targeted toward the study of the effects of exercise on blood lipid metabolism, and on other accepted heart and cardiovascular disease risk factors in men and women, young and old. Current research in exercise physiology is focused on the adaptive response of the cardiovascular and musculoskeletal system to exercise, nutrition, and physical training using aquatic, endurance, and resistance modalities of exercise. In progress are research projects in sports physiology to profile elite athletes and study factors that contribute to the health of athletes, including nutritional supplements.",Professor,Kinesiology and Sport Management,https://scholars.library.tamu.edu/vivo/display/n7e212aee
Stephen,Talcott,Professor and Associate Department Head,"Dr. Talcott's research is focused on phytochemicals in fruits and vegetables, antioxidant stability and assessment, postharvest retention, beverage processing and value-added products. Intake of compounds such as phenolic acids, flavonoids, anthocyanins, procyanidins, carotenoids, tocopherols and ascorbic acid are suggested to have an inverse association with the risk of certain cancers and diseases. These compounds are investigated as antioxidants, enzyme inhibitors, and bioactive agents and changes in their concentration and activity are investigated following postharvest handling and processing. Current investigations include phytochemical identification, quantification and stability in tropical and subtropical fruits and vegetables including acai, mango, guava, passion fruit, grapes. As well as peanuts, strawberries, bell peppers and food-grade botanicals.",Professor and Associate Department Head,Nutrition,https://scholars.library.tamu.edu/vivo/display/n8247cf18
Peter,Davies,Professor,,Interim Department Head||Professor and Director,Center for Translational Cancer Research||Translational Medical Sciences,https://scholars.library.tamu.edu/vivo/display/n83f40a4a
Allison,Rice-Ficht,Senior Associate Vice President for Research,"Studies in the our lab are currently focused on the use of unique biomaterials for controlled release of live and subunit vaccines. Our focus is currently directed to the production of vaccines against human Brucellosisand Q fever, but will be applied to the storage and delivery of other vaccines. A study of specific immune mechanisms and potentiation through controlled releases is underway. Another focus is the study of alpha crystalline structure and function. These unique proteins protect against thermal insult and modulate folding and activity of other proteins",Professor||Senior Associate Vice President for Research,Cell Biology and Genetics||Division of Research,https://scholars.library.tamu.edu/vivo/display/n84a56c5b
Chunlin,Qin,Professor and Associate Department Head,,Professor and Associate Department Head,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n8539b9ab
Rosemary,Walzem,Professor,"Dr. Walzem's core research focus within the laboratory is directed towards understanding how the structure of triglyceride-rich lipoproteins influences their ability to carry out specific nutrient delivery tasks. Her studies include identification of mechanisms and regulatory processes that control the assembly of trigylceride-rich lipoproteins in issues, structural studies of lipoproteins themselves and physiological studies to determine substrate properties and metabolic fates of different types of lipoproteins. Diet can significantly alter lipoprotein physiology through multiple mechanisms, and studies of diet effects provides a significant sub-theme to the research program. A variety of species are used to address specific questions, however, avian and human lipoprotein metabolism as it relates to egg production and atherogenesis, respectively, are emphasized.",Professor,Poultry Science,https://scholars.library.tamu.edu/vivo/display/n85cd191f
Daniel,Ebbole,Professor,"Development and pathogenesis share the common features of responding to environmental conditions to execute a program of gene expression resulting in new cell types.
An important question in plant pathogenesis is to understanding the functions of pathogen effectors and their host target(s). Fungal effectors play roles in suppressing host defense mechanisms, however, other biotrophic functions, such as manipulating host physiology to promote nutrient acquisition and cell-to-cell movement are possible. Therefore, identification of the full set of fungal proteins secreted during host invasion is a major effort in plant pathology research. Candidate effectors are generally identified by virtue of i) their expression in planta ii) assessing their activity on the host using purified proteins or by manipulating expression iii) detecting the rapid evolution of effector genes due to selective pressure from the host. My lab is using a combination of these approaches to identify and characterize a gene family of putative effectors from Magnaporthe oryzae, the rice blast fungus and define interactions with monocot hosts.",Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/n86da3f1b
Deborah,Threadgill,Assistant Professor,,Research Assistant Professor||Assistant Professor,Veterinary Pathobiology||School of Medicine,https://scholars.library.tamu.edu/vivo/display/n8734a809
Mohammed,Al-Hashimi (FRSC),Engineering Professor,"Dr. M. Al-Hashimi has extensive experience in organic polymers with a focus on the design and synthesis of organic semiconductor materials for a range of optoelectronic applications, including field effect transistors, photovoltaic devices, light emitting diodes and sensors. His other interests center on the development of well-defined novel polymeric materials for Ring Opening Metathesis Polymerisation (ROMP) and synthesis of recoverable, reusable homogeneous and heterogeneous catalysts.",Faculty Affiliate,Energy Institute,https://scholars.library.tamu.edu/vivo/display/n87f91e74
Clifford,Stephan,Certification Officer and Associate Professor,"The Stephan Lab is focused on drug discovery research. Dr. Stephan directs both the Combinatorial Drug Discovery Program (CDDP) core and the Microphysiological Lead Optimization and Toxicity Screening (MLOTS) facilities. The CDDP is a high throughput screening and automated microscopy core focused on discovering new therapeutics from library screening and drug repurposing alone or in multi-drug combinations. MLOTS is a low to medium throughput core focused on lead optimization for new chemical entities with the capability of testing compounds in complex in vitro models (e.g., spheroids, organoids) and de-risking drug leads by evaluating their potential cardiovascular or CNS toxicities via micro electrode array or hepatotoxcity in a microfluidic liver model.",Research Associate Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/n8c431f98
Qingwu,Xue,Professor,"Develop a competitive and extramurally funded research program in the area of crop water use, water use efficiency, and abiotic and biotic stress resistance in major field crops in the Texas High Plains. The overall goal of my research program is to provide selection tools for breeders and geneticists and management tools for agronomists and producers, through better understanding the physiological mechanisms of crop performance under stress conditions. The major research focuses include understanding physiological and molecular mechanisms of drought tolerance, identifying plant traits conferring to stress tolerance, understanding the interactions of abiotic and biotic stresses, evaluating and developing field phenotyping tools, and developing management strategies under stress conditions. Advise graduate student research.",Professor||Professor||Adjunct Professor,"Soil and Crop Sciences||Texas A&M AgriLife Research||West Texas A&M University - (Canyon, Texas, United States)",https://scholars.library.tamu.edu/vivo/display/n8c76b901
James,Sacchettini,Professor,"My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n90385563
Jay,Groppe,Associate Professor,,Associate Professor,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n93572b3e
Timothy,Phillips,Professor,food safety; molecular toxicology; elucidation of fundamental chemical mechanisms of toxic action/interaction of food-borne carcinogens; mutagens; and developmental toxicants; and development of methods to detect and detoxify foodborne and environmental toxins.,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n94eef946
Kristen,Maitland,Associate Professor,"The focus of Dr. Maitland's research is on the development of light-based technologies for applications in medicine and biology. Technologies include novel light sources, optical fiber based imaging systems, handheld microscopes, multiscale optical microscopes, volumetric imaging systems, portable spectrometers, and point-of-care devices.",Director||Associate Professor,Biomedical Engineering||Microscopy and Imaging Center,https://scholars.library.tamu.edu/vivo/display/n96bdddbb
Susan,Payne,Associate Professor,"Molecular aspects of viral replication, pathogenesis, and evolution. The major focus of the laboratory is the retrovirus, equine infectious anemia virus. EIAV studies include evolution of virulence during rapid virus passage, modification of cell signaling pathways mediated by viral glycoproteins, effects of proinflammatory cytokines on virus replication and disease, and detailed mapping of EIAV virulence determinants. We also study the recently discovered avian bornavirus, etiological agent of proventricular dilatation disease of parrots, in conjunction with colleagues from the Schubot center.",Associate Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n97844057
Larry,Suva,Professor and Head,"The development, control and diseases of the musculoskeletal system have been my scholarly interests for the past 35+ years. Understanding how the musculoskeletal system adapts and progresses throughout life is the basis of my expertise. My research focus has been the skeletal consequences of disease, such as breast cancer bone metastasis and multiple myeloma, fracture healing, osteoporosis, and most recently rare bone diseases. Current research efforts include a focus on utilizing in vivo models (murine and large animals) to discover regulatory pathways fundamental to bone physiology and the development of rare bone disease preclinical model(s) that may provide novel insight into future therapeutic directions. A critical aspect of my academic philosophy is an open door policy and the importance of one-on-one interactions. We must strive to provide training and exposure for our students as they prepare for careers both in and out of academic medicine and research. I emphatically believe that these teaching and mentoring experiences have shaped my scientific career and have helped mold my teaching and mentoring philosophy of placing the best professional, academic, social and personal development of faculty, students and staff above all else.",Professor and Head,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n98338eea
Nancy,Ing,Professor,"Dr. Ing's research interests focus on understanding how hormones regulate gene expression in animal tissues. Current research projects investigate the earliest days of pregnancy in the sheep uterus and the regulation of estrogen receptor gene expression, as well as stress hormone effects on gene expression in the stallion testes. Most recently, we have been studying the RNAs in sperm from stallions and honey bees in order to find a pattern consistent with high fertility.",Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/n98a4a111
Daniel,Alge,Associate Professor,"My research is in biomaterials, with an emphasis on biocompatibility and applications in tissue engineering and regenerative medicine.",Faculty Affiliate||Associate Professor,Biomedical Engineering||Institute for Engineering Education and Innovation,https://scholars.library.tamu.edu/vivo/display/n99feb009
Bhimanagouda,Patil,"Leonard Pike Inagural University Professor and Interim Head, Food Science and Technology","Dr. Bhimu Patil is internationally recognized for his expertise and research on 'foods for health' and his related educational programs. His systems-wide farm-to-table approaches include examining pre- and postharvest effects on bioactive compounds, isolating and characterizing these compounds from different fruits and vegetables, and understanding their roles in human health. Moreover, he has a strong working relationship with produce industry stakeholders. Dr. Patil has a distinguished record of achievements in education, including leading the development of three unique courses linking agriculture, human health, and sustainability. Texas A&M University has been a leader in this area, due in part to Dr. Patil's seminal contributions in these first-of-their-kind multidisciplinary courses. Dr. Patil's contributions to education are no less distinguished. He developed and taught three unique, innovative multi-state and multi-disciplinary courses, ""Phytochemicals in Fruits and Vegetables to Improve Human Health"", ""Science of Foods for Health"" and ""The Nexus of Food & Nutritional Security, Hunger, and Sustainability"".",Professor||Professor,Nutrition||Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/n9a0e203e
Hung-Jen,Wu,Associate Professor,"Dr. Wu uses nanostructured materials and analytical tools to develop diagnostic techniques for medical applications. His laboratory recently focuses on understanding the influences of multivalency and cell membrane environment on pathogen-host cell recognition. The applications of his techniques include, infectious diseases screening, exploring cell membrane function, and targeted drug delivery.",Associate Professor,Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/n9cbcca3e
Xiaohua,Liu,Professor,"As a bioengineer, I have a broad background in biomedical science and engineering, with specific training and expertise in novel biomaterials design/fabrication, controlled protein release, and the use of stem cells for bone, dental and other tissues repair and regeneration. Some of the our current research projects include:
1. Development of novel biomimetic materials/scaffolds for dental and craniofacial tissue regeneration.
2. Development of controlled drug/growth factor delivery system
3. Development of bio-inspired platform to explore cell-material interactions in three-dimension (3D).",Associate Professor||Professor,School of Dentistry||Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n9cd6704b
Masako,Suzuki,Assistant Professor,,Assistant Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n9fd0c6a8
Jodie,Lutkenhaus,Professor,"Dr. Lutkenhaus's lab explores polymers for plastic power, enabling flexible or structural batteries and capacitors, as well as polyelectrolytes, which are integral components in smart surfaces and coatings.",Professor,Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/na0bd3380
Karen-Beth,Scholthof,Professor,"My molecular plant virology research is on a virus complex of Panicum mosaic virus (PMV) and its satellite virus (SPMV). For molecular genetic studies on the PMV/SPMV virus:host interactions we are using the model grass, Brachypodium distachyon. My primary area of research is the historiography of Tobacco mosaic virus (TMV) in the early 20th century in the United States.",Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/na173b2b4
Mohammad,Nutan,Associate Professor,,Associate Professor,Pharmaceutical Sciences,https://scholars.library.tamu.edu/vivo/display/na26fd78d
Gregory,Reinhart,Professor and Head,"Our laboratory is interested in the mechanisms by which enzymes are regulated in the cell. In particular, we are interested in allosteric regulation of enzyme activity. Consequently, we are interested in understanding the nature of the conformational change in proteins that can be effected by the binding of ligands, and specifically how these changes alter the catalytic behavior of enzymes subject to allosteric regulation. We endeavor to investigate properties that are complementary to those determined by x-ray crystallography in order to develop a comprehensive picture of the structure-function relationships involved in the regulatory phenomenon. For example, we are interested in how the dynamics of protein structure might dictate the nature of an allosteric effect. Techniques and approaches that we use in the laboratory include analysis of enzyme kinetics; analysis of the thermodynamics of enzyme-ligand interactions; time-resolved and steady-state fluorescence spectroscopy; analysis of the effects of temperature and hydrostatic pressure (up to 4 kbar) on enzyme properties, site-specific mutagenesis, isothermal titration calorimetry, and molecular graphics.",Professor and Head,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/na6e2a0db
Frank,Raushel,Distinguished Professor,"Enzymes catalyze a remarkable variety of chemical reactions with extremely high rate enhancements and very selective substrate specificity. The research efforts in our laboratory are directed towards a more complete understanding of the fundamental principles involved in enzyme-catalyzed chemistry and the dependence on protein structure. The pursuit of this information will provide the framework for the rational and combinatorial redesign of these complex molecules in an effort to exploit and develop the properties of enzyme active sites for a variety of chemical, biological, and medicinal uses. The techniques that we are using to solve these problems include steady-state and stopped-flow kinetics, NMR and EPR spectroscopy, X-ray crystallography, and the synthesis of inhibitors and suicide substrates. We are also using recombinant DNA methods to construct new proteins with novel catalytic properties. These efforts are currently being directed to the reactions catalyzed by phosphotriesterase and enzymes involves in the degradation of lignin and the metabolism of novel carbohydrates from the human gut microbiome.
The phosphotriesterase enzyme catalyzes the hydrolysis of organophosphate insecticides and other toxic organophosphate nerve agents. We have discovered that the active site of this protein consists of a unique binuclear metal center for the activation of water. We are now investigating the structure and properties of this metal center as a model system for the evolution of enzyme structure and function. Toward this end we have mutated the active site of this enzyme in a research project to create novel enzymes with the ability to detect, destroy, and detoxify various chemical warfare agents such as sarin, soman, and VX. The Raushel laboratory is also engaged in a large scale research project that is focused on the development of novel strategies for the discovery of new enzymes.",Distinguished Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/na84f2fec
Karen,Snowden,Professor and Associate Department Head,"Parasites of public health importance, host-parasite interactions, development of animal models for the study of parasitologic diseases and treatments, and development of molecular and immunologic methods for parasitologic diagnosis.",Professor and Associate Department Head,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/naab1ec85
Michael,Benedik,Regents Professor,My laboratory studies basic biological problems using molecular genetic methods with simple microbial systems. Additionally we are developing novel microbial approaches for biotechnological applications.,Regents Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nac9856e5
Ian,Tizard,Dr.,"Immunology with an emphasis on innovative vaccine technology and on the immunology of domestic mammals.Avian diseases with an emphasis on diseases of psittacines, Paleovirology,Genomics with an emphasis on whole avian genomes.The intestinal microbiome and its role in immunity.",University Distinguished Professor,School of Veterinary Medicine and Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/naefbabcf
Lisa,Perez,Director for Advanced Computing Enablement,,Associate Director,Texas A&M High Performance Research Computing,https://scholars.library.tamu.edu/vivo/display/naf9f7163
Stephen,Safe,Distinguished Professor,The aryl hydrocarbon receptor (AhR) is a nuclear helix-loop-helix transcription factor which forms a ligand-induced nuclear heterodimer with the AhR nuclear translocator (Arnt) protein. Research in this laboratory is focused on the molecular mechanism of crosstalk between the AhR and estrogen receptor (ER) signaling pathways in which the AhR inhibits estrogen-induced gene expression. The antiestrogenic activities of some AhR agonists are also being developed as drugs for clinical treatment of breast and endometrial cancers in women. Research on estrogen-dependent gene expression in various cancer cell lines is focused on analysis of several gene promoters to determine the mechanisms of ERa and ERb action. This includes several genes that are activated through interactions of the ER with Sp1 protein and other DNA-bound transcription factors.,Distinguished Professor||Distinguished Professor||Syd Kyle Chair,School of Veterinary Medicine and Biomedical Sciences||Biochemistry and Biophysics||Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/nb20fdbd9
Charles,Patrick,Professor of the Practice,"His current research within the Ideas to Innovation Engineering Education Excellence Laboratory focuses on enhancing undergraduate and graduate student learning, engagement and workforce development by transforming biomedical engineering education through scholarship and research of innovative teaching and learning practices and technologies.",Professor of the Practice,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/nb2ed7577
Xiaofang,Wang,Associate Professor,"My research interests are focused on the signaling regulation of bone and tooth development. Currently, my lab is focused on two kinases on the secretory pathway that are critical for bone and tooth development, Fam20B and Fam20C. I am also interested in mapping the pathogenic genes for bone and tooth diseases in mutant mice/humans. We characterize the gene function using multidisciplinary methods, including genetically engineered animal models, tissue/organ culture/transplantation, Single Cell RNA-Seq, ISH, IHC, and proteomic approaches.
Key words: bone, cartilage, tooth, dentin, enamel, chondrocytes, transgenic, genetics, signaling, FAM20C, FAM20B, kinase, mineralization, FGF23",Associate Professor,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/nb47c8381
Warren,Zimmer,Scott Exter Professor,"Our research interests are directed towards understanding the complex mechanisms which regulate the expression of specific gene sequences in development. We have focused our studies upon the factors that influence the smooth muscle component of the developing gastrointestinal (G.I.) tract. It has been shown that smooth muscle cells are predominantly derived from mesodermal precursor cells, however the factors regulating the selection of the smooth muscle myogenic pathway is not well defined.",Scott Exter Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/nb6da0749
Joseph,Awika,Professor,"Dr. Awika's broad interest is in developing technologies that maximize the ability of food to protect humans against chronic disease. His research focuses on the chemistry behind the behavior and properties of specific micro (polyphenols) and macro (starch and proteins) food constituents derived from grains. The interactions of the starch and proteins with the polyphenols, and how these interactions affect the rheological and biologically relevant properties of the molecules are of interest. How the structure of the polyphenols can be used to predict and manipulate their chemical behavior and function in food systems, as well as predict their interactions relevant inflammatory response in biological models is a major area of focus.
Dr. Awika's research involves multidisciplinary and international collaborations with geneticists, nutritional biochemists, agronomists, plant breeders, among others, from around the world.",Professor||Professor,Soil and Crop Sciences||Nutrition,https://scholars.library.tamu.edu/vivo/display/nb760602b
Siegfried,Musser,Professor,"The primary focus of my laboratory is to decipher how proteins partition into different sub-compartments of the cell. Cellular membranes serve to compartmentalize biochemical reactions to specific microenvironments. Proteins cross these membranes via a diverse array of protein translocation systems, or translocons. My laboratory has investigated the detailed molecular function of three different protein transport machineries, the human nuclear pore complex (NPC) and the bacterial Sec and Tat general secretion machineries. We are a biophysics lab and our primary tools for deciphering molecular mechanisms and dynamics are super-resolution imaging and single molecule particle tracking approaches. Our aim is to develop detailed, molecular-scale, mechanistic models of protein transport processes. We recently demonstrated 3D imaging of cargo transport through nuclear pores on the millisecond timescale with 5-15 nm precision in all three dimensions. This will be a major tool going forward for multiple projects.
In 2018, we began a new project on membrane-less organelles, which are micrometer-scale cellular structures known as biomolecular condensates (BMCs) that contain high concentrations of intrinsically disordered proteins and RNA. These BMCs are generally agreed to arise from liquid-liquid phase separation (LLPS), which is the spontaneous partitioning into dense and dilute phases due to favorable interactions between the separating molecules. The high density of aggregation prone proteins in BMCs is thought to lead to the cellular inclusions found in patients with multiple neurological diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Parkinson's and Alzheimer's diseases. We are using super-resolution and single molecule methods to probe the structural and dynamic heterogeneity of condensates formed from the fused in sarcoma (FUS) protein to identify the conditions that lead to solidification of liquid condensates (phase maturation).",Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/nb824aefa
Roula,Mouneimne,Research Professor,"For the past 24 years my research focused on: 1- The development of methods in the fluorescence microscopy field that achieve data acquisition and analysis in real time, quantitative analysis, and mathematical modeling of cellular signaling. 2- The development of novel technological tools to decipher molecular and physiological events in cells and immunological tissues under normal toxin exposure and disease conditions.",Research Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/nbb6c8c2a
Richard,Kreider,Professor,"Director of the Exercise and Sport Nutrition Lab.
We study the role of exercise and nutrition on health, performance, disease and rehabilitation.","Faculty Fellow||Professor and Head||Director||DIrector, Human Clinical Core||Professor",Center for Health Systems and Design||Kinesiology and Sport Management||School of Education and Human Development||The Exercise and Sport Nutrition Laboratory||Nutrition,https://scholars.library.tamu.edu/vivo/display/nbc81b4e0
Amanda,Macfarlane,Director Food and Nutrition Evidence Center,,Director Food and Nutrition Evidence Center||Professor,Texas A&M AgriLife Research||Nutrition,https://scholars.library.tamu.edu/vivo/display/nbd1502ad
Vernon,Tesh,Professor,,Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/nc2165f28
Ron,Eytan,Assistant Professor,"My lab studies the origin and maintenance of marine biodiversity, primarily in coral reef fishes, using genomic and computational methods. My lab has broad interests in phylogenomics and phylogeography, population genetics/genomics, and the geography and genetics of speciation in reef fishes.",Assistant Professor,Marine Biology,https://scholars.library.tamu.edu/vivo/display/nc2f8ea4a
Nicholas,Sears,Instructional Assistant Professor,,Instructional Assistant Professor,College of Engineering,https://scholars.library.tamu.edu/vivo/display/nc6e4970a
Zhilei,Chen,Associate Professor,"The Chen Medicinal Protein Lab aims to accelerate the discovery, development and clinical translation of protein therapeutics through innovative protein engineering research. We believe that better medicine enables a higher quality of living, and protein engineers are charged to create the better medicine for today and tomorrow. We are particularly interested in the creation and engineering of affordable protein therapeutics to prevent and treat infectious diseases and cancer.",Associate Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/nc9a6c3ae
Paul,Lindahl,Professor,"One of our two current research areas involves iron metabolism in mitochondria. The iron imported into these organelles is assembled into iron-sulfur clusters and heme prosthetic groups. Some of these centers are exported into the cytosol, while others are installed into mitochondrial apo-proteins. All of these processes are regulated in healthy cells, but various genetic mutations giving rise to diseases can cause iron to accumulate (e.g. Friedreich's ataxia) or become depleted (e.g. Sideroblastic anemia). We have developed a biophysical approach involving Mossbauer, electron paramagnetic resonance, and electronic absorption spectroscopy, to study the entire iron content of intact mitochondria in healthy and genetically altered cells. This Systems Biology approach allows us to characterize the ""iron-ome"" of mitochondria at an unprecedented level of detail. We are also using analytical tools (e.g. liquid chromatography) to identify complexes that are involved in ""trafficking"" iron into and out of the organelle.
Our other research area involves mathematical modeling of cellular self-replication on the mechanistic biochemical level. We collaborate on this multidisciplinary NSF-sponsored project with a mathematician at the University of Houston (Professor Jeffrey Morgan). We have developed a modeling framework that facilitates such modeling efforts, and have designed a number of very simple and symbolic in silico cells that exhibit self-replicative behavior. Our minimal in silico cell model includes just 5 components and 5 reactions. A second generation model includes a more realistic mechanism of mitotic regulation. One novel aspect of our approach is that cellular concentration dynamics impact (and are impacted by) cellular geometry. By minimizing membrane bending energies, we are now calculating cell geometry during growth and division. Our results suggest that the ""pinching"" observed in real cells is enforced by cytoskeletal structures.",Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/nc9ce621b
Robin,Autenrieth,Professor and Head,"My research is focused on microbial systems for the degradation of target compounds (hormones, crude oil, petroleum products, explosives, chemical warfare agents, chlorinated agents, among a few others) contaminating soils and waters. Physical and chemical processes are coupled to the microbial activity to understand the controlling parameters for optimization of performance. With an interest in improving the link between contaminant concentrations and human exposures for predicting the potential for adverse health effects, my students and I have been working on methods to improve the risk assessment of select compounds.",Department Head||A.P. and Florence Wiley Professor III,Civil Engineering||Civil Engineering,https://scholars.library.tamu.edu/vivo/display/nca139916
Jeanmarie,Verchot,Professor Plant Virology,"Our long-term interest has been to understand the mechanisms of virus disease, specifically in potyviruses and potexviruses -- common families infecting a wide range of crops. We endeavor to use our understanding in engineering novel methods for crop disease control.
We have focused over the last decade on how virus proteins interact with cellular membranes in their host plants. We have uncovered genetic stress response machinery that appears to down-regulate virus infection, creating a tolerant state in the plant. When this stress response is compromised, the host plant becomes sick and necrotic. Our research aims to identify ways to increase plant vigor and yields in the face of virus infection, by empowering this cellular stress response machinery.",Professor Plant Virology,Texas A&M AgriLife Research,https://scholars.library.tamu.edu/vivo/display/ncb9981be
Yongbo,Lu,Associate Professor,,Associate Professor,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/ncce6bd83
Vytas,Bankaitis,Professor,"My laboratory is interested in the regulatory interfaces between novel lipid-mediated signal transduction pathways and important cellular functions. The focus of our work is the phosphatidylinositol/ phosphatidylcholine transfer proteins (PITPs), a ubiquitous but enigmatic class of proteins. Ongoing projects in the laboratory derive from a multidisciplinary approach that encompasses biochemical characterization of novel members of the metazoan PITP family, and the application of genetic, molecular and biophysical approaches to detailed structural and functional analyses of PITPs.",E.L. Wehner-Welch Foundation Chair||Professor||Professor,Cell Biology and Genetics||Biochemistry and Biophysics||Chemistry,https://scholars.library.tamu.edu/vivo/display/ncff8dc21
Fen,Wang,Professor,"The laboratory focuses on understanding the molecular basis of cell signaling, and how aberrant cell signaling leads to birth defects and causes cancers. Using in vitro cell culture systems and in vivo mouse models, we study how the fibroblast growth factor (FGF) activates its receptor (FF) tyrosine kinase, and how the activated FF transmits the signals to downstream targets and regulates proliferation, differentiation, homeostasis, and function of the cells, as well as in organogenesis and development, including prostate and cardiovascular system development. The laboratory also employs molecular biology, cell biology, and mouse genetic technologies to study how aberrant FGF signals promote tumor initiation, progression, and metastasis. In addition, how environmental factors contribute to tumorigenesis and congenital birth defects by modulating FGF signal intensity and specificity is also under the scope of our research interests.",Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/nd5ef47ba
Kim,Dunbar,Distinguished Professor,"Research in the Dunbar group spans topics in synthetic, structural and physical inorganic and bioinorganic chemistry. The use of a range of tools including spectroscopy, X-ray crystallography, magnetometry, electron microscopy, mass spectrometry and electrochemistry reflect the breadth of problems under investigation.",Distinguished Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/ndd473437
Michael,Manson,Professor,"Bacteria have a limited behavioral repertoire. Their most conspicuous behavior is chemotaxis - the pursuit of molecules that are favorable to acquire and the avoidance of chemicals that are best to avoid. The simplicity of bacterial motility and chemotaxis and the amenability of the model species Escherichia coli to genetic, biochemical and physiological manipulation have facilitated rapid advances in understanding the molecular mechanisms of biological energy conversion and signal transduction.
Our laboratory studies the inputs and outputs of chemotaxis. Ligands interact with the periplasmic receptor domain of a chemotactic signal transducer that spans the cell membrane. This interaction is converted into an intracellular signal that is communicated to the flagella. Molecules can be sensed either by binding directly to a receptor or by first interacting with a periplasmic binding protein, which then interacts with a receptor.",Professor||Professor,Biology||Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/ne190242a
Julian,Leibowitz,Professor,We have two projects in my lab. The first project is focused on identifying evolutionarily conserved RNA secondary structures in the coronavirus RNA genome and functionally examining their role in viral replication through reverse genetic and biochemical approaches. We have previously done this for a number of RNA secondary structures contained within the 5? and 3? regions of the genome and shown that they function as cis-acting elements in replication. Studies in my laboratory have identified a structurally dynamic region of the 5'UTR that interacts with the 3'UTR to facilitate transcription.
A second project in my laboratory has been to develop a reverse genetic system for MHV-1. In collaboration with investigators in Toronto and Pennsylvania my laboratory has demonstrated that MHV-1 infection of susceptible mice provides a safe and convenient rodent model for severe coronavirus infections such as SARS and MERS. The development of a reverse genetic system will allow us to investigate the contributions of individual viral genes to the pathogenesis of the severe pulmonary disease caused by this virus.,Professor||Professor,Microbial Pathogenesis and Immunology||Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/ne2185aa0
Deborah,Siegele,Associate Professor,"Phenotypes are observable characteristics of an organism that result from the expression of a particular genotype in a particular environment. Examples of phenotypic traits in microbes are motility, sporulation, ability to perform anaerobic respiration, and resistance/sensitivity to an antibiotic.
Until recently, phenotypic information has been captured as free text descriptions in research papers. Ambiguities in natural language confound attempts to retrieve information across sources. For example, ""serotype"" and ""serovar"" both refer to the same phenotype, but a simple text-based query with either word alone would miss the other. Or a single term, such as ""sporulation"" is used to refer to multiple, distinct processes in different organisms. Issues such as these hamper the ability to integrate different phenotypic data sets for the same organism or to use phenotypic information in one organism to predict possible phenotypes in another organism. Ideally, phenotype information should be stored in a consistent, computable format for ease of data integration and mining.
Controlled vocabularies are used to provide both consistent terminology and a structured data format for the capture of biological information. Ontologies are controlled vocabularies of defined terms with unique identifiers and precise relationships to each other. There are phenotype ontologies available for many eukaryotic organisms, including fungi. However, when the OMP project was initiated, none of the existing ontologies was appropriate to comprehensively capture phenotypes for Bacteria or Archaea or to enable comparisons across microbial taxa.
The Siegele lab and our collaborators at TAMU and the Univ. of Maryland (IGS) are developing a formal Ontology of Microbial Phenotypes (OMP). Our lab is focused on term development and annotating microbial phenotypes. OMP can be accessed at microbialphenotypes.org. Releases of OMP are available at github.com/microbialphenotypes.",Associate Professor,Biology,https://scholars.library.tamu.edu/vivo/display/ne333d587
Susanne,Talcott,Professor,"Dr. Susanne Talcott's research revolves around botanical compounds (polyphenols, terpenoids and alkaloids) and the impact of their metabolites on inflammation, cognitive function, and intestinal health. She primarily focuses on conducting human clinical studies to understand the pharmacokinetics and pharmacodynamics of these compounds.
Recently, the impact of bioactive metabolites produced by the gut microbiota on intestinal and cognitive health through the gut-brain axis has been of great interest.
Dr. Susanne Talcott is working on federally funded projects (USDA, NIH) and collaborates with the dietary supplement and functional food industry on health-related product claims that are supported by unbiased scientific evidence and comply with FDA- and FTC-regulations.",Professor||Professor,Food Science and Technology||Nutrition,https://scholars.library.tamu.edu/vivo/display/ne4324c37
Victor,Ugaz,Professor,"I am the world's smallest plumber--my research involves manipulating fluid flow in tiny channels the size of a human hair. Harnessing microfluidic phenomena makes it possible to build pocket-sized systems that can perform sophisticated chemical and biochemical tests outside the confines of a conventional lab. But achieving precise control over the flow of liquids at these small size scales is extremely challenging. Therefore, we are working to understand fundamental transport phenomena in microfluidic systems, and how they can be exploited to enable innovative applications including:
Fast and inexpensive diagnosis of infection and disease.
Sensitive screening for early detection of cancer.
Biodegradable sponges for easy cleanup of oil spills.
Spontaneous organization of chemical building blocks to form long-chain molecules--a key unanswered question in the origin of life.",Professor,Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/ne76e71aa
Chao,Tian,Associate Professor - Term Appoint,,Associate Professor - Term Appoint,Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/ne78dd90b
Michael,McShane,Professor and Department Head,,Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/ne7c17cfc
Hays,Rye,Associate Professor,"A fundamental principle of biology is the use of chemical energy in the form of ATP to assemble, disassemble and alter macromolecular structure. Specialized control proteins known as molecular chaperones are often responsible for this activity and have been recognized in recent years to be essential for regulating many aspects of cellular biology. Using a variety of biophysical and biochemical techniques, the Rye lab focuses on three fundamental cellular processes that require molecular chaperones: (1) protein folding (2) protein disaggregation and (3) vesicle trafficking. In each of these cases, large quantities ATP are burned, resulting in molecular organization in the case of protein folding, and molecular disassembly and remodeling in the case of protein disaggregation and vesicle trafficking. We are interested in understanding the detailed biophysical mechanisms that underpin these events. Why are these processes so energetically expensive? Are there any similarities in how the energy is used between these very different molecular processes? Are there general principles of energy transduction in biology that can be gleaned by comparing these examples with other molecular machines, such as cytoskeletal motors? Understanding how molecular chaperones control protein and membrane organization will provide key insights into not only basic cell biology, but will also illuminate aspects of many diseases that spring from aberrant protein and membrane dynamics.",Associate Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/ne7fb85e1
Darrell,Pilling,Research Assistant Professor,,Research Assistant Professor,Biology,https://scholars.library.tamu.edu/vivo/display/ne8a9ecc1
Leif,Andersson,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ne8ae2a28
Jeffrey,Cirillo,Professor,"Our laboratory is interested in the pathogenesis of bacterial lung infections particularly tuberculosis and Legionnaires' disease. We are examining the virulence mechanisms of bacteria using cellular, molecular and genetic techniques. Our primary research goal is to obtain a better understanding of the roles of the pathogen and host in disease. These studies should contribute to our understanding of host-pathogen interactions at the molecular and cellular level that can be used for prevention, treatment and diagnosis. We hope that through a better understanding of the mechanisms by which these organisms cause disease we can prevent some, if not all, of these infections in the future.",Professor||Director,Microbial Pathogenesis and Immunology||Center for Airborne Pathogen Research and Tuberculosis Imaging,https://scholars.library.tamu.edu/vivo/display/ne8bc1122
Albert,Mulenga,"Professor and Interim head, Veterinary Pathobiology","For generations ticks and tick borne diseases have had significant impact of animal health and livestock productivity around the world. In public health the effect of ticks and tick borne diseases is also tremendous. Since the 1980s when the causative agent of Lyme disease was described, numerous human tick borne diseases have been reported. In absence of effective vaccines against major tick borne diseases, prevention of animal and human tick borne disease infections relies on the use chemicals (acaricides) to kill ticks. Although acaricide based tick control methods are effective in the short-term, they do not offer a permanent solution because of serious limitations such as ticks developing resistance and contamination of the environment and the food chain. Immunization of animals against is a validated alternative tick control method. The attraction is that tick vaccines will be effective against both acaricide resistant and susceptible tick populations. The major limiting factor is the availability of effective tick vaccine targets. The tick cannot cause damage to host or transmit disease agents without successful feeding. Thus, our plan is to understand molecular mechanisms of how ticks accomplish feeding. In this way we will find targets that will be used for development of effective tick vaccines. We are currently studying the feeding physiology of the blacklegged tick (Ixodes scapularis) and the Lone Star tick (Amblyomma americanum). According to the US Centers for Disease Control, these two medically important tick species transmit a combined nine of the 14 human tick borne disease agents in the United States. Major work is on discovery and characterization of proteins that the Lone Star and the Blacklegged tick into animals every 24h through out feeding. The area of particular emphasis is to understanding roles of serine protease inhibitors (serpins) the blacklegged tick and the Lone Star tick inject into animals during feeding. We have identified serpins",Professor and associate head||Professor & Interim Head,School of Veterinary Medicine and Biomedical Sciences||Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/ne8f0c620
Ryland,Young,Professor,"Most bacterial viruses (phages) cause lysis of their host cell to release the progeny virions. Large phages elaborate an enzyme (""endolysin"") to degrade the cell wall and also a small membrane protein (""holin""). The holin accumulates in the membrane and then, at a precisely scheduled time, suddenly forms a hole to allow release of endolysin through the cytoplasmic membrane to gain access to the wall. We use molecular genetics and biochemistry to study how this small protein is able to act as a molecular ""clock"" and punch holes in membranes. Small phages make single proteins which cause host lysis in a different way. This strategy is to target the host cell wall synthesis machinery; that is, the virus makes a ""protein antibiotic"" that causes lysis in the same way as antibiotics like penicillin by inhibiting an enzyme in the multi-step pathway of murein biosynthesis. Thus, when the infected cell tries to divide, it blows up, or lyses, because it can't make the new cell wall between the daughter cells. Remarkably, each of three different, small phages blocks a different step in the pathway. These small lysis proteins are models for a completely new class of antibacterial antibiotics. Also, the E. coli SlyD protein is required for this mode of lysis in one case. SlyD is a member of an ubiquitous family of proteins related to human ""immunophilins,"" the targets of immune-suppression drugs. We study SlyD to learn about the role of this class of proteins in biology.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/nea775348
Steven,Maxwell,Associate Professor,"My primary interests include Cancer; Oncogenes; Tumor Suppressor; Genes Programmed Cell Death (apoptosis); Chemoresistance, and Angiogenesis. My laboratory studies mechanisms of evolution of chemoresistance in diffuse large B-cell lymphoma (DLBCL). One current primary objective is to conduct a Phase I study that (1) confirms RTI-79 safety in platinum-resistant/refractory ovarian cancer patients, and (2) demonstrates signals of efficacy in humans (ex: time-to-disease progression and changes in CA125 biomarker). A second objective is to better define the RTI-79 mechanism of action (MOA) by (1) determining how RTI-79 causes a rapid burst in superoxides, and (2) elucidating the basis of Nrf-2 pathway downregulation.",Associate Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/neb5b702f
Stephen,Smith,Professor,"Dr. Smith teaches meat science, nutrition and physiological nutrition courses. He also conducts research on the growth and development of adipose tissue, particularly in the bovine species. He has investigated the limitation of cattle to marble and has used his background in molecular biology to investigate lipid metabolism in the bovine muscle.",Professor||Professor,Animal Science||Nutrition,https://scholars.library.tamu.edu/vivo/display/nee8e5966
David,Bergbreiter,Professor,"Our group explores new chemistry related to catalysis and polymer functionalization using the tools and precepts of synthetic organic chemistry to prepare functional oligomers or polymers that in turn are used to either effect catalysis in a greener, more environmentally benign way or to more efficiently functionalize polymers. Often this involves creatively combining the physiochemical properties of a polymer with the reactivity of a low molecular weight compound to form new materials with new functions. These green chemistry projects involve undamental research both in synthesis and catalysis but has practical aspects because of its relevance to practical problems.
A common theme in our catalysis studies is exploring how soluble polymers can facilitate homogeneous catalysis. Homogeneous catalysts are ubiquitously used to prepare polymers, chemical intermediates, basic chemicals and pharmaceuticals. Such catalysts often use expensive or precious metals or expensive ligands or are used at relatively high catalyst loadings. The products often contain traces of these catalysts or ligands - traces that are undesirable for esthetic reasons or because of the potential toxicity of these impurities. Both the cost of these catalysts of these issues require catalyst/product separation - separations that often are inefficient and lead to chemical waste. These processes also use volatile organic solvents - solvents that have to be recovered and separated. Projects underway in our lab explore how soluble polymers can address each of these problems. Examples of past schemes that achieve this goal in a general way as highlighted in the Figure below.
We also use functional polymers to modify existing polymers. Ongoing projects involve molecular design of additives that can more efficiently modify polymers' physical properties. We also use functional polymers in covalent layer-by-layer assembly to surface polymers' surface chemistry.",Faculty Affiliate||Professor,Energy Institute||Chemistry,https://scholars.library.tamu.edu/vivo/display/nf01e95dd
Jan,Suchodolski,Professor,"Our research is focused on gastrointestinal function testing, gastrointestinal pathogens, and intestinal microbial ecology with an emphasis on probiotics and prebiotics and how intestinal pathogens lead to disturbances in the intestinal microbiome of companion animals.",Associate Director of GI Lab||Professor,Small Animal Clinical Sciences||Small Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/nf0f36949
Joseph,Rutkowski,Assistant Professor,"Current ongoing projects are mostly focused on the Lymphatic Physiology of Metabolic Systems. Herein, we are utilizing an extensive toolkit of genetic mouse models and physiologically-relevant in vitro systems to identify how changes in lymphatic biology impact metabolite transport and whole animal metabolism. Other projects use our toolkit in identifying factors driving the pathology of lymphatic diseases such as generalized lymphatic anomalies (GLA) and lymphedema. Additional collaborative efforts employ our models in renal and pulmonary health.",Assistant Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/nf1902e01
John,Mullet,Professor,"Functional genomics, bioinformatics, and DNA chip technology are fundamentally changing research on biological systems. Knowledge of complete genome sequences and high resolution genome technology provide an extraordinary opportunity to understand complex biological processes and to relate detailed understanding of protein structure and biochemical mechanism to the function of whole organisms and biological systems in nature.
Our research team is helping to build genome maps and DNA diagnostic microarrays/chips for analysis of global gene expression and biodiversity. This new technology is being used to explore the molecular basis of several fundamental plant responses: (1) light responsive genetic systems that help protect plants from damage by high intensity UV/blue light; (2) genetic systems that allow plants to adapt to the environment; (3) genes and signal transduction pathways that help protect plants from insects and disease; and (4) genes that regulate plant development (flowering time, fertility restoration, chloroplast development/number).",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/nf1c81fcb
Richard,Gomer,Distinguished Professor,"Our laboratory is working on three areas of biomedicine, trying to move observations from basic research into the clinic. First, we are studying how the sizes of tissues and tumors are regulated, and how this can be manipulated for therapeutic purposes. As a model system, we are using the simple eukaryote Dictyostelium discoideum, which allows us to combine techniques such as biochemistry, genetics, computer modeling, and cell biology to study tissue size regulation. We have found that a secreted protein as well as the unusual molecule polyphosphate are signals in negative feedback loops that inhibit Dictyostelium cell proliferation, and we are studying the signal transduction pathway to understand similar mechanisms in humans.
Second, we are studying how some secreted proteins can make cells move away from the source of the signal. We found such a signal (called a chemorepellent) in Dictyostelium, and then found a similar signal in humans. We are working to understand the signal transduction pathway for both. The human signal repels neutrophils, and we found that this can be used therapeutically in mouse models of neutrophil-driven diseases such as rheumatoid arthritis and acute respiratory distress syndrome.
Third, we have found that a human blood protein called Serum Amyloid P (SAP) regulates a key step in the formation of scar tissue as well as the formation of the scar-like lesions in fibrosing diseases such as congestive heart failure and pulmonary fibrosis. We are studying this mechanism, and a biotech company (Promedior, now sold to Roche) we co-founded is testing SAP as a therapy for fibrosis in patients in a Phase 3 trials.",Distinguished Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nf41f3898
James,Erickson,Associate Professor,"Alternative developmental fates are often determined by small differences in the concentrations of signaling molecules. In many cases, cells respond to these signals within narrowly defined temporal windows and are unresponsive to the same signal molecules at other times in development. A number of aspects of Drosophila sex determination make it an ideal experimental system to study how strict temporal controls and small quantitative differences in protein concentration can elicit different developmental fates.",Associate Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nf4575bc8
Joerg,Steiner,Professor,"My veterinary career has mainly focused on two aspects, patient care and clinically-relevant research. As a veterinary clinician and clinical teacher I am exposed to a wide variety of canine and feline patients with complex medical conditions. These patients serve as a constant source of new clinical problems that beckon to be studied further. Sometimes these studies are merely clinical, relating to characterization of an uncommon condition, diagnosis of a difficult-to-diagnose condition, or a novel therapeutic approach to a well-described condition. In other instances studies that are spurred by clinical cases are more basic-science based, utilizing state-of-the-art technologies to further evaluate the etiology or pathogenesis of a disease. In some instances, studies may provide comparative aspects related to experimental animals, such as rodents or primates, or even to human patients with similar conditions. I believe that my role as a mentor can be unique in that I can help graduate students bridge the gap between science and clinical aspects and between veterinary and human medical interests - giving us further opportunities to advance the concept of one-health.","Professor||Director, Gastrointestinal Laboratory",School of Veterinary Medicine and Biomedical Sciences||Small Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/nf4de66a0
Randall,Davis,Regents Professor,"Randall William Davis is an educator and researcher who studies the physiology and behavioral ecology of marine mammals and other aquatic vertebrates. His physiological research focuses on adaptations of marine mammals for deep, prolonged diving. Davis has continually emphasized the importance of studying aquatic animals in their natural environment and has spent many years developing animal-borne instruments that record video and monitor three-dimensional movements, swimming performance and environmental variables to better understand their behavior and ecology. His academic endeavors and 100 research expeditions have taken him to 65 countries and territories on seven continents and all of the world's oceans.
https://en.wikipedia.org/wiki/Randall_William_Davis",Regents Professor||Regents Professor,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences||Marine Biology",https://scholars.library.tamu.edu/vivo/display/nf5158696
Zivko,Nikolov,Professor and Associate Department Head,"Nikolov's Bioseparations Lab conducts transformative research in bioprocess engineering aimed at the development of novel and cost-effective strategies for extraction and purification of recombinant and native biomolecules. Bioseparations Lab leverages scientific and engineering expertise of lab members to find solutions for a variety of bioprocessing and separations challenges that currently face plant and algal biotechnology. To guide early process development and identify constraints posed by biological system and final product lab members use process simulation. Past and current research projects directed by Dr. Nikolov include industrial protein products derived from rice, sugarcane, tobacco, Lemna minor, and microalgae.",Faculty Affiliate||Professor and Associate Department Head,Biological and Agricultural Engineering||Energy Institute,https://scholars.library.tamu.edu/vivo/display/nf84893f5
Daniel,Leskovar,Agrilife Center Director,"Dr. Leskovar's vegetable physiology program focuses on understanding plant morphological and physiological adaptation mechanisms to environmental stresses, and development of integrated sustainable vegetable cropping systems. His research emphasis is on: 1) seed-transplant production and physiology to increase plant survival and enhance stand establishment; 2) plant hormones to modulate seedling growth; 3) root/shoot developmental responses to water conservation strategies and irrigation technologies; 4) impact of cropping systems on antioxidants and sensory attributes of vegetable crops; and 5) genotype selection for drought resistance, high yield, quality, and phytochemical content. Dr. Leskovar's program involves international cooperators.",Agrilife Center Director||Professor||Professor,Dallas Research and Extension Center||Uvalde Research and Extension Center||Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/nfa1a6351
Mansoor,Khan,Professor and Vice Dean,"Dr. Mansoor A. Khan serves as a professor and Vice Dean of the Texas A&M University Rangel College of Pharmacy at College Station, Texas. Prior to joining Texas A&M in 2015, he served as the Director of Product Quality Research and a Senior Biomedical Research Scientist (SBRS) at CDER in US Food and Drug Administration for over eleven years. In FDA, he led the research and review teams to promote manufacturing science, and served as a founding member of the FDA Emerging Technology Team. Dr. Khan received his Ph.D. degree in industrial pharmacy form St. Johns University in NY. He has published over 335 peer-reviewed manuscripts in pharmaceutical formulations and manufacturing sciences, and delivered over 300 presentations world-wide. Dr. Khan's research, currently supported by the NIH and FDA, spans drug delivery and formulations, and he has received over ten million dollars in funding as a principal investigator.
Dr. Khan has held leadership positions at the AAPS including elected chair of formulations design and development (FDD) section. He serves on the editorial board of Pharmaceutical Technology, International Journal of Pharmaceutics, AAPSPharmsciTech, and the Drug Delivery and Translational Research. He has received about 20 FDA/CDER review, research, and exemplary achievement awards, outstanding alumni award at St. Johns University College of Pharmacy, Excellence Award in Texas A&M University. He received the 2012 AAPS Research Achievement Award in Formulations Design and Development. He is also an AAPS and AAiPS Fellow. Dr. Khan served as FDA representative to the World Health Organization (WHO), United States Pharmacopoeia (USP), European Medicine Agency (EMA), DARPA, NIH, National Institute of Pharmaceutical Technology and Education (NIPTE), and International Pharmaceutical Federation (FIP). He is also a member of the European Union Academy of Sciences.",Regents Professor and Presidential Impact Fellow,Center for Microencapsulation and Drug Delivery,https://scholars.library.tamu.edu/vivo/display/nfc5f1cd6
Darwin,Prockop,Professor,,Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/nfcfd0990
Magnus,Hook,Professor,"The primary interest of our laboratory is to try to understand the structural function of the extracellular matrix. Of particular interest is the study of the molecular mechanisms of microbial adhesion to host tissue. This process, which is believed to represent a critical initial step in the development of infections, involves specific cell-surface proteins that recognize and bind with a high affinity to components in the host tissue. Our goal is to decipher these events at a molecular level and, based on structural analysis of the interacting components, design new strategies to prevent and treat infections.",Regents & Distinguished Professor and Director,Center for Infectious and Inflammatory Diseases,https://scholars.library.tamu.edu/vivo/display/nfd8d37d6
Craig,Nessler,Professor,,Adjunct Professor||Professor||Faculty Fellow,Center for Health Systems and Design||Soil and Crop Sciences||Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/nfe5a2ef4