First name,Last name,Preferred title,Overview,Position,Department,Individual
William,Murphy,Professor,"Mammalian comparative genomics, phylogeny, biogeography, and molecular evolution, with a specific emphasis on feline evolutionary genomics, including: gene mapping, sex chromosome genetics, speciation and mechanisms of male hybrid sterility.",Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n08093092
Guoyao,Wu,Distinguished Professor,"Dr. Wu teaches graduate courses in protein metabolism and nutritional biochemistry. He conducts research in protein and amino acid metabolism at molecular, cellular, and whole body levels . The animal models used in his research include cattle, chicks, pigs, rats, sheep, fish, and shrimp. He has also conducted research on amino acid nutrition in humans.",Faculty Fellow||University Faculty Fellow||Distinguished Professor||Senior Faculty Fellow||Distinguished Professor,Veterinary Integrative Biosciences||Animal Science||Texas A&M AgriLife Research||Texas A&M AgriLife Research||Nutrition,https://scholars.library.tamu.edu/vivo/display/n169f9a74
Dana,Gaddy,Professor,"My laboratory has been engaged in multiple areas of NIH-funded musculoskeletal research since 1996. We were the first to identify the non-steroidal gonadal inhibin hormones in regulating the hypothalamic-pituitary-gonadal-skeletal axis in mice, and the role of changes in inhibins that signal the onset of menopause (reproductive aging) to the onset of increasing bone turnover. We also demonstrated the anabolic effect of continual Inhibin exposure in normal mice and in bone repair. Our cellular focus on Inhibins and the related factor, Activin A revealed that Activin A suppresses local bone resorption through suppression of osteoclast formation, motility and survival. Our ongoing work is in the area of specific inhibin/betaglycan receptor interactions that mediate the effects on bone cells. We are also greatly interested in improving the low bone mass that we were the first to identify in both humans with Down Syndrome (DS) and in mouse models of DS as a low bone turnover disease. Our current NIH-funded research is working to identify the mechanisms of reduced fracture healing and compromised bone regeneration in Down Syndrome. We have demonstrated the efficacy of both PTH and SclAb in DS, and are now actively testing nutriceuticals to increase bone mass in mouse models of Down Syndrome. The limitations of using mouse models to study bone disease led us to our most recent and exciting endeavors in collaboration with TAMU experts in reproduction and embryo transfer technologies to develop a large platform model of bone disease, using sheep. We have generated the first large animal model of hypophosphatasia (HPP) via high efficiency gene editing of a knock-in point mutation in the ALPL gene, whose musculoskeletal and dental phenotypes are consistent with human HPP. We are now using this model to determine the etiology of mineralization deficiencies, muscle weakness and premature tooth loss by analysis of longitudinal biopsies and analysis of muscle, bone and dental specimens using CT, microCT, mechanical testing, immunohistochemistry, histomorphometry and ex vivo bone marrow cultures.",Professor||Adjunct Professor,Veterinary Integrative Biosciences||Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n2dc10a1a
Barbara,Gastel,Professor,,Professor||Professor,Veterinary Integrative Biosciences||Humanities in Medicine,https://scholars.library.tamu.edu/vivo/display/n2f554fb7
Paul,Samollow,Professor,"Comparative functional genomics and genome evolution in vertebrates; structural organization of genetic material and its relationship to patterns of gene regulation and expression within and among species. Epigenetics of meiotic recombination; patterns and epigenetic determinants of sexual dimorphism in meiotic recombination rates and chromosomal distributions. Population genomics: genetic and ecological processes that influence the distribution of genetic diversity within and among populations in nature; population structure, isolation, and speciation. QTL mapping: linkage mapping to detect genes that influence physiologic and health-related traits. Research in my laboratory focuses primarily on the genome of the gray, short-tailed opossum, Monodelphis domestica, the world's primary laboratory marsupial model for genomic, biomedical, and evolutionary research. We also study isolated desert populations of pupfishes of the genus Cyprinodon in west Texas.nature, and their roles in promoting population structuring, isolation, and speciation. QTL mapping: linkage mapping to detect genes that influence physiologic and health-related traits. Research in my laboratory focuses primarily on the genome of the gray, short-tailed opossum, Monodelphis domestica, the world's primary laboratory marsupial model for genomic, biomedical, and evolutionary research. We also study isolated desert populations of pupfishes of the genus Cyprinodon in west Texas.",Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n38c16b10
Jianrong,Li,"Professor, Neurobiology and Neuroimmunology, Veterinary Integrative Biosciences","The central goal of our research is to understand how oligodendroglial development and function in the mammalian central nervous system is regulated in health and disease. Specifically, we are interested in molecular and cellular mechanisms involved in oligodendrocyte damage/dysfunction in white matter injuries such as multiple sclerosis and cerebral palsy and in aging-related neurodegenerative diseases such as Alzheimer's disease. Because in most CNS diseases, multiple cell types including neurons, glial cells and vascular cells are involved via complex interactions, we investigate, at the cellular and molecular level, the role of microglia and astrocytes in the process of oligodendrocyte development, differentiation and damage. We use a variety of methods including primary cell cultures and transgenic and knockout animals to elucidate cellular pathways mediating oligodendrocyte injury.
The second focus of our laboratory is to elucidate the signals that promote oligodendrocyte survival and regeneration/remyelination after injury, and to study cell-cell interactions that regulate remyelination. These studies should contribute significantly to our understanding of mechanisms of oligodendrocyte development and injury, and provide new clues for potential prevention and treatment of human white matter diseases.",Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n3ef91dcf
Sakhila,Banu,Professor,"My long-term goals are two-fold: 1) to understand the molecular mechanism of prenatal CrVI exposure on placental and fetal development, ovarian and uterine function, and pregnancy outcome, and; 2) to understand the protective effects of various natural and synthetic antioxidants (such as edaravone, glutathione, vitamin C and resveratrol) against the deleterious effects of heavy-metals, CrVI in particular. Current research in my lab is focused on the study of reproductive and developmental toxicity of CrVI. Drinking water contamination with CrVI in the United States is a growing problem due to increased usage of CrVI and improper disposal of Cr waste into the environment. Significant contamination with CrVI has been found in the drinking water sources of all the states in the U.S. Effects of Cr on reproductive health in women and development in children have received less attention. Epidemiological data document that women exposed to Cr in environmental or occupational settings suffer from infertility, gynecological problems, congenital malformation of fetuses, neonatal mortality, and premature abortions with increased levels of Cr in their blood, urine and placenta. Cr can bind directly to DNA and nuclear proteins, cause DNA strand breaks and mutations, alter the balance between reactive oxygen species (ROS) and antioxidants, and activate several cell signaling pathways. Therefore, my current research objective is to determine molecular pathways and identify target genes/proteins by which Cr alters prenatal development and organogenesis of female reproductive system in the offspring.",Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n4783d1f1
Robert,Burghardt,Professor,"Research in the laboratory is focused on investigating mechanisms by which a variety of biological response modifiers ranging from mechanical signals, hormones and growth factors to environmental chemicals alter cellular signaling pathways and cellular homeostasis.","Professor||Director, Image Analysis Laboratory",School of Veterinary Medicine and Biomedical Sciences||Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n70a3d026
Larry,Johnson,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n72de4d00
Martial,Ndeffo,Assistant Professor,"My research uses transdisciplinary modeling approaches to address public health challenges for a wide range of infectious diseases. A focus of my research has been to develop data-driven models to 1) understand and predict epidemiological risk, patterns, and burden of infectious diseases, 2) identify and evaluate optimal strategies for disease control and prevention, and 3) perform economic analyses of public health intervention measures for preventing or curtailing disease outbreaks. Such research is paramount for informing public health policy for infectious diseases prevention and control and ultimately saving lives.",Assistant Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n7f958dd8
James,Cai,Professor,"Dr. Cai's research lies at the interface of single-cell biology, computational statistics, and data science. Current research focuses on using machine learning, network science and quantum computing to better understand the diverse behaviors of cells. Dr. Cai's group develops novel algorithms and analytical frameworks to study single-cell omics data from various types of cells, and the genetic basis of phenotypic variability to identify genetic variants that modulate complex phenotypic traits and susceptibility of genetic disorders.",Professor||Professor||Faculty,Veterinary Integrative Biosciences||Center for Statistical Bioinformatics||Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n8d287cea
Weston,Porter,Professor,y laboratory is interested in determining the role of factors in normal development and how disruption of these pathways results in associated pathologies.,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n90e6f6c0
Timothy,Phillips,Professor,food safety; molecular toxicology; elucidation of fundamental chemical mechanisms of toxic action/interaction of food-borne carcinogens; mutagens; and developmental toxicants; and development of methods to detect and detoxify foodborne and environmental toxins.,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n94eef946
Monique,Rijnkels,Research Associate Professor,"We are studying transcriptional regulation and the genomics of the mammary gland and the role of epigenetic events during mammary gland development and lactation. We use various genomics approaches to mammary gland biology and my laboratory has been using ChIP-seq, DNase-seq, ATAC-seq and other epigenomic approaches to determine chromosomal states at different developmental time points to determine the role of epigenetic regulation in mammary gland development and understand gene regulation in the mammary gland in general. We use transgenic mouse models to study gene regulation in mammary gland development and lactation.",Research Associate Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/na956415b
Roula,Mouneimne,Research Professor,"For the past 24 years my research focused on: 1- The development of methods in the fluorescence microscopy field that achieve data acquisition and analysis in real time, quantitative analysis, and mathematical modeling of cellular signaling. 2- The development of novel technological tools to decipher molecular and physiological events in cells and immunological tissues under normal toxin exposure and disease conditions.",Research Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/nbb6c8c2a
Peter,Nghiem,Associate Professor,"Molecular, cellular, and phenotypic characterization of the canine models for Duchenne muscular dystrophy (golden retriever muscular dystrophy [GRMD]; german short-haired pointer muscular dystrophy [GSHPMD]; cavalier king charles spaniel muscular dystrophy). Molecular characterization with genome-wide mRNA and microRNA profiling via Affymetrix chip and proteomic profiling with mass spectrometry. Confirmation of molecular targets with qRT-PCR, western blot, immunofluorescence microscopy, etc. Cellular characterization of the canine models utilizing biopsy extracted muscle stem cells (myoblasts), including evaluation of the molecular and phenotypic effects of various treatments. Phenotypic characterization of the canine models using internationally established functional outcome measures developed in the Kornegay laboratory. Current research focus is on preclinical drug trials, including gene therapy (dystrophin gene replacement) via adeno-associated viral vector delivery; utilzing gene editing techniques such as CRISPR/Cas9 and TALENs for treatments of genetic disease; characterization of genetic modifiers via whole-genome next generation sequencing (discovery approach); and evaluation of muscle metabolism in dystrophin deficiency.",Associate Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/nc223f624
Sarah,Hamer,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ndc2c4e3e
Christine,Budke,Professor,,Professor and interim Head,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ndf6eb879
Robert,Taylor,Research Professor,,Research Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ne49b235c
Joe,Arosh,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ne8898820
Louise,Abbott,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/nf56a7148