First name,Last name,Preferred title,Overview,Position,Department,Individual
James,Samuel,Regents Professor and Head,"Our laboratory works with the obligate intracellular bacterial pathogen, Coxiella burnetii, the etiologic agent of Q fever and a category B biothreat agent. The long-term goal of this research is to understand the molecular pathogenic mechanisms involved in the host-pathogen interaction. To accomplish this broad goal, project in the lab are designed to test the molecular mechanisms employed by both the host and pathogen. Current pathogen studies include 1) broad survey of proteins secreted via a type 4 secretion system (T4SS) followed by determination of essentiality of each substrate for virulence and detailed analysis of mechanism of host modulation 2) survey of essential virulence loci identified by specific mutant screens, and 3) definition of the relative virulence of phylogenetically distinct isolate groups.",Regents Professor and Head,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n01c3216f
Aniruddha,Datta,Professor,"My research focuses on adaptive control, parametric robust control, and genomic signal processing and control.",Professor||Faculty Affiliate,Energy Institute||Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n01f8748c
Yuxiang,Sun,Professor,"Dr. Sun is an expert on ""hunger hormone"" ghrelin. She generated the first set of ghrelin and ghrelin receptor knockout mice, and discovered novel roles of ghrelin signaling in diabetes, thermogenesis, and inflammation. Her laboratory uses state-of-the-art tools to study ghrelin system in energy sensing, metabolism and immunity, and aging. Her work suggests that ghrelin signal might be a promising drug target for obesity, diabetes, inflammation, and Alzheimer's disease.",Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n0228c22e
Vishal,Gohil,Associate Professor,"Despite the fundamental role of the mitochondrion in cellular energy production and its involvement in numerous human diseases, we still do not know the function of nearly 20% of the known mitochondrial proteins. My laboratory applies genomic, genetic, and biochemical tools to uncover the role of these uncharacterized proteins in the mitochondrial respiratory chain (MRC) biogenesis. MRC is the main site of cellular respiration and energy production and since the core components of the MRC are evolutionarily conserved, we reason that the assembly factors required to build the MRC should also be conserved. Therefore, we utilize multiple models systems, including yeast, zebrafish, and human cell lines, to determine the role of these conserved, uncharacterized mitochondrial proteins in bioenergetics, organismal development, and human disease pathogenesis.
Another poorly understood aspect of the mitochondrial energy metabolism is the role of phospholipids in maintaining the structural and functional integrity of the MRC. Although it is well known that the MRC is localized in the inner mitochondrial membrane, how the unique lipid milieu of the mitochondrial membrane influences the assembly and activity of the MRC is not fully understood. We have constructed yeast mutants with defined mitochondrial phospholipid compositions to systematically determine each lipid's role in MRC assembly and activity. Ultimately, defining the roles of mitochondrial proteins and phospholipids will allow us to develop better diagnostic and therapeutic options for human disorders resulting from mitochondrial dysfunction.",Faculty Affiliate||Assistant Professor,Energy Institute||Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n03100e49
Raymond,Carroll,Distinguished Professor,,Distinguished Professor,Statistics,https://scholars.library.tamu.edu/vivo/display/n032647a0
Anja,Schulze,Professor,"My research on marine invertebrates spans evolution, ecology, development and physiology. My lab is interested in how invertebrate animals have diversified over time and space. Which morphological and physiological characteristics have led to the evolutionary success of a species? Which environmental factors drive its geographic distribution? To address these questions, we focus on marine annelids, a ubiquitous and diverse taxon with at least 15,000 described species and a wide range of habitats and lifestyles.",Professor,Texas A&M University at Galveston,https://scholars.library.tamu.edu/vivo/display/n042bccf8
Gregory,Reeves,Associate Professor,,Associate Professor,Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/n05d3cae9
Dorothy,Shippen,Professor,"We are taking biochemical, molecular genetic and cytological approaches to study the structure, function and maintenance of telomeres. Telomeres are higher order nucleoprotein complexes that cap the ends of eukaryotic chromosomes and play essential roles in conferring genome stability and cell proliferation capacity. The protective cap of the telomere is comprised of specific telomere binding proteins that regulate the length of telomeric DNA tract and allow the cell distinguish the chromosome terminus from a double-strand break. Telomeric DNA is synthesized by the action of telomerase, an unusual reverse transcriptase that replenishes telomeric DNA lost as a consequence of replication by conventional DNA polymerases. We have developed the genetically tractable flowering plant Arabidopsis thaliana as a model system for studying telomeres in higher eukaryotes. With its sequenced genome, abundant genetic and transgenic tools, and extraordinarily high tolerance to genome instability, Arabidopsis has proven to be an excellent model for investigating fundamental processes in telomere biology. Current studies focus on defining the function and molecular evolution of telomere capping proteins and components of the telomerase ribonucleoprotein complex.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n07e86cac
Christopher,Seabury,Associate Professor,"Mammalian molecular genetics, genomics, and population genetics; animal disease genomics; utilization of population and quantitative genetics to elucidate host loci and relevant variation influencing differential susceptibility to disease, adaptability, and feed efficiency; next generation sequencing and de novo genome assembly as a mechanism to enable novel research programs in non-model mammalian and avian species of interest.",Associate Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n08037241
William,Murphy,Professor,"Mammalian comparative genomics, phylogeny, biogeography, and molecular evolution, with a specific emphasis on feline evolutionary genomics, including: gene mapping, sex chromosome genetics, speciation and mechanisms of male hybrid sterility.",Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n08093092
Hubert,Amrein,Professor,"My broad research interests are concerned with the sensory perception of the external chemical world. The central questions investigated in our laboratory are concerned with how animals detect and discriminate among the thousands of different chemical signals that ""flood"" the olfactory and taste organs. Our laboratory uses Drosophila as a model to study these problems because the Drosophilachemosensory systems are structurally and functionally very similar to those of mammals, yet they are smaller and somewhat less complex, which makes them excellent models to investigate the molecular and neural basis of olfaction and taste.",Senior Associate Dean of Research||Professor||Professor,Cell Biology and Genetics||School of Medicine||Nutrition,https://scholars.library.tamu.edu/vivo/display/n0839ec95
James,Muir,Professor,"I teach graduate courses at Tarleton State University, Stephenville, TX 76401. I mentor MSc & PhD students at various universities around the world. My research program focuses on grassland ecology, mostly at the plant-animal interface, with special emphasis on legumes. Topics include grassland restoration, ecosystems services, native legume domestication and the role of condensed tannins in ruminant systems.
I have current cooperative research projects in Tanzania, Botswana and Brazil. In the past I have worked extensively in Kenya, Senegal, South Africa, Malawi, Argentina and Portugal.",Regents Professor||Regents Professor,"Texas A&M AgriLife Research||Tarleton State University - (Stephenville, Texas, United States)",https://scholars.library.tamu.edu/vivo/display/n08762c08
Byung-Jun,Yoon,Professor,"Dr. Yoon's main theoretical interests include objective-based uncertainty quantification, optimal experimental design (OED), machine learning, and signal processing. Application areas of interest include bioinformatics, computational network biology, and AI-driven drug/materials discovery.",Professor,Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n08866781
Paul,Morley,Professor and Director of Research,"Dr. Morley is an epidemiologist and veterinary internal medicine specialist that studies infectious diseases affecting animals and people. Major emphasis for his professional activities includes using analytical epidemiology to improve our understanding and control of diseases in animals and people, investigating the ecology of pathogens and antimicrobial resistance determinants in animals and food production systems, and using infection control and biosecurity to manage health risks that are important in veterinary medicine, agriculture, and public health. Most recently he has used metagenomic methods to investigate the effects of agriculture production practices on antimicrobial resistance and microbial ecology as these affect human, animal, and ecosystem health. In 2019, he was appointed the Director of Research for VERO - the Veterinary Education, Research & Outreach Program - in the College of Veterinary Medicine and Biomedical Sciences at Texas A&M University. In this role, he supports the growth of research programs for all VERO faculty, supervises and provides oversight for research staff and laboratories, and promotes research exposure programs for veterinary and undergraduate students. Previously, Dr. Morley served for 20 years as Professor of Epidemiology and the Director of Infection Control at Colorado State University's Veterinary Teaching Hospital. He is a recognized authority on infection control in animal populations and has consulted on infection control and biosecurity issues at veterinary hospitals, veterinary colleges, and animal production facilities around the world.",Professor and Director,Large Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/n0b0778fb
Yi,Xu,Associate Professor,"Our current research activities focus on understanding the pathogenic mechanism of Streptococcus gallolyticus subsp. gallolyticus (Sgg). Sgg is a gram-positive opportunistic pathogen that causes life-threatening bacteremia and infective endocarditis (IE). It is also strongly associated with colorectal cancer (CRC). My lab was the first to demonstrate that Sgg actively promotes the development of colon tumors, elevating a long-stranding clinical association to a functional causal role of Sgg in tumor development. Despite its medical importance, the pathogenic mechanism of Sgg remains poorly understood. Our recent studies have demonstrated that a type VII secretion system of Sgg plays a key role in pathogenesis. Currently we are interested in understanding the mechanism underlying following key steps in Sgg pathogenesis: 1) colonization of the intestinal epithelium, 2) modulation of intestinal homeostasis in normal and tumor-bearing colons, and 3) dissemination from the gastrointestinal tract to the circulatory system.
Keywords: bacterial pathogenesis, infectious diseases, virulence, colorectal cancer, microbiome, microbiota, type VII secretion system, gastrointestinal tract",Associate Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/n0c22439a
Bruce,Riley,Professor,"My lab studies inner ear development in zebrafish. A prominent feature of our research is to investigate how cell-cell signaling and downstream gene-interactions control development. One project in the lab focuses on how cell signaling regulates ectodermal patterning during gastrulation to establish the otic placode, the precursor of the inner ear. Our recent work shows that localized Fgf signaling is especially critical for inducing formation of the otic placode, and members of the Pax2/5/8 family of transcription factors are important mediators of Fgf signaling. During later stages of inner ear development, we are exploring how sensory hair cells and neurons are regulated. Our studies address how these cells initially form, how they are genetically maintained, and how they become specialized for hearing vs. balance. We are also investigating how zebrafish can replace dead and damaged hair cells, an ability that mammals have lost. The inability to regenerate hair cells explains why humans show progressive irreversible hearing loss as we age. It is hoped that activating or augmenting human homologs of genes shown to operate in zebrafish might help restore hearing and balance in humans.",Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n0dbb8253
James,Womack,Distinguished Professor,"Comparative mammalian genomics with emphasis on bovids and laboratory animals. Study of evolution of gene families and genomic variation underlying disease resistance. Investigation of genetic mechanisms in innate immunity with focus on livestock, select agents, and agricultural biosecurity.",Distinguished Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n0e1a49e2
Qian,Wang,Associate Professor,"Dr. Wang's earlier work focused on the comparative morphology of craniofacial skeletons of Mid Pleistocene hominin fossils. During his postdoctoral training, he was involved in a number of studies examining the internal structure of craniofacial bone and suture morphology and how it is related to skeletal growth, function and adaptation. His recent research focuses on the functional morphology and biomechanics of the craniofacial skeleton. He has incorporated a range of methods, including geometric morphometrics (e.g., 3D Euclidean Distance Matrix Analysis and Generalized Procrustes Analysis/GPA), experimental approaches (e.g., in vitro strain measurements and ultrasonic techniques), computer-aided modeling and biomechanical analysis ( e.g., Finite Element Analysis), as well as phenotypic analyses. He has worked intensively on the various primate skeletal collections and has developed protocols for data collection and analyses of museum skeletal collections. In addition, he is a member of a multi-institutional research team made up of anatomists and anthropologists who have specialized in various aspects of functional morphology in order to systematically reassess the reconstruction and biomechanical interpretation of the face of early human types, based on current morphological and phylogenetic evidence and advances in biomechanical methods.",Associate Professor,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n10bc652f
Timothy,Devarenne,Associate Professor,"We study the biochemical and molecular mechanisms underlying the control of programmed cell death (PCD) in plants and how PCD is manipulated during plant-pathogen interactions. Specifically we study the interaction between tomato and Pseudomonas syringae pv. tomato (Pst) the causative agent of bacterial spot disease. Resistance to this disease is conferred by the host Pto serine/threonine protein kinase which recognizes Pst strains expressing the type III effector protein AvrPto.
PCD is induced during both resistant and susceptible plant-pathogen interactions. In the case of a resistant interaction, PCD induced by the plant, known as the hypersensitive response (HR), and acts to limit the spread of the pathogen. In susceptible plant-pathogen interactions plant PCD is induced by the pathogen after infection leading to death of the host. Studies have indicated that the genes controlling host PCD during the HR are the same genes that are manipulated by the pathogen during susceptible interactions. The difference lies in the timing of controlling the activity of these genes; HR PCD occurs within 12 hours of pathogen recognition while pathogen-induced PCD occurs several days after infection.
Many of these genes that control plant PCD are serine/threonine (S/T) protein kinase. We are interested in studying a specific class of S/T protein kinases that control PCD in plants called AGC kinases and how they are regulated in both resistant and susceptible plant-pathogen interactions. Additionally, when plants are not attacked by pathogens, PCD is a process that requires constant control so that cell death does not occur. We are looking at the signaling mechanisms and pathways employed to keep PCD under check in non-pathogen challenged plants.",Faculty Affiliate||Associate Professor,Energy Institute||Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n11411275
Richard,Woodward,Professor,Dr. Woodward's research is in the general area of environmental and resource economics. Recent research projects have focused on the use of transferable permits to address water quality and fisheries problems and problems of choice under uncertainty.,Professor||Faculty Affiliate,Energy Institute||Agricultural Economics,https://scholars.library.tamu.edu/vivo/display/n115a5961
Michael,Criscitiello,Professor and Associate Dean for Research and Graduate Studies,"My Comparative Immunogenetics Laboratory studies immunology, molecular genetics and evolution. Most of our group's research focuses on the natural history and future application of the vertebrate adaptive immune system, with particular attention given to the genetics of lymphocyte antigen receptors. Particular expertise lies in the evolution of vertebrate immunoglobulin loci, T cell receptor loci and the major histocompatibility complex. Additionally, we are interested in the evolution of diversification mechanisms at work there (e.g., recombination activating genes (RAG), activation-induced cytidine deaminase (AID), and the high allelic polymorphism maintained by classical MHC genes). Most recently, we have been working on lymphocyte development in shark thymus that suggests plasticity across the B lymphocyte/T lymphocyte divide, immunoglobulin heavy and light chain isotype pairing in an amphibian system, immunogenetics in marine mammals of conservation importance, mucosal humoral immunity in diverse tetrapods and cattle antibodies with an unheralded domain extending for novel antigen binding possibilities.",Associate Dean for Research and Graduate Studies||Professor,School of Veterinary Medicine and Biomedical Sciences||Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n11e21ca8
Hongmin,Qin,Associate Professor,"Live bioreactor for synthetic biology
The lab is developing live bioreactors to synthesize products of commercial value. The system we are developing is capable of resisting contamination, and withstanding harsh conditions. We are translating the technology developed for potential industrial usages.
The biogenesis of a cilium/flagellum
Our lab is interested in the conceptual frameworks that govern organelle biogenesis and the corresponding regulations. The current main research effort in our lab is to understand. Cilia and flagella are microtubule-based appendages extending from the basal body of almost all eukaryotic cells, and are classified as either motile or primary. Motile cilia or flagella such as Chlamydomonas flagella, sperm flagella and respiratory tract epithelial cell cilia are responsible for movement or generation of fluid flow. In contrast, primary cilia are non-motile organelles that are critically involved in visual, olfactory and auditory signal transduction and play key roles in regulation of gene expression, development and animal behavior. Ciliary defects are linked to ciliopathies such as polycystic kidney disease, nephronophthisis, retinal degeneration, situs inversus, hydrocephalus, polydactyly and obesity. Our lab uses a combination of biochemistry, cell biology, and genetics approaches to understand the principles of ciliogenesis and its regulation.
Flagellar axoneme structure and motility
The waveform of cilia is conserved, no matter whether the cilia are on green algae Chlamydomonas or mammalian epithelia found in the airways, the uterus and fallopian tubes, the efferent ducts of the testes, and the ventricular system of the brain. These motile cilia beat with a conserved planar asymmetrical waveform. We are beginning to learn how the asymmetry of the waveform is established and the mutant analyses are underway.",Associate Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n11e70177
Iman,Borazjani,Associate Professor,"My research interests are in developing advanced computational tools for biofluids and fluid-structure interaction problems, which we employ to advance knowledge and gain insights into the physics of important biological/engineering flows.",Associate Professor,Mechanical Engineering,https://scholars.library.tamu.edu/vivo/display/n12f81112
Rodolfo,Aramayo,Associate Professor,"My current research primarily focuses on understanding the organization, distribution, and comparison of information in Biological Systems. Our work encompasses two key levels of investigation:
Molecular Genetics: We employ the filamentous fungus Neurospora crassa as a model organism to uncover and comprehend the intricate molecular components responsible for sequence-based comparisons between homologous chromosomes, leading to the initiation of Meiotic Silencing, a phenomenon driven by RNA-mediated processes. Currently, our primary focus centers on the exploration of whether genes recognized for their significance in Meiotic Transvection/Silencing also contribute to the occurrence of Repeat Induced Point Mutation (RIP) phenomena.
Computational Analysis: We are developing novel computational pipelines dedicated to detecting sequence variations within related genomes. We are particularly intrigued by the prospect of simplifying (i.e., digitizing) the information present in DNA, RNA, and Proteins so as to simplify its manipulation and analysis. We think that digitizing emerging genomic data will not only enable us to use this data effectively but also to integrate it into Artificial Intelligence, Data Clustering, and Image Recognition Algorithms, in ways not done before. We posit that this process of converting biological features into digital equivalents has the potential to simplify genomic information, making it easier to uncover previously unnoticed patterns through complex computational comparisons. This approach has already yielded promising results by revealing unexpected informational patterns across various organisms' chromosomes. We believe that it will streamline and enhance our ability to comprehend different cellular and organismal states. Moreover, it holds significant promise in revolutionizing our understanding of diseases, particularly Cancer and Metagenomics. This informational perspective also contributes to our comprehension of genome evolution, especially in the field of comparative genomics and microbial metagenomics.",Associate Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n14287b36
Mary,Bryk,"Associate Professor and Associate Dean for Academic Affairs, College of Agriculture and Life Sciences",,Associate Professor and Associate Dean for Academic Affairs,College of Agriculture and Life Sciences,https://scholars.library.tamu.edu/vivo/display/n145a2ab4
Friedhelm,Schroeder,Professor,Intracellular lipid transfer proteins; lipid metabolism; multiphoton imaging of intracellular lipid transport and targeting in living cells and tissues of gene targeted animals.,Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n157063e2
Guoyao,Wu,Distinguished Professor,"Dr. Wu teaches graduate courses in protein metabolism and nutritional biochemistry. He conducts research in protein and amino acid metabolism at molecular, cellular, and whole body levels . The animal models used in his research include cattle, chicks, pigs, rats, sheep, fish, and shrimp. He has also conducted research on amino acid nutrition in humans.",Faculty Fellow||University Faculty Fellow||Distinguished Professor||Senior Faculty Fellow||Distinguished Professor,Veterinary Integrative Biosciences||Animal Science||Texas A&M AgriLife Research||Texas A&M AgriLife Research||Nutrition,https://scholars.library.tamu.edu/vivo/display/n169f9a74
Elizabeth,Pierson,Professor,"Dr. Pierson's areas of research include plant-microbe interactions, biological control, and sustainable agriculture. She also conducts research related to zebra chip disease of potato, microbe-insect interactions, and terrestrial plant ecology. She teaches the undergraduate course Garden Science and the graduate course Plant-associated Microorganisms, which is available to students in three different graduate programs. Dr. Pierson is active in graduate education, currently serving as a member of the Horticultural Sciences Graduate Program Committee and the MEPS admissions committee and as the advisor for the Horticulture Graduate Council. She also serves as a chair or member of graduate research committees and provides undergraduate laboratory research experience.",Professor||Adjunct Professor,Plant Pathology and Microbiology||Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/n1757e534
Sarah,Bondos,Associate Professor,"My laboratory works in two research areas. First, we are combining biophysical and genetic approaches to understand how proteins use unstructured regions to sense cellular information and respond by adjusting their function. We developed methods to purify Ultrabithorax, a full-length, active Hox transcription factor, and have used this unique opportunity to investigate the role of intramolecular regulatory interactions in tissue-specific protein regulation. Second, we discovered methods to self-assemble Ultrabithorax into robust, extensible materials that are biocompatible and provide unique opportunities for functionalization. These materials are being developed for use as biosensors and to pattern and instruct vascularization in tissue engineering scaffolds.",,,https://scholars.library.tamu.edu/vivo/display/n18de9127
Benjamin,Neuman,Professor,,Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n193ea580
Fatima,Alshbool,Assistant Professor,"Dr. Fatima Alshbool is an Assistant Professor, who joined the Rangel College of Pharmacy in February 2020. She is a pharmacist and a pharmacologist by training, having received her Pharm.D. degree (2006) from Jordan University of Science & Technology and her PhD degree (2014) from Loma Linda University. Dr. Alshbool's research program is focused on studying cardiovascular/thromboembolic disorders, such as heart attacks and stroke, particularly as they relate to platelet activation and signal transduction, including in the context of environmental health. One of her laboratory's main areas of focus has been investigating the impact of a relatively new form of tobacco smoking, namely e-cigarettes on platelet biology and associated diseases. She is also interested in defining the structural biology of platelet G-protein Coupled Receptors; amongst others. Dr. Alshbool's ultimate goal is to identify new therapeutic agents for the prevention or treatment of cardiovascular disease, and to gain insight into the negative impact of ""tobacco"" exposure on cardiovascular health.",Assistant Professor,Pharmacy Practice,https://scholars.library.tamu.edu/vivo/display/n1989ad2e
Michael,Golding,Associate Professor,,Associate Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n19ac3c74
Stratos,Pistikopoulos,Professor,"The objective of my research programme is to develop fundamental theory and optimization based methodologies and computational tools that enable process engineers to analyze, design and evaluate process manufacturing systems which are economically attractive, energy efficient and environmentally benign, while at the same time exhibit good performance characteristics like flexibility, controllability, robustness, reliability and safety.",Director||Professor,Energy Institute||Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/n1aaac28f
Tatyana,Igumenova,,"My laboratory is broadly interested in understanding the structural basis of signal transduction events that occur at the membrane surface. These events are mediated by signaling proteins that reversibly associate with membranes in response to binding second messengers, such as Ca2+ ions, diacylglycerol, and phosphoinositides. One of the key kinases regulating these signal transduction pathways is the Protein Kinase C (PKC) family. Aberrant levels of PKC expression or activity have been implicated in a large number of human diseases, such as cancer, cardiac failure, Alzheimer's disease, and diabetes. Despite the significance of PKC in signal transduction and human health, the structural and dynamical basis of its activation upon binding to lipid membranes remains elusive.",Associate Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n1c6e6632
Kayla,Bayless,Associate Professor,"My laboratory conducts research in two areas of molecular and cellular medicine: the mechanism through which primary human endothelial cells invade into 3D matrices, and communication between invading endothelial cells and their surrounding 3D collagen matrix.",Associate Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/n1dd3799c
Xiuren,Zhang,Professor,"Our laboratory focuses on systemic analysis of biochemical, molecular and biological functions of AGO family proteins (AGOs-mics) in genetically tractable Arabidopsis and economically important crops (i.e. rice). We'd like to identify the small RNAs, mRNA targets and protein components which associate with these AGOs. We will study protein/RNA and protein/protein interactions in these RISC assembly events. Our goal is to understand how these AGOs are functionally specialized or redundant corresponding to endogenous development cues and external environmental stimuli. Particularly, we'd like to learn how plants reprogram their gene expression through the small RNAs and AGOs to construct a new cellular niche in responses to environmental challenges and biotic stresses.
Another aspect of our research involves host/virus interaction. Plants take advantage of RNA silencing pathways to defend themselves from exogenous nucleic acid invaders (i.e. viruses). As an anti-host defense mechanism, viruses encode suppressors that can block RNA silencing responses. We have recently demonstrated that CMV 2b disables AGO1 cleavage activity to inhibit RNA silencing and to counter host defense. We are now extending our study to suppressors of several other viruses and the molecular mechanisms of their suppression.",Associate Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n220933ad
Gregory,Johnson,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n22b3a445
Umesh,Bageshwar,Research Assistant Professor,Our current work focuses on identifying the interaction site(s) between the Tat precursor pre-SufI and the TatBC receptor complex based on chemical crosslinking and the complementation of the Escherichia coli Tat pathway by the Mycobacterium tuberculosis Tat pathway.,Research Assistant Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/n23071727
Jennifer,Gillett-Kaufman,Instructional Associate Professor,I conduct applied research related to olive pest identification and management. My students work to develop research based answers that meet the needs of Texas citizens. Student research projects are driven by their interests and include (but are not limited to):
o olive pest management
o native pollinator abundance
o orchid pollination,Instructional Associate Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/n23de7371
Lisa,Even,Manager Laboratory,,Manager Laboratory,Small Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/n24b36cbf
Susie,Dai,Associate Professor,"My research group is interested in evaluating environmental hazard substances, their interactions with the environment and species, and biological systems that can degrade and detoxify the pollutants. We have established broad analytical platforms to survey a wide spectrum of natural or man-made toxic chemicals such as mycotoxins, microcystins, agricultural, and industrial chemicals.
We integrate electrocatalysis/photoelectrocatalytic processes and material engineering with biological systems for 1) chemical degradation and 2) energy storage. Meanwhile, our laboratory has built a modern analytical tool suite, which includes mass spectrometry-based platforms for monitoring and surveillance, hydrogen-deuterium exchange mass spectrometry for protein structure dynamics analysis, and gel free mass spectrometry-based proteomics analysis. We develop qualitative and quantitative methods for molecular characterizations, protein analysis and proteomics when working in different environmental systems.",Associate Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/n27690618
Satish,Bukkapatnam,Professor,"Dr. Bukkapatnam's research addresses the harnessing of high-resolution nonlinear dynamic information, particularly from wireless MEMS sensors, to improve the monitoring and prognostics of real-world systems, including ultraprecision and nanomanufacturing processes and machines, and cardiorespiratory processes. His research has led to 185 peer-reviewed publications (115 published/ accepted in journals and 70 in conference proceedings), 1 granted and five pending patents, and has been the basis for 17 Ph.D. dissertations. His research has received support from federal agencies including National Science Foundation, Department of Energy, and Department of Defense, and the private sector including General Motors, Ford, National Instruments, and the Central Rural Electric Cooperative.",Faculty Affiliate||Professor,Energy Institute||Industrial and Systems Engineering,https://scholars.library.tamu.edu/vivo/display/n277d780c
Christopher,Marshall,Professor,"My research focuses on the functional, ecological, & evolutionary aspects of how vertebrates detect, acquire, ingest and digest food. My program is integrative and comparative in nature. This work falls within the conceptual framework of ecological morphology & physiology and is conducted at the functional organismal level (morphology and physiology), behavioral, and ecological levels. The central concept of this field is that morphology and physiology influences an organism's ecology through constraints of behavioral performance, which is the capacity of an animal to exploit its natural resources, and explore its environment. Although investigations of morphology, physiology, and behavior stand on their own, ultimately the integration of these studies can explain how organisms interact with their environment, the evolution of functional complexes, and the pressure selections involved in driving adaptations.",Professor||Professor,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences||Marine Biology",https://scholars.library.tamu.edu/vivo/display/n27bd8535
David,Russell,Professor,"My research focuses on proteomics, lipidomics, biophysical chemistry and application and development of mass spectrometry, such as ""label-free"" nano-particle based biosensors and novel peptide/protein isolation and purification strategies. We are also investigating the structure(s) of model peptides in an effort to better describe folding/unfolding and structure of membrane and intrinsically disordered (IDP) proteins. Peptides take on very different 2?, 3? and 4? structure, which determine or influence bio-activity. In the presence of lipid vesicles peptides can exist as solution-phase species, ""absorbed"" on lipid bilayers or ""inserted"" (as a monomer or multimer) in lipid bilayers. By what mechanism do peptides interact with lipid membranes to affect these structural changes, how do peptide-lipid interactions promote self-assembly to form intermediates that eventually yield aggregates, i.e., amyloid fibrils, or how does metal ion coordination affect the structure of metalloproteins? Mass spectrometry-based experiments, hydrogen/deuterium (H/D) exchange, chemical 'foot-printing' and gas-phase (ion-molecule and ion-ion reaction chemistry) and solution-phase chemical modifications, have expanded our abilities to address such questions, and new instrumental approaches, esp. ion mobility spectrometry (IMS) combined with enhanced molecular dynamics simulations (MDS), have become standard tools for structural-mass spectrometry studies. Over the past several years we have either acquired or developed novel, next-generation IM-MS instruments that are redefining cutting-edge structural-mass spectrometry research as well as cutting-edge computational tools essential to carry out these studies. Our new laboratories in the Interdisciplinary Life Sciences Building (ILSB) provides exciting opportunities for collaborative, interdisciplinary research with chemical-biologists, biochemists and other chemists.",Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n280e03e6
Won-Bo,Shim,Professor and Associate Department Head,"Fungal pathogens of cereal crops can cause devastating disruption to the global food supply, and the economic loss due to crop diseases can add up to billions of dollars annually worldwide. The Shim lab at Texas A&M University focused on studying fungal pathogens of field crops, particularly Fusarium species. Notably, hazardous Fusarium mycotoxins pose a significant threat to global food safety and human health. Crop losses as well as the regulatory, testing, and management costs associated with mycotoxins in the US tops $1 billion annually.
The Genus Fusarium has had a great negative impact on agriculture and food safety but also presents a great opportunity for answering many fundamental questions. We are pursuing new discoveries that will ultimately lead to innovative tools for controlling crop diseases and mycotoxin contamination. To broaden the impact, we are actively collaborating with colleagues at Texas A&M as well as other prominent institutions worldwide. We are also very excited about our collaborations with colleagues in Texas A&M Engineering to spearhead multidisciplinary projects that can innovate plant pathology research.",Professor and Associate Department Head,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/n28234bb8
Stephen,Webb,Research Assistant Professor,"Stephen Webb, Ph.D., is a research assistant professor in the Texas A&M Natural Resources Institute and the Department of Rangeland, Wildlife and Fisheries Management. His research focuses primarily on game and large mammal species such as white-tailed deer, mule deer, elk, bighorn sheep, domestic cattle and wild pigs. He uses advanced and novel tracking and sensor devices, including autonomous recording units, to develop behaviorally and spatially explicit models of animal movement, habitat selection, animal interaction and changes in population demographics. Webb is the current book review editor for the ""Journal of Wildlife Management,"" and has served as associate editor for ""Rangeland Ecology and Management."" He enjoys teaching about rigorous research design and analysis as well as scientific writing and publishing. Webb is a 7th generation Texan who enjoys spending as much time as possible with his wife and daughter. He also enjoys hunting, fishing and nature photography.",Research Assistant Professor,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences",https://scholars.library.tamu.edu/vivo/display/n28412a74
Mariappan,Muthuchamy,Professor,"The main goal of our laboratory is to understand the molecular mechanisms of cardiac muscle dynamics in normal and diseased states. Particularly, our interests focus on the relationships between thin filament activation and crossbridge kinetics, and how the mechanotransduction signaling transmits to myofilament activation. We use multiple techniques, molecular, cellular, biochemistry, structural and biophysical, to obtain information on the fundamental regulatory mechanisms of cardiac muscle contraction.
Our lab group is also investigating the role of lymphatics in different tissue beds, including mesentery, skeletal muscle, and brain using various animal models.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n2877399b
Deborah,Bell-Pedersen,Professor,"Research in the Bell-Pedersen lab focuses on determining how the circadian clock functions in organisms to regulate daily rhythms in gene expression, behavior, and physiology. The molecular clock in higher eukaryotes involves a master clock in the brain regulating clocks in peripheral tissues, posing significant obstacles for understanding circadian output mechanisms. Thus, a major strength of our work is using a single-celled model eukaryote, Neurospora crassa, to elucidate the underlying mechanisms of rhythmic gene expression and protein synthesis. Clock dysfunction in humans is associated with a wide range of diseases, including cardiovascular disease, cancer, metabolic disorders, mental illness, sleep disorders, and aging. In addition, daily changes in metabolism and cell division rates influence the efficacy and toxicity of many pharmaceuticals, including cancer drugs. Therefore, knowing how clocks work to control rhythmic gene expression, and what they regulate, is critical for the development of therapeutics. Research to understand clock-controlled rhythmic gene expression has focused primarily on transcriptional mechanisms, and little was known about posttranscriptional control. We discovered that the clock regulates highly conserved translation initiation and elongation factors, tRNA synthetase levels, and ribosome heterogeneity. This regulation determines what mRNAs are rhythmically translated and the accuracy of the translation process (translation fidelity). We are capitalizing on these exciting discoveries to determine how the clock regulates translation fidelity. These studies will provide the foundation for understanding the impact of daily rhythms in translation fidelity on protein diversity beyond what is encoded for in the genome.",Professor and Associate Department Head,Biology,https://scholars.library.tamu.edu/vivo/display/n2a2bfb97
Pushkar,Lele,Assistant Professor,"We combine sensitive biophysical techniques such as single-molecule fluorescence and force-spectroscopy with mechanistic modeling and molecular genetics to study bacterial motility, adaptability and antibiotic resistance.",Assistant Professor,Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/n2a9b2ef2
Jian,Feng,Professor and Assistant Dean,,Assistant Dean for Research and Professor,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n2b3403fd
Muhammad Shamsul Arefeen,Zilany,Instructional Assistant Professor,"The goal of our study is to understand the neural mechanisms underlying the perception of complex sounds. We use a comprehensive approach of combining neurophysiological, behavioral, and computational modeling techniques towards that goal. We are interested in applying the results from these studies to the design of physiologically based signal-processing strategies to aid listeners with hearing loss.",Instructional Assistant Professor,Texas A&M University at Qatar,https://scholars.library.tamu.edu/vivo/display/n2b730583
Libo,Shan,Professor,"Earth is the planet of the plants. Being autotrophic, sessile, and long-living entities, plants have evolved fascinating strategies to cope with various environmental stresses. Our research is driven by the desire to understand the fundamental principles underlying plant disease resistance, and pathogen virulence, and to improve crop resilience to pathogen infections. We are probing the biochemical and genetic basis of plant signal transduction pathways from cell surface receptors sensing the presence of pathogens to signaling cascades and target genes and proteins that are central to launch effective immune responses in the context of balanced growth and development. We deploy cutting-edge molecular and biochemical technologies coupled with powerful genetic tractability of plants for discovering regulatory networks of living organisms fending off infections. In addition to the acquisition of foundational principles in biology, we further translate knowledge and platforms into the areas for the improvement of crop stress adaptation.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n2c655431
Herman,Scholthof,Professor,,Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/n2c6ec1cb
Xiaoning,Qian,Associate Professor,"Xiaoning Qian's research interests include machine learning and Bayesian experimental design as well as their applications in computational network biology, genomic signal processing, and biomedical signal and image analysis. He is affiliated with the Center for Bioinformatics and Genomic Systems Engineering and the Center for Translational Environmental Health Research at Texas A&M.",Associate Professor,Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n2c8e24e9
Dana,Gaddy,Professor,"My laboratory has been engaged in multiple areas of NIH-funded musculoskeletal research since 1996. We were the first to identify the non-steroidal gonadal inhibin hormones in regulating the hypothalamic-pituitary-gonadal-skeletal axis in mice, and the role of changes in inhibins that signal the onset of menopause (reproductive aging) to the onset of increasing bone turnover. We also demonstrated the anabolic effect of continual Inhibin exposure in normal mice and in bone repair. Our cellular focus on Inhibins and the related factor, Activin A revealed that Activin A suppresses local bone resorption through suppression of osteoclast formation, motility and survival. Our ongoing work is in the area of specific inhibin/betaglycan receptor interactions that mediate the effects on bone cells. We are also greatly interested in improving the low bone mass that we were the first to identify in both humans with Down Syndrome (DS) and in mouse models of DS as a low bone turnover disease. Our current NIH-funded research is working to identify the mechanisms of reduced fracture healing and compromised bone regeneration in Down Syndrome. We have demonstrated the efficacy of both PTH and SclAb in DS, and are now actively testing nutriceuticals to increase bone mass in mouse models of Down Syndrome. The limitations of using mouse models to study bone disease led us to our most recent and exciting endeavors in collaboration with TAMU experts in reproduction and embryo transfer technologies to develop a large platform model of bone disease, using sheep. We have generated the first large animal model of hypophosphatasia (HPP) via high efficiency gene editing of a knock-in point mutation in the ALPL gene, whose musculoskeletal and dental phenotypes are consistent with human HPP. We are now using this model to determine the etiology of mineralization deficiencies, muscle weakness and premature tooth loss by analysis of longitudinal biopsies and analysis of muscle, bone and dental specimens using CT, microCT, mechanical testing, immunohistochemistry, histomorphometry and ex vivo bone marrow cultures.",Professor||Adjunct Professor,Veterinary Integrative Biosciences||Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n2dc10a1a
Luis,Cisneros-Zevallos,Professor,The mission of our research program at the Plant Bioactives & Bioprocessing Research Laboratory is to generate information that can benefit the agriculture and processing industry by adding value to crops through bioactive compound discovery and the design of appropriate methods to enhance their content in plants as well as extend their post-harvest shelf-life.,Professor,Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/n2e6bb4c1
Delbert,Gatlin,Professor and Associate Department Head,,Professor and Associate Department Head,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences",https://scholars.library.tamu.edu/vivo/display/n2eb4270c
Suresh,Pillai,Professor,"Dr. Pillai's research focuses on bacterial cell-to-cell signaling, the molecular ecology of pathogens in natural and man-made ecosystems and the use of novel technologies to concentrate, detect, and decontaminate pathogens. His research on molecular microbial ecology and cell-cell signaling is targeted at understanding the complex and hitherto poorly understood relationship between microbial communities and human behavior. His research is aimed at understanding the role that the GI tract-associated microbiome has on human behavior.",Professor,Poultry Science,https://scholars.library.tamu.edu/vivo/display/n3009b050
Edward,Vargo,Professor,"We use molecular genetic tools, primarily microsatellite markers and mtDNA sequence data, to conduct basic and applied studies of termites and other insect pests of human structures. Our work on termites encompasses the breeding structure of colonies, colony and population genetic structure, invasion biology, foraging areas, colony densities and population dynamics. Research on other structural pests, mainly ants, cockroaches and bedbugs, focuses on population genetic structure, invasion biology, and dispersal.",Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/n3165cf9e
Ping,He,Professor,"Our laboratory is interested in elucidating novel plant immune signaling pathways as well as studying the myriad actions of pathogen virulence factors that intercept host immune responses. In order to provide a complete view of host-microbe interactions, we are using cellular, functional genomic, genetic, biochemical and bioinformatic approaches. In addition, plant immunity is inextricably linked with plant development and environmental stresses. We are also interested in understanding the signaling crosstalk that orchestrates plant responses to different extrinsic and intrinsic signals. Ultimately, knowledge gained from studying model plants, such as Arabidopsis, will be applied to improve crop plants for resistance against different biotic and abiotic stresses.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n330081c7
Henry,Fadamiro,Professor & Associate Dean for Research,,Professor||Associate Director and Chief Scientific Officer||Associate Dean for Research,College of Agriculture and Life Sciences||Entomology||Texas A&M AgriLife Research,https://scholars.library.tamu.edu/vivo/display/n355a075f
Jennifer,Herman,Associate Professor,"The study of how bacteria organize important cellular processes and determining the functional/physiological implications of this organization for the cell is one of the most exciting areas of research in microbiology. In the Herman lab, we utilize the model organism Bacillus subtilis, a bacterium with superb molecular, genetic and cell biological tools, that that can also differentiate into a resting cell type called a spore. Our research goal is to elucidate how bacteria coordinate key biological processes, with their cellular architecture using molecular, biochemical, and cell biological techniques.",Associate Professor||Associate Professor,Texas A&M AgriLife Research||Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n359e91fd
Jim,Ji,Professor,"Technological advances in magnetic resonance imaging (MRI) and magnetic resonance spectroscopic imaging (MRSI) provide unprecedented opportunities for revealing the anatomical, pathological, and functional information of biological systems and improving our understanding of the biological processes. During the last two decades, MR hardware and sequence design have been significantly improved, which make MRI and MRSI faster and finer than they have ever been. However, dynamic imaging of 3D objects, a beating heart or a working brain, for examples, is still a big challenge.
The research in our group is to develop 3-D, real-time imaging capability to visualize biological events as they are happening, and advanced analysis techniques to extract the desired information from biological images automatically, accurately and consistently.",Professor||Professor,Electrical and Computer Engineering (Qatar)||Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n35d3773d
William,Rogers,Professor,,Professor,Ecology and Conservation Biology,https://scholars.library.tamu.edu/vivo/display/n35d640a4
Thomas,Ioerger,Professor - Term Appoint,"Dr. Ioerger's research interests are in the areas of Artificial Intelligence, Intelligent Agents, and Machine Learning. His work has covered diverse areas, from spatial reasoning, to simulating team-work, to modeling emotions. Currently, his primary focus is on designing multi-agent system architectures to simulate collaborative behavior and teamwork. He also applies AI and machine learning methods to various problems in the area of Bioinformatics, including the improvement of protein sequence alignments, molecular modeling, and X-ray crystallography. The latter research has lead to the development of an automated software system for protein model-building called TEXTAL, which is currently being used by crystallographers throughout the world.",Professor - Term Appoint,Computer Science and Engineering,https://scholars.library.tamu.edu/vivo/display/n36a51a43
Sara,Lawhon,Professor,"My research group studies zoonotic bacterial pathogens and focuses primarily on salmonellosis and staphylococcal infections with emphasis on molecular host-pathogen interactions and antimicrobial resistance. We are particularly interested in how bacteria sense environmental signals, communicate with each other (quorum sensing), cause disease, and resist antimicrobial therapy. These fundamental processes are common to the organisms in which we work. We use basic, applied, and clinical science approaches in our studies. Salmonella, Staphylococcus, and Campylobacter infect a broad range of animal host species as well as humans thus making our work relevant to both human and animal health. In addition to this work, we conduct clinical research projects to support the mission of our veterinary teaching hospital and we provide support to other researchers who need microbiology expertise or access resources for their work. Our work has been funded by the FDA, CDC, and several foundations focused on diseases in veterinary species.",Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n370f31f1
Vijay,Joshi,Assistant Professor,"The Systems Plant Physiology program is developing crops with enhanced nutritional qualities and identifying new methods to improve environmental attributes. This program focuses on plant biology and its integrations with micro and macro environments, utilizing physiological, molecular, or metabolic traits to understand associated biological processes. Our broad goal is developing crop varieties with enhanced crop productivity, nutritional qualities and tolerance to abiotic stresses for greater adaptability. The critical areas of research we focus on are: Nitrogen use efficiency, nitrogen sensing, transport and assimilation, Molecular and genetic aspects of plant metabolism.",Assistant Professor,Uvalde Research and Extension Center,https://scholars.library.tamu.edu/vivo/display/n375e2b34
Bharathi,Hattiangady,Assistant Professor,,Assistant Professor,School of Medicine,https://scholars.library.tamu.edu/vivo/display/n37cbdcf0
Luis,Tedeschi,Professor,"Dr. Tedeschi conducts research on energy and nutrient requirements of grazing and feedlot animals, growth biology and bioenergetics, chemical composition and kinetics of fermentation of feeds, modeling and simulation of decision support systems, and evaluation of models (http://nutritionmodels.tamu.edu). He has collaborated with several researchers overseas to develop models for small ruminants (sheep and goats). He utilizes System Dynamics concepts applied to nutrition.",Associate Professor||Professor,Animal Science||Nutrition,https://scholars.library.tamu.edu/vivo/display/n387904d6
Arun,Srinivasa,Professor,"My research focuses on plasticity of metals and polymers; thermomechanics of dissipative processes, dislocation dynamics, Cosserat continua, design and dynamics of compliant mechanisms.",Professor||Faculty Affiliate,Mechanical Engineering||Institute for Engineering Education and Innovation,https://scholars.library.tamu.edu/vivo/display/n3b0f1d01
Douglas,Baxter,Instructional Professor,,Instructional Professor,Neuroscience and Experimental Therapeutics,https://scholars.library.tamu.edu/vivo/display/n3e6ac00a
Robert,Chapkin,Distinguished Professor,"Research in the Chapkin lab focuses on dietary/microbial modulators related to the prevention of cancer and chronic inflammatory diseases.
Our central goal is to (1) understand cancer chemoprevention at a fundamental level, and (2) to test pharmaceutical agents in combination with dietary/microbial (countermeasures to the Western diet) to more effectively improve gut health and reduce systemic chronic inflammation. Since diet influences gut microbiota composition and metabolite production, to unravel the interrelationships among gut health and the structure of the gut microbial ecosystem, we are in the process of evaluating (using transgenic mouse, Drosophila models and humans) how the gut microbiome modulates intestinal cells, innate immune cells and tumors. As part of this endeavor, we are modeling at the molecular level the dynamic relationship between diet and gut microbe-derived metabolites which modulate chronic inflammation and the hierarchical cellular organization of the intestine, e.g., stem cell niche.",Distinguished Professor||Professor,Biochemistry and Biophysics||Nutrition,https://scholars.library.tamu.edu/vivo/display/n3fbb59f8
Ryang,Lee,Associate Professor,"Our group specializes in determining the cellular and molecular mechanisms of beneficial effects of mesenchymal stem cells (MSCs) in diseases that include heart disease, diabetes, and peritonitis. The goal is to develop a cellular therapy for human diseases either (a) with adult stem/progenitor cells (MSCs), or (b) with therapeutic factors that MSCs produce in response to signals from injured tissues.",Associate Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/n3ffcdcc1
Thomas,Mcdonald,Professor,"My research focuses on environmental chemistry, petroleum geochemistry, and general organic chemistry.",Professor,Environmental and Occupational Health,https://scholars.library.tamu.edu/vivo/display/n407d0459
Qinglei,Li,Professor,"My long-term research goal is to identify the cellular and molecular basis of pregnancy failure and uterine dysfunction, thereby contributing to a framework for developing novel diagnostic and therapeutic strategies to improve reproductive potential. To benefit human and animal health, research in my lab focuses on defining the mechanism underlying uterine development and the pathogenesis of gynecologic cancers. My laboratory has created mouse models that harbor genetic modifications of critical transforming growth factor ? (TGF?) signaling components using conditional loss-of-function and gain-of-function approaches in the uterus. These models have yielded new insights into the fundamental roles of TGF? signaling in reproductive tract development and function. We have also developed pre-clinical mouse models for ovarian granulosa cell tumor and endometrial cancer. These disease models may be harnessed to uncover new opportunities for cancer treatment.",Professor||Professor,The Texas A&M University System||Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n408645cd
Muthukumar,Bagavathiannan,Associate Professor,"My research interests fall within the broader area of Weed Science and Agronomy, with particular emphasis on weed ecology and management. The threat of herbicide resistance is immense in broad-acre systems, leading to loss of effective herbicide options, increased herbicide use and unintended impacts on the broader environment. To this effect, the prime goal of my research program is to understand the evolutionary biology and dynamics of herbicide resistance in weed communities and develop integrated pest management (IPM) solutions encompassing chemical and non-chemical tactics to prevent/effectively manage herbicide resistance. I particularly use simulation modeling tools to answer some of the fundamental research questions surrounding herbicide resistance evolution and guide management decision-making. My research takes an inter-disciplinary approach in addressing knowledge gaps (problem-centric rather than discipline-centric) by integrating tools and knowledge from a wide range of disciplines. I actively collaborate with eminent research groups within and outside the United States.",Associate Professor,Soil and Crop Sciences,https://scholars.library.tamu.edu/vivo/display/n40b31913
Micky,Eubanks,Professor,,Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/n40f09614
Geoffrey,Kapler,Professor and Chair,"Dr. Kapler's broad research interests are concerned with the replication and transmission of eukaryotic chromosomes. The failure to completely replicate the genome during S phase or partially re-replicate chromosomes leads to genome instability- a hallmark of cancer cells. The central questions investigated in the laboratory are concerned with how replication initiation sites are established in chromosomes and how they are regulated during conventional (G1/S/G2/M) and alternative cell cycles, including endoreplication (gap-S-gap-S...) and locus-specific gene amplification. The current focus of the lab is to use high throughput (nascent strand) DNA sequencing to generate a comprehensive map of replication initiation sites under different physiological conditions.",Professor and Chair||Professor,Cell Biology and Genetics||Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n4128afa1
Leland,Pierson,Professor and Head,,Professor and Head,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/n4162e884
Bradley,Verhulst,Research Assistant Professor,,Research Assistant Professor,Psychiatry and Behavioral Sciences,https://scholars.library.tamu.edu/vivo/display/n419fa124
Charles,Criscione,Professor,"I examine fundamental ecological and evolutionary questions in parasite systems and consider my research to be at the interface of ecology, evolution, and genetics. Parasitology provides a rich subject area for studies of ecology and evolutionary biology. Numerous topics such as ecosystem dynamics, mating systems, or coevolution can be addressed because parasites are extremely diverse. By diversity, I include not only the myriad of taxa that have independently evolved a parasitic lifestyle, but also the diversity in life cycles, modes of reproduction, host species, and ecosystems utilized by parasites. This diversity also allows for comparative studies to address theories or unifying principles that span ecosystems or taxonomic groups. Furthermore, there are many practical applications such as studying the evolution of drug resistance, or using parasite community structure to assess ""ecosystem health"". My research interests address both basic and applied questions, and span three overlapping subject areas: 1) Evolution: Population Genetics, Mating Systems, and Molecular Epidemiology, 2) Ecology: Biodiversity, Conservation, and Natural History, and 3) Genetics and Ecological Genomics.",Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n41a8b584
Samikkannu,Thangavel,Associate Professor,"Our lab is predominantly interested in the neuropathogenesis of HIV and drug abuse. We are elucidating the role of HIV and drugs of abuse in energy dysregulation, which ultimately may lead the neurodegeneration. We examine the metabolic signatures through inflammasome profiles, mitochondrial biogenesis, and epigenetics. We use in vitro, ex vivo and a transgenic rat model system in our experiments. Our goal is to develop novel diagnostics tests and treatments for neuroAIDs and neurologic damage related to drugs of abuse.",Associate Professor,Pharmacy Practice,https://scholars.library.tamu.edu/vivo/display/n42fbd1a8
Joseph,Szule,Research Assistant Professor,,Research Assistant Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n43b79a10
Phillip,Kaufman,Professor and Department Head,"My research program focuses on the development of new pest management tools for Florida's livestock operators. Beef cattle, dairy cattle and horses are the predominant livestock in Florida and are the focus of this program. Insecticide resistance and control failures are commonplace for many of the fly pests; therefore, innovative systems are needed to assist in their management. However, to successfully manage these pests, studies investigating their biology and ecology are needed.
The role that biological control can play in assisting with pest control is another research avenue. Producer pesticide selection and the resultant impacts on non-target, beneficial arthropods in grazing systems are of particular interest.",Professor and Department Head,Entomology,https://scholars.library.tamu.edu/vivo/display/n44fc312d
Van,Wilson,Professor,"My area of specialization is the molecular biology of papovaviruses, with a primary focus on how viral proteins modify the host cell environment. Recently, we determined that the viral replication proteins, E1 and E2, are post-translationally modified by addition of 1 or more SUMO moieties. Sumoylation is a widespread modification whose biological functions are only recently becoming understood. Studies are in progress to 1) determine the role of sumoylation in the viral life cycle, 2) evaluate the effect of sumoylation on the structure and activity of the E1 helicase, 3) understand the mechanism by which sumoylation influences E2 stability and transcriptional activity, and 4) determine how sumoylation is modulated by the viral E6 oncoprotein. In addition to the role of sumoylation in the viral life cycle, we are also exploring how sumoylation participates in normal keratinocyte differentiation. We have developed a keratinocyte cell line inducibly expressing a tagged SUMO moiety to facilitate proteomics studies of sumoylation changes and regulation during controlled differentiation.",Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n4837bbf9
Mary,Wicksten,Professor,"I am studying the Thoridae, a family of small-sized marine shrimp that are remarkably diverse in the cold waters of the North Pacific. Evidence suggests that these shrimp may be losing range due to global warming. They may be replaced by members of a different family, the Palaemonidae, a group of more aggressive predatory shrimp. But to study such a replacement, one must identify the shrimp. The last major study was in 1906. All previous work has been morphological. Evidence from my own work and that of Greg Jensen, University of Washington, suggests that not only have species been confused (one species is actually two, three species actually are only one) but the generic designation may depend on temperature-dependent features. With a small start-up grant from the Arctic Biodiversity Study, I am collaborating with Luis Hurtado,, Department of Wildlife and Fisheries Science, to obtain some molecular data on genetic affinities within the Thoridae and potentially allied shrimp taxa. These data may at least indicate which of the supposed genera are distinct or even if the Thoridae is indeed a natural group. Examination of the 150 or more presumed species will begin following an assessment of the genera.",Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n48bee4d6
Tadhg,Begley,Distinguished Professor,"The Begley Group is interested in the mechanistic chemistry and enzymology of complex organic transformations, particularly those found on the vitamin biosynthetic pathways. We are currently working on the biosynthesis of thiamin, molybdopterin, pyridoxal phosphate and menaquinone. Our research involves a combination of molecular biology, protein biochemistry, organic synthesis and structural studies and provides a strong training for students interested in understanding the organic chemistry of living systems and in pursuing careers in biotechnology, drug design or academia.
Thiamin pyrophosphate plays a key role in the stabilization of the acyl carbanion synthon in carbohydrate and amino acid metabolism. The biosyntheses of the thiamin pyrimidine and thiazole are complex and are different from any of the characterized chemical or biochemical routes to these heterocycles. We are particularly interested in cellular physiology and the mechanistic enzymology of thiamin biosynthesis. As an example of one of the complex transformations on this pathway, the figure below shows the structure of the pyrimidine synthase catalyzing the complex rearrangement of aminoimidazole ribotide (left) to the thiamin pyrimidine (right).",Distinguished Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n498aa35b
Thomas,Kent,Professor,"Neurologist and clinician scientist with a basic, translational and clinical research program, focused mostly on stroke and other brain injuries. The laboratory utilizes a variety of cell free, tissue culture and in-vivo techniques to design and characterize a series of carbon nanomaterials that possess the ability to act as catalytic antioxidants as well as support key mitochondrial functions. This NIH-supported research is in collaboration with synthetic nano-chemists at Rice University (Tour Lab) and biochemists at University of Texas Health Science Center Houston (Tsai Lab). The group is testing a variety of engineered modifications of these versatile, non-toxic materials to address specific cell injury and death mechanisms including ferroptosis and interruption in electron transport and oxidative phosphorylation.
A major interest of ours is the role of diabetes in worsening outcome from stroke, a condition that affects minority and rural Texans disproportionally. With a range of research from molecular interactions to whole animal and clinical studies, the work in this lab is deeply translational, leveraging the group's clinical training and experience to insure that conclusions have direct relevance to the disease state, with the ultimate goal of facilitating the identification of new therapies for these major contributors to disability and mortality.",Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/n4acd1da6
Yinan,Wei,Professor,"We are interested in studying the interaction between microbes and host systems, in the context of antibiotic resistance, infection, and the innate immune response.",Professor,Pharmacy Practice,https://scholars.library.tamu.edu/vivo/display/n4bb89912
Tanmay,Lele,Professor,"Dr. Tanmay Lele's research is in the area of mechanobiology with a focus on cancer mechanobiology. His lab is interested in the molecular mechanisms by which cell generated mechanical forces and associated signaling pathways enable cell and tissue functions, and how these relationships become altered in cancer. Current research projects in the laboratory include quantitative measurements of nuclear forces, the effect of mechanical stresses on nuclear functions and gene expression, cellular adaptation to mechanical properties of the extracellular matrix, and the mechanics of cancer tissue development.
Lele is a scholar in cancer research at the Cancer Prevention and Research Institute of Texas.",Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/n4c5b9ade
Timothy,Elliott,University Distinguished Professor,"My research has examined adjustment processes among persons living with chronic and disabling health conditions, with particular emphasis on the role of social problem-solving abilities and other factors that predict adjustment following disability.",Faculty Fellow||University Distinguished Professor,Educational Psychology||Center for Health Systems and Design,https://scholars.library.tamu.edu/vivo/display/n4cbad106
Luis,Garcia,Professor,"I am interested in understanding how behavioral states are regulated at the molecular and genetic level. My lab addresses this complex question in the well-studied nematode Caenorhabditis elegans. Several physical aspects of this worm make it convenient for integrating whole organism system biology studies with genetic/molecular analysis of neurobiology and behavior. C. elegans is an anatomically simple organism; it is 1mm in size, and it contains ~ 1000 somatic cells, a third of which are neurons. The worm is also transparent, and thus every cell can be visualized by light microscopy. Behavioral mutants can be efficiently generated through standard chemical mutagenesis. In addition, gene functions involved in motivational and behavioral regulation can be determined by transgenic techniques.
My lab investigates the interplay between feeding and sex-specific mating behavior to understand how chemo/mechano-sensory and motor outputs are controlled under various physiological conditions. We study male mating by using genetics to de-construct this behavior into its fundamental sensory-motor components. We then use a combination of transgenics, pharmacology, classical genetics and laser microsurgery to understand how individual motor sub-behaviors are coordinated to produce gross behaviors during periods when the animal is food deprived, and when it is food satiated.",Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n4cd2f794
Michelle,Lawing,Associate Professor,"Dr. Lawing is an Associate Professor in the Department of Ecology and Conservation Biology. She is primarily interested in using methods and models from modern ecology and evolutionary biology combined with evidence from the fossil record to inform our understanding of how species and communities respond to environmental change through time. Her work includes the investigation of geographic, evolutionary, and morphological responses of species and communities to environmental changes in the Late Pleistocene and throughout the Miocene to present. She is involved in developing species distribution models (SDM), geometric morphometric methods (GMM), and phylogenetic comparative methods (PCM). Before becoming an Assistant Professor, Dr. Lawing was a postdoctoral fellow at the National Institute for Mathematical and Biological Synthesis (NIMBioS). She earned a PhD double major in Evolution, Ecology, and Behavior and in Geological Sciences from Indiana University, Bloomington.",Associate Professor,Ecology and Conservation Biology,https://scholars.library.tamu.edu/vivo/display/n4d1c74b5
Zhenyu,Li,Professor,My research focuses on the mechanism of platelet activation and arterial thrombotic diseases such as heart attack and stroke. We are also interested in the crosstalk between thrombosis and inflammation in sepsis.,Professor,Pharmaceutical Sciences,https://scholars.library.tamu.edu/vivo/display/n4e244e5e
Thomas,Boutton,Professor,"Dr. Boutton is interested in the ecology of grassland and savanna ecosystems, particularly the impacts of land cover/land use changes on ecosystem processes (productivity, decomposition, biogeochemistry, hydrology). At present, most of his work is oriented towards understanding the influence of woody plant invasion into grasslands and savannas on biogeochemistry and soil biology. He is also interested in understanding ecosystem responses to global changes predicted for the future. The effects of climate, land use, and atmospheric composition on ecosystem structure and function are being investigated at time scales ranging from a few years (contemporary ecosystems) to thousands of years (paleo ecosystems), and spatial scales ranging from the soil aggregate to the landscape. Dr. Boutton also serves as Director of the Stable Isotope Biogeochemistry Laboratory, and teaches two graduate level courses (ESSM 600 - Principles of Ecosystem Science and Management, and ESSM 622 - Biogeochemistry of Terrestrial Ecosystems).",Regents Professor & Sid Kyle Endowed Chair,Ecology and Conservation Biology,https://scholars.library.tamu.edu/vivo/display/n50abe2cc
Thomas,Diekwisch,Professor and Department Head,"Stem Cells and Tissue Engineering In previous studies we have generated and characterized stem cell populations in dental tissues. We have also developed novel extracellular matrix-based scaffold materials. Currently we are performing a number of studies to examine the use of stem cells and scaffolds to regenerate periodontal and other tissues.
Chromatin, Epigenetics, and microRNAs Twenty years ago, we discovered the cp27 chromatin factor in our laboratory. This factor is part of the large SRCAP chromatin complex that plays important roles in development and cell division. A second aspect of our epigenetics research is focused on the role of histone methylation in odontogenic tissue differentiation and disease.
Periodontics Our lab works on the development and differentiation of periodontal tissues as a means to generate new progenitor based approaches for the regeneration of periodontal tissues. More recently, we have conducted studies to understand how epigenetic changes affect periodontal tissue response to pathogens.
Enamel Formation and Evolution Our lab is interested in determining the mechanisms of enamel crystal formation. We are asking how mineral ions are transported toward the enamel layer and what factors govern the nucleation and elongation of enamel crystals. Using an evolutionary biology approach, we are studying the relationship between the amelogenin molecule and enamel mechanical properties.
Evolution and Development Our lab focuses on the evolution of jaws and teeth, especially tooth enamel and periodontal ligament. Specifically, we are interested in the effects of changes in the amelogenin protein on the evolution of the amazing physical properties of enamel. We are also trying to understand how the non-mineralized state of the periodontal ligament evolved in vertebrates.","Director, Center for Craniofacial Research and Diagnosis||Bernhard Gottlieb Endowed Chair for Craniofacial Research||Professor and Head, Department of Periodontics",School of Dentistry||School of Dentistry||School of Dentistry,https://scholars.library.tamu.edu/vivo/display/n52565fe6
Sarah,Capik,Assistant Professor,"Dr. Capik's research interests include the characterization, transmission dynamics, diagnosis, and control of Bovine Respiratory Disease (BRD). She has investigated potential methods to mitigate stress in cattle, used behavioral monitoring to identify sick cattle, and evaluated diagnostic sampling strategies for BRD.",Assistant Professor||Assistant Professor,School of Veterinary Medicine and Biomedical Sciences||Texas A&M AgriLife Research,https://scholars.library.tamu.edu/vivo/display/n551442f5
Paul,Straight,Associate Professor,"Our goal is to understand how microorganisms interact in complex communities. Specifically, we study how small molecules produced in a microbial community affect the growth, development and metabolic output of the organisms. We use a combination of microbiology, genetic, genomic, and biochemical approaches to dissect complex interspecies interactions. Currently, our research focuses on the interactions of the soil bacteria Bacillus subtilis and members of the genus Streptomyces, known for their prolific production of bioactive small molecules and development of aerial structures and spores.",Associate Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n5540637b
Phanourios,Tamamis,Assistant Professor,,Associate Professor,Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/n5673e0c8
David,Bapst,Assistant Instructional Professor,"I am an analytical paleobiologist, focused how we infer evolutionary relationships in the fossil record, date when lineages diverge from each other, and how we can use relationships among extinct organisms to say something about evolutionary processes in deep time. I work on whatever group of organism is best for a particular question (because every fossil record is different), so my research includes everything from living brachiopods to fossil birds. I most often work on the planktonic graptolites, a group of colonial zooplankton that diversified rapidly and went extinct during the Ordovician, Silurian and Devonian periods, hundreds of millions of years ago. Graptolites have a fantastically detailed fossil record for asking evolutionary questions, but they have also long been important as a biostratigraphic tool in economic geology in the early Paleozoic.",Assistant Instructional Professor,Geology and Geophysics,https://scholars.library.tamu.edu/vivo/display/n56db717f
Joseph,Bernardo,Research Associate Professor,"I am an Integrative Evolutionary Ecologist, meaning that my research addresses a range of fundamental questions in Ecology and Evolutionary Biology from a multi-disciplinary, integrative perspective and using a diverse array of tools including field experiments, phylogenetically-rooted comparative statistical analyses, quantitative estimates of physiological performance, experimental analyses of reproductive behavior, and molecular genetics. I often work at the nexus of typically disparate fields of study, for example combining genetic, phylogenetic, physiological and macroecological perspectives in a single analysis of distribution and dispersal (Bernardo et al. 2007). Because multiple causality is inherent in understanding ecological and evolutionary problems, my research emphasizes a strong inference approach that therefore relies on both large datasets and multivariate statistical models to evaluate competing hypotheses. Most of my active work involves vertebrates and insects and other major invertebrate groups.
General areas of interest include: o determinants of range size and position o biodiversity conservation in the face of climate change o detection, and ecological and conservation implications of cryptic speciation and diversity o vertebrate ecology and life history o biology of amphibians and reptiles, especially salamanders and lizards o speciation and evolution of reproductive isolation o evolutionary ecology of body size including its role in species packing and community assembly o clinal variation in life history and physiological traits o comparative animal physiology and physiological ecology especially as they relate to life history variation and range occupation (macrophysiology) o life history evolution o evolution and implications of maternal effects, especially propagule size o experimental ecology",Research Associate Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n5787076f
Peregrine,Barboza,Professor,"The principal focus of our research is the consequences of life history and environmental change on nutrition. Our current projects are focused on ungulates (e.g., reindeer, caribou, moose, muskoxen, white-tailed deer) but we also study waterfowl (e.g. ducks and geese) as well as non-game species (e.g. porcupines and bats) in both wild and captive populations. We attempt to provide information that will expand policy options for managing wildlife populations and their habitats.",Professor,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences",https://scholars.library.tamu.edu/vivo/display/n57f7ebef
Jean-Philippe,Pellois,Professor,"Our goal is to determine how proteins function in space and time in the context of complex cellular networks. We focus on chemistry-driven approaches to manipulate protein structure beyond what is feasible with standard genetics. In particular, we use semi-synthetic light-activatable proteins as biophysical probes to investigate protein mechanisms inside living cells. Areas of interest include the important but poorly understood process of protein S-acylation, signal transduction, and protein trafficking.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n5815f42d
M,Benson,Associate Professor,,Associate Professor,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n58e9bd13
Qing,Sun,Assistant Professor,"Dr. Sun's research focuses on synthetic biology with advancing designs and applications. Using expertise in molecular engineering, protein engineering, and microbial consortia engineering, to develop new techniques to reprogram gut microbiome, protein machinery and biomaterials. Our current application areas include health, environment and energy. Her research interests are synthetic biology with focus on protein engineering, genetic circuits design and biomaterial development for environmental and biomedical applications.",Assistant Professor,Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/n5a061e0f
Christine,Merlin,Associate Professor,"Our research broadly lies in understanding how organisms respond and adapt to changing environments, with an emphasis on circadian biology. Organisms from bacteria to humans use circadian clocks to control a plethora of biochemical, physiological and behavioral rhythms. These clocks are synchronized to daily and seasonal environmental changes to allow organisms to tune specific activities at the appropriate times of day or year.
In our laboratory, we use the eastern North American migratory monarch butterfly (Danaus plexippus) as a model system to study animal clock mechanisms and the role of circadian clocks and clock genes in a fascinating biological output, the animal long-distance migration. Every fall, like clockwork, millions of monarch butterflies start migrating thousands of miles from North America to reach their overwintering sites in central Mexico. During their journey south, migrating monarchs use a time-compensated sun compass orientation mechanism to maintain a constant flight bearing. Circadian clocks located in the antennae provide the critical internal timing device for compensation of the sun movement across the sky over the course of the day. The recent sequencing of the monarch genome and the establishment of genetic tools to knockout clock genes (and others) in vivo using nuclease-mediated gene targeting approaches provides us with a unique opportunity to uncover the molecular and cellular underpinnings of the butterfly clockwork, its migratory behavior and their interplay.",Assistant Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n5a23a5d7
Israel,Liberzon,Professor and Department Head,,Professor and Department Head,Psychiatry and Behavioral Sciences,https://scholars.library.tamu.edu/vivo/display/n5a37dec0
David,Hala,Assistant Professor,,Assistant Professor,Marine Biology,https://scholars.library.tamu.edu/vivo/display/n5a79eeee
Linglin,Xie,Associate Professor,,Assistant Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n5aa6a1af
Shreya,Raghavan,Assistant Professor,"The Raghavan lab utilizes biomaterials and regenerative engineering strategies to create engineered microenvironments - these engineered niches allow the study of cancer stem cell, neural cell and immune interactions as it pertains to cancer metastasis and inflammation.",Assistant Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/n5b94a943
Thomas,Mcknight,Professor and Head,"My lab is currently investigating mechanisms that regulate telomerase activity in plants. We previously showed that the pattern of telomerase expression in plants is remarkably similar to the pattern seen in humans, despite fundamental differences in development between plants and animals. Telomerase is abundantly expressed in reproductive organs but is undetectable in most vegetative organs (Fitzgerald et al., 1996). Additionally, telomerase can be induced in leaves and other vegetative organs by exposure to exogenous auxin.
To isolate genes that regulate telomerase, we screened a large population of activation tagged lines of Arabidopsis thaliana, and found that several lines that ectopically express telomerase in leaves. The first line we characterized over-expressed a gene encoding a small zinc finger transcription factor we designated TELOMERASE ACTIVATOR 1 (Ren et al., 2004). This factor does not bind to the promoter for TERT, which encodes the catalytically active subunit of telomerase. Instead, it binds to and activates transcription of BT2, a gene encoding a component of a ubiquitin ligase (Ren et al., 2007). Our working model is that the BT2 ubiquitin ligase marks a telomerase repressor for destruction, thereby allowing expression of telomerase. Efforts in the lab are currently focused on identifying the presumed telomerase repressor protein and other proteins that interact with BT2.",Professor and Head,Biology,https://scholars.library.tamu.edu/vivo/display/n5c3b294a
Jason,West,Associate Professor,,Associate Professor,Ecology and Conservation Biology,https://scholars.library.tamu.edu/vivo/display/n5c5021e0
Jason,Karpac,Associate Professor,"The Karpac Lab is broadly interested in the origins of signaling networks that provide animals with metabolic flexibility, and thus the capacity to balance energy homeostasis. These ancient networks, under intense evolutionary pressure, both respond to and are shaped by diverse inputs, such as nutrient availability, pathogens, and aging. We primarily use the fruit fly Drosophila melanogaster as a genetic model to investigate the function and integration of these signaling networks at multiple levels of biological organization: from molecules, to cells and tissues, to inter-organ communication, to organismal physiology and aging.",Associate Professor,School of Medicine,https://scholars.library.tamu.edu/vivo/display/n5d657b49
Kirk,Winemiller,Professor,"The Winemiller Aquatic Ecology Lab investigates fish ecology and evolution, community ecology, and ecosystem ecology in aquatic habitats. Our research is strongly field oriented, with studies conducted at sites throughout Texas, Latin America, Africa, and, more recently, Southeast Asia. Our field research is conducted mostly in fluvial ecosystems (streams, rivers, estuaries) and adopts descriptive, comparative and experimental approaches. The research is strongly oriented towards advancement of both basic scientific understanding as well as options for better conservation of biodiversity and the ecosystems that support it.",Professor,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences",https://scholars.library.tamu.edu/vivo/display/n5d80ec88
Wenshe,Liu,Bovay Chair and Professor in Chemistry,"Our research interest is to design methods for the genetic incorporation of noncanonical amino acids into proteins in living cells and apply these methods in three major directions: deciphering functions of protein posttranslational modifications, small molecule sensing, and expanding chemical diversities of phage display libraries. To study protein posttranslational modifications, we have constructed methods for the site-specific installation of lysine acetylation and methylation in proteins and will apply them to study functional roles of these two modifications on p53, a tumor suppressor protein. We have also developed a strategy to site-specifically install two noncanonical amino acids into one protein in E. coli and are applying this approach to construct biosensors for small organic molecules and metal ions. Phage display is an efficient method to identify peptides for therapeutic interventions. However, a phage display peptide library has limited structure motifs and functional groups because only 20 natural amino acids can be used to generate a library. We plan to expand the chemical diversity of a phage display library by incorporating multiple noncanonical amino acids and chemically modifying them to extend functional diversities. Screening this unnatural phage display library against therapeutic targets such as c-Abl tyrosine kinase is expected to identify highly potent inhibitors.",Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n5d9506ea
Paul,de Figueiredo,Associate Professor,I have strong interests in elucidating the molecular mechanisms that mediate interactions between the intracellular bacterial pathogen Brucella spp. and host cells.,Associate Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n5e6f7b12
Gladys,Ko,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n5e930c1f
Stephen,Maren,University Distinguished Professor,"My research focuses on the neural mechanisms underlying emotional learning and memory in animals and the relevance of these mechanisms to clinical disorders of fear and anxiety, including post-traumatic stress disorder (PTSD).",Professor,Psychological and Brain Sciences,https://scholars.library.tamu.edu/vivo/display/n606b4fd1
Jon,Skare,Regents Professor and Associate Head,"Jon Skare is Regents Professor and Associate Head of the Department of Microbial Pathogenesis and Immunology in the College of Medicine at Texas A&M University. He has been a faculty member at Texas A&M since 1996 and has led a research laboratory centered around the pathogenic mechanisms operative in Borrelia burgdorferi, the spirochetal bacterium that causes Lyme disease. He has published over 50 peer reviewed manuscript, reviews, and book chapters and been funded continuously by the NIH since 1999 with over $20 million dollars in total costs. Dr. Skare has trained ten graduate students, sixteen postdoctoral fellows, and numerous undergraduate students in his research group during his time at Texas A&M. The majority of his postdoctoral trainees and students have gone on to hold academic or industry positions in the medical sciences.
Research interests are focused on microbial pathogenesis with an emphasis in spirochetal infections, particularly Borrelia burgdorferi, the etiologic agent of Lyme disease. Broad training in the molecular biology, genetics, and biochemistry of prokaryotic systems is employed to answer research-related questions. Long-term interests in the lab are centered on understanding how B. burgdorferi promotes its pathogenic potential and persists in the disparate hosts it occupies in nature (e.g., both ticks and mammals). In this regard, the research program is aligned with: (i) regulatory pathways that contribute to the establishment of infection during the arthropod to mammalian transition; (ii) identifying and characterizing surface structures that contribute to the colonization and maintenance of infection via adherence mechanisms; and (iii) the ability of B. burgdorferi and relapsing fever Borrelia to persistently infect hosts in the face of a potent innate and adaptive immune response.",Professor and Associate Head,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n638ae603
David,Earnest,Professor,"Research in my laboratory employs multidisciplinary approaches to study the cellular and molecular neurobiology of cell-autonomous circadian clocks and the signal transduction pathway responsible for circadian photoentrainment. The aims of current projects are to study: 1) the role of microRNAs (miRNAs) and other signaling molecules in the local temporal coordination of cell- and tissue-specific circadian clocks; 2) mutual interactions between the circadian clock mechanism, inflammatory signaling and metabolism; and 3) the mechanisms linking circadian rhythm disruption with metabolic disorders such as obesity and diabetes, and with pathological changes in neuroprotective responses to stroke.",Professor,Neuroscience and Experimental Therapeutics,https://scholars.library.tamu.edu/vivo/display/n640c528f
Kristin,Patrick,Assistant Professor,"Using a multi-disciplinary toolset, we probe the molecular mechanisms that macrophages use to activate an innate immune response that is rapid, robust, and regulated. We mainly study how RNA binding proteins control the ability of macrophages to respond to infection, using a variety of bacterial and viral models. By working to uncover how RNA binding proteins work and how macrophages functionalize RNA binding proteins to orchestrate a fine-tuned innate immune response, our work furthers our understanding of a variety of human diseases.",Assistant Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n6431d695
Michael,Kolomiets,Professor,The focus of research interests of my laboratory is to investigate genes and metabolites of lipid-based biochemical and signal transduction pathways and the role they play in plant development and survival in response to pathogens.,Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/n64753966
Mary,Mcdougall,Associate Professor,,Associate Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/n64af6396
Lee,Fitzgerald,Professor and Curator,"My program is best described as evolutionary ecology and conservation biology of amphibians and reptiles. I use reptiles and amphibians as study systems at the community and landscape level to address the general questions, ""What are mechanisms influencing the fit between organism and environment?"", and ""How do community-level processes influence species persistence and distribution of species across the landscape?"" This program addresses various conservation issues, for example, habitat requirements of single species, determinants of local and regional diversity, or mechanisms determining the fate of invasive and native species.",Professor and Curator,Ecology and Conservation Biology,https://scholars.library.tamu.edu/vivo/display/n65c121ba
Michael,Deveau,Clinical Associate Professor,,Clinical Associate Professor,Small Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/n67ff7535
Joseph,Kwon,Associate Professor and holder of the Kenneth R. Hall Career Development Professorship,,Associate Professor||Faculty Affiliate,Energy Institute||Artie Mcferrin Department of Chemical En,https://scholars.library.tamu.edu/vivo/display/n680c5a23
Shaunna,Clark,Associate Professor,"Dr. Clark's research seeks to understand how biological and environmental factors shape substance use and addiction. Specifically, the lab focuses on the role of genetics and epigenetics in the etiology of substance use and addiction and identifying (epi)genetic biomarkers. This line of research will eventually lead to the improvement of diagnosis, prognosis and treatment of substance addiction and its related health effects. We approach these research questions using a translational framework that incorporates both human and animal studies, big data, and advanced statistical modeling techniques.",Associate Professor,Psychiatry and Behavioral Sciences,https://scholars.library.tamu.edu/vivo/display/n69871e1f
William,Grant,Professor,,Professor,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences",https://scholars.library.tamu.edu/vivo/display/n6d094941
Weihsueh,Chiu,Professor,,Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n6e29f354
Heath,Blackmon,Associate Professor,,Assistant Professor||Associate Professor,Biology||Biology,https://scholars.library.tamu.edu/vivo/display/n6e56235d
Ivan,Ivanov,Clinical Professor,,Clinical Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n6fa588a3
Robert,Burghardt,Professor,"Research in the laboratory is focused on investigating mechanisms by which a variety of biological response modifiers ranging from mechanical signals, hormones and growth factors to environmental chemicals alter cellular signaling pathways and cellular homeostasis.","Professor||Director, Image Analysis Laboratory",School of Veterinary Medicine and Biomedical Sciences||Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n70a3d026
Yubin,Zhou,Professor & Presidential Impact Fellow,"We are a synthetic biology and bioengineering lab focused on developing technologies that enable remote and programmable control of protein activity, cell signaling and designer cells. We pioneer chemical and synthetic biology approaches to address challenges in health and disease. We are particularly interested in (i) illuminating novel regulatory mechanisms of signal transduction that remain unresolved in Ca2+ signaling and inter-organelle communications; (ii) pioneering widely-applicable molecular tools for precise control of cellular events, (epi)genome engineering, and gene transcription; and (iii) developing innovative theranostic devices, programmable biologics and intelligent cell-based therapies (CAR-T) for cancer and neurodegeneration intervention. The tight integration among mechanistic studies, biomedical engineering, and translational sciences is a hallmark of my research. See highlights in: ""Let there be light"" (Scientia); ""Optogenetics sparks new research tool"" (NIH Biomedical Beat)",,,https://scholars.library.tamu.edu/vivo/display/n70ef0d4e
Keyan,Zhu Salzman,Professor,"Over millions of years of co-evolution with insects, plants have developed various defense machineries that can be activated in response to insect herbivory. Insects, in turn, have developed a variety of strategies to evade these plant defense mechanisms. An improved understanding of this complex plant defense and insect counter-defense relationship will facilitate development of better strategies to improve host plant defense. Currently, we are using Arabidopsis to study plant defense signal transduction pathways against insect pests. Meanwhile, since effectiveness of plant defense is also determined by the insect response, my laboratory is also investigating how insects adapt to the challenge of plant defense molecules, as well as to human imposed management strategies, and is working to identify new insect vulnerable systems.",Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/n716ece47
Anne,Shiu,Professor,"I have research interests in algebraic, geometric, and combinatorial approaches to mathematical biology; biochemical
dynamical systems; neural coding; algebraic statistics; and genomics.",Professor,The Texas A&M University System,https://scholars.library.tamu.edu/vivo/display/n733b25e3
A. Phillip,West,Assistant Professor,"Mitochondria are complex and dynamic organelles integral to many processes including energy generation, programmed cell death, signal transduction, and immunity. Research in my laboratory centers on understanding how mitochondria regulate innate immunity and inflammatory processes to influence human health and disease.",Assistant Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n739a434b
Michael,Thomson,Professor,"My research expertise is in plant molecular breeding with an emphasis on rice genetics and genomics, international agriculture, and developing CRISPR-based gene editing approaches for efficient gene validation and trait development. My primary objective is to apply new genetics discoveries to rice improvement to help Texas producers and rice farmers around the world produce higher yields of superior quality rice in an environmentally sustainable manner. I am also leading the AgriLife Research Crop Genome Editing Lab to optimize high-throughput gene editing across a number of diverse crop species.",Professor,Soil and Crop Sciences,https://scholars.library.tamu.edu/vivo/display/n74c30954
Ignacio,Rodriguez-Iturbe,Distinguished Professor,"My research focuses on coastal ecosystems, hydrogeomorphology, ecohydrology, river basin functioning and organization, and stochastic modelling of natural phenomena.",Distinguished Research Professor||Distinguished Professor,Texas A&M Engineering Experiment Station (TEES)||Ocean Engineering,https://scholars.library.tamu.edu/vivo/display/n74fab617
Phapanin,Charoenphol,Instructional Assistant Professor,,Instructional Assistant Professor,Mechanical Engineering,https://scholars.library.tamu.edu/vivo/display/n754c604c
Mike,Morrison,Professor,,Professor,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences",https://scholars.library.tamu.edu/vivo/display/n7568c6ec
Brani,Vidakovic,Professor and Department Head,"Dr. Vidakovic's research interests include wavelets, Bayesian statistics, biostatistics, statistics in medicine, environmental statistics, and statistical signal and image processing.",Professor and Department Head,Statistics,https://scholars.library.tamu.edu/vivo/display/n75843957
Leslie,Adams,Senior Professor,"My research is focused on the: 1) investigation of the comparative molecular pathogenesis of zoonotic intracellular bacterial pathogens in natural animal models, particularly brucellosis, salmonellosis, and mycobacterial diseases; 2) development of vaccines and host gene expression-based diagnostics for zoonotic and select agent caused diseases, and especially 3) development of in silico host:pathogen interactome predictive models based upon bi-directional in vivo host (bovine/murine) and Brucella spp., Mycobacterium spp.and Salmonella enterica Typhimurium interactions. We developed an in silico computational infection biology model based on actuall temporal in vivo bovine model microarray-based transcriptomic and proteomic profiling of the acute infectious process. We developed a systems biology analysis of both host and pathogen comprehensive transcriptomic and proteomic datasets derived from our in vivo biological model. We computationally fused the datasets based on actual Salmonella, Brucella and Mycobacterium data and computationally predicted bovine host structural proteins to identify maximum likelihoods of host and pathogen protein:protein interactions as the basis for our preliminary in silico interactome model to predict mechanistic genes and linked perturbed cellular pathways.",Senior Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n75fee121
Christina,Belanger,Assistant Professor,"Identifying how organisms respond, why they respond, and to which environmental factors they are primarily responding is integral to understanding how future climate change will affect the modern biota as well as to inform efforts to sustain biodiversity and economically important fisheries.
Shelled organisms, such as molluscs and foraminifera, are abundant and well-preserved in the fossil record and in museum collections of modern specimens. These preserved assemblages allow longer-term perspectives on biotic response and climate change - millennia to millions of years - than is possible in exclusively present-day ecological studies. The fossil record also allows trends in these natural communities to be analyzed before, during, and after changes in climate without needing to wait for the events to occur in real time.",Assistant Professor,Geology and Geophysics,https://scholars.library.tamu.edu/vivo/display/n7665a171
Farida,Sohrabji,University Distinguished Professor and Department Head,"My research interests lie at the intersection of neuroendocrinology, neuroinflammation and aging. For the last 10 years, my work has focused on ischemic stroke, specifically, to understand how the aging brain copes with stroke. In North America, stroke risk increases with age and in this aging demographic, women are more likely to sustain a stroke and more likely to have long term disability, poor quality of life and have more neuropsychiatric problems after stroke such as depression and cognitive impairment. This problem is compounded by the fact that few stroke therapies are available. Most stroke neuroprotectants have not been successfully translated from the bench to bedside. Using preclinical models, we have focused on acute pathological changes at the blood brain barrier and central and peripheral inflammation as well as long-term consequences, such as changes to reward pathways and post-stroke depression and dementia. I am also interested in developing novel stroke therapies for stroke in this population and our studies on epigenetic modifications such as histone methylation and non-coding (mi)RNA due to aging/stroke have provided several candidate molecules. Our recent work focuses on the role of the gut microbiome and gut metabolites on stroke recovery, and its potential for understanding the pathophysiology of stroke.
Related to my research goals, I am actively interested in promoting the inclusion of sex as a biological variable and attention to sex differences in medicine. Through medical and graduate coursework, research seminars and community talks, I am a vocal advocate for recognizing sex and gender differences in disease processes and drug therapies. I founded the Women's Health in Neuroscience program at Texas A&M University College of Medicine to create a community of researchers and foster collaboration on gender medicine and women's health, and to train new scholars in this area.",University Distinguished Professor and Department Headd,Neuroscience and Experimental Therapeutics,https://scholars.library.tamu.edu/vivo/display/n772c9962
Brian,Davis,Assistant Professor,"I focus on big-data-omics such as genomics, epigenomics, transcriptomics, and others, to address questions of basic biological processes. I am an evolutionary biologist that is interested in how genomes and organisms evolve when under natural and artificial selection, whether in natural populations or in domesticated animals. I extend this research to study phenotypic traits, heritable disease, and cancer in companion, agricultural, and wild animals using large datasets. My interests focus on companion animals such as cats, dogs, and horses, but extend to numerous wild species of carnivores, ruminants, and others.",Assistant Professor of Biomedical Genetics,School of Veterinary Medicine and Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n795552bb
Charles,Johnson,"Director, Genomics and Bioinformatics Service","Agrigenomics and bioinformatics research and technology development. Research focusing on high throughput next generation sequencing technologies and its application in agriculture. Building an ever growing collaborative network of spanning 62 departments across Texas A&M system, and a rapidly growing list of international collaborators ( 45 countries) and industrial partners. Founding Executive Director of the Center for Bioinformatics and Genomic Systems Engineering (CBGSE).",Director Institute,Texas A&M AgriLife Research,https://scholars.library.tamu.edu/vivo/display/n79e93fe9
Isabella,Farhy,Assistant Professor,"The Farhy lab studies the cross talk of two major cell types in the brain, neurons and astrocytes, focusing on how they shape synapse development and activity. Correct formation of synapses is crucial for normal brain function and synapse deficits have been implicated in most brain disorders, including autism, schizophrenia, major depression and Alzheimer's disease.
To investigate these interactions, we use rodents as model system, combining in vitro pure cell cultures with in vivo transgenic and knockout mice. These are analyzed using cutting-edge omics approaches such as mass-spectrometry, bulk and single cell RNAseq, as well as histology and functional assays.
We aim to uncover the cellular pathways activated in both neurons and astrocytes following their interaction at the synapse, leading to identification of novel therapeutic targets for the treatment of synaptic dysfunctions in brain disorders.",Assistant Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n7a18a20a
Kung-Hui (Bella),Chu,Professor,"Our research interests are in enhancing our understanding of microbial-mediated processes in natural and engineered systems, and in application and development of biotechnology to address various environmental challenges in water, soils, and energy. The Chu lab applies molecular biology, isotopic techniques, chemical analysis, and phage biology to study environmental and biological systems, with focuses on (i) microbial ecology, fate and transport, biodegradation of environmental pollutants such as emerging contaminants and persistent organic pollutants, (ii) production of biofuels and bioproducts from renewable resources, and (iii) detection, tracking, and quantification of microorganisms that play roles in water quality, bioremediation, carbon sequestration and nitrogen cycle in the environment. Other research areas include development and application of novel sorbents and catalysts (bio and non-bio) for removing and/or monitoring emerging environmental pollutants.",Faculty Affiliate||Professor,Civil Engineering||Energy Institute,https://scholars.library.tamu.edu/vivo/display/n7a373eec
Roderick,Dashwood,University Distinguished Professor,"Research integrates multiomic, genetic, epigenetic and immune approaches for precision oncology. Epigenetic readers, writers and erasers that reversibly regulate immune players in the antigen presentation pathway are of current mechanistic interest. Molecular and cell-based assays are combined with preclinical models coupled to polypectomy. Clinical specimens and organoids from patients undergoing colectomy provide for human translation. Supported by the NCI, NINDS/NIA, and the John S. Dunn Foundation.",John S. Dunn Chair in Disease Prevention||Distinguished Professor||Director,Institute of Biosciences and Technology||Center for Epigenetics and Disease Prevention||School of Medicine,https://scholars.library.tamu.edu/vivo/display/n7a63dbe7
Fuller,Bazer,Distinguished Professor,"Dr. Bazer's research in reproductive biology focuses on uterine biology and pregnancy, particularly pregnancy recognition signaling from the conceptus to the maternal uterus by interferon tau and estrogen from ruminant and pig conceptuses, respectively. The roles of uterine secretions as transport proteins, regulatory molecules, growth factors and enzymes and endocrine regulation of their secretion is another major research interest. The endocrinology of pregnancy, especially the roles of lactogenic and growth hormones in fetal-placental development and uterine functions are being studied. The mechanism(s) of action and potential therapeutic value of conceptus interferons and uterine-derived hematopoietic growth factors are areas of research with both pigs and sheep as models for human disease.",Distinguished Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/n7ad91d50
Gerard,Cote,Professor,,Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/n7bbfddf5
Robert,Nevels,Professor,"My research interests include electromagnetics, nanophotonics, electromagnetic scattering, and antennas.",Professor,Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n7c0bf755
Ulisses,Braga Neto,Professor,"My research interests focus on statistical signal processing and control, and pattern recognition and machine learning, with applications in bioinformatics, materials informatics, and epidemiological models.",Professor,Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n7cac0956
Daniel,Roelke,Professor,Why is it that so many microscopic organisms can be found in a single drop of water? And how is it that these minute species can shape entire ecosystems? How might our knowledge of ecological principals governing these microbes be used to protect our living natural resources? Teaching and Research in the Roelke Lab addresses these questions. Understanding lower foodweb dynamics of aquatic ecosystems with an emphasis on interactions between biota and the physicochemical environment is the focus of much of this research.,Professor and Department Head,Marine Biology,https://scholars.library.tamu.edu/vivo/display/n7db49674
Arul,Jayaraman,Professor,,Professor,Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/n7deb8230
Lewis,Ntaimo,Professor,"Dr. Ntaimo's research interests are in stochastic programming, systems modeling and engineering processes, and discrete event modeling and simulation. Applications of interest include wildfire planning, healthcare, wind energy, and homeland security.",Professor||Faculty Affiliate,Industrial and Systems Engineering||Institute for Engineering Education and Innovation,https://scholars.library.tamu.edu/vivo/display/n7ead4771
J Timothy,Lightfoot,Professor,"My research focuses on on the genetics of daily physical activity and exercise endurance, as well as the physiological response to high-G exposure and hemorrhage, and the genetics of physical activity. My lab also has a unique interest in the physiological responses of athletes in a variety of non-traditional venues such as auto racing and in musicians.",Professor,Kinesiology and Sport Management,https://scholars.library.tamu.edu/vivo/display/n7ec5bc99
Martial,Ndeffo,Assistant Professor,"My research uses transdisciplinary modeling approaches to address public health challenges for a wide range of infectious diseases. A focus of my research has been to develop data-driven models to 1) understand and predict epidemiological risk, patterns, and burden of infectious diseases, 2) identify and evaluate optimal strategies for disease control and prevention, and 3) perform economic analyses of public health intervention measures for preventing or curtailing disease outbreaks. Such research is paramount for informing public health policy for infectious diseases prevention and control and ultimately saving lives.",Assistant Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n7f958dd8
Burak,Guneralp,Assistant Professor,"Dr. Burak Guneralp's research interests center on socio-economic and environmental aspects of contemporary urbanization, particularly in relation to urban sustainability. He uses various theoretical frameworks and methodologies, in particular, systems analysis and geospatial analysis.",Assistant Professor,Geography,https://scholars.library.tamu.edu/vivo/display/n80a1013a
Arum,Han,Professor,"His research interests are in solving grand challenge problems in the broad areas of health and energy through the use of micro/nano systems technologies. His work in these areas has focused on the development of in vivo like in vitro systems through microfluidic lab-on-a-chip technologies (e.g., organ-on-a-chip & microphysiological systems, developmental neurobiology models of the central nervous system, blood-brain-barrier-on-a-chip, gastrointestinal tract-on-a-chip, high throughput live cell arrays), development of high throughput single-cell physio-chemical analysis platforms, and development of microbial systems as biorefineries for bioelectricity and biofuel production while simultaneously utilizing wastewater.
He has co-authored more than 80 peer-reviewed publications and has received funding from the Bill and Melinda Gates Foundation, National Institutes of Health (NIH), National Science Foundation (NSF), Defense Threat Reduction Agency (DTRA), United States Department of Agriculture (USDA), U.S. Army Corp of Engineers, Qatar National Research Foundation (QNRF), and several other international sponsors and private companies. He currently serves as the editorial board member of the journal PLoS ONE and as an associate editor for the journal Biomedical Microdevices.",Professor||Faculty Affiliate,Energy Institute||Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n8289e950
David,Wells,Associate Professor,"Biology and ecology of bony fishes, sharks, and rays. Research focus on life history, habitat use, movement, and feeding ecology of marine species throughout sub-tropical and temperate ecosystems.",Associate Professor,Marine Biology,https://scholars.library.tamu.edu/vivo/display/n82b3898a
Francis,Rouquette,Professor,"Primary aspects of this plant-animal interface research program includes simultaneous quantifying of forage persistence and sustainability with animal responses to stocking strategies and grazing intensities. Component research areas include forage germplasm evaluations for team-released varieties; assessment of soil nutrient status under long-term nutrient cycling with fertilizer-stocking regimens; cow-calf and stocker performance on bermudagrass, small grains, ryegrass, and clover; and lifetime animal performance attributes from birth-to-pasture-to-feedlot-carcass with database archival on BeefSys.",Professor||Professor,Soil and Crop Sciences||Overton Research and Extension Center,https://scholars.library.tamu.edu/vivo/display/n82f8d1bd
Patricia,Klein,Professor,"Dr. Klein's research focuses on developing the genomic tools and resources in crops to enable map base cloning of economically important genes, and to understand the underlying mechanisms that plants use to withstand biotic and abiotic stress. Dr. Klein conducts genetic studies on several plant species including sorghum, rose, and pecan. In 2012, Dr. Klein was awarded the College of Agriculture and Life Sciences Dean's Outstanding Achievement Award for excellence as a member of the Sorghum Bioenergy Breeding and Genomics Interdisciplinary Research Team.",Executive Associate Dean||Professor,College of Agriculture and Life Sciences||Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/n83864ec9
Xinping,Hu,Professor,"I am the Endowed Chair for Ecosystem Science and Modeling at Harte Institute for Gulf of Mexico Studies and a Professor in the Department of Physical & Environmental Sciences at Texas A&M University-Corpus Christi.
Our research focuses on understanding the dynamics of estuarine and ocean acidification and the controlling factors, in an effort to understand its impact on marine organisms. We employ a multitude of techniques, including in situ and shipboard observations, as well as statistical and numerical modeling to unravel the linkages between the changes in the water and the factors that are behind. Our research aims to provide most up-to-date information to stakeholders that include coastal communities, fishing and aquaculture industries, and state and federal agencies for management purposes.","Professor||Associate Professor, Physical and Environmental Sciences||TEES Researcher at TAMU-Corpus Christi","Texas A&M University - Corpus Christi - (Corpus Christi, Texas, United States)||Texas A&M University - Corpus Christi - (Corpus Christi, Texas, United States)||TEES Regional Divisions",https://scholars.library.tamu.edu/vivo/display/n83cd1943
Harvey,Scott,Professor,"Dr. H. Morgan Scott is a graduate veterinarian holding a PhD in epidemiology and post-doctoral training in public health. In addition to private veterinary practice, he has worked in both government (food safety surveillance) and academic settings. He is currently professor of epidemiology in the Department of Veterinary Pathobiology at Texas A&M University. He was recruited to Texas A&M University in 2014 as part of the Texas A&M University System Chancellor's Research Initiative and the University President's Initiative on One Health and Infectious Diseases. He relocated from Kansas State University, where he previously held the E.J. Frick Professorship in Veterinary Medicine. Much of his research emphasis has been on studying factors impacting antimicrobial resistance among commensal and pathogenic enteric bacteria in food animal production systems, with a program spanning the realm from the molecular to the sociological. In particular, he is interested in applying both epidemiological and ecological approaches to quantify the emergence, propagation, dissemination, and persistence of resistant enteric bacterial strains in integrated populations of animals, their food products, and humans. Using this knowledge, he hopes to identify opportunities to prevent and intervene against resistance among enteric pathogens in animal agriculture; preferably, by developing readily adoptable and cost-effective management practices suited to modern animal and food production systems.",Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n8499539d
Michael,Longnecker,Professor and Associate Department Head,"Statistical Consulting, Statistical Education.",Professor and Associate Department Head,Statistics,https://scholars.library.tamu.edu/vivo/display/n8500d0ea
Chunlin,Qin,Professor and Associate Department Head,,Professor and Associate Department Head,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n8539b9ab
Bradley,Johnston,Associate Professor,"My areas of interest include evidence-based practice and policy, and the application of advanced randomized trial, systematic review, meta-analysis and guideline recommendation methods to a wide range of applied health science topics, with a particular interest in nutrition and health behavior. As the Director and Co-founder of NutriRECS research and education program (www.nutrirecs.com), I work with an international consortium of over 50 researchers and research trainees aiming to improve the quality of systematic reviews and nutritional guideline recommendations on major nutrition, food and dietary pattern questions. As both first and senior author, my work has been published in the Journal of the American Medical Association (JAMA), British Medical Journal (BMJ), Annals of Internal Medicine and The Cochrane Library. My Google H-Index is 55, and my groups work has been cited over 12,000 times.",Associate Professor (cross appointment)||Associate Professor,Epidemiology and Biostatistics||Nutrition,https://scholars.library.tamu.edu/vivo/display/n85552a5a
Rosemary,Walzem,Professor,"Dr. Walzem's core research focus within the laboratory is directed towards understanding how the structure of triglyceride-rich lipoproteins influences their ability to carry out specific nutrient delivery tasks. Her studies include identification of mechanisms and regulatory processes that control the assembly of trigylceride-rich lipoproteins in issues, structural studies of lipoproteins themselves and physiological studies to determine substrate properties and metabolic fates of different types of lipoproteins. Diet can significantly alter lipoprotein physiology through multiple mechanisms, and studies of diet effects provides a significant sub-theme to the research program. A variety of species are used to address specific questions, however, avian and human lipoprotein metabolism as it relates to egg production and atherogenesis, respectively, are emphasized.",Professor,Poultry Science,https://scholars.library.tamu.edu/vivo/display/n85cd191f
Gilbert,Rowe,Senior Professor,,Senior Professor,Marine Biology,https://scholars.library.tamu.edu/vivo/display/n88019914
Luca,Doro,Research Scientist,"Dr. Doro has a great interest in the development and application of simulation models to agro-ecosystems at field and small watershed scale to assess their performances, sustainability, and dynamics considering factors such as the conservation of natural resources and the impact of climate change while defining possible adaptation and mitigation strategies.",Research Scientist,Temple Research and Extension Center,https://scholars.library.tamu.edu/vivo/display/n882049e0
Clifford,Stephan,Certification Officer and Associate Professor,"The Stephan Lab is focused on drug discovery research. Dr. Stephan directs both the Combinatorial Drug Discovery Program (CDDP) core and the Microphysiological Lead Optimization and Toxicity Screening (MLOTS) facilities. The CDDP is a high throughput screening and automated microscopy core focused on discovering new therapeutics from library screening and drug repurposing alone or in multi-drug combinations. MLOTS is a low to medium throughput core focused on lead optimization for new chemical entities with the capability of testing compounds in complex in vitro models (e.g., spheroids, organoids) and de-risking drug leads by evaluating their potential cardiovascular or CNS toxicities via micro electrode array or hepatotoxcity in a microfluidic liver model.",Research Associate Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/n8c431f98
Qingwu,Xue,Professor,"Develop a competitive and extramurally funded research program in the area of crop water use, water use efficiency, and abiotic and biotic stress resistance in major field crops in the Texas High Plains. The overall goal of my research program is to provide selection tools for breeders and geneticists and management tools for agronomists and producers, through better understanding the physiological mechanisms of crop performance under stress conditions. The major research focuses include understanding physiological and molecular mechanisms of drought tolerance, identifying plant traits conferring to stress tolerance, understanding the interactions of abiotic and biotic stresses, evaluating and developing field phenotyping tools, and developing management strategies under stress conditions. Advise graduate student research.",Professor||Professor||Adjunct Professor,"Soil and Crop Sciences||Texas A&M AgriLife Research||West Texas A&M University - (Canyon, Texas, United States)",https://scholars.library.tamu.edu/vivo/display/n8c76b901
Michael,Polymenis,Professor,"The promise for the treatment of proliferative disorders, with incalculable potential benefits to human health, has driven basic research into the genetic control of cell division for decades. However, what determines when cells initiate their division remains mysterious. It is as if we are staring at a beautiful engine, with little knowledge about what turns it on. How cells are set off to a new round of cell division, remains as one of the most fundamental, unanswered questions. It is virtually unknown which cellular pathways affect initiation of division, which factors operate within each pathway, the extent of interactions between pathways, and how each pathway is molecularly linked to the machinery of cell division. Our studies aim to answer these questions using baker's yeast. This model organism has a machinery of cell division that is very similar to that of human cells, and it is suited for genetic and biochemical studies.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n8c9420b2
David,Threadgill,Professor,"Our laboratory uses the mouse as an experimental genetic model to investigate factors that contribute to inter-individual differences in health and disease. Ourcurrent research activities include the identification and functional characterization of alleles contributing to cancer susceptibility, the function of theErbbgenefamily in development and disease, and the role of genetic variation in response to environmental stimuli. To support these investigations, we also aredeveloping new genetic tools to support mammalian systems genetic approaches to phenotypes with complex genetic and environmental etiologies.",Director||Professor||Professor||Professor,Cell Biology and Genetics||Institute of Genome Sciences and Society||Biochemistry and Biophysics||Nutrition,https://scholars.library.tamu.edu/vivo/display/n8ee0b54f
Lloyd,Wilson,Agrilife Center Director,"Dr. Wilson's research program is broad-based and focuses on the theory and application of quantitative principles as they pertain to agroecosystem management. His current research largely focuses on rice, energycane, and high biomass sorghum cropping systems management. He has extensive expertise in field experimental design and analysis, in the development of soils, road network, and cropland databases, and in the development of physiologically based food, feed, fiber, and bioenergy crop models.",Agrilife Center Director||Center Director,Beaumont Research and Extension Center||Texas A&M AgriLife Research,https://scholars.library.tamu.edu/vivo/display/n8f424136
Nancy,Turner,Research Professor,"Dr. Turner's research program focuses on determining the impact of dietary constituents on regulatory processes that may protect against carcinogenesis and inflammation in the colon. Her lab is evaluating the effects of fiber sources and the specific phytochemicals contained within them on aspects of cellular proliferation or apoptosis, and microbial/epithelial cell interactions. The goal is to determine how these normal processes are being perturbed by chemical carcinogens, radiation or pro-inflammatory compounds, and how diet may mitigate the damage caused by them. Work conducted in the laboratory is currently funded by the United Sorghum Checkoff Board, the California Dried Plum Board, and the National Space Biomedical Research Institute.",Research Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n8f7d7c90
James,Sacchettini,Professor,"My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n90385563
Marielle,Engelen,Professor,"My research focuses on the metabolic alterations underlying involuntary weight loss and muscle wasting in chronic inflammatory diseases, involving the use of stable isotope methodologies, and the effects of dietary modulation and exercise intervention to restore metabolism and physical performance in these patients.",Professor||Professor,Kinesiology and Sport Management||Center for Translational Research in Aging and Longevity,https://scholars.library.tamu.edu/vivo/display/n90a05e0d
Ken,Muneoka,Professor,My lab is focused on understanding epimorphic and tissue regeneration in mammals.,Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n9156816d
Hisashi,Koiwa,Professor,,Professor,Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/n931bc4cc
Jay,Groppe,Associate Professor,,Associate Professor,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n93572b3e
Xudong,Zhang,Professor,"My research centers on modeling, analysis, and simulation of the human musculoskeletal system and its multi-scale structures and components during functional, particularly dynamic activities. The overarching goal is to advance the musculoskeletal biomechanical science bases and applications in healthcare and human-machine systems engineering.",Professor||Professor,Mechanical Engineering||Industrial and Systems Engineering,https://scholars.library.tamu.edu/vivo/display/n93a0024f
Nova,Silvy,Regents Professor,,Professor,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences",https://scholars.library.tamu.edu/vivo/display/n9474c27a
Timothy,Phillips,Professor,food safety; molecular toxicology; elucidation of fundamental chemical mechanisms of toxic action/interaction of food-borne carcinogens; mutagens; and developmental toxicants; and development of methods to detect and detoxify foodborne and environmental toxins.,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n94eef946
Brian,Shaw,Professor,,Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/n94f2923f
Chia Shan,Wu,Research Assistant Professor,,Research Assistant Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n954c969e
Andreea,Trache,Associate Professor,"The research in my laboratory focuses on the study of cellular responses to mechano-chemical stresses from a biophysical perspective. Biophysics research represents an applied field of science at the interface of physics, biology, engineering, and medicine. Our lab uses live vascular cells as a model system because endothelial and smooth muscle cells reside 'in vivo' in a mechanically active environment that is continuously changing. Using real-time imaging of live cells is the only way to directly monitor cellular responses to mechano-chemical stimulation. Moreover, single-cell imaging experiments allow discrete measurements of transient microscopic events that may be masked by a macroscopic average behavior, and will aid in understanding such behavior.",Associate Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n955af1bf
Gabriella,Ten Have,Research Assistant professor,"My current expert position within the Center for Translational Research in Aging & Longevity (CTRAL) is based on 25-years of expertise on nutrition, metabolism, and in vivo (patho)physiological studies involving the use of stable isotope approaches and methodologies in animals. I was heavily involved in the design and construction of the new Human Clinical Research Facility at Texas A&M University in 2016 (current home of CTRAL) which further increased my laboratory design, management, and leadership skills. As Director of Animal Research within CTRAL, I design the animal use and the stable isotope use protocols, and perform complex surgical procedures. I develop and implement new quantitative metabolic and stable isotope techniques and procedures in large and small animals. As co-director of the CTRAL analytical lab, I review, design, and collect data pertaining to human and animal stable isotope studies collaborating with national and international researchers. I am also responsible for the administrative responsibilities related to regulatory affairs, (budget) management of the labs and clinic. I oversee the coordination of analyses, all pharmacy related activities, quality control, lab personnel, general equipment maintenance, and laboratory safety procedures. I mentor CTRAL research assistants, graduate students and postdocs, and assist faculty and (inter)national collaborating faculty with grant writing and scientific publications. Finally, I'm a Managing editor of the journals Clinical Nutrition (IF:6.4) and Clinical Nutrition ESPEN.
Complete List of Published Work in MyBibliography http://www.ncbi.nlm.nih.gov/pubmed/?term=Ten+Have+GA",Research Assistant Professor,Center for Translational Research in Aging and Longevity,https://scholars.library.tamu.edu/vivo/display/n95e3ae10
Kristen,Maitland,Associate Professor,"The focus of Dr. Maitland's research is on the development of light-based technologies for applications in medicine and biology. Technologies include novel light sources, optical fiber based imaging systems, handheld microscopes, multiscale optical microscopes, volumetric imaging systems, portable spectrometers, and point-of-care devices.",Director||Associate Professor,Biomedical Engineering||Microscopy and Imaging Center,https://scholars.library.tamu.edu/vivo/display/n96bdddbb
Xinyue,Ye,Professor,"Dr. Xinyue Ye is Harold Adams Endowed Professor on Interdisciplinary Built Environment Science Research and Stellar Faculty Provost Target Hire for Urban Computing at Texas A&M University. With the career experience in urban planning, economic geography, geographic information system, and computational science, his research focuses on geospatial artificial intelligence, big data, smart cities, and urban computing. Dr. Ye models the space-time perspective of socioeconomic inequality and human dynamics for applications in various domains, such as economic development, disaster response, transportation and land use, public health and urban crime.
Prof. Ye is Editor-in-Chief of the Journal of Computational Urban Science (indexed in EI and Web of Science), published by Springer. He also serves as the co-editor of Journal of Planning Education and Research. He is Vice President of Spatial Decision Support Consortium. He directs the focus of smart cities and transportation in the PhD program of Urban and Regional Science at Texas A&M University. He established Urban Data Science Lab as a platform to fly the imaginations of urban solution. He leads Design and Analytics Lab for Urban Artificial Intelligence (AI), funded through the Texas A&M Institute of Data Science. This lab develops digital twins and virtual/augmented reality (VR/AR) for multi-scaled simulations and scenarios for dynamically analyzing real-time built environments and testing scenarios for sustainable growth and climate action. This involves 55 faculty members across nine colleges at TAMU, including the Galveston campus, Texas A&M Engineering Experiment Station, AgriLife Research, and Texas A&M Transportation Institute. In addition, he leads the development of urban data science course series, among the seven selected across campus. As the interim director of Center for Housing & Urban Development, Dr. Ye promotes the vision of ""urban informatics+"" to integrate human-centered urban and regional science research across disciplines. As the Director of the Center for Geospatial Sciences, Applications and Technology (GeoSAT) established by the Texas A&M Board of Regents, Dr. Ye aims to facilitate the convergence of computing and geospatial science.",Professor||Faculty Affiliate||Professor||Faculty Affiliate||Professor||Faculty Affiliate||Faculty Affiliate||Director||Professor||Faculty Fellow (Strategic Initiatives and Partnerships),"Division of Research||Center for Geospatial Science, Applications & Technology||Institute for Science, Technology, and Public Policy||Landscape Architecture and Urban Planning||Energy Institute||Multidisciplinary Engineering||Hazard Reduction and Recovery Center||Geography||Computer Science and Engineering||Texas A&M Institute of Data Science",https://scholars.library.tamu.edu/vivo/display/n96eca29a
Wonmuk,Hwang,Associate Professor,,Associate Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/n96f41d07
Terje,Raudsepp,Professor,"Comparative genomics and molecular cytogenetics of animals, birds and other vertebrates organization, function and evolution of sex chromosomes; equine genomics - genomics of genetic diseases and disorders of sexual development and reproduction; alpaca and camelid genomics.",Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n970d3a82
Fei,Liu,Associate Professor,"Our laboratory conducts research in:
1. The characterization and application of standardized mesenchymal stem cells (MSCs) derived from iPS cells and their extracellular vesicles (EVs). Current application focuses on treating diseases caused by over-activation of immune system, such as Sjogren's syndrome, an autoimmune disease causing dry eyes and dry mouth, and cytokine storm caused by infections.
2. Roles of tissue-resident macrophages in the development, homeostasis, and regeneration of salivary glands damaged by radiation therapy for cancer.",Associate Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/n9732f08e
Larry,Suva,Professor and Head,"The development, control and diseases of the musculoskeletal system have been my scholarly interests for the past 35+ years. Understanding how the musculoskeletal system adapts and progresses throughout life is the basis of my expertise. My research focus has been the skeletal consequences of disease, such as breast cancer bone metastasis and multiple myeloma, fracture healing, osteoporosis, and most recently rare bone diseases. Current research efforts include a focus on utilizing in vivo models (murine and large animals) to discover regulatory pathways fundamental to bone physiology and the development of rare bone disease preclinical model(s) that may provide novel insight into future therapeutic directions. A critical aspect of my academic philosophy is an open door policy and the importance of one-on-one interactions. We must strive to provide training and exposure for our students as they prepare for careers both in and out of academic medicine and research. I emphatically believe that these teaching and mentoring experiences have shaped my scientific career and have helped mold my teaching and mentoring philosophy of placing the best professional, academic, social and personal development of faculty, students and staff above all else.",Professor and Head,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n98338eea
Holly,Gibbs,Research Assistant Professor,"We have yet to understand how embryonic brain development gives rise to brain function and how deficits in this process lead to brain disorders. To help improve this understanding, I'm interested in developing accessible microscopy, labeling, visualization, and bioimage informatics tools for creating multi-scale models of the emergence of brain structure and function.",Research Assistant Professor||Associate Research Scientist,Biomedical Engineering||Microscopy and Imaging Center,https://scholars.library.tamu.edu/vivo/display/n986a1aee
Nicholas,Jeffery,Professor,,Professor,Small Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/n989eab0c
Nancy,Ing,Professor,"Dr. Ing's research interests focus on understanding how hormones regulate gene expression in animal tissues. Current research projects investigate the earliest days of pregnancy in the sheep uterus and the regulation of estrogen receptor gene expression, as well as stress hormone effects on gene expression in the stallion testes. Most recently, we have been studying the RNAs in sperm from stallions and honey bees in order to find a pattern consistent with high fertility.",Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/n98a4a111
James,Grau,Professor,,Professor,,https://scholars.library.tamu.edu/vivo/display/n99939828
Guolin,Ma,Research Assistant Professor,"I obtained my Ph.D. with a major in Bioinorganic Chemistry, focusing on metallodrugs against cancer and Alzheimer's disease (AD). After then, I worked at the Institute of Biosciences & Technology (IBT), Texas A&M University (TMAU) as a postdoc and research scientist dissecting and regulating Calcium Signaling by biochemistry, cell biology, and synthetic biology strategies. I accumulated strong research expertise on Ca2+ signaling in the immune system from mechanistic dissection of SOCE channels to tailoring cell functions using optical and chemical tools. I was promoted as a Research Assistant Professor in Oct 2020 to pursue my independent research program with interests in (i) Design and screening of Ca2+ channel modulators (compounds & peptide/protein drugs) to treat channelopathy or improve T cell immunotherapy; (ii) Delineate novel regulatory mechanisms of Ca2+ signaling in health and disease; (iii) Devise optogenetic, chemical and synthetic biology tools for translational research and biomedical applications. I have been engaged in the interface between chemistry and biology for almost 15 years, with specific training and expertise in Ca2+ imaging, protein engineering, protein chemistry, cell biology, and immunotherapy. So far, I have published 20+ publications as a lead author or corresponding author in well-respected journals, including Nature Communications, JACS, Angew Chem, Advanced Science, Chemical Science, eLife, and PLOS Biology with citations > 2000 times.
My current research interests:
1. Design and screening of CRAC Ca2+ channel modulators including small molecules, peptide/protein drugs, and antibody/nanobody to treat Channelopathy or improve T cell-based immunotherapy.
2. Delineate the regulatory network of the CRAC channel in healthy and diseased states
3. Devising optogenetic, chemical, and synthetic biology tools for precise control of cellular physiology",Research Assistant Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/n99aac0c9
Bhimanagouda,Patil,"Leonard Pike Inagural University Professor and Interim Head, Food Science and Technology","Dr. Bhimu Patil is internationally recognized for his expertise and research on 'foods for health' and his related educational programs. His systems-wide farm-to-table approaches include examining pre- and postharvest effects on bioactive compounds, isolating and characterizing these compounds from different fruits and vegetables, and understanding their roles in human health. Moreover, he has a strong working relationship with produce industry stakeholders. Dr. Patil has a distinguished record of achievements in education, including leading the development of three unique courses linking agriculture, human health, and sustainability. Texas A&M University has been a leader in this area, due in part to Dr. Patil's seminal contributions in these first-of-their-kind multidisciplinary courses. Dr. Patil's contributions to education are no less distinguished. He developed and taught three unique, innovative multi-state and multi-disciplinary courses, ""Phytochemicals in Fruits and Vegetables to Improve Human Health"", ""Science of Foods for Health"" and ""The Nexus of Food & Nutritional Security, Hunger, and Sustainability"".",Professor||Professor,Nutrition||Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/n9a0e203e
Alan,Dabney,Associate Professor,,Associate Professor,Statistics,https://scholars.library.tamu.edu/vivo/display/n9b774f13
Jeetain,Mittal,Professor,Dr. Mittal's research focuses on biomolecular self-assembly processes with a specialization in protein phase separation and nanoparticle superlattice design.,Professor,Artie Mcferrin Department of Chemical En,https://scholars.library.tamu.edu/vivo/display/n9c511486
Hung-Jen,Wu,Associate Professor,"Dr. Wu uses nanostructured materials and analytical tools to develop diagnostic techniques for medical applications. His laboratory recently focuses on understanding the influences of multivalency and cell membrane environment on pathogen-host cell recognition. The applications of his techniques include, infectious diseases screening, exploring cell membrane function, and targeted drug delivery.",Associate Professor,Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/n9cbcca3e
Ke,Zhang,Associate Professor,"Dr. Zhang's long-term goal is to decode genetic events and molecular interactions of biological processes, and rigorously represent the complex molecular behaviors with mathematical models. We use advanced high-throughput technology and robust stochastic models to obtain the systematic picture of a biological process. Multiple types of omics data, such as microarray, RNA-seq, ChIP-seq, lipidomics and proteomics are collected through innovative study designs in animals and humans, and are modeled for integrative analysis. Using embryonic mouse as a model system, one of our current focuses is to untangle the spatial and dynamic gene-gene interaction networks during heart development, and illustrate how environmental factors introduce adverse molecular changes and morphological defects. We are also investigating the transgenerational epigenetic variations carried from overweight mother to the offspring, and how the change of lifestyles would prevent childhood obesity.",Associate Professor||Associate Professor,Institute of Biosciences and Technology||Nutrition,https://scholars.library.tamu.edu/vivo/display/n9d8b0bca
John,Stallone,Professor,"Research in my lab focuses on male-female differences in normal cardiovascular function, and in the development of various diseases, including hypertension, coronary artery disease, and stroke, and the roles of the sex hormones in these male-female differences in cardiovascular disease. A major topic of study in my lab is the so-called ""estrogen paradox"" which reveals protective effects of this female sex hormone in younger women and animals, but deleterious effects in older females.",Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n9dab7ff2
Roland,Kaunas,Associate Professor,"Dr. Roland Kaunas' laboratory focuses on the engineering of micro-tissues containing mesenchymal stem cells as vehicles for regenerating musculoskeletal tissues and as cell-based models for studying bone tumor biology. This work employs sophisticated microfluidic platforms, custom bioreactors, and novel scaffolding strategies involving composites of natural and synthetic polymers.
Kaunas' group also studies how mechanical stresses and strains, such as tensile stretch and fluid shear stress, regulate cell function in vascular tissues including arteries, capillaries and lymphatics. This work involves integration of experiments and theory to elucidate the roles of intracellular contractility, applied forces and scaffold material properties on cell architecture and transduction of mechanical stimuli into intracellular signals leading to changes in cell behavior.",Associate Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/n9eb05d66
Karen-Beth,Scholthof,Professor,"My molecular plant virology research is on a virus complex of Panicum mosaic virus (PMV) and its satellite virus (SPMV). For molecular genetic studies on the PMV/SPMV virus:host interactions we are using the model grass, Brachypodium distachyon. My primary area of research is the historiography of Tobacco mosaic virus (TMV) in the early 20th century in the United States.",Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/na173b2b4
Chaodong,Wu,Professor and Presidential Impact Fellow,"The long-term goal of Dr. Wu's research program is to elucidate the mechanisms underlying the pathogenesis of obesity and overnutrition-associated metabolic diseases including insulin resistance, diabetes, and fatty liver disease so that novel dietary and/or pharmacological approaches can be developed for preventing and/or treating metabolic diseases. Using molecular, cellular, and integrative approaches, the Wu lab is focused on investigating the interaction between metabolism and inflammation.",Professor||Professor,Texas A&M AgriLife Research||Nutrition,https://scholars.library.tamu.edu/vivo/display/na24a9d43
Patrick,Stover,Vice Chancellor and Dean,,Professor||Vice Chancellor and Dean,College of Agriculture and Life Sciences||Nutrition,https://scholars.library.tamu.edu/vivo/display/na2e4838e
John,Thaden,Research Scientist,Chromatography and mass spectrometry of small molecules in applications related to research on human metabolism and nutrition.,Research Scientist,Center for Translational Research in Aging and Longevity,https://scholars.library.tamu.edu/vivo/display/na40b0f3b
Chavela,Carr,Lecturer,,Lecturer,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/na40e43dd
Krishna,Narayanan,Professor,"I teach and conduct research in the areas of information theory, coding theory, data science, signal processing and machine learning. I am particularly interested in applications to 6G wireless communications and emerging paradigms in data storage.",Associate Director for Educational Initiatives||Professor,Electrical and Computer Engineering||Texas A&M Institute of Data Science,https://scholars.library.tamu.edu/vivo/display/na5215b26
Bani,Mallick,Distinguished Professor,"Bayesian hierarchical Modeling, Nonparametric Regression and classification, Bioinformatics, Spatio-temporal Modeling, Machine learning, Functional Data analysis, Bayesian nonparametrics, Petroleum reservoir characterization, Uncertainty analysis of Computer Model outputs",Distinguished Professor,Statistics,https://scholars.library.tamu.edu/vivo/display/na73654e3
Julian,Hurdle,Associate Professor,,Associate Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/na747fce2
Dongsheng,Yao,Postdoctoral Research Associate,,Postdoctoral Research Associate,Texas A&M AgriLife Research,https://scholars.library.tamu.edu/vivo/display/na75f1f17
Jerome,Trzeciakowski,Professor and Associate Department Head,,Professor and Associate Department Head,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/na90a7aab
Xiaohui,Xu,Professor,"Dr. Xu is an environmental epidemiologist whose research focuses on studying the health impacts of global or emerging environmental exposures such as air pollution, climate change, and hydraulic fracture. He is interested in conducting community-engaged research to understand the impacts of physical, chemical, and biological environmental factors on public health and aims to promote a healthy and safe environment through interventions and education.",Professor,Epidemiology and Biostatistics,https://scholars.library.tamu.edu/vivo/display/na9c51203
George,Perry,Associate Professor,,Associate Professor,Texas A&M AgriLife Research,https://scholars.library.tamu.edu/vivo/display/nacfdace6
David,Zawieja,Regents Professor and Department Head,"My lab has had a number of research projects focusing on the study of lymphatic structure and function. Each of these projects has, as one of their objectives, the evaluation of the mechanisms (molecular, cellular, mechanical and tissue-level) regulating different aspects of lymphatic function. These projects focus on the ionic/calcium, contractile/regulatory proteins, molecular pathways that regulate lymph transport, lymphatic muscle function, the role of lymphatic function in the generation and resolution of tissue inflammation and the interactions between immune cells and the lymphatic cells. To support this work we have established cultured cell lines of both endothelial and muscle isolated from microlymphatics, acute and cultured isolated microlymphatic tissues, methodologies to evaluate lymphatic function at the single vessel, whole tissue and animal levels, methodologies to target cell-specific gene manipulation in isolated lymphatic tissues, approaches to microscopically image and model lymphatic network structure and function in 3D in lab animals. We have also evaluated the effects of space flight, various inflammatory mediators and other immune activation processes on lymphatic contractile and transport function and how these affect immunity. Finally, we have evaluated different types of lymphatic pathology resulting in lymphedema, various inflammatory diseases and immune dysfunction.",Regents Professor and Head||Professor and Associate Department Head,The Texas A&M University System||Medical Physiology,https://scholars.library.tamu.edu/vivo/display/nad1e71e4
Alex,Walsh,Assistant Professor,,Assistant Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/nadf9994b
Lan,Zhou,Associate Professor,"My research focuses on statistical methodology and application in bioinformatics, nutrition, biostatistics and epidemiology, and functional/longitudinal data analysis.",Associate Professor,Statistics,https://scholars.library.tamu.edu/vivo/display/nae08b001
Aaron,Tarone,Professor,"The Tarone laboratory is interested in factors that lead to local adaptations of fly development times and body sizes. These traits are influenced by numerous genetic and environmental factors. They are also ecologically important life history traits for any organism and are frequently found to be under differential selection across populations of numerous fly species. Accordingly, there are many applied and theoretical reasons for dissecting the causes of variation in these phenotypes in flies that influence human activities.",Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/nae6767b7
Yang,Shen,Associate Professor,"My main motivation is to unravel molecular mechanisms and to modulate emergent behavior of biomolecular networks with the development and application of computational tools (including molecular modeling, network simulation, optimization, machine learning, graph theory, and systems and control theory). To that end, I aim at an iterative process that models and experiments can feed each other.",Faculty Affiliate||Associate||Assistant Professor,Energy Institute||Electrical and Computer Engineering||Aggie STEM,https://scholars.library.tamu.edu/vivo/display/naee36a69
Kranthi,Mandadi,Associate Professor,"World-wide, pathogens, insects and abiotic stresses cause major losses to agricultural production and productivity. Our lab employs integrated approaches for basic and translational studies of crop stress responses in model and crops. We are using the latest genomics, genetics, and bioinformatics tools to study plant stress responses to diverse plant biotic and abiotic stress conditions, as well as enhance their stress tolerance using biotechnology and breeding tools.",Associate Professor||Associate Professor,Plant Pathology and Microbiology||Texas A&M AgriLife Research,https://scholars.library.tamu.edu/vivo/display/nb05fab89
Stephen,Safe,Distinguished Professor,The aryl hydrocarbon receptor (AhR) is a nuclear helix-loop-helix transcription factor which forms a ligand-induced nuclear heterodimer with the AhR nuclear translocator (Arnt) protein. Research in this laboratory is focused on the molecular mechanism of crosstalk between the AhR and estrogen receptor (ER) signaling pathways in which the AhR inhibits estrogen-induced gene expression. The antiestrogenic activities of some AhR agonists are also being developed as drugs for clinical treatment of breast and endometrial cancers in women. Research on estrogen-dependent gene expression in various cancer cell lines is focused on analysis of several gene promoters to determine the mechanisms of ERa and ERb action. This includes several genes that are activated through interactions of the ER with Sp1 protein and other DNA-bound transcription factors.,Distinguished Professor||Distinguished Professor||Syd Kyle Chair,School of Veterinary Medicine and Biomedical Sciences||Biochemistry and Biophysics||Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/nb20fdbd9
David,Reiner,Associate Professor,he Reiner lab research is divided into two general areas: mechanisms of cell signaling and harnessing model genetic organisms for drug discovery and translational biology.,Associate Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/nb2849771
Ivan,Rusyn,Professor,"My laboratory has an active research portfolio funded by the National Institutes of Health and the US EPA with a focus on the mechanisms of action of environmental toxicants and the genetic determinants of the susceptibility to toxicant-induced injury. Through a combination of in vivo animal studies and experiments that utilize cellular and molecular models, we aim to better understand why certain chemicals cause cancer or organ damage in rodents and whether humans in general, or any susceptible sub-population in particular, are at risk from similar exposures.
The main focus of our inter-disciplinary research is on improving the linkages between exposures and adverse health effects Specifically, we develop innovative experimental methods and computational tools which enable analysis of data across multiple dimensions including SNPs, -omic endpoints, multiple chemicals and traditional toxicity phenotypes.","Professor, Veterinary Physiology and Pharmacology",School of Veterinary Medicine and Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/nb3daa5ce
Thomas,DeWitt,Associate Professor,,Associate Professor,Ecology and Conservation Biology,https://scholars.library.tamu.edu/vivo/display/nb4aed80b
Mustafa,Akbulut,Associate Professor,"The Akbulut Lab is involved in research in various areas of nanotechnology, surface and interface science, with a special focus on the areas of drug delivery, biomedical interfaces, tribology, surface and intermolecular forces, colloidal stabilization, and crystallization.",Associate Professor||Faculty Affiliate||Associate Professor,Energy Institute||Chemical Engineering||Materials Science and Engineering,https://scholars.library.tamu.edu/vivo/display/nb5e5f93d
Warren,Zimmer,Scott Exter Professor,"Our research interests are directed towards understanding the complex mechanisms which regulate the expression of specific gene sequences in development. We have focused our studies upon the factors that influence the smooth muscle component of the developing gastrointestinal (G.I.) tract. It has been shown that smooth muscle cells are predominantly derived from mesodermal precursor cells, however the factors regulating the selection of the smooth muscle myogenic pathway is not well defined.",Scott Exter Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/nb6da0749
Siegfried,Musser,Professor,"The primary focus of my laboratory is to decipher how proteins partition into different sub-compartments of the cell. Cellular membranes serve to compartmentalize biochemical reactions to specific microenvironments. Proteins cross these membranes via a diverse array of protein translocation systems, or translocons. My laboratory has investigated the detailed molecular function of three different protein transport machineries, the human nuclear pore complex (NPC) and the bacterial Sec and Tat general secretion machineries. We are a biophysics lab and our primary tools for deciphering molecular mechanisms and dynamics are super-resolution imaging and single molecule particle tracking approaches. Our aim is to develop detailed, molecular-scale, mechanistic models of protein transport processes. We recently demonstrated 3D imaging of cargo transport through nuclear pores on the millisecond timescale with 5-15 nm precision in all three dimensions. This will be a major tool going forward for multiple projects.
In 2018, we began a new project on membrane-less organelles, which are micrometer-scale cellular structures known as biomolecular condensates (BMCs) that contain high concentrations of intrinsically disordered proteins and RNA. These BMCs are generally agreed to arise from liquid-liquid phase separation (LLPS), which is the spontaneous partitioning into dense and dilute phases due to favorable interactions between the separating molecules. The high density of aggregation prone proteins in BMCs is thought to lead to the cellular inclusions found in patients with multiple neurological diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Parkinson's and Alzheimer's diseases. We are using super-resolution and single molecule methods to probe the structural and dynamic heterogeneity of condensates formed from the fused in sarcoma (FUS) protein to identify the conditions that lead to solidification of liquid condensates (phase maturation).",Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/nb824aefa
Margarita,Martinez-Moczygemba,Research Associate Professor,"The research focus of the Moczygemba laboratory is to develop interventional strategies that block allergic inflammation through our increased understanding of cytokine signaling and eosinophil biology. The eosinophil and its major activator, IL-5, play an important role in the pathogenesis of allergies and asthma. Thus, one of our goals is to understand regulatory mechanisms that control the intensity and duration of IL-5-mediated eosinophilic signaling. To this end, we employ various cellular, immunological, and biochemical techniques to help us identify novel targets capable of modulating inflammatory signals triggered by eosinophils.","Advisor to the Dean for Internal Affairs||Director, Flow Cytometry and Cell Sorting Core Facility",Institute of Biosciences and Technology||School of Engineering Medicine,https://scholars.library.tamu.edu/vivo/display/nb8971d17
Roy,Pool,Clinical Professor,Diagnostic orthopedic pathology and oncology,Clinical Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/nb973c892
Raquel,Sitcheran,Associate Professor,"The goal of our research is to understand the molecular mechanisms that control NF-kappaB regulatory networks in the central nervous system (CNS). NF-kappaB is a ubiquitously expressed, evolutionarily conserved transcription factor that responds to a variety of signals and regulates fundamental processes, including cell growth and proliferation, inflammation, invasion and angiogenesis. Indeed, aberrant NF-kappaB activity or expression is associated with many cancers, as it can promote tumorigenesis, tumor progression and resistance to therapy. Our focus is on glioblastoma, a common and highly lethal CNS tumor that is very resistant to current treatment strategies.",Associate Professor,The Texas A&M University System,https://scholars.library.tamu.edu/vivo/display/nb97a02a1
Rhonda,Miller,Professor,,Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/nb97c5e3d
Terry,Wade,Deputy Director,,Research Scientist,College of Geosciences,https://scholars.library.tamu.edu/vivo/display/nba3197b7
Ashok,Shetty,Professor and Associate Director,"Dr. Ashok K. Shetty's laboratory is interested in developing clinically applicable strategies efficacious for enhancing brain function after injury, disease, or aging. The central areas of investigation are focused on:
o Mechanisms by which intranasally administered stem cell-derived extracellular vesicles (EVs) promote neuroprotection, neuroregeneration, neural plasticity, and alleviate neuroinflammation. The sources of EVs include human bone marrow mesenchymal stem cells (hMSCs), and human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSCs), astrocytes, and microglia. The model systems include traumatic brain injury (TBI), closed head injury (CHI), Aging, Alzheimer's disease (AD) and temporal lobe epilepsy (TLE).
o Mechanisms by which transplanted human neural stem cells or human GABA-ergic precursor cells derived from hiPSCs promote brain repair, and alleviate spontaneous seizures, and cognitive and mood impairments in prototypes of SE, TLE, and TBI.
o Elucidating mechanisms of brain dysfunction and chronic neuroinflammation in prototypes of Gulf War Illness. Developing therapeutic strategies to alleviate neuroinflammation, systemic inflammation, and cognitive and mood impairments in models of GWI.
o Developing clinically feasible strategies for improving brain function in aging and AD models via stimulation of endogenous neural stem cells using drugs and biologics.
Dr. Shetty has received continuous extramural research funding as PI for >25 years from sources such as the NIH, DOD, Dept of Veterans Affairs (VA), and industry. These include seven R01 grant awards and an R21 grant award from the NIH; seven CDMRP grant awards from the DOD; five Merit Grant awards and two Research Career Scientist Awards from the VA; and two industry grants. He has also served as Co-I of 8 other DOD grants. Grants from the NIH, DOD, and industry fund Dr. Shetty's current research. Dr. Shetty has authored 181 peer-reviewed publications (147 as senior/first author) and edited a book on Neural Stem Cells in Health and Disease. His work has appeared in many prestigious and high-impact journals. Dr. Shetty has received >17,000 citations for his publications with an h-index of 64. Dr. Shetty has the distinction of serving on two NIH Study Sections and one VA study section as a Chartered Member. Besides, he has served as a member of many other study section panels of the NIH, DOD, VA, and Maryland State Stem Cell Research Fund. Dr. Shetty is Co-Editor-in-Chief of the journal, Aging & Disease and Associate Editor of 6 Neuroscience journals. He is also a Member of the Editorial Board of many prestigious journals, including The Journal of Extracellular Vesicles, Aging Cell, and Stem Cells. Dr. Shetty is a Fellow of the American Society for Neural Transplantation and Repair. Dr. Shetty received the Senior Research Excellence Award in 2021 from the TAMU College of Medicine and is among the ""World's Top 2% Scientists"" across all scientific fields.","Associate Director, Institute for Regenerative Medicine||Professor",Cell Biology and Genetics||Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/nba613a86
Yu (Yvette),Zhang,Professor,"Dr. Zhang's research interests include Behavioral Economics, Applied Econometrics, Experimental Economics, Food Safety and Policy, Environmental Economics, Nutrition and Health, Development Economics, International Economics, and Neuroeconomics.",Faculty Affiliate||Professor,Energy Institute||Agricultural Economics,https://scholars.library.tamu.edu/vivo/display/nbada46b6
Christabel Jane,Welsh,Professor,Mechanisms of disease pathogenesis of neurotropic viruses. Immunological therapies for multiple sclerosis and epilepsy. Neuroimmunological changes in the injured CNS,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/nbb081247
Roula,Mouneimne,Research Professor,"For the past 24 years my research focused on: 1- The development of methods in the fluorescence microscopy field that achieve data acquisition and analysis in real time, quantitative analysis, and mathematical modeling of cellular signaling. 2- The development of novel technological tools to decipher molecular and physiological events in cells and immunological tissues under normal toxin exposure and disease conditions.",Research Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/nbb6c8c2a
Joseph,Veldman,Associate Professor,"In the Veldman Lab at Texas A&M University, we study relationships among plant species, ecosystem functions, and human-induced environmental change. Fire - both as an ancient ecological force and as a management tool - is central to our research on the conservation and restoration of tropical and subtropical savannas and forests. Through interdisciplinary collaborations and outreach to environmental organizations, we work to improve public policies that impact fire-dependent ecosystems and human livelihoods.",Assistant Professor,Ecology and Conservation Biology,https://scholars.library.tamu.edu/vivo/display/nbc6131af
Nicolaas,Deutz,Professor,"My research background and expertise focus on nutrition, metabolism, and physiology studies involving the use of stable isotope methodologies, both in humans and animals. I also have extensive experience with isotopic calculations, validation and data interpretation.",Professor,Primary Care and Rural Medicine,https://scholars.library.tamu.edu/vivo/display/nbd596655
Clint,Magill,Professor,"The use of molecular probes is allowing us to gain new insights into fungal plant pathogens and to host responses to potential pathogens. We are currently developing real-time PCR primers for two downy mildews that are considered to be a threat to maize production if introduced into the US. We are also developing PCR-based tags genes for resistance to headsmut, anthracnose, downy mildew and grain mold in sorghum. These molecular tags will be useful for breeding cultivars with more durable resistance and for cloning specific resistance genes. We have also used PCR to clone segments of the cotton and sorghum equivalents of genes that function in known host defense pathways. These clones are being used to compare the rate and timing of induction of each gene in resistant and susceptible lines following inoculation with a pathogen. Genome wide association studies are being used to identify genes associated with disease response (susceptible or resistant) to several pathogens in sorghum.",Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/nc127cd28
Gabriel,Hamer,Associate Professor,"Research in the Hamer Lab broadly investigates the ecology of infectious diseases of humans, wild animals, and domestic animals, with particular attention to those transmitted by arthropod vectors (e.g. mosquitoes, ticks, kissing bugs). We have focused primarily on vector-host interactions that lead to parasite amplification and increased disease risk. We utilize multidisciplinary tools to studying these complex disease systems, including molecular biology, landscape epidemiology, eco-immunology, and ecological modeling. A goal of our research is to elucidate mechanisms of transmission across space and time that facilitate ecological management of diseases with effective intervention and preventative strategies.",Assistant Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/nc1f3fc64
Susan,Bloomfield,Professor,"My research interests focus on the integrative physiology of bone, with specific reference to adaptations to disuse, microgravity, and caloric deficiency.",Professor,Kinesiology and Sport Management,https://scholars.library.tamu.edu/vivo/display/nc2a60db1
James,Fluckey,Professor,"My research focuses on mechanisms associated with protein turnover and glucoregulatory function in muscle and how these mechanisms may be altered by exercise, aging, obesity, diabetes or periods of microgravity. More currently, we are interested in small molecules arising from contracting skeletal muscle that impact other cells/tissues in the body, including cancer.",Professor,Kinesiology and Sport Management,https://scholars.library.tamu.edu/vivo/display/nc58f05ea
Deanna,Kennedy,Associate Professor,"My research examines the mechanisms and constraints that facilitate or interfere with the neural control of human movement, with a specific focus on bimanual coordination. My overarching line of research interweaves two focus areas, which include theoretical questions related to bimanual coordination as well as more applied questions that have important implication for rehabilitation and space exploration.",Associate Professor,Kinesiology and Sport Management,https://scholars.library.tamu.edu/vivo/display/nc62c5d43
Pete,Teel,Regents Professor,"Biology, ecology and management of ticks associated with humans, livestock, wildlife and companion animals.",Professor and Associate Department Head,Entomology,https://scholars.library.tamu.edu/vivo/display/nc6ba6feb
William,Rooney,Professor,"The long-range goal of my sorghum improvement program is to enhance the productivity and profitability of grain, forage and bioenergy sorghum production systems. The sorghum breeding program is used as a mechanism to develop and release sorghum germplasm to meet this goal. In addition to the release of improved sorghum genotypes, research in the program emphasizes the genetic and molecular genetic inheritance of disease resistance, grain quality and agronomic productivity and adaptability. The research provides opportunities for graduate student training in fundamental and applied aspects of plant improvement. Specific research interests include the development of sorghum germplasm for bioenergy (both sweet and biomass), grain and forage Instruct SCSC 642 annually each fall semester.",Professor,Soil and Crop Sciences,https://scholars.library.tamu.edu/vivo/display/nc74bd61f
Abhishek,Jain,Associate Professor,"The overarching theme of my research is to design patient-specific and digital microengineered models of cardiovascular and hematologic diseases (such as, atherosclerosis) for enabling basic scientific discoveries and the advancement of precision and personalized healthcare.",Associate Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/nc7e6af54
Sakiko,Okumoto,Associate Professor,"The overall goal of my research is to understand how nitrogen (N), quantitatively the most important nutrient in crops, is managed in plants. Specifically, my research aims at how amino acids, one of the main forms of organic N in plant body, is transported. In order to study such mechanisms in detail, we have developed protein-based, fluorescent sensors that allow us to track amino acids in live cells. We utilize these sensors to discover novel molecular mechanisms that are involved in the regulation of amino acids. We are currently interrogating the processes in which amino acid exporters are involved in, using various genetic resources such as T-DNA insertion mutants and gene editing tools. We are also interested in developing novel sensors for other biologically important molecules.",Associate Professor,Soil and Crop Sciences,https://scholars.library.tamu.edu/vivo/display/nc97dd3d8
Paul,Lindahl,Professor,"One of our two current research areas involves iron metabolism in mitochondria. The iron imported into these organelles is assembled into iron-sulfur clusters and heme prosthetic groups. Some of these centers are exported into the cytosol, while others are installed into mitochondrial apo-proteins. All of these processes are regulated in healthy cells, but various genetic mutations giving rise to diseases can cause iron to accumulate (e.g. Friedreich's ataxia) or become depleted (e.g. Sideroblastic anemia). We have developed a biophysical approach involving Mossbauer, electron paramagnetic resonance, and electronic absorption spectroscopy, to study the entire iron content of intact mitochondria in healthy and genetically altered cells. This Systems Biology approach allows us to characterize the ""iron-ome"" of mitochondria at an unprecedented level of detail. We are also using analytical tools (e.g. liquid chromatography) to identify complexes that are involved in ""trafficking"" iron into and out of the organelle.
Our other research area involves mathematical modeling of cellular self-replication on the mechanistic biochemical level. We collaborate on this multidisciplinary NSF-sponsored project with a mathematician at the University of Houston (Professor Jeffrey Morgan). We have developed a modeling framework that facilitates such modeling efforts, and have designed a number of very simple and symbolic in silico cells that exhibit self-replicative behavior. Our minimal in silico cell model includes just 5 components and 5 reactions. A second generation model includes a more realistic mechanism of mitotic regulation. One novel aspect of our approach is that cellular concentration dynamics impact (and are impacted by) cellular geometry. By minimizing membrane bending energies, we are now calculating cell geometry during growth and division. Our results suggest that the ""pinching"" observed in real cells is enforced by cytoskeletal structures.",Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/nc9ce621b
Jeanmarie,Verchot,Professor Plant Virology,"Our long-term interest has been to understand the mechanisms of virus disease, specifically in potyviruses and potexviruses -- common families infecting a wide range of crops. We endeavor to use our understanding in engineering novel methods for crop disease control.
We have focused over the last decade on how virus proteins interact with cellular membranes in their host plants. We have uncovered genetic stress response machinery that appears to down-regulate virus infection, creating a tolerant state in the plant. When this stress response is compromised, the host plant becomes sick and necrotic. Our research aims to identify ways to increase plant vigor and yields in the face of virus infection, by empowering this cellular stress response machinery.",Professor Plant Virology,Texas A&M AgriLife Research,https://scholars.library.tamu.edu/vivo/display/ncb9981be
John,Hettema,Professor,"I am Professor in the Department of Psychiatry at Texas A&M Health Sciences Center and affiliate faculty member at the Virginia Institute for Psychiatric and Behavioral Genetics (VIPBG) at Virginia Commonwealth University (VCU). As a clinician-scientist, I have participate in patient care, clinical teaching, and research activities. Before coming to TAMU in 2019, I directed the VCU Anxiety Disorders Specialty Clinic for 19 years, providing residency training and patient care via the assessment and treatment of all the major anxiety and related disorders. My research efforts focus on the epidemiology, genetics, and biology of the anxiety and related internalizing disorders. I have extensive experience applying advanced statistical genetic methodology to these questions via analyses conducted in twin, family, and population-based samples. My recent projects include conducting meta-analyses of genomewide association data on anxiety spectrum disorders (ANGST GWAS project, R01MH087646 and PGC-ANX project, R01MH113665), examining the effects of novel candidate genes derived from GWAS on internalizing psychopathology (R01MH039096), and collecting and analyzing endophenotypic measures underlying the development of internalizing disorders in a juvenile twin sample (R01MH098055). My research has been funded by NIH and private foundation grants. I am founding co-chair of the PGC-ANX Working Group which provides active collaborations with anxiety and depression researchers around the world.",Professor,Psychiatry and Behavioral Sciences,https://scholars.library.tamu.edu/vivo/display/ncd3506c7
Bobak,Mortazavi,Associate Professor,"My research interests include end-to-end research on medical embedded systems and the application of data mining and machine learning algorithms necessary to make personalized, preventative medical treatments possible through advanced health analytics . My background is in embedded systems design, where I studied sensor fusion, reconfigurable architectures and systems, hardware accelerators, and gpu computing. During my Ph.D. I applied data mining and machine learning techniques to these systems to develop a personalized, exercise-level activity-recognition video game with wearable sensors. I am now primarily concerned with the ability to use supervised and unsupervised techniques to learn more about medical prediction and risk-stratification in order to better develop personalized medical systems, prediction models, comparative effectiveness techniques, and combine wearable sensors and other necessary data to make a clinical impact at the system level, provider level, and patient level.",Associate Professor||Assistant Professor,Computer Science and Engineering||Computer Science and Engineering,https://scholars.library.tamu.edu/vivo/display/nce4143cc
Gregory,Sword,Professor,"I've been very fortunate to have studied many things in many places with many people. Much of my research to date has focused on the biology and ecology of grasshoppers, locusts and Mormon crickets. More recently, I've been given the chance to expand my research program to problems in cotton entomology. It's a pretty unique opportunity, and I am happy to say that the lab is up and running on multiple fronts. Although the emphasis has shifted to cotton research, locust biology and anything else that strikes an interest continues to be fair game in the lab.",Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/ncf7fa344
Vytas,Bankaitis,Professor,"My laboratory is interested in the regulatory interfaces between novel lipid-mediated signal transduction pathways and important cellular functions. The focus of our work is the phosphatidylinositol/ phosphatidylcholine transfer proteins (PITPs), a ubiquitous but enigmatic class of proteins. Ongoing projects in the laboratory derive from a multidisciplinary approach that encompasses biochemical characterization of novel members of the metazoan PITP family, and the application of genetic, molecular and biophysical approaches to detailed structural and functional analyses of PITPs.",E.L. Wehner-Welch Foundation Chair||Professor||Professor,Cell Biology and Genetics||Biochemistry and Biophysics||Chemistry,https://scholars.library.tamu.edu/vivo/display/ncff8dc21
Mark,Holtzapple,Professor,"Our group is dedicated to the research and development of the sustainable and renewable technologies which, when implemented on a commercial scale, will impact future fuel, chemical, food, and water production.",Faculty Affiliate||Professor,Energy Institute||Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/nd303ef41
Steven,Wright,Professor,"My research focuses on magnetic resonance imaging, particularly instrumentation and methodology. I also have research interests in antenna theory - numerical methods, and phased arrays electromagnetics.",Professor,Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/nd4e8f968
Fen,Wang,Professor,"The laboratory focuses on understanding the molecular basis of cell signaling, and how aberrant cell signaling leads to birth defects and causes cancers. Using in vitro cell culture systems and in vivo mouse models, we study how the fibroblast growth factor (FGF) activates its receptor (FF) tyrosine kinase, and how the activated FF transmits the signals to downstream targets and regulates proliferation, differentiation, homeostasis, and function of the cells, as well as in organogenesis and development, including prostate and cardiovascular system development. The laboratory also employs molecular biology, cell biology, and mouse genetic technologies to study how aberrant FGF signals promote tumor initiation, progression, and metastasis. In addition, how environmental factors contribute to tumorigenesis and congenital birth defects by modulating FGF signal intensity and specificity is also under the scope of our research interests.",Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/nd5ef47ba
Yun,Huang,Associate Professor,"Dr. Huang is currently an Assistant Professor at the Center for Epigenetics and Disease Prevention, Institute of Biosciences & Technology, Texas A&M University. Her long-term goal is to elucidate the molecular basis of epigenetic changes in the human genome and to develop novel therapies by targeting aberrant DNA methylation and demethylation associated with human diseases, including cancer, immunoinflammatory and cardiovascular diseases.
Dr. Huang's laboratory is focused on elucidating the physiological and pathophysiological functions of TET2 protein and its 5-methylcytosine oxidation products (5hmC, 5fC and 5caC) in cancer and development (Nature Genet 2014; Trends in Genetics 2014).",Associate Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/nd7ed0926
Alan,Pepper,Associate Professor,"My laboratory uses genetic, molecular, and genomic tools to study how terrestrial plants adapt, both in a short-term sense (phenotypic plasticity) and in a long-term sense (adaptive evolution), to the vast diversity of environments found on our planet.
My laboratory is studying the molecular and physiological mechanisms of 'downstream' developmental responses to light using genetic and molecular tools available in the model plant Arabidopsis thaliana. In another project, we are using comparative genomics to investigate the genetic basis of the evolution-under-domestication of developmental processes in cultivated cottons (Gossypium spp.) and their wild relatives. Gossypium is in the Malvaceae family and, as such, shares a recent common ancestor with Arabidopsis and other plants in the Brassicaceae family.
We are also investigating the genetic mechanisms of plant adaptation to the stresses of extreme environments such as drought, low mineral nutrients (N,P,K) and heavy metals, in wild relatives of Arabidopsis, such as the rare endemic plant Caulanthus amplexicaulis (Brassicaceae.) This work has led us to become more broadly interested in the conservation and ecological genetics of rare plants, particularly geoendemics.",Associate Professor,Biology,https://scholars.library.tamu.edu/vivo/display/ndc106a4d
Sarah,Hamer,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ndc2c4e3e
Zachary,Adelman,Professor,,Associate Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/ndc81a8e5
Fadi,Khasawneh,Associate Professor and Department Head of Pharmaceutical Sciences,,Associate Professor and Department Head of Pharmaceutical Sciences,Pharmacy Practice,https://scholars.library.tamu.edu/vivo/display/ndc85f0d1
Valen,Johnson,Professor,,Professor,Statistics,https://scholars.library.tamu.edu/vivo/display/ndd7ffe32
Christine,Budke,Professor,,Professor and interim Head,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ndf6eb879
John,Buchanan,Professor,,Professor||Faculty Fellow,Center for Health Systems and Design||Kinesiology and Sport Management,https://scholars.library.tamu.edu/vivo/display/ne059b760
Brett,Mitchell,Professor,Our research focuses on understanding the mechanisms by which immune system activation causes organ dysfunction and various forms of hypertension.,Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/ne0d93385
Susanne,Talcott,Professor,"Dr. Susanne Talcott's research revolves around botanical compounds (polyphenols, terpenoids and alkaloids) and the impact of their metabolites on inflammation, cognitive function, and intestinal health. She primarily focuses on conducting human clinical studies to understand the pharmacokinetics and pharmacodynamics of these compounds.
Recently, the impact of bioactive metabolites produced by the gut microbiota on intestinal and cognitive health through the gut-brain axis has been of great interest.
Dr. Susanne Talcott is working on federally funded projects (USDA, NIH) and collaborates with the dietary supplement and functional food industry on health-related product claims that are supported by unbiased scientific evidence and comply with FDA- and FTC-regulations.",Professor||Professor,Food Science and Technology||Nutrition,https://scholars.library.tamu.edu/vivo/display/ne4324c37
X. Ben,Wu,Professor,"The current research of Dr. Wu's lab is focused on the spatial ecology and pyric herbivory in savanna landscapes and associated education program focused on educator development and educational innovations. Other recent projects include landscape biogeochemistry of savanna systems, ecology of terracette landscapes, and authentic scientific inquiries in introductory ecology courses and their effects on student learning.",Professor,Ecology and Conservation Biology,https://scholars.library.tamu.edu/vivo/display/ne4645fcf
Chao,Tian,Associate Professor - Term Appoint,,Associate Professor - Term Appoint,Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/ne78dd90b
Michael,McShane,Professor and Department Head,,Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/ne7c17cfc
Sanjukta,Chakraborty,Assistant Professor,"Tumor cell metastasis to the regional or draining lymph nodes (LN) is the primary indicator of tumor aggressiveness. Tumor cells lodged in nodes acquire significant vulnerabilities that enable them to evade therapy. In addition, expansion of the vasculature near the primary tumor bed activates multiple pathways that induce lymphangiogenesis and angiogenesis. The primary research focus of my laboratory is to determine how an inflammatory tumor-lymphatic microenvironment contributes to cancer metastasis and progression by reprograming molecular pathways in a) primary tumor niche and b) metastatic tumor draining LNs. We use tumor-LEC 3D spheroids, orthotopic tumor models and clinical samples to evaluate the tumor-lymphatic crosstalk in different solid tumors. In addition, we are also interested in delineating the role of the microbiota and specific tryptophan metabolites in cancer progression, tumor associated lymphangiogenesis and alterations to the metastatic node.",Assistant Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/ne7dd93d7
Hays,Rye,Associate Professor,"A fundamental principle of biology is the use of chemical energy in the form of ATP to assemble, disassemble and alter macromolecular structure. Specialized control proteins known as molecular chaperones are often responsible for this activity and have been recognized in recent years to be essential for regulating many aspects of cellular biology. Using a variety of biophysical and biochemical techniques, the Rye lab focuses on three fundamental cellular processes that require molecular chaperones: (1) protein folding (2) protein disaggregation and (3) vesicle trafficking. In each of these cases, large quantities ATP are burned, resulting in molecular organization in the case of protein folding, and molecular disassembly and remodeling in the case of protein disaggregation and vesicle trafficking. We are interested in understanding the detailed biophysical mechanisms that underpin these events. Why are these processes so energetically expensive? Are there any similarities in how the energy is used between these very different molecular processes? Are there general principles of energy transduction in biology that can be gleaned by comparing these examples with other molecular machines, such as cytoskeletal motors? Understanding how molecular chaperones control protein and membrane organization will provide key insights into not only basic cell biology, but will also illuminate aspects of many diseases that spring from aberrant protein and membrane dynamics.",Associate Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/ne7fb85e1
Masami,Fujiwara,Associate Professor,"My research interest is in quantitative population ecology, with a particular emphasis on understanding the dynamics of fish and wildlife populations. My studies focus on individual and population level processes because I believe a deeper knowledge of these processes will lead to a deeper understanding of how the environment affects ecological processes.",Associate Professor,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences",https://scholars.library.tamu.edu/vivo/display/ne81c8383
Joe,Arosh,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ne8898820
Leif,Andersson,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ne8ae2a28
Jeffrey,Cirillo,Professor,"Our laboratory is interested in the pathogenesis of bacterial lung infections particularly tuberculosis and Legionnaires' disease. We are examining the virulence mechanisms of bacteria using cellular, molecular and genetic techniques. Our primary research goal is to obtain a better understanding of the roles of the pathogen and host in disease. These studies should contribute to our understanding of host-pathogen interactions at the molecular and cellular level that can be used for prevention, treatment and diagnosis. We hope that through a better understanding of the mechanisms by which these organisms cause disease we can prevent some, if not all, of these infections in the future.",Professor||Director,Microbial Pathogenesis and Immunology||Center for Airborne Pathogen Research and Tuberculosis Imaging,https://scholars.library.tamu.edu/vivo/display/ne8bc1122
Jeffery,Tomberlin,Professor,"My areas of interest and expertise are the ecology and biology of flies associated with decomposing matter. Primarily, my research falls into two categories, 1) determine proper methods for suppressing fly populations associated with animal waste on confined animal facilities, 2) understanding the biology of insects that colonize human remains in order to assist law enforcement personnel in estimating the time of colonization of a corpse in order to provide a minimum postmortem interval.",Associate Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/ne8fb4d5b
Carl,Gregory,Associate Professor,"Our lab has been examining the biology of MSCs with a view to developing rapid molecular markers and tests for evaluating/purifying maximally efficacious cultures of MSCs. The group also specializes in bone repair by MSCs. Based on detailed characterization of the molecular mechanism of osteoblast differentiation by MSCs, a novel and effective bone regeneration strategy has been developed. Additionally, we are currently examining the effects of various small molecules and immunological strategies for the safe and effective inhibition of Dkk-1 activity in bone tumors.We have recently established methods to model bone-tumor interactions using bioreactors that simulate microgravity.",Associate Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/ne92fd9fb
Ryland,Young,Professor,"Most bacterial viruses (phages) cause lysis of their host cell to release the progeny virions. Large phages elaborate an enzyme (""endolysin"") to degrade the cell wall and also a small membrane protein (""holin""). The holin accumulates in the membrane and then, at a precisely scheduled time, suddenly forms a hole to allow release of endolysin through the cytoplasmic membrane to gain access to the wall. We use molecular genetics and biochemistry to study how this small protein is able to act as a molecular ""clock"" and punch holes in membranes. Small phages make single proteins which cause host lysis in a different way. This strategy is to target the host cell wall synthesis machinery; that is, the virus makes a ""protein antibiotic"" that causes lysis in the same way as antibiotics like penicillin by inhibiting an enzyme in the multi-step pathway of murein biosynthesis. Thus, when the infected cell tries to divide, it blows up, or lyses, because it can't make the new cell wall between the daughter cells. Remarkably, each of three different, small phages blocks a different step in the pathway. These small lysis proteins are models for a completely new class of antibacterial antibiotics. Also, the E. coli SlyD protein is required for this mode of lysis in one case. SlyD is a member of an ubiquitous family of proteins related to human ""immunophilins,"" the targets of immune-suppression drugs. We study SlyD to learn about the role of this class of proteins in biology.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/nea775348
Gang,Han,Professor,"My research efforts have been in Statistics, Computer Science, and their applications to Biomedical Research and Bioinformatics. I have been working on the design and analysis of complex computer models since 2004. I developed statistical approaches for modeling the output from complex computer codes having quantitative and qualitative inputs, as well as the calibration and tuning for computer models. My recent research includes modeling cancer survivorship data, modeling epidemiological data, and applying statistical learning tools to the early detection of ovarian cancer.",Professor,Epidemiology and Biostatistics,https://scholars.library.tamu.edu/vivo/display/neb4e64eb
Thomas,Iliffe,Professor,"For the past 40 years, Iliffe has conducted studies of biodiversity, ecology, evolution, and conservation of animals inhabiting saltwater caves. In addition to his extensive cave investigations in Bermuda, he has led biospeleological research expeditions to the Bahamas, Belize, Mexico, Jamaica, Dominican Republic, Canary Islands, Iceland, Mallorca, Romania, former Czechoslovakia, Gal?pagos, Hawaii, and numerous locations in the Indo-Pacific. This research has resulted in the discovery of more than 300 new species of marine animals, mostly crustaceans, inhabiting caves in the Atlantic, Caribbean, and Indo-Pacific. Iliffe's research has been funded by grants from the National Science Foundation, National Oceanic and Atmospheric Administration, and the National Geographic Society, among others. He has published 250 papers, including 30 invited book chapters. TV documentaries featuring his cave diving research expeditions can be seen on the National Geographic Channel, BBC, PBS, History Channel, Discovery Channel, and others.",Professor,Marine Biology,https://scholars.library.tamu.edu/vivo/display/ned849b62
Stephen,Smith,Professor,"Dr. Smith teaches meat science, nutrition and physiological nutrition courses. He also conducts research on the growth and development of adipose tissue, particularly in the bovine species. He has investigated the limitation of cattle to marble and has used his background in molecular biology to investigate lipid metabolism in the bovine muscle.",Professor||Professor,Animal Science||Nutrition,https://scholars.library.tamu.edu/vivo/display/nee8e5966
Jessica,Light,Associate Professor,,Associate Professor,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences",https://scholars.library.tamu.edu/vivo/display/nef845312
Hojun,Song,Associate Professor,"The Song Lab focuses on the study of an insect order Orthoptera (grasshoppers, crickets, and katydids) and other insects and aims at understanding behavioral, ecological, physiological, morphological and molecular evolution in a phylogenetic framework.",Associate Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/nf14bbe4a
John,Mullet,Professor,"Functional genomics, bioinformatics, and DNA chip technology are fundamentally changing research on biological systems. Knowledge of complete genome sequences and high resolution genome technology provide an extraordinary opportunity to understand complex biological processes and to relate detailed understanding of protein structure and biochemical mechanism to the function of whole organisms and biological systems in nature.
Our research team is helping to build genome maps and DNA diagnostic microarrays/chips for analysis of global gene expression and biodiversity. This new technology is being used to explore the molecular basis of several fundamental plant responses: (1) light responsive genetic systems that help protect plants from damage by high intensity UV/blue light; (2) genetic systems that allow plants to adapt to the environment; (3) genes and signal transduction pathways that help protect plants from insects and disease; and (4) genes that regulate plant development (flowering time, fertility restoration, chloroplast development/number).",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/nf1c81fcb
Noah,Cohen,Distinguished Professor and Associate Department Head,,Distinguished Professor and Associate Department Head,Large Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/nf22c59c1
Paul,Hardin,Distinguished Professor,"A diverse array of organisms including prokaryotic and eukaryotic microbes, plants, and animals display daily rhythms in physiology, metabolism and/or behavior. These rhythms are not passively driven by environmental cycles of light and temperature, but are actively controlled by endogenous circadian clocks that are set by environmental cycles, keep time in the absence of environmental cues, and activate overt physiological, metabolic and behavioral rhythms at the appropriate time of day. This remarkable conservation of circadian clock function through evolution suggests that maintaining synchrony with the environment is of fundamental importance. Our understanding of the circadian clock is particularly important for human health and well-being. The clearest examples of circadian clock dysfunction are those that result in abnormal sleep-wake cycles, but clock disturbances are also associated with other ailments including epilepsy, cerebrovascular disease, depression, and seasonal affective disorder. The realization that disorders of the sleep-wake cycle such as Familial Advanced Sleep Phase Syndrome can result from alterations in clock gene function underscores the clinical importance of understanding the molecular organization of the circadian system.
Work in my laboratory focuses on defining the molecular mechanisms that drive circadian clock function in the fruit fly, Drosophila melanogaster. We previously found that the core timekeeping mechanism is based on core and interlocked transcriptional feedback loops. Our studies currently focus on (1) defining post-translational regulatory mechanisms that operate in the core loop to set the 24 hour period, (2) determining whether interlocked loops are important for circadian timekeeping and/or output, (3) understanding how circadian oscillator cells are determined during development, and (4) defining mechanisms that control rhythms in olfactory and gustatory physiology and behavior.",Distinguished Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nf27056c4
Jennifer,Schleining,Clinical Professor,"Dr. Jennifer Schleining is a board-certified large animal surgeon, clinical professor, and head of the Department of Large Animal Clinical Sciences at Texas A&M University College of Veterinary Medicine and Biomedical Sciences. She received a Bachelor's Degree in Agriculture from South Dakota State University in 1999 and graduated with her Doctor of Veterinary Medicine degree from Iowa State University in 2001. She then went on to complete an internship in equine medicine and surgery at Arizona Equine Medical and Surgical Centre in Gilbert, AZ. Prior to returning to Iowa State for a surgical residency, she spent time as an associate veterinarian in mixed animal practice in Ft. Pierre, South Dakota, was employed in equine practice at Southwest Equine Medical and Surgical Center in Scottsdale, AZ, and as a Large Animal Clinical Fellow at Oregon State University. She holds a Master's Degree in Veterinary Clinical Science with an emphasis in biomechanics. Dr. Schleining's professional interests include veterinary medical education, advancing surgical procedures and knowledge in large animals, communication and leadership development, and veterinary history.",Clinical Professor,Large Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/nf2a66714
Richard,Gomer,Distinguished Professor,"Our laboratory is working on three areas of biomedicine, trying to move observations from basic research into the clinic. First, we are studying how the sizes of tissues and tumors are regulated, and how this can be manipulated for therapeutic purposes. As a model system, we are using the simple eukaryote Dictyostelium discoideum, which allows us to combine techniques such as biochemistry, genetics, computer modeling, and cell biology to study tissue size regulation. We have found that a secreted protein as well as the unusual molecule polyphosphate are signals in negative feedback loops that inhibit Dictyostelium cell proliferation, and we are studying the signal transduction pathway to understand similar mechanisms in humans.
Second, we are studying how some secreted proteins can make cells move away from the source of the signal. We found such a signal (called a chemorepellent) in Dictyostelium, and then found a similar signal in humans. We are working to understand the signal transduction pathway for both. The human signal repels neutrophils, and we found that this can be used therapeutically in mouse models of neutrophil-driven diseases such as rheumatoid arthritis and acute respiratory distress syndrome.
Third, we have found that a human blood protein called Serum Amyloid P (SAP) regulates a key step in the formation of scar tissue as well as the formation of the scar-like lesions in fibrosing diseases such as congestive heart failure and pulmonary fibrosis. We are studying this mechanism, and a biotech company (Promedior, now sold to Roche) we co-founded is testing SAP as a therapy for fibrosis in patients in a Phase 3 trials.",Distinguished Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nf41f3898
James,Erickson,Associate Professor,"Alternative developmental fates are often determined by small differences in the concentrations of signaling molecules. In many cases, cells respond to these signals within narrowly defined temporal windows and are unresponsive to the same signal molecules at other times in development. A number of aspects of Drosophila sex determination make it an ideal experimental system to study how strict temporal controls and small quantitative differences in protein concentration can elicit different developmental fates.",Associate Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nf4575bc8
Spencer,Behmer,Professor,,Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/nf4d10236
Edward,Dougherty,Distinguished Professor,My research focuses on genomic signal processing and image analysis.,Distinguished Professor,Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/nf4ef0ac5
Louise,Abbott,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/nf56a7148
Jerome,Menet,Associate Professor,"Most organisms from bacteria to humans exhibit 24-hours rhythms in their biochemistry, physiology and behavior. Best exemplified by the sleep/wake cycle, these rhythms are remarkably widespread and include in humans hormonal (e.g., melatonin, insulin, cortisol), metabolic (e.g., glucose, cholesterol), physiological and behavioral oscillations. In fact, most biological functions are rhythmic and are set to perform optimally at the most appropriate time of the day. For example, the human digestion process performs better during the day when we are supposed to eat.
These circadian rhythms are generated by ""molecular clocks"", which consist of a few ""clock genes"" interacting in feedback loops, and which drive the rhythmic expression of a large number of genes, i.e. ~10% of the transcriptome in any tissues. This wide impact of clock genes in regulating gene expression is underscored by the surprisingly large number of pathologies developed by clock-deficient mice. In addition to being arrhythmic, these mice indeed develop pathologies as diverse as mania-like behaviors, learning and memory defects, depression, drug addiction, insomnia, metabolic diseases, arthropathy, hematopoiesis defects and cancers.
Research in our lab aims at characterizing how circadian clocks and clock genes regulate gene expression to provide insights into how and why clock dysfuntion leads to a wide spectra of pathologies. To this end, we are using a wide-range of molecular and biochemical techniques to investigate the circadian clock function at the genome-wide level (e.g., next-generation sequencing). We are currently extending some of our recent results and focus on 1) how clock genes rhythmically regulate chromatin environment and 2) the mechanisms involved in rhythmic post-transcriptional regulation of gene expression.",Associate Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nf680fb91
Jiang,Chang,Professor,"Heart failure (impaired ventricular pump function) is an eventual outcome for diverse cardiovascular disorders and the leading cause of combined morbidity and mortality in the United States and other developed industrial nations. The focus of my lab is to understand the molecular and cellular mechanisms that initiate and mediate the pathogenesis of maladaptive cardiac remodeling, such as cardiac hypertrophy and fibrosis as result of various pathological scenarios such as myocardial infarction, hypertension, obesity, diabetes, aging and post-traumatic stress disorder. The overall approach consists of generation and analysis of clinically-relevant genetic mouse models including a tool mouse enabling tracking endogenous cardiac exosomes, and conduct mechanistic studies using cutting-edge technology. The ultimate goal of our efforts is to provide clinical translation for the prevention and treatment of pathological cardiac remodeling from our mechanistic studies.",Professor,Center for Genomic and Precision Medicine,https://scholars.library.tamu.edu/vivo/display/nf80a9dad
Carolyn,Arnold,Associate Professor,equine microbiome
equine surgery
antibiotic associated diarrhea,Associate Professor,Large Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/nf8b5ca76
Thomas,Chappell,Assistant Professor,,Assistant Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/nf900c0d0
J,Johnston,Professor,"I estimate genome size for sequencing projects for a very wide range of vertebrates, invertebrates and plants..
I work on genome size evolution, & genomics.
My other areas of research include cytological, ecological and population genetics of arthropods.",Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/nfc3f68fb
Yina,Liu,Assistant Professor,"I am an organic biogeochemist with particular interests in how organic compounds', both natural and anthropogenic, cycling affect biological and ecological processes and vice versa. These interconnected processes are important drivers for organic carbon and contaminant cycling at regional and global scales. My group uses untargeted and targeted analyses as well as data science to shed light on different aspects of organic biogeochemistry.",Assistant Professor,Oceanography,https://scholars.library.tamu.edu/vivo/display/nfc7a9688
Darwin,Prockop,Professor,,Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/nfcfd0990
Magnus,Hook,Professor,"The primary interest of our laboratory is to try to understand the structural function of the extracellular matrix. Of particular interest is the study of the molecular mechanisms of microbial adhesion to host tissue. This process, which is believed to represent a critical initial step in the development of infections, involves specific cell-surface proteins that recognize and bind with a high affinity to components in the host tissue. Our goal is to decipher these events at a molecular level and, based on structural analysis of the interacting components, design new strategies to prevent and treat infections.",Regents & Distinguished Professor and Director,Center for Infectious and Inflammatory Diseases,https://scholars.library.tamu.edu/vivo/display/nfd8d37d6
Matthew,Sachs,Professor,"Understanding the mechanisms by which upstream open reading frames (uORFs) in mRNA transcripts control gene expression is currently the major focus of my laboratory. A substantial component of this work is focused on the uORF-encoded fungal arginine attenuator peptide (AAP). The major goal of this work is to understand the mechanism by which a nascent peptide encoded by this uORF controls the movement of ribosomes on mRNA and regulates gene expression. Control mechanisms mediated by uORFs and nascent peptides exist in mammals, fungi, plants, viruses, and bacteria, but relatively little is known of the molecular details of such control. The AAP is encoded by a uORF in the 5?-leader regions of mRNAs specifying the first enzyme in fungal arginine (Arg) biosynthesis. Synthesis of the AAP rapidly reduces gene expression in response to Arg. AAP-mediated regulation is observed in vivo in both Neurospora crassa and Saccharomyces cerevisiae and in vitro, using fungal, plant and animal extracts. The nascent AAP causes the ribosome to stall when the concentration of Arg is high.",Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nfe74574c
David,Stelly,Professor,"My scientific research, graduate and post-graduate programs employs multi-disciplinary approaches to conduct and study use of naturally occurring germplasm for crop improvement. Elements of the research include wild-species germplasm introgression, chromosome substitution, reproductive and ploidy manipulations, conventional cytogenetics and fluorescence in situ hybridization, genetic analysis, DNA marker and assay (SNP) development, marker assisted selection, reproductive cytology and genetics, and various types of genome mapping, sequencing, and their integration for genome sequencing and assembly. Most of my research aims to enhance the germplasm, knowledge, science and technologies for genetic improvement Upland cotton, e.g., economic yield and sustainability; some, however, is devoted to sorghum and peanut, especially wide hybridization and germplasm utilization.",Professor||Chair,Soil and Crop Sciences||Molecular and Environmental Plant Sciences,https://scholars.library.tamu.edu/vivo/display/nfec36db0