First name,Last name,Preferred title,Overview,Position,Department,Individual
Guoyao,Wu,Distinguished Professor,"Dr. Wu teaches graduate courses in protein metabolism and nutritional biochemistry. He conducts research in protein and amino acid metabolism at molecular, cellular, and whole body levels . The animal models used in his research include cattle, chicks, pigs, rats, sheep, fish, and shrimp. He has also conducted research on amino acid nutrition in humans.",Faculty Fellow||University Faculty Fellow||Distinguished Professor||Senior Faculty Fellow||Distinguished Professor,Veterinary Integrative Biosciences||Animal Science||Texas A&M AgriLife Research||Texas A&M AgriLife Research||Nutrition,https://scholars.library.tamu.edu/vivo/display/n169f9a74
Dana,Gaddy,Professor,"My laboratory has been engaged in multiple areas of NIH-funded musculoskeletal research since 1996. We were the first to identify the non-steroidal gonadal inhibin hormones in regulating the hypothalamic-pituitary-gonadal-skeletal axis in mice, and the role of changes in inhibins that signal the onset of menopause (reproductive aging) to the onset of increasing bone turnover. We also demonstrated the anabolic effect of continual Inhibin exposure in normal mice and in bone repair. Our cellular focus on Inhibins and the related factor, Activin A revealed that Activin A suppresses local bone resorption through suppression of osteoclast formation, motility and survival. Our ongoing work is in the area of specific inhibin/betaglycan receptor interactions that mediate the effects on bone cells. We are also greatly interested in improving the low bone mass that we were the first to identify in both humans with Down Syndrome (DS) and in mouse models of DS as a low bone turnover disease. Our current NIH-funded research is working to identify the mechanisms of reduced fracture healing and compromised bone regeneration in Down Syndrome. We have demonstrated the efficacy of both PTH and SclAb in DS, and are now actively testing nutriceuticals to increase bone mass in mouse models of Down Syndrome. The limitations of using mouse models to study bone disease led us to our most recent and exciting endeavors in collaboration with TAMU experts in reproduction and embryo transfer technologies to develop a large platform model of bone disease, using sheep. We have generated the first large animal model of hypophosphatasia (HPP) via high efficiency gene editing of a knock-in point mutation in the ALPL gene, whose musculoskeletal and dental phenotypes are consistent with human HPP. We are now using this model to determine the etiology of mineralization deficiencies, muscle weakness and premature tooth loss by analysis of longitudinal biopsies and analysis of muscle, bone and dental specimens using CT, microCT, mechanical testing, immunohistochemistry, histomorphometry and ex vivo bone marrow cultures.",Professor||Adjunct Professor,Veterinary Integrative Biosciences||Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n2dc10a1a
Jianrong,Li,"Professor, Neurobiology and Neuroimmunology, Veterinary Integrative Biosciences","The central goal of our research is to understand how oligodendroglial development and function in the mammalian central nervous system is regulated in health and disease. Specifically, we are interested in molecular and cellular mechanisms involved in oligodendrocyte damage/dysfunction in white matter injuries such as multiple sclerosis and cerebral palsy and in aging-related neurodegenerative diseases such as Alzheimer's disease. Because in most CNS diseases, multiple cell types including neurons, glial cells and vascular cells are involved via complex interactions, we investigate, at the cellular and molecular level, the role of microglia and astrocytes in the process of oligodendrocyte development, differentiation and damage. We use a variety of methods including primary cell cultures and transgenic and knockout animals to elucidate cellular pathways mediating oligodendrocyte injury.
The second focus of our laboratory is to elucidate the signals that promote oligodendrocyte survival and regeneration/remyelination after injury, and to study cell-cell interactions that regulate remyelination. These studies should contribute significantly to our understanding of mechanisms of oligodendrocyte development and injury, and provide new clues for potential prevention and treatment of human white matter diseases.",Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n3ef91dcf
Gladys,Ko,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n5e930c1f
Robert,Burghardt,Professor,"Research in the laboratory is focused on investigating mechanisms by which a variety of biological response modifiers ranging from mechanical signals, hormones and growth factors to environmental chemicals alter cellular signaling pathways and cellular homeostasis.","Professor||Director, Image Analysis Laboratory",School of Veterinary Medicine and Biomedical Sciences||Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n70a3d026
Larry,Johnson,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n72de4d00
Terje,Raudsepp,Professor,"Comparative genomics and molecular cytogenetics of animals, birds and other vertebrates organization, function and evolution of sex chromosomes; equine genomics - genomics of genetic diseases and disorders of sexual development and reproduction; alpaca and camelid genomics.",Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n970d3a82
Penny,Riggs,"Associate Professor, Animal Science",,Adjunct Associate Professor||Associate Professor,Veterinary Integrative Biosciences||Animal Science,https://scholars.library.tamu.edu/vivo/display/nab0c8ffe
Roula,Mouneimne,Research Professor,"For the past 24 years my research focused on: 1- The development of methods in the fluorescence microscopy field that achieve data acquisition and analysis in real time, quantitative analysis, and mathematical modeling of cellular signaling. 2- The development of novel technological tools to decipher molecular and physiological events in cells and immunological tissues under normal toxin exposure and disease conditions.",Research Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/nbb6c8c2a
Leif,Andersson,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ne8ae2a28