First name,Last name,Preferred title,Overview,Position,Department,Individual
Michael,Criscitiello,Professor and Associate Dean for Research and Graduate Studies,"My Comparative Immunogenetics Laboratory studies immunology, molecular genetics and evolution. Most of our group's research focuses on the natural history and future application of the vertebrate adaptive immune system, with particular attention given to the genetics of lymphocyte antigen receptors. Particular expertise lies in the evolution of vertebrate immunoglobulin loci, T cell receptor loci and the major histocompatibility complex. Additionally, we are interested in the evolution of diversification mechanisms at work there (e.g., recombination activating genes (RAG), activation-induced cytidine deaminase (AID), and the high allelic polymorphism maintained by classical MHC genes). Most recently, we have been working on lymphocyte development in shark thymus that suggests plasticity across the B lymphocyte/T lymphocyte divide, immunoglobulin heavy and light chain isotype pairing in an amphibian system, immunogenetics in marine mammals of conservation importance, mucosal humoral immunity in diverse tetrapods and cattle antibodies with an unheralded domain extending for novel antigen binding possibilities.",Associate Dean for Research and Graduate Studies||Professor,School of Veterinary Medicine and Biomedical Sciences||Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n11e21ca8
Bradley,Weeks,Professor Emeritus,"Retired Professor, Veterinary Pathobiology Department. Collaborator as ACVP board-certified anatomic pathologist in research projects that include implanted medical devices inflammatory and neoplastic gastrointestinal diseases, and cardiovascular diseases.",Professor Emeritus,School of Veterinary Medicine and Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n3d42a32c
Robert,Chapkin,Distinguished Professor,"Research in the Chapkin lab focuses on dietary/microbial modulators related to the prevention of cancer and chronic inflammatory diseases.
Our central goal is to (1) understand cancer chemoprevention at a fundamental level, and (2) to test pharmaceutical agents in combination with dietary/microbial (countermeasures to the Western diet) to more effectively improve gut health and reduce systemic chronic inflammation. Since diet influences gut microbiota composition and metabolite production, to unravel the interrelationships among gut health and the structure of the gut microbial ecosystem, we are in the process of evaluating (using transgenic mouse, Drosophila models and humans) how the gut microbiome modulates intestinal cells, innate immune cells and tumors. As part of this endeavor, we are modeling at the molecular level the dynamic relationship between diet and gut microbe-derived metabolites which modulate chronic inflammation and the hierarchical cellular organization of the intestine, e.g., stem cell niche.",Distinguished Professor||Professor,Biochemistry and Biophysics||Nutrition,https://scholars.library.tamu.edu/vivo/display/n3fbb59f8
Jianxun,Song,Professor,T cell biology
T cell-based immunotherapy
Cell metabolism,Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n5b9879a8
Ivan,Ivanov,Clinical Professor,,Clinical Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n6fa588a3
David,Threadgill,Professor,"Our laboratory uses the mouse as an experimental genetic model to investigate factors that contribute to inter-individual differences in health and disease. Ourcurrent research activities include the identification and functional characterization of alleles contributing to cancer susceptibility, the function of theErbbgenefamily in development and disease, and the role of genetic variation in response to environmental stimuli. To support these investigations, we also aredeveloping new genetic tools to support mammalian systems genetic approaches to phenotypes with complex genetic and environmental etiologies.",Director||Professor||Professor||Professor,Cell Biology and Genetics||Institute of Genome Sciences and Society||Biochemistry and Biophysics||Nutrition,https://scholars.library.tamu.edu/vivo/display/n8ee0b54f
Stephen,Safe,Distinguished Professor,The aryl hydrocarbon receptor (AhR) is a nuclear helix-loop-helix transcription factor which forms a ligand-induced nuclear heterodimer with the AhR nuclear translocator (Arnt) protein. Research in this laboratory is focused on the molecular mechanism of crosstalk between the AhR and estrogen receptor (ER) signaling pathways in which the AhR inhibits estrogen-induced gene expression. The antiestrogenic activities of some AhR agonists are also being developed as drugs for clinical treatment of breast and endometrial cancers in women. Research on estrogen-dependent gene expression in various cancer cell lines is focused on analysis of several gene promoters to determine the mechanisms of ERa and ERb action. This includes several genes that are activated through interactions of the ER with Sp1 protein and other DNA-bound transcription factors.,Distinguished Professor||Distinguished Professor||Syd Kyle Chair,School of Veterinary Medicine and Biomedical Sciences||Biochemistry and Biophysics||Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/nb20fdbd9
Ashok,Shetty,Professor and Associate Director,"Dr. Ashok K. Shetty's laboratory is interested in developing clinically applicable strategies efficacious for enhancing brain function after injury, disease, or aging. The central areas of investigation are focused on:
o Mechanisms by which intranasally administered stem cell-derived extracellular vesicles (EVs) promote neuroprotection, neuroregeneration, neural plasticity, and alleviate neuroinflammation. The sources of EVs include human bone marrow mesenchymal stem cells (hMSCs), and human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSCs), astrocytes, and microglia. The model systems include traumatic brain injury (TBI), closed head injury (CHI), Aging, Alzheimer's disease (AD) and temporal lobe epilepsy (TLE).
o Mechanisms by which transplanted human neural stem cells or human GABA-ergic precursor cells derived from hiPSCs promote brain repair, and alleviate spontaneous seizures, and cognitive and mood impairments in prototypes of SE, TLE, and TBI.
o Elucidating mechanisms of brain dysfunction and chronic neuroinflammation in prototypes of Gulf War Illness. Developing therapeutic strategies to alleviate neuroinflammation, systemic inflammation, and cognitive and mood impairments in models of GWI.
o Developing clinically feasible strategies for improving brain function in aging and AD models via stimulation of endogenous neural stem cells using drugs and biologics.
Dr. Shetty has received continuous extramural research funding as PI for >25 years from sources such as the NIH, DOD, Dept of Veterans Affairs (VA), and industry. These include seven R01 grant awards and an R21 grant award from the NIH; seven CDMRP grant awards from the DOD; five Merit Grant awards and two Research Career Scientist Awards from the VA; and two industry grants. He has also served as Co-I of 8 other DOD grants. Grants from the NIH, DOD, and industry fund Dr. Shetty's current research. Dr. Shetty has authored 181 peer-reviewed publications (147 as senior/first author) and edited a book on Neural Stem Cells in Health and Disease. His work has appeared in many prestigious and high-impact journals. Dr. Shetty has received >17,000 citations for his publications with an h-index of 64. Dr. Shetty has the distinction of serving on two NIH Study Sections and one VA study section as a Chartered Member. Besides, he has served as a member of many other study section panels of the NIH, DOD, VA, and Maryland State Stem Cell Research Fund. Dr. Shetty is Co-Editor-in-Chief of the journal, Aging & Disease and Associate Editor of 6 Neuroscience journals. He is also a Member of the Editorial Board of many prestigious journals, including The Journal of Extracellular Vesicles, Aging Cell, and Stem Cells. Dr. Shetty is a Fellow of the American Society for Neural Transplantation and Repair. Dr. Shetty received the Senior Research Excellence Award in 2021 from the TAMU College of Medicine and is among the ""World's Top 2% Scientists"" across all scientific fields.","Associate Director, Institute for Regenerative Medicine||Professor",Cell Biology and Genetics||Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/nba613a86
Leif,Andersson,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ne8ae2a28