First name,Last name,Preferred title,Overview,Position,Department,Individual
Peter,Murano,Associate Professor,,Associate Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n01908cad
Yuxiang,Sun,Professor,"Dr. Sun is an expert on ""hunger hormone"" ghrelin. She generated the first set of ghrelin and ghrelin receptor knockout mice, and discovered novel roles of ghrelin signaling in diabetes, thermogenesis, and inflammation. Her laboratory uses state-of-the-art tools to study ghrelin system in energy sensing, metabolism and immunity, and aging. Her work suggests that ghrelin signal might be a promising drug target for obesity, diabetes, inflammation, and Alzheimer's disease.",Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n0228c22e
Raymond,Carroll,Distinguished Professor,,Distinguished Professor,Statistics,https://scholars.library.tamu.edu/vivo/display/n032647a0
Mark,Westhusin,Professor,My laboratory is interested in developing transgenic animal models of disease and novel platforms for the production of biopharmaceuticals. We are currently exploring methods to produce vaccines in the milk of transgenic animals.,Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n088680ea
Carolyn,Cannon,Associate Professor,"Our goal is to develop novel, non-toxic antimicrobial formualtions with efficacy against gram-positive and gram-negative multi-drug resistant pathogens.",Associate Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n0b3870aa
Nancy,Fahrenwald,Professor and Dean,"As a board certified advanced public health nurse, Dr. Fahrenwald has worked in collaboration with local, state, regional and national organizations and groups to translate research evidence into sustainable programs that support tobacco cessation and prevention, improve access to primary health care, and impact chronic disease prevention and control. She has led or provided consultation to 30 funded research or training projects. Her extensive experience with multiple federal agencies focuses on rural health care access and the needs of underserved populations, especially organ and tissue donation education for American Indians.",Dean||Faculty Fellow,Center for Health Systems and Design||School of Nursing,https://scholars.library.tamu.edu/vivo/display/n0cb1b858
Bruce,Riley,Professor,"My lab studies inner ear development in zebrafish. A prominent feature of our research is to investigate how cell-cell signaling and downstream gene-interactions control development. One project in the lab focuses on how cell signaling regulates ectodermal patterning during gastrulation to establish the otic placode, the precursor of the inner ear. Our recent work shows that localized Fgf signaling is especially critical for inducing formation of the otic placode, and members of the Pax2/5/8 family of transcription factors are important mediators of Fgf signaling. During later stages of inner ear development, we are exploring how sensory hair cells and neurons are regulated. Our studies address how these cells initially form, how they are genetically maintained, and how they become specialized for hearing vs. balance. We are also investigating how zebrafish can replace dead and damaged hair cells, an ability that mammals have lost. The inability to regenerate hair cells explains why humans show progressive irreversible hearing loss as we age. It is hoped that activating or augmenting human homologs of genes shown to operate in zebrafish might help restore hearing and balance in humans.",Professor,Biology,https://scholars.library.tamu.edu/vivo/display/n0dbb8253
Michael,Criscitiello,Professor and Associate Dean for Research and Graduate Studies,"My Comparative Immunogenetics Laboratory studies immunology, molecular genetics and evolution. Most of our group's research focuses on the natural history and future application of the vertebrate adaptive immune system, with particular attention given to the genetics of lymphocyte antigen receptors. Particular expertise lies in the evolution of vertebrate immunoglobulin loci, T cell receptor loci and the major histocompatibility complex. Additionally, we are interested in the evolution of diversification mechanisms at work there (e.g., recombination activating genes (RAG), activation-induced cytidine deaminase (AID), and the high allelic polymorphism maintained by classical MHC genes). Most recently, we have been working on lymphocyte development in shark thymus that suggests plasticity across the B lymphocyte/T lymphocyte divide, immunoglobulin heavy and light chain isotype pairing in an amphibian system, immunogenetics in marine mammals of conservation importance, mucosal humoral immunity in diverse tetrapods and cattle antibodies with an unheralded domain extending for novel antigen binding possibilities.",Associate Dean for Research and Graduate Studies||Professor,School of Veterinary Medicine and Biomedical Sciences||Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n11e21ca8
Guoyao,Wu,Distinguished Professor,"Dr. Wu teaches graduate courses in protein metabolism and nutritional biochemistry. He conducts research in protein and amino acid metabolism at molecular, cellular, and whole body levels . The animal models used in his research include cattle, chicks, pigs, rats, sheep, fish, and shrimp. He has also conducted research on amino acid nutrition in humans.",Faculty Fellow||University Faculty Fellow||Distinguished Professor||Senior Faculty Fellow||Distinguished Professor,Veterinary Integrative Biosciences||Animal Science||Texas A&M AgriLife Research||Texas A&M AgriLife Research||Nutrition,https://scholars.library.tamu.edu/vivo/display/n169f9a74
Fatima,Alshbool,Assistant Professor,"Dr. Fatima Alshbool is an Assistant Professor, who joined the Rangel College of Pharmacy in February 2020. She is a pharmacist and a pharmacologist by training, having received her Pharm.D. degree (2006) from Jordan University of Science & Technology and her PhD degree (2014) from Loma Linda University. Dr. Alshbool's research program is focused on studying cardiovascular/thromboembolic disorders, such as heart attacks and stroke, particularly as they relate to platelet activation and signal transduction, including in the context of environmental health. One of her laboratory's main areas of focus has been investigating the impact of a relatively new form of tobacco smoking, namely e-cigarettes on platelet biology and associated diseases. She is also interested in defining the structural biology of platelet G-protein Coupled Receptors; amongst others. Dr. Alshbool's ultimate goal is to identify new therapeutic agents for the prevention or treatment of cardiovascular disease, and to gain insight into the negative impact of ""tobacco"" exposure on cardiovascular health.",Assistant Professor,Pharmacy Practice,https://scholars.library.tamu.edu/vivo/display/n1989ad2e
Tatyana,Igumenova,,"My laboratory is broadly interested in understanding the structural basis of signal transduction events that occur at the membrane surface. These events are mediated by signaling proteins that reversibly associate with membranes in response to binding second messengers, such as Ca2+ ions, diacylglycerol, and phosphoinositides. One of the key kinases regulating these signal transduction pathways is the Protein Kinase C (PKC) family. Aberrant levels of PKC expression or activity have been implicated in a large number of human diseases, such as cancer, cardiac failure, Alzheimer's disease, and diabetes. Despite the significance of PKC in signal transduction and human health, the structural and dynamical basis of its activation upon binding to lipid membranes remains elusive.",Associate Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n1c6e6632
Charles,Long,Professor,"My laboratory is currently working on a number of projects involving genetic engineering in cattle, goats, sheep and horses. We use CRISPR/Cas gene editing to specifically alter the coding sequence of genes in sheep to produced biomedical models of human disease, specifically hypophosphatasia. My lab is actively working on projects to produce gene edited cattle that are resistant to respiratory disease. We have also successfully used gene editing to correct the glycogen branching enzyme deficiency mutation in horses. We are also interested in altering the carcass characteristics of beef cattle by genetic engineering genes specifically related to meat tenderness in Bos indicus cattle. Other projects in the lab involve the use of mesenchymal stem cell-based therapies for treatment of equine disease and in particular methods for using these cells to over express proteins that can modulate the inflammatory response. We also have interest in using livestock as bioreactors to produce biotherapeutics and vaccine antigens in their milk. I have extensive experience in using genetic engineering in combination with assisted reproductive technologies (including somatic cell nuclear transfer) to produce live animals.",Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n1dc326d5
Kayla,Bayless,Associate Professor,"My laboratory conducts research in two areas of molecular and cellular medicine: the mechanism through which primary human endothelial cells invade into 3D matrices, and communication between invading endothelial cells and their surrounding 3D collagen matrix.",Associate Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/n1dd3799c
Paul,Dechow,Regents Professor and Associate Dean,"My research activities at the College of Dentistry (COD) have a focus on (1) the development of translational and clinical research in dentistry and (2) research on the development and biomechanics of mineralized tissues from a translational and organismal perspective. Research in my laboratory includes studies of phenotypic assessment of skeletal tissues, with an emphasis on material properties, gross and micro structure, biomechanics, and temporal and evolutionary adaptations. Methods that we use include techniques for determining 3D material properties (ultrasound, nanoindentation), 2D and 3D bone histomorphometry, 3D scanning technologies (cone beam CT, micro CT), and various biomechanical modeling techniques, such as finite element analysis. Recent projects have included studies of cranial bone adaptation during wound healing and distraction osteogenesis, and studies of phenotypic adaptations in mouse genetic models related to alterations of pathways associated with Wnt/?-catenin signaling in osteoblasts (with J. Feng) and osteoclasts (with Y. Wan).
Mentoring Experience: 4 Postdocs; 18 PhD; 21 MS; 22 Undergrad DDS Research; 8 Undergrad BS Research; 53 Grad Advisor (as Graduate Program Director); 2 KL2 scholars",Associate Dean||Regents Professor,Office of Academic Affairs||Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n1ec430cb
Leslie,Braby,Research Professor,,Research Professor,Nuclear Engineering,https://scholars.library.tamu.edu/vivo/display/n219b92ba
Susie,Dai,Associate Professor,"My research group is interested in evaluating environmental hazard substances, their interactions with the environment and species, and biological systems that can degrade and detoxify the pollutants. We have established broad analytical platforms to survey a wide spectrum of natural or man-made toxic chemicals such as mycotoxins, microcystins, agricultural, and industrial chemicals.
We integrate electrocatalysis/photoelectrocatalytic processes and material engineering with biological systems for 1) chemical degradation and 2) energy storage. Meanwhile, our laboratory has built a modern analytical tool suite, which includes mass spectrometry-based platforms for monitoring and surveillance, hydrogen-deuterium exchange mass spectrometry for protein structure dynamics analysis, and gel free mass spectrometry-based proteomics analysis. We develop qualitative and quantitative methods for molecular characterizations, protein analysis and proteomics when working in different environmental systems.",Associate Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/n27690618
Satish,Bukkapatnam,Professor,"Dr. Bukkapatnam's research addresses the harnessing of high-resolution nonlinear dynamic information, particularly from wireless MEMS sensors, to improve the monitoring and prognostics of real-world systems, including ultraprecision and nanomanufacturing processes and machines, and cardiorespiratory processes. His research has led to 185 peer-reviewed publications (115 published/ accepted in journals and 70 in conference proceedings), 1 granted and five pending patents, and has been the basis for 17 Ph.D. dissertations. His research has received support from federal agencies including National Science Foundation, Department of Energy, and Department of Defense, and the private sector including General Motors, Ford, National Instruments, and the Central Rural Electric Cooperative.",Faculty Affiliate||Professor,Energy Institute||Industrial and Systems Engineering,https://scholars.library.tamu.edu/vivo/display/n277d780c
William,Dees,Senior Professor,,Senior Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n27f7a2f5
Anne,Newell-Fugate,Assistant Professor,"Polycystic ovary syndrome (PCOS) is the most prevalent reproductive endocrine disorder in women and results in a substantial financial burden to the American healthcare system. PCOS is characterized by an/oligoovulation, polycystic ovaries, and hyperandrogenism. PCOS patients are also at risk for the development of metabolic syndrome, type 2 diabetes, and cardiovascular disease. My laboratory focuses on the effects of obesity, hyperinsulinemia, and insulin resistance on androgen steroidogenesis and the interrelationship between androgens and insulin signaling in steroidogenic tissues and adipose tissue. An additional focus of my laboratory is the effect of novel fat sources on metabolic and reproductive function in the context of obesity. Using cell culture and rodent and porcine models, my research program examines the direct and indirect effects of obesity and resulting hyperandrogenemia on steroidogenesis and reproductive function in females. I also have a strong interest in wildlife and zoo animal endocrinology and reproductive physiology. In the past, I have conducted endocrine based research projects on the Pallas' Cat and African Wild Dog. My current research examines the effect of the introduction of novel pheromones versus novel animals on fecal steroid metabolite concentrations, behavior, and estrous cyclicity in captive, female Red River Hogs. I am also working with zoo-based collaborators to develop an eletroejaculation and artificial insemination protocol for Suidae (pig) and Tayassuidae (peccary) species and am engaged in a retrospective characterization of reproductive tract lesions in pigs and peccaries in relation to age, parity and contraceptive use.",Assistant Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n283bcbde
Deborah,Bell-Pedersen,Professor,"Research in the Bell-Pedersen lab focuses on determining how the circadian clock functions in organisms to regulate daily rhythms in gene expression, behavior, and physiology. The molecular clock in higher eukaryotes involves a master clock in the brain regulating clocks in peripheral tissues, posing significant obstacles for understanding circadian output mechanisms. Thus, a major strength of our work is using a single-celled model eukaryote, Neurospora crassa, to elucidate the underlying mechanisms of rhythmic gene expression and protein synthesis. Clock dysfunction in humans is associated with a wide range of diseases, including cardiovascular disease, cancer, metabolic disorders, mental illness, sleep disorders, and aging. In addition, daily changes in metabolism and cell division rates influence the efficacy and toxicity of many pharmaceuticals, including cancer drugs. Therefore, knowing how clocks work to control rhythmic gene expression, and what they regulate, is critical for the development of therapeutics. Research to understand clock-controlled rhythmic gene expression has focused primarily on transcriptional mechanisms, and little was known about posttranscriptional control. We discovered that the clock regulates highly conserved translation initiation and elongation factors, tRNA synthetase levels, and ribosome heterogeneity. This regulation determines what mRNAs are rhythmically translated and the accuracy of the translation process (translation fidelity). We are capitalizing on these exciting discoveries to determine how the clock regulates translation fidelity. These studies will provide the foundation for understanding the impact of daily rhythms in translation fidelity on protein diversity beyond what is encoded for in the genome.",Professor and Associate Department Head,Biology,https://scholars.library.tamu.edu/vivo/display/n2a2bfb97
Jeffrey,Savell,Distinguished Professor,,Distinguished Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/n2a814ea8
Robert,Rosa,Research Professor,,Research Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n2ab0c984
Jian,Feng,Professor and Assistant Dean,,Assistant Dean for Research and Professor,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n2b3403fd
Herman,Scholthof,Professor,,Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/n2c6ec1cb
Dana,Gaddy,Professor,"My laboratory has been engaged in multiple areas of NIH-funded musculoskeletal research since 1996. We were the first to identify the non-steroidal gonadal inhibin hormones in regulating the hypothalamic-pituitary-gonadal-skeletal axis in mice, and the role of changes in inhibins that signal the onset of menopause (reproductive aging) to the onset of increasing bone turnover. We also demonstrated the anabolic effect of continual Inhibin exposure in normal mice and in bone repair. Our cellular focus on Inhibins and the related factor, Activin A revealed that Activin A suppresses local bone resorption through suppression of osteoclast formation, motility and survival. Our ongoing work is in the area of specific inhibin/betaglycan receptor interactions that mediate the effects on bone cells. We are also greatly interested in improving the low bone mass that we were the first to identify in both humans with Down Syndrome (DS) and in mouse models of DS as a low bone turnover disease. Our current NIH-funded research is working to identify the mechanisms of reduced fracture healing and compromised bone regeneration in Down Syndrome. We have demonstrated the efficacy of both PTH and SclAb in DS, and are now actively testing nutriceuticals to increase bone mass in mouse models of Down Syndrome. The limitations of using mouse models to study bone disease led us to our most recent and exciting endeavors in collaboration with TAMU experts in reproduction and embryo transfer technologies to develop a large platform model of bone disease, using sheep. We have generated the first large animal model of hypophosphatasia (HPP) via high efficiency gene editing of a knock-in point mutation in the ALPL gene, whose musculoskeletal and dental phenotypes are consistent with human HPP. We are now using this model to determine the etiology of mineralization deficiencies, muscle weakness and premature tooth loss by analysis of longitudinal biopsies and analysis of muscle, bone and dental specimens using CT, microCT, mechanical testing, immunohistochemistry, histomorphometry and ex vivo bone marrow cultures.",Professor||Adjunct Professor,Veterinary Integrative Biosciences||Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n2dc10a1a
Katherine,Brakora,Instructional Associate Professor,,Instructional Associate Professor,Neuroscience and Experimental Therapeutics,https://scholars.library.tamu.edu/vivo/display/n2f4bb1bf
Brent,Auvermann,AgriLife Center Director,"Emission rate, ambient concentrations, fate, and transport of antimicrobial resistance elements associated with fugitive dust from livestock facilities; use of unmanned aerial vehicles for agricultural remote sensing.",Professor||Center Director,Biological and Agricultural Engineering||Amarillo Research and Extension Center,https://scholars.library.tamu.edu/vivo/display/n32b32697
Randolph,Stewart,Clinical Professor,cardiovascular physiology; lymphatic function; microvascular physiology; interstitial and cavity fluid balance,Clinical Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n332dadae
John,Criscione,Professor,,Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/n33d294c3
Kathrin,Dunlap,"Associate Department Head, Academic Programs",,Instructional Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/n3469d15f
Shannon,Washburn,Clinical Professor,"Dr. Washburn's research provides advancement of knowledge in the field of both veterinary and human medicine with a focus on the field of fetal-maternal health, as well as educational research on teaching and learning methodology. She has devoted considerable effort to investigating the mechanisms mediating injury to the fetus from prenatal exposure factors such as nutrition, alcohol, environment, therapeutic drugs and anesthetics utilizing the highly translational sheep model.",Clinical Professor||Clinical Associate Professor,Veterinary Physiology and Pharmacology||Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n34cde2bc
John,Green,Clinical Professor,My research is focused in two areas: 1. The interaction of exercise and estrogen replacement on the cardiovascular system in postmenopausal women. and 2. The perception of heart disease risk as it relates to actual physiological risk markers.,Clinical Professor,Kinesiology and Sport Management,https://scholars.library.tamu.edu/vivo/display/n3c299e59
Bradley,Weeks,Professor Emeritus,"Retired Professor, Veterinary Pathobiology Department. Collaborator as ACVP board-certified anatomic pathologist in research projects that include implanted medical devices inflammatory and neoplastic gastrointestinal diseases, and cardiovascular diseases.",Professor Emeritus,School of Veterinary Medicine and Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n3d42a32c
Robert,Chapkin,Distinguished Professor,"Research in the Chapkin lab focuses on dietary/microbial modulators related to the prevention of cancer and chronic inflammatory diseases.
Our central goal is to (1) understand cancer chemoprevention at a fundamental level, and (2) to test pharmaceutical agents in combination with dietary/microbial (countermeasures to the Western diet) to more effectively improve gut health and reduce systemic chronic inflammation. Since diet influences gut microbiota composition and metabolite production, to unravel the interrelationships among gut health and the structure of the gut microbial ecosystem, we are in the process of evaluating (using transgenic mouse, Drosophila models and humans) how the gut microbiome modulates intestinal cells, innate immune cells and tumors. As part of this endeavor, we are modeling at the molecular level the dynamic relationship between diet and gut microbe-derived metabolites which modulate chronic inflammation and the hierarchical cellular organization of the intestine, e.g., stem cell niche.",Distinguished Professor||Professor,Biochemistry and Biophysics||Nutrition,https://scholars.library.tamu.edu/vivo/display/n3fbb59f8
Shannon,Glaser,Professor,"The long-term goal of my research program is to understand how activated (proliferating) cholangiocytes participate in the progression of cholestatic liver diseases and eventual development of cholangiocarcinoma. My research is focused on elucidating the factors (such as, mechanical stress) and intracellular signaling mechanisms that regulate cholangiocyte proliferation and biliary fibrosis during extrahepatic cholestasis.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n424a02f1
Travis,Hein,Professor,"My laboratory studies the regulation of microvascular function at the level of arterioles in the retinal and coronary circulations. Sufficient blood flow supply of oxygen and nutrients to tissues to maintain normal function is controlled in large part by changes in the diameter of arterioles. Vasoconstriction or vasodilation of these small arteries will decrease or increase blood flow and nutrient delivery to the tissue, respectively. Two key chemical factors that are produced within the endothelial cells of blood vessels to control their diameter are nitric oxide (NO), a vasodilator, and endothelin-1, a vasoconstrictor. An imbalance in the production and/or release of these vasoactive factors has been implicated in the early stages of several cardiovascular diseases, but the underlying mechanisms contributing to these pathophysiological changes remain unclear. To address this knowledge gap, our research focuses on identifying cellular and molecular mechanisms that contribute to the vasomotor responses of arterioles to NO and endothelin-1 under conditions of health and disease. Current approaches that we use to investigate these mechanisms in the microcirculation include isolated and perfused arterioles, cultured vascular endothelial and smooth muscle cells, biochemical and molecular techniques (for detection of NO, superoxide anion, protein, and mRNA in arterioles), pharmacological and silencing RNA (siRNA) treatments, and blood flow velocity assessment via Doppler ultrasound.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n45051e1b
Tadhg,Begley,Distinguished Professor,"The Begley Group is interested in the mechanistic chemistry and enzymology of complex organic transformations, particularly those found on the vitamin biosynthetic pathways. We are currently working on the biosynthesis of thiamin, molybdopterin, pyridoxal phosphate and menaquinone. Our research involves a combination of molecular biology, protein biochemistry, organic synthesis and structural studies and provides a strong training for students interested in understanding the organic chemistry of living systems and in pursuing careers in biotechnology, drug design or academia.
Thiamin pyrophosphate plays a key role in the stabilization of the acyl carbanion synthon in carbohydrate and amino acid metabolism. The biosyntheses of the thiamin pyrimidine and thiazole are complex and are different from any of the characterized chemical or biochemical routes to these heterocycles. We are particularly interested in cellular physiology and the mechanistic enzymology of thiamin biosynthesis. As an example of one of the complex transformations on this pathway, the figure below shows the structure of the pyrimidine synthase catalyzing the complex rearrangement of aminoimidazole ribotide (left) to the thiamin pyrimidine (right).",Distinguished Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n498aa35b
Yinan,Wei,Professor,"We are interested in studying the interaction between microbes and host systems, in the context of antibiotic resistance, infection, and the innate immune response.",Professor,Pharmacy Practice,https://scholars.library.tamu.edu/vivo/display/n4bb89912
Harry,Hogan,Professor,,Professor,Mechanical Engineering,https://scholars.library.tamu.edu/vivo/display/n4c1aaeda
Tanmay,Lele,Professor,"Dr. Tanmay Lele's research is in the area of mechanobiology with a focus on cancer mechanobiology. His lab is interested in the molecular mechanisms by which cell generated mechanical forces and associated signaling pathways enable cell and tissue functions, and how these relationships become altered in cancer. Current research projects in the laboratory include quantitative measurements of nuclear forces, the effect of mechanical stresses on nuclear functions and gene expression, cellular adaptation to mechanical properties of the extracellular matrix, and the mechanics of cancer tissue development.
Lele is a scholar in cancer research at the Cancer Prevention and Research Institute of Texas.",Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/n4c5b9ade
Thomas,Boutton,Professor,"Dr. Boutton is interested in the ecology of grassland and savanna ecosystems, particularly the impacts of land cover/land use changes on ecosystem processes (productivity, decomposition, biogeochemistry, hydrology). At present, most of his work is oriented towards understanding the influence of woody plant invasion into grasslands and savannas on biogeochemistry and soil biology. He is also interested in understanding ecosystem responses to global changes predicted for the future. The effects of climate, land use, and atmospheric composition on ecosystem structure and function are being investigated at time scales ranging from a few years (contemporary ecosystems) to thousands of years (paleo ecosystems), and spatial scales ranging from the soil aggregate to the landscape. Dr. Boutton also serves as Director of the Stable Isotope Biogeochemistry Laboratory, and teaches two graduate level courses (ESSM 600 - Principles of Ecosystem Science and Management, and ESSM 622 - Biogeochemistry of Terrestrial Ecosystems).",Regents Professor & Sid Kyle Endowed Chair,Ecology and Conservation Biology,https://scholars.library.tamu.edu/vivo/display/n50abe2cc
Cynthia,Meininger,Professor,"My research focuses primarily on the vascular complications of diabetes. Using animal models of human diabetes, we have demonstrated that an inability of endothelial cells to produce nitric oxide may be partly responsible for these vascular complications. We are developing a gene/drug therapy approach for treating cardiovascular disease associated with diabetes. Targeted nanoparticles will deliver either the gene for GTPCH or BH4 itself into endothelial cells oxidatively damaged by diabetes to correct endothelial GTPCH deficiency, increase tetrahydrobiopterin levels, restore nitric oxide production and reverse the vascular dysfunction seen in diabetes. Our endothelium-targeting nanoparticle approach will not only reverse the damage caused by disease but will increase antioxidant levels to protect the endothelial cells from future damage and/or dysfunction.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n531a623d
Mahua,Choudhury,Associate Professor,"Epigenetics, diabetes, obesity, pregnancy, preeclampsia, biomarker",Associate Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n55b81876
Glen,Laine,Regents Professor,,"Director , Michael E BeBakey Institute||Professor",Michael E. DeBakey Institute||Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n58440639
Joanne,Hardy,Clinical Associate Professor,,Clinical Associate Professor,Large Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/n588d993a
Yava,Jones-Hall,Associate Professor,,Associate Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n5b5cb520
Jianxun,Song,Professor,T cell biology
T cell-based immunotherapy
Cell metabolism,Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n5b9879a8
Narendra,Kumar,Associate Professor,"1. Obesity associated metabolic syndrome (MetS) is both a US and a worldwide epidemic and a major burden to healthcare system. Chronic low-grade inflammation (CLGI) is a well-established characteristic of the obese-human condition and though, the gastrointestinal (GI) mucosa is the first tissue that interacts with dietary components and luminal microbiota both of which are known to regulate obesity, the research on the role of GI-mucosa in obesity associated MetS is lacking. Findings from my lab support a key role of Janus kinase 3 (Jak3), a non-receptor tyrosine kinase, in intestinal and systemic CLGI associated obesity and diabetes in both an animal-model and in humans. Our publications, and unpublished data indicate that Jak3 regulates; colonic and systemic CLGI, and multiple symptoms of metabolic syndrome. Our goal is to determine the associated underlying mechanisms. Our current focus is on tissue-specific roles of Jak3 and associated signaling complexes in CLGI-onset as a precursor for; (a) obesity and diabetes, (b) Obesity and Alzheimer's disease, and (c) inflammatory bowel disease.
2. Inflammatory bowel disease (IBD) that includes Crohn's disease and Ulcerative colitis is a chronic inflammatory condition of gastrointestinal tract. Annual death from these diseases are over 70,000.00, and the incidences of new cases have been rising over the years. Because the repairs of intestinal mucosa (Restitution) are compromised during IBD, the research focus of our lab is to dissect the roles of intestinal epithelial, intestinal immune cells and gut microbiota in mucosal restitution. Our lab was pioneered the functions of Jak3 in intestinal epithelial mucosa. We show that IL-2 (a cytokine produced during intestinal inflammation) promotes mucosal wound repair through Jak3 complexed with villin, ShcA, and ?-catenin. Studies are underway to define the tissue-specific Jak3-mediated signaling pathways that regulate CLGI as a precursor for the onset of IBD.",Associate Professor and Director of Graduate Studies||Associate Professor,Pharmaceutical Sciences||Pharmaceutical Sciences,https://scholars.library.tamu.edu/vivo/display/n5bcfc45e
Wenshe,Liu,Bovay Chair and Professor in Chemistry,"Our research interest is to design methods for the genetic incorporation of noncanonical amino acids into proteins in living cells and apply these methods in three major directions: deciphering functions of protein posttranslational modifications, small molecule sensing, and expanding chemical diversities of phage display libraries. To study protein posttranslational modifications, we have constructed methods for the site-specific installation of lysine acetylation and methylation in proteins and will apply them to study functional roles of these two modifications on p53, a tumor suppressor protein. We have also developed a strategy to site-specifically install two noncanonical amino acids into one protein in E. coli and are applying this approach to construct biosensors for small organic molecules and metal ions. Phage display is an efficient method to identify peptides for therapeutic interventions. However, a phage display peptide library has limited structure motifs and functional groups because only 20 natural amino acids can be used to generate a library. We plan to expand the chemical diversity of a phage display library by incorporating multiple noncanonical amino acids and chemically modifying them to extend functional diversities. Screening this unnatural phage display library against therapeutic targets such as c-Abl tyrosine kinase is expected to identify highly potent inhibitors.",Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n5d9506ea
Gary,Kunkel,Associate Professor,"An important step to control the amount of RNA or protein in particular types of cells is at the level of transcription of genes. Our lab studies a multifunctional vertebrate transcriptional activator protein known as SBF/Staf/ZNF143. This protein binds to SPH sites within promoters of many genes that produce small stable RNAs (e.g., snRNAs and others) PLUS probably over 2000 promoters of genes that produce mRNAs. Two separate activation domains in this protein direct its action at small RNA vs. mRNA gene promoters. We are using zebrafish as a vertebrate model organism to study the roles of SBF/Staf during development. In vivo studies are coupled with biochemical and molecular biology methods to decipher the mechanisms by which this protein stimulates transcription of various types of genes.",Associate Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n638b96b2
David,Earnest,Professor,"Research in my laboratory employs multidisciplinary approaches to study the cellular and molecular neurobiology of cell-autonomous circadian clocks and the signal transduction pathway responsible for circadian photoentrainment. The aims of current projects are to study: 1) the role of microRNAs (miRNAs) and other signaling molecules in the local temporal coordination of cell- and tissue-specific circadian clocks; 2) mutual interactions between the circadian clock mechanism, inflammatory signaling and metabolism; and 3) the mechanisms linking circadian rhythm disruption with metabolic disorders such as obesity and diabetes, and with pathological changes in neuroprotective responses to stroke.",Professor,Neuroscience and Experimental Therapeutics,https://scholars.library.tamu.edu/vivo/display/n640c528f
Lynne,Opperman,Regents Professor and Department Head,,Regents Professor and Head,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n6542ca2e
Paul,Wellman,Professor,I maintain several research areas within behavioral pharmacology. My current research focus is on the interactions between feeding control systems (i.e. ghrelin) and the reinforcing actions of drugs such as cocaine and amphetamine. My research has been funded by NIDA and by corporate sponsors such as Thompson Medical Company and Knoll Pharmaceutical.,Professor,Psychological and Brain Sciences,https://scholars.library.tamu.edu/vivo/display/n67571474
Gwendolyn,Levine,Clinical Associate Professor,,Clinical Associate Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n68f0c0ae
Yan,Jing,Research Assistant Professor,,Research Assistant Professor,Orthodontics,https://scholars.library.tamu.edu/vivo/display/n69206683
John,Lawler,Professor,,Professor,Kinesiology and Sport Management,https://scholars.library.tamu.edu/vivo/display/n69cbc828
Guan,Zhu,Professor,"Our laboratory conducts translational research with an ultimate goal to discover new anti-parasitic therapeutics by targeting metabolic enzymes and other molecules critical or essential to the parasite infection, survival and development, such as those involved in the lipid and energy metabolisms and interacting with host cells in Cryptosporidium and other protozoan parasites. Other research areas include functional genomics and molecular evolution of apicomplexan parasites, and parasitic diseases important to the conservation of wild animals.",Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n6d62f33b
Craig,Coates,Instructional Associate Professor,,Instructional Associate Professor,Entomology,https://scholars.library.tamu.edu/vivo/display/n6f8163e8
Ivan,Ivanov,Clinical Professor,,Clinical Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n6fa588a3
Robert,Burghardt,Professor,"Research in the laboratory is focused on investigating mechanisms by which a variety of biological response modifiers ranging from mechanical signals, hormones and growth factors to environmental chemicals alter cellular signaling pathways and cellular homeostasis.","Professor||Director, Image Analysis Laboratory",School of Veterinary Medicine and Biomedical Sciences||Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n70a3d026
Frances,Ligler,Professor,,Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/n74321a1f
Leslie,Adams,Senior Professor,"My research is focused on the: 1) investigation of the comparative molecular pathogenesis of zoonotic intracellular bacterial pathogens in natural animal models, particularly brucellosis, salmonellosis, and mycobacterial diseases; 2) development of vaccines and host gene expression-based diagnostics for zoonotic and select agent caused diseases, and especially 3) development of in silico host:pathogen interactome predictive models based upon bi-directional in vivo host (bovine/murine) and Brucella spp., Mycobacterium spp.and Salmonella enterica Typhimurium interactions. We developed an in silico computational infection biology model based on actuall temporal in vivo bovine model microarray-based transcriptomic and proteomic profiling of the acute infectious process. We developed a systems biology analysis of both host and pathogen comprehensive transcriptomic and proteomic datasets derived from our in vivo biological model. We computationally fused the datasets based on actual Salmonella, Brucella and Mycobacterium data and computationally predicted bovine host structural proteins to identify maximum likelihoods of host and pathogen protein:protein interactions as the basis for our preliminary in silico interactome model to predict mechanistic genes and linked perturbed cellular pathways.",Senior Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n75fee121
Roderick,Dashwood,University Distinguished Professor,"Research integrates multiomic, genetic, epigenetic and immune approaches for precision oncology. Epigenetic readers, writers and erasers that reversibly regulate immune players in the antigen presentation pathway are of current mechanistic interest. Molecular and cell-based assays are combined with preclinical models coupled to polypectomy. Clinical specimens and organoids from patients undergoing colectomy provide for human translation. Supported by the NCI, NINDS/NIA, and the John S. Dunn Foundation.",John S. Dunn Chair in Disease Prevention||Distinguished Professor||Director,Institute of Biosciences and Technology||Center for Epigenetics and Disease Prevention||School of Medicine,https://scholars.library.tamu.edu/vivo/display/n7a63dbe7
Fuller,Bazer,Distinguished Professor,"Dr. Bazer's research in reproductive biology focuses on uterine biology and pregnancy, particularly pregnancy recognition signaling from the conceptus to the maternal uterus by interferon tau and estrogen from ruminant and pig conceptuses, respectively. The roles of uterine secretions as transport proteins, regulatory molecules, growth factors and enzymes and endocrine regulation of their secretion is another major research interest. The endocrinology of pregnancy, especially the roles of lactogenic and growth hormones in fetal-placental development and uterine functions are being studied. The mechanism(s) of action and potential therapeutic value of conceptus interferons and uterine-derived hematopoietic growth factors are areas of research with both pigs and sheep as models for human disease.",Distinguished Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/n7ad91d50
Arul,Jayaraman,Professor,,Professor,Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/n7deb8230
Stephen,Crouse,Professor,"My research focus is in the general area of Exercise as Medicine. My specific health-related research aims have been targeted toward the study of the effects of exercise on blood lipid metabolism, and on other accepted heart and cardiovascular disease risk factors in men and women, young and old. Current research in exercise physiology is focused on the adaptive response of the cardiovascular and musculoskeletal system to exercise, nutrition, and physical training using aquatic, endurance, and resistance modalities of exercise. In progress are research projects in sports physiology to profile elite athletes and study factors that contribute to the health of athletes, including nutritional supplements.",Professor,Kinesiology and Sport Management,https://scholars.library.tamu.edu/vivo/display/n7e212aee
J Timothy,Lightfoot,Professor,"My research focuses on on the genetics of daily physical activity and exercise endurance, as well as the physiological response to high-G exposure and hemorrhage, and the genetics of physical activity. My lab also has a unique interest in the physiological responses of athletes in a variety of non-traditional venues such as auto racing and in musicians.",Professor,Kinesiology and Sport Management,https://scholars.library.tamu.edu/vivo/display/n7ec5bc99
Paula,Shireman,Professor,"Dr. Shireman is a Professor in the TAMU School of Medicine. She is board certified in vascular surgery, general surgery, wound care and clinical informatics. She is the PI of a pilot clinical trial with the College of Engineering on establishing artificial intelligence algorithms to monitor activities of daily living (ADL) in elderly subjects. Potential applications include aging in place, improved monitoring in healthcare/assisted living institutions and remote monitoring.
She is the PI of an NIH multicenter U01 grant developing predictive models for surgical outcomes including frailty and social risk factors. The goal is to use data to transform health care, influence federal policy and design financially sustainable care pathways improving outcomes for frail and low socioeconomic status patients. Her interests include predictive modeling, machine learning and simulation. She was a member of the MACRA Episode-Based Cost Measure Clinical Subcommittee to develop measures for Peripheral Vascular Disease Management and Chair of the Clinical Subcommittee Workgroup for Hemodialysis Access Creation.","Professor||Professor, Primary Care & Rural Medicine",Medical Physiology||School of Medicine,https://scholars.library.tamu.edu/vivo/display/n7fcb580a
David,Peterson,Professor and Associate Department Head,"We are interested in the molecular mechanisms of transcriptional regulation in mammalian cells. Many of our experiments have focused on the transcription of the proviral genome of the retrovirus mouse mammary tumor virus, which is subject to both positive and negative control. A number of cellular proteins that are important for viral transcription have been identified, and we would like to define the precise roles of these proteins in establishing correct levels of viral gene expression. We are also exploring some specific questions related to the general mechanism of transcription initiation by RNA polymerase II and the biochemical details of transcriptional regulation. In particular, we are developing assays to directly assess effects of transcriptional regulatory proteins on discrete steps in the initiation process, including transcription complex assembly, separation of the two strands of template DNA at the initiation site, and promoter clearance by the polymerase as it begins RNA synthesis.",Professor and Associate Department Head,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n8186cf95
Stephen,Talcott,Professor and Associate Department Head,"Dr. Talcott's research is focused on phytochemicals in fruits and vegetables, antioxidant stability and assessment, postharvest retention, beverage processing and value-added products. Intake of compounds such as phenolic acids, flavonoids, anthocyanins, procyanidins, carotenoids, tocopherols and ascorbic acid are suggested to have an inverse association with the risk of certain cancers and diseases. These compounds are investigated as antioxidants, enzyme inhibitors, and bioactive agents and changes in their concentration and activity are investigated following postharvest handling and processing. Current investigations include phytochemical identification, quantification and stability in tropical and subtropical fruits and vegetables including acai, mango, guava, passion fruit, grapes. As well as peanuts, strawberries, bell peppers and food-grade botanicals.",Professor and Associate Department Head,Nutrition,https://scholars.library.tamu.edu/vivo/display/n8247cf18
John,Ford,Associate Professor,,Associate Professor,Nuclear Engineering,https://scholars.library.tamu.edu/vivo/display/n83d50875
Peter,Davies,Professor,,Interim Department Head||Professor and Director,Center for Translational Cancer Research||Translational Medical Sciences,https://scholars.library.tamu.edu/vivo/display/n83f40a4a
Kamlesh,Yadav,Instructional Associate Professor,"Dr. Yadav's primary interest is in translational research, specifically biomarker discoveries and novel therapeutics in cancer (especially prostate) through a combination of biochemistry and genomics. He is also interested in mining EMRs for personalized diagnosis, prognosis and therapeutics using real worlds evidence (RWE) data coupled with machine-learning/AI-algorithms.",Instructional Associate Professor,School of Medicine,https://scholars.library.tamu.edu/vivo/display/n855387b4
Rosemary,Walzem,Professor,"Dr. Walzem's core research focus within the laboratory is directed towards understanding how the structure of triglyceride-rich lipoproteins influences their ability to carry out specific nutrient delivery tasks. Her studies include identification of mechanisms and regulatory processes that control the assembly of trigylceride-rich lipoproteins in issues, structural studies of lipoproteins themselves and physiological studies to determine substrate properties and metabolic fates of different types of lipoproteins. Diet can significantly alter lipoprotein physiology through multiple mechanisms, and studies of diet effects provides a significant sub-theme to the research program. A variety of species are used to address specific questions, however, avian and human lipoprotein metabolism as it relates to egg production and atherogenesis, respectively, are emphasized.",Professor,Poultry Science,https://scholars.library.tamu.edu/vivo/display/n85cd191f
Deborah,Threadgill,Assistant Professor,,Research Assistant Professor||Assistant Professor,Veterinary Pathobiology||School of Medicine,https://scholars.library.tamu.edu/vivo/display/n8734a809
Jonathan,Levine,Professor and Head,,Professor and Head,Small Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/n8ae2a0a7
Clifford,Stephan,Certification Officer and Associate Professor,"The Stephan Lab is focused on drug discovery research. Dr. Stephan directs both the Combinatorial Drug Discovery Program (CDDP) core and the Microphysiological Lead Optimization and Toxicity Screening (MLOTS) facilities. The CDDP is a high throughput screening and automated microscopy core focused on discovering new therapeutics from library screening and drug repurposing alone or in multi-drug combinations. MLOTS is a low to medium throughput core focused on lead optimization for new chemical entities with the capability of testing compounds in complex in vitro models (e.g., spheroids, organoids) and de-risking drug leads by evaluating their potential cardiovascular or CNS toxicities via micro electrode array or hepatotoxcity in a microfluidic liver model.",Research Associate Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/n8c431f98
Jayshree,Mishra,Research Assistant Professor,Role of drug transporter proteins in colonic mucosal innate immunity.
Post-translational modification of drug transporter proteins and its role in Multidrug resistance.
Biomarker development for colon cancer
Drug discovery for the treatment of breast cancer metastasis,Research Assistant Professor||Research Assistant Professor,Pharmaceutical Sciences||Pharmacy Practice,https://scholars.library.tamu.edu/vivo/display/n8c995b51
James,Cai,Professor,"Dr. Cai's research lies at the interface of single-cell biology, computational statistics, and data science. Current research focuses on using machine learning, network science and quantum computing to better understand the diverse behaviors of cells. Dr. Cai's group develops novel algorithms and analytical frameworks to study single-cell omics data from various types of cells, and the genetic basis of phenotypic variability to identify genetic variants that modulate complex phenotypic traits and susceptibility of genetic disorders.",Professor||Professor||Faculty,Veterinary Integrative Biosciences||Center for Statistical Bioinformatics||Electrical and Computer Engineering,https://scholars.library.tamu.edu/vivo/display/n8d287cea
David,Threadgill,Professor,"Our laboratory uses the mouse as an experimental genetic model to investigate factors that contribute to inter-individual differences in health and disease. Ourcurrent research activities include the identification and functional characterization of alleles contributing to cancer susceptibility, the function of theErbbgenefamily in development and disease, and the role of genetic variation in response to environmental stimuli. To support these investigations, we also aredeveloping new genetic tools to support mammalian systems genetic approaches to phenotypes with complex genetic and environmental etiologies.",Director||Professor||Professor||Professor,Cell Biology and Genetics||Institute of Genome Sciences and Society||Biochemistry and Biophysics||Nutrition,https://scholars.library.tamu.edu/vivo/display/n8ee0b54f
Nancy,Turner,Research Professor,"Dr. Turner's research program focuses on determining the impact of dietary constituents on regulatory processes that may protect against carcinogenesis and inflammation in the colon. Her lab is evaluating the effects of fiber sources and the specific phytochemicals contained within them on aspects of cellular proliferation or apoptosis, and microbial/epithelial cell interactions. The goal is to determine how these normal processes are being perturbed by chemical carcinogens, radiation or pro-inflammatory compounds, and how diet may mitigate the damage caused by them. Work conducted in the laboratory is currently funded by the United Sorghum Checkoff Board, the California Dried Plum Board, and the National Space Biomedical Research Institute.",Research Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n8f7d7c90
James,Sacchettini,Professor,"My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n90385563
Ken,Muneoka,Professor,My lab is focused on understanding epimorphic and tissue regeneration in mammals.,Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n9156816d
Hisashi,Koiwa,Professor,,Professor,Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/n931bc4cc
Jay,Groppe,Associate Professor,,Associate Professor,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/n93572b3e
Chia Shan,Wu,Research Assistant Professor,,Research Assistant Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n954c969e
Andreea,Trache,Associate Professor,"The research in my laboratory focuses on the study of cellular responses to mechano-chemical stresses from a biophysical perspective. Biophysics research represents an applied field of science at the interface of physics, biology, engineering, and medicine. Our lab uses live vascular cells as a model system because endothelial and smooth muscle cells reside 'in vivo' in a mechanically active environment that is continuously changing. Using real-time imaging of live cells is the only way to directly monitor cellular responses to mechano-chemical stimulation. Moreover, single-cell imaging experiments allow discrete measurements of transient microscopic events that may be masked by a macroscopic average behavior, and will aid in understanding such behavior.",Associate Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n955af1bf
Jill,Hiney,Research Assistant Professor,"Current Research: Analysis of Mercury and trace element toxins in marine mammals and fish in areas of Alaska, Mexico and California.
Former Research areas: Toxicology of Alcohol on Female puberty and neuroendocrine pathways.
Pb (Lead) effects on female reproduction and puberty
Manganese effects on female reproduction and puberty.",Research Assistant Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n96892f3f
Elizabeth,Racine,Center Director,,"Professor||Associate Department Head for Nutrition, Texas A&M AgriLife Extension||AgriLife Research Center at El Paso Director",Texas A&M AgriLife Research||Nutrition||Nutrition,https://scholars.library.tamu.edu/vivo/display/n9707e148
Larry,Suva,Professor and Head,"The development, control and diseases of the musculoskeletal system have been my scholarly interests for the past 35+ years. Understanding how the musculoskeletal system adapts and progresses throughout life is the basis of my expertise. My research focus has been the skeletal consequences of disease, such as breast cancer bone metastasis and multiple myeloma, fracture healing, osteoporosis, and most recently rare bone diseases. Current research efforts include a focus on utilizing in vivo models (murine and large animals) to discover regulatory pathways fundamental to bone physiology and the development of rare bone disease preclinical model(s) that may provide novel insight into future therapeutic directions. A critical aspect of my academic philosophy is an open door policy and the importance of one-on-one interactions. We must strive to provide training and exposure for our students as they prepare for careers both in and out of academic medicine and research. I emphatically believe that these teaching and mentoring experiences have shaped my scientific career and have helped mold my teaching and mentoring philosophy of placing the best professional, academic, social and personal development of faculty, students and staff above all else.",Professor and Head,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n98338eea
Nancy,Ing,Professor,"Dr. Ing's research interests focus on understanding how hormones regulate gene expression in animal tissues. Current research projects investigate the earliest days of pregnancy in the sheep uterus and the regulation of estrogen receptor gene expression, as well as stress hormone effects on gene expression in the stallion testes. Most recently, we have been studying the RNAs in sperm from stallions and honey bees in order to find a pattern consistent with high fertility.",Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/n98a4a111
Bhimanagouda,Patil,"Leonard Pike Inagural University Professor and Interim Head, Food Science and Technology","Dr. Bhimu Patil is internationally recognized for his expertise and research on 'foods for health' and his related educational programs. His systems-wide farm-to-table approaches include examining pre- and postharvest effects on bioactive compounds, isolating and characterizing these compounds from different fruits and vegetables, and understanding their roles in human health. Moreover, he has a strong working relationship with produce industry stakeholders. Dr. Patil has a distinguished record of achievements in education, including leading the development of three unique courses linking agriculture, human health, and sustainability. Texas A&M University has been a leader in this area, due in part to Dr. Patil's seminal contributions in these first-of-their-kind multidisciplinary courses. Dr. Patil's contributions to education are no less distinguished. He developed and taught three unique, innovative multi-state and multi-disciplinary courses, ""Phytochemicals in Fruits and Vegetables to Improve Human Health"", ""Science of Foods for Health"" and ""The Nexus of Food & Nutritional Security, Hunger, and Sustainability"".",Professor||Professor,Nutrition||Horticultural Sciences,https://scholars.library.tamu.edu/vivo/display/n9a0e203e
Alan,Dabney,Associate Professor,,Associate Professor,Statistics,https://scholars.library.tamu.edu/vivo/display/n9b774f13
Hung-Jen,Wu,Associate Professor,"Dr. Wu uses nanostructured materials and analytical tools to develop diagnostic techniques for medical applications. His laboratory recently focuses on understanding the influences of multivalency and cell membrane environment on pathogen-host cell recognition. The applications of his techniques include, infectious diseases screening, exploring cell membrane function, and targeted drug delivery.",Associate Professor,Chemical Engineering,https://scholars.library.tamu.edu/vivo/display/n9cbcca3e
John,Stallone,Professor,"Research in my lab focuses on male-female differences in normal cardiovascular function, and in the development of various diseases, including hypertension, coronary artery disease, and stroke, and the roles of the sex hormones in these male-female differences in cardiovascular disease. A major topic of study in my lab is the so-called ""estrogen paradox"" which reveals protective effects of this female sex hormone in younger women and animals, but deleterious effects in older females.",Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/n9dab7ff2
Roland,Kaunas,Associate Professor,"Dr. Roland Kaunas' laboratory focuses on the engineering of micro-tissues containing mesenchymal stem cells as vehicles for regenerating musculoskeletal tissues and as cell-based models for studying bone tumor biology. This work employs sophisticated microfluidic platforms, custom bioreactors, and novel scaffolding strategies involving composites of natural and synthetic polymers.
Kaunas' group also studies how mechanical stresses and strains, such as tensile stretch and fluid shear stress, regulate cell function in vascular tissues including arteries, capillaries and lymphatics. This work involves integration of experiments and theory to elucidate the roles of intracellular contractility, applied forces and scaffold material properties on cell architecture and transduction of mechanical stimuli into intracellular signals leading to changes in cell behavior.",Associate Professor,Biomedical Engineering,https://scholars.library.tamu.edu/vivo/display/n9eb05d66
Karen-Beth,Scholthof,Professor,"My molecular plant virology research is on a virus complex of Panicum mosaic virus (PMV) and its satellite virus (SPMV). For molecular genetic studies on the PMV/SPMV virus:host interactions we are using the model grass, Brachypodium distachyon. My primary area of research is the historiography of Tobacco mosaic virus (TMV) in the early 20th century in the United States.",Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/na173b2b4
Jeremy,Wasser,Associate Professor,,Associate Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/na2c152a7
Patrick,Stover,Vice Chancellor and Dean,,Professor||Vice Chancellor and Dean,College of Agriculture and Life Sciences||Nutrition,https://scholars.library.tamu.edu/vivo/display/na2e4838e
Alison,Diesel,Clinical Assistant Professor,"I am a clinical associate professor focused primarily on clinical service to dermatology patients and teaching veterinary students. My teaching interests lie in developing integrated and novel teaching methods to enhance the veterinary curriculum along with clinical teaching to fourth year veterinary students on the hospital floor. Additionally, I aim to spread knowledge on practical veterinary dermatology to veterinary practitioners through various local, regional, and national continuing education lectures. My research interests focus on inflammatory skin disease in companion animals (most specifically feline allergic skin disease), potential clinical applications of microbiome research, methicillin-resistant Staphylococcal skin infections, and applications of radiation therapy in the dermatology patient.",Clinical Assistant Professor,Small Animal Clinical Sciences,https://scholars.library.tamu.edu/vivo/display/na5d385d9
Gregory,Reinhart,Professor and Head,"Our laboratory is interested in the mechanisms by which enzymes are regulated in the cell. In particular, we are interested in allosteric regulation of enzyme activity. Consequently, we are interested in understanding the nature of the conformational change in proteins that can be effected by the binding of ligands, and specifically how these changes alter the catalytic behavior of enzymes subject to allosteric regulation. We endeavor to investigate properties that are complementary to those determined by x-ray crystallography in order to develop a comprehensive picture of the structure-function relationships involved in the regulatory phenomenon. For example, we are interested in how the dynamics of protein structure might dictate the nature of an allosteric effect. Techniques and approaches that we use in the laboratory include analysis of enzyme kinetics; analysis of the thermodynamics of enzyme-ligand interactions; time-resolved and steady-state fluorescence spectroscopy; analysis of the effects of temperature and hydrostatic pressure (up to 4 kbar) on enzyme properties, site-specific mutagenesis, isothermal titration calorimetry, and molecular graphics.",Professor and Head,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/na6e2a0db
Frank,Raushel,Distinguished Professor,"Enzymes catalyze a remarkable variety of chemical reactions with extremely high rate enhancements and very selective substrate specificity. The research efforts in our laboratory are directed towards a more complete understanding of the fundamental principles involved in enzyme-catalyzed chemistry and the dependence on protein structure. The pursuit of this information will provide the framework for the rational and combinatorial redesign of these complex molecules in an effort to exploit and develop the properties of enzyme active sites for a variety of chemical, biological, and medicinal uses. The techniques that we are using to solve these problems include steady-state and stopped-flow kinetics, NMR and EPR spectroscopy, X-ray crystallography, and the synthesis of inhibitors and suicide substrates. We are also using recombinant DNA methods to construct new proteins with novel catalytic properties. These efforts are currently being directed to the reactions catalyzed by phosphotriesterase and enzymes involves in the degradation of lignin and the metabolism of novel carbohydrates from the human gut microbiome.
The phosphotriesterase enzyme catalyzes the hydrolysis of organophosphate insecticides and other toxic organophosphate nerve agents. We have discovered that the active site of this protein consists of a unique binuclear metal center for the activation of water. We are now investigating the structure and properties of this metal center as a model system for the evolution of enzyme structure and function. Toward this end we have mutated the active site of this enzyme in a research project to create novel enzymes with the ability to detect, destroy, and detoxify various chemical warfare agents such as sarin, soman, and VX. The Raushel laboratory is also engaged in a large scale research project that is focused on the development of novel strategies for the discovery of new enzymes.",Distinguished Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/na84f2fec
Jerome,Trzeciakowski,Professor and Associate Department Head,,Professor and Associate Department Head,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/na90a7aab
Monique,Rijnkels,Research Associate Professor,"We are studying transcriptional regulation and the genomics of the mammary gland and the role of epigenetic events during mammary gland development and lactation. We use various genomics approaches to mammary gland biology and my laboratory has been using ChIP-seq, DNase-seq, ATAC-seq and other epigenomic approaches to determine chromosomal states at different developmental time points to determine the role of epigenetic regulation in mammary gland development and understand gene regulation in the mammary gland in general. We use transgenic mouse models to study gene regulation in mammary gland development and lactation.",Research Associate Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/na956415b
Samba,Reddy,Professor,"My major research goals are to understand the molecular pathophysiology and develop novel therapeutic strategies for epilepsy, with an emphasis on neurosteroids and GABA inhibition in the brain. Neurosteroids are steroids synthesized locally within the brain that rapidly change neural excitability by non-genomic mechanisms, principally via postsynaptic GABAA receptors that play critical role in epilepsy. Current work in his lab is focused on uncovering molecular mechanisms of neurosteroids in epilepsy and brain disorders, and testing the efficacy of mechanism-based, rationale therapeutic strategies for epilepsy and epileptogenesis. Reddy lab is utilizing multidisciplinary approaches such as pharmacological, molecular, electrophysiological (patch-clamp), mass spectrometry, and transgenic mouse models in research projects.",Professor,Neuroscience and Experimental Therapeutics,https://scholars.library.tamu.edu/vivo/display/na96b32aa
Michael,Benedik,Regents Professor,My laboratory studies basic biological problems using molecular genetic methods with simple microbial systems. Additionally we are developing novel microbial approaches for biotechnological applications.,Regents Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nac9856e5
David,Zawieja,Regents Professor and Department Head,"My lab has had a number of research projects focusing on the study of lymphatic structure and function. Each of these projects has, as one of their objectives, the evaluation of the mechanisms (molecular, cellular, mechanical and tissue-level) regulating different aspects of lymphatic function. These projects focus on the ionic/calcium, contractile/regulatory proteins, molecular pathways that regulate lymph transport, lymphatic muscle function, the role of lymphatic function in the generation and resolution of tissue inflammation and the interactions between immune cells and the lymphatic cells. To support this work we have established cultured cell lines of both endothelial and muscle isolated from microlymphatics, acute and cultured isolated microlymphatic tissues, methodologies to evaluate lymphatic function at the single vessel, whole tissue and animal levels, methodologies to target cell-specific gene manipulation in isolated lymphatic tissues, approaches to microscopically image and model lymphatic network structure and function in 3D in lab animals. We have also evaluated the effects of space flight, various inflammatory mediators and other immune activation processes on lymphatic contractile and transport function and how these affect immunity. Finally, we have evaluated different types of lymphatic pathology resulting in lymphedema, various inflammatory diseases and immune dysfunction.",Regents Professor and Head||Professor and Associate Department Head,The Texas A&M University System||Medical Physiology,https://scholars.library.tamu.edu/vivo/display/nad1e71e4
Steven,Riechman,Associate Professor,My research interests include human muscle and cognitive performance and fatigue. Specifically nutritional and exercise interaction on sustained cognitive and physical performance in challenging environments.,Associate Professor||Associate Professor,Kinesiology and Sport Management||Nutrition,https://scholars.library.tamu.edu/vivo/display/nad2da75c
Ian,Tizard,Dr.,"Immunology with an emphasis on innovative vaccine technology and on the immunology of domestic mammals.Avian diseases with an emphasis on diseases of psittacines, Paleovirology,Genomics with an emphasis on whole avian genomes.The intestinal microbiome and its role in immunity.",University Distinguished Professor,School of Veterinary Medicine and Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/naefbabcf
Kranthi,Mandadi,Associate Professor,"World-wide, pathogens, insects and abiotic stresses cause major losses to agricultural production and productivity. Our lab employs integrated approaches for basic and translational studies of crop stress responses in model and crops. We are using the latest genomics, genetics, and bioinformatics tools to study plant stress responses to diverse plant biotic and abiotic stress conditions, as well as enhance their stress tolerance using biotechnology and breeding tools.",Associate Professor||Associate Professor,Plant Pathology and Microbiology||Texas A&M AgriLife Research,https://scholars.library.tamu.edu/vivo/display/nb05fab89
Christopher,Bailey,Professor,"Research areas include actively seeking to reduce the environmental impact of poultry production primarily by seeking improvements in nutrient utilization. Strategies include seeking improvements in ingredient processing and feed manufacture, evaluation of alternate rearing/feeding strategies such a continuous multiphase feeding, dietary incorporation of exogenous enzymes, use of prebiotic materials such as mannan oligosaccharides (MOS), and use of antibiotic like growth promoters.",Professor,Poultry Science,https://scholars.library.tamu.edu/vivo/display/nb0813ee5
Stephen,Safe,Distinguished Professor,The aryl hydrocarbon receptor (AhR) is a nuclear helix-loop-helix transcription factor which forms a ligand-induced nuclear heterodimer with the AhR nuclear translocator (Arnt) protein. Research in this laboratory is focused on the molecular mechanism of crosstalk between the AhR and estrogen receptor (ER) signaling pathways in which the AhR inhibits estrogen-induced gene expression. The antiestrogenic activities of some AhR agonists are also being developed as drugs for clinical treatment of breast and endometrial cancers in women. Research on estrogen-dependent gene expression in various cancer cell lines is focused on analysis of several gene promoters to determine the mechanisms of ERa and ERb action. This includes several genes that are activated through interactions of the ER with Sp1 protein and other DNA-bound transcription factors.,Distinguished Professor||Distinguished Professor||Syd Kyle Chair,School of Veterinary Medicine and Biomedical Sciences||Biochemistry and Biophysics||Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/nb20fdbd9
Ivan,Rusyn,Professor,"My laboratory has an active research portfolio funded by the National Institutes of Health and the US EPA with a focus on the mechanisms of action of environmental toxicants and the genetic determinants of the susceptibility to toxicant-induced injury. Through a combination of in vivo animal studies and experiments that utilize cellular and molecular models, we aim to better understand why certain chemicals cause cancer or organ damage in rodents and whether humans in general, or any susceptible sub-population in particular, are at risk from similar exposures.
The main focus of our inter-disciplinary research is on improving the linkages between exposures and adverse health effects Specifically, we develop innovative experimental methods and computational tools which enable analysis of data across multiple dimensions including SNPs, -omic endpoints, multiple chemicals and traditional toxicity phenotypes.","Professor, Veterinary Physiology and Pharmacology",School of Veterinary Medicine and Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/nb3daa5ce
Warren,Zimmer,Scott Exter Professor,"Our research interests are directed towards understanding the complex mechanisms which regulate the expression of specific gene sequences in development. We have focused our studies upon the factors that influence the smooth muscle component of the developing gastrointestinal (G.I.) tract. It has been shown that smooth muscle cells are predominantly derived from mesodermal precursor cells, however the factors regulating the selection of the smooth muscle myogenic pathway is not well defined.",Scott Exter Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/nb6da0749
Ranjeet,Dongaonkar,Assistant Professor,,Assistant Professor,Veterinary Physiology and Pharmacology,https://scholars.library.tamu.edu/vivo/display/nb8d90977
Ashok,Shetty,Professor and Associate Director,"Dr. Ashok K. Shetty's laboratory is interested in developing clinically applicable strategies efficacious for enhancing brain function after injury, disease, or aging. The central areas of investigation are focused on:
o Mechanisms by which intranasally administered stem cell-derived extracellular vesicles (EVs) promote neuroprotection, neuroregeneration, neural plasticity, and alleviate neuroinflammation. The sources of EVs include human bone marrow mesenchymal stem cells (hMSCs), and human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSCs), astrocytes, and microglia. The model systems include traumatic brain injury (TBI), closed head injury (CHI), Aging, Alzheimer's disease (AD) and temporal lobe epilepsy (TLE).
o Mechanisms by which transplanted human neural stem cells or human GABA-ergic precursor cells derived from hiPSCs promote brain repair, and alleviate spontaneous seizures, and cognitive and mood impairments in prototypes of SE, TLE, and TBI.
o Elucidating mechanisms of brain dysfunction and chronic neuroinflammation in prototypes of Gulf War Illness. Developing therapeutic strategies to alleviate neuroinflammation, systemic inflammation, and cognitive and mood impairments in models of GWI.
o Developing clinically feasible strategies for improving brain function in aging and AD models via stimulation of endogenous neural stem cells using drugs and biologics.
Dr. Shetty has received continuous extramural research funding as PI for >25 years from sources such as the NIH, DOD, Dept of Veterans Affairs (VA), and industry. These include seven R01 grant awards and an R21 grant award from the NIH; seven CDMRP grant awards from the DOD; five Merit Grant awards and two Research Career Scientist Awards from the VA; and two industry grants. He has also served as Co-I of 8 other DOD grants. Grants from the NIH, DOD, and industry fund Dr. Shetty's current research. Dr. Shetty has authored 181 peer-reviewed publications (147 as senior/first author) and edited a book on Neural Stem Cells in Health and Disease. His work has appeared in many prestigious and high-impact journals. Dr. Shetty has received >17,000 citations for his publications with an h-index of 64. Dr. Shetty has the distinction of serving on two NIH Study Sections and one VA study section as a Chartered Member. Besides, he has served as a member of many other study section panels of the NIH, DOD, VA, and Maryland State Stem Cell Research Fund. Dr. Shetty is Co-Editor-in-Chief of the journal, Aging & Disease and Associate Editor of 6 Neuroscience journals. He is also a Member of the Editorial Board of many prestigious journals, including The Journal of Extracellular Vesicles, Aging Cell, and Stem Cells. Dr. Shetty is a Fellow of the American Society for Neural Transplantation and Repair. Dr. Shetty received the Senior Research Excellence Award in 2021 from the TAMU College of Medicine and is among the ""World's Top 2% Scientists"" across all scientific fields.","Associate Director, Institute for Regenerative Medicine||Professor",Cell Biology and Genetics||Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/nba613a86
Roula,Mouneimne,Research Professor,"For the past 24 years my research focused on: 1- The development of methods in the fluorescence microscopy field that achieve data acquisition and analysis in real time, quantitative analysis, and mathematical modeling of cellular signaling. 2- The development of novel technological tools to decipher molecular and physiological events in cells and immunological tissues under normal toxin exposure and disease conditions.",Research Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/nbb6c8c2a
Lih,Kuo,Regents Professor,"My research focuses on the physiological and pathophysiological regulation of coronary and retinal microcirculation. In the circulatory system, the amount of blood delivered to each tissue can be regulated by the activity of arterial microvessels (<100 m in diameter). Changes in vascular tone, i.e., constriction or dilation of these microvessels, will decrease or increase blood supply to the tissue, respectively. However, the mechanisms involved in the regulation of vascular tone are not completely understood. Our current research focuses on the regulation of microvascular tone by hemodynamic (e.g., pressure and shear stress), metabolic (e.g., adenosine, osmolarity, K+, pH, pO2) and neural (adrenergic receptors) factors. To have an integrative view on the flow regulation, this basic information are reconstructed using mathematical model and computer simulation technology. This research provides a basic foundation critical to our understanding of blood flow regulation in the microvascular network under normal and disease states.",Regents Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/nbc742025
Richard,Kreider,Professor,"Director of the Exercise and Sport Nutrition Lab.
We study the role of exercise and nutrition on health, performance, disease and rehabilitation.","Faculty Fellow||Professor and Head||Director||DIrector, Human Clinical Core||Professor",Center for Health Systems and Design||Kinesiology and Sport Management||School of Education and Human Development||The Exercise and Sport Nutrition Laboratory||Nutrition,https://scholars.library.tamu.edu/vivo/display/nbc81b4e0
Amanda,Macfarlane,Director Food and Nutrition Evidence Center,,Director Food and Nutrition Evidence Center||Professor,Texas A&M AgriLife Research||Nutrition,https://scholars.library.tamu.edu/vivo/display/nbd1502ad
Nicolaas,Deutz,Professor,"My research background and expertise focus on nutrition, metabolism, and physiology studies involving the use of stable isotope methodologies, both in humans and animals. I also have extensive experience with isotopic calculations, validation and data interpretation.",Professor,Primary Care and Rural Medicine,https://scholars.library.tamu.edu/vivo/display/nbd596655
David,Huston,Professor,The overall goal of my laboratory is to understand mechanisms regulating inflammation and thereby develop strategies for modulating immune responses. One project focuses on the role of the cytokine thymic stromal lymphopoietin (TSLP) as the master switch in the pathobiology of allergic inflammation and asthma. The role of allergens and respiratory viruses on the induction of TSLP transcription by mast cells and epithelial cells is being studied in vitro and in human subjects.,Professor,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/nbd68089f
Pamela,Ferro,"Section Head, Molecular Diagnostics",,"Section Head, Molecular Diagnostics||Adjunct Faculty",Texas A&M Veterinary Medical Diagnostic Laboratory||Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/nc1e62471
James,Fluckey,Professor,"My research focuses on mechanisms associated with protein turnover and glucoregulatory function in muscle and how these mechanisms may be altered by exercise, aging, obesity, diabetes or periods of microgravity. More currently, we are interested in small molecules arising from contracting skeletal muscle that impact other cells/tissues in the body, including cancer.",Professor,Kinesiology and Sport Management,https://scholars.library.tamu.edu/vivo/display/nc58f05ea
Paul,Lindahl,Professor,"One of our two current research areas involves iron metabolism in mitochondria. The iron imported into these organelles is assembled into iron-sulfur clusters and heme prosthetic groups. Some of these centers are exported into the cytosol, while others are installed into mitochondrial apo-proteins. All of these processes are regulated in healthy cells, but various genetic mutations giving rise to diseases can cause iron to accumulate (e.g. Friedreich's ataxia) or become depleted (e.g. Sideroblastic anemia). We have developed a biophysical approach involving Mossbauer, electron paramagnetic resonance, and electronic absorption spectroscopy, to study the entire iron content of intact mitochondria in healthy and genetically altered cells. This Systems Biology approach allows us to characterize the ""iron-ome"" of mitochondria at an unprecedented level of detail. We are also using analytical tools (e.g. liquid chromatography) to identify complexes that are involved in ""trafficking"" iron into and out of the organelle.
Our other research area involves mathematical modeling of cellular self-replication on the mechanistic biochemical level. We collaborate on this multidisciplinary NSF-sponsored project with a mathematician at the University of Houston (Professor Jeffrey Morgan). We have developed a modeling framework that facilitates such modeling efforts, and have designed a number of very simple and symbolic in silico cells that exhibit self-replicative behavior. Our minimal in silico cell model includes just 5 components and 5 reactions. A second generation model includes a more realistic mechanism of mitotic regulation. One novel aspect of our approach is that cellular concentration dynamics impact (and are impacted by) cellular geometry. By minimizing membrane bending energies, we are now calculating cell geometry during growth and division. Our results suggest that the ""pinching"" observed in real cells is enforced by cytoskeletal structures.",Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/nc9ce621b
Giuliana,Noratto,Research Assistant Professor,"Research is focused on the role of bioactive compounds in dairy products/by-products and botanicals with effects for prevention of chronic/inflammatory diseases using in vitro and in vivo models. Emphasis is on molecular mechanisms modulated by non-digestible bioactive compounds, partially through changes in intestinal bacteria.
Research projects look to integrate microbiome, metabolomics, and proteomics analyses to investigate the biological mechanisms influenced by dietary interventions and their correlations with end point biomarkers of obesity-related diseases including diabetes, cancer, and cardiovascular diseases. Research is funded by the Western Dairy Center, National Raspberry Council, Northwest Cherry Growers/ Washington State Fruit Commission, and Washington State Department of Agriculture.",Associate Research Scientist,Texas A&M AgriLife Research,https://scholars.library.tamu.edu/vivo/display/nca14d7e6
Cristine,Heaps,Dr.,,Associate Professor and Associate Department Head,School of Veterinary Medicine and Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/ncbe2c8d8
Vytas,Bankaitis,Professor,"My laboratory is interested in the regulatory interfaces between novel lipid-mediated signal transduction pathways and important cellular functions. The focus of our work is the phosphatidylinositol/ phosphatidylcholine transfer proteins (PITPs), a ubiquitous but enigmatic class of proteins. Ongoing projects in the laboratory derive from a multidisciplinary approach that encompasses biochemical characterization of novel members of the metazoan PITP family, and the application of genetic, molecular and biophysical approaches to detailed structural and functional analyses of PITPs.",E.L. Wehner-Welch Foundation Chair||Professor||Professor,Cell Biology and Genetics||Biochemistry and Biophysics||Chemistry,https://scholars.library.tamu.edu/vivo/display/ncff8dc21
Paul,Brandt,Associate Professor,"Understanding how the target cells ""interpret"" hormonal signals is the primary focus of our laboratory.Most of our research centers on regulation of steroid hormone-transduced signals. One area of study is the calcium-dependent regulation of glucocorticoid and androgen receptor-mediated transcription. A second major area of interest concerns glucocorticoid and steroid sex hormone regulation of nitric oxide (NO) production. Other areas of interest in our laboratory are: development of androgen-independence in prostate cancer; stress responses in PMCA1(-) cell lines; and the involvement of NO in dry eye syndrome.",Associate Dean for Academic Technology and Curriculum Innovation||Associate Professor,Neuroscience and Experimental Therapeutics||School of Medicine,https://scholars.library.tamu.edu/vivo/display/nd24a6df6
Sarah,White-Springer,Dr,,Associate Professor||Associate Professor,Kinesiology and Sport Management||Animal Science,https://scholars.library.tamu.edu/vivo/display/nd387aff4
Fen,Wang,Professor,"The laboratory focuses on understanding the molecular basis of cell signaling, and how aberrant cell signaling leads to birth defects and causes cancers. Using in vitro cell culture systems and in vivo mouse models, we study how the fibroblast growth factor (FGF) activates its receptor (FF) tyrosine kinase, and how the activated FF transmits the signals to downstream targets and regulates proliferation, differentiation, homeostasis, and function of the cells, as well as in organogenesis and development, including prostate and cardiovascular system development. The laboratory also employs molecular biology, cell biology, and mouse genetic technologies to study how aberrant FGF signals promote tumor initiation, progression, and metastasis. In addition, how environmental factors contribute to tumorigenesis and congenital birth defects by modulating FGF signal intensity and specificity is also under the scope of our research interests.",Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/nd5ef47ba
Brett,Mitchell,Professor,Our research focuses on understanding the mechanisms by which immune system activation causes organ dysfunction and various forms of hypertension.,Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/ne0d93385
Susanne,Talcott,Professor,"Dr. Susanne Talcott's research revolves around botanical compounds (polyphenols, terpenoids and alkaloids) and the impact of their metabolites on inflammation, cognitive function, and intestinal health. She primarily focuses on conducting human clinical studies to understand the pharmacokinetics and pharmacodynamics of these compounds.
Recently, the impact of bioactive metabolites produced by the gut microbiota on intestinal and cognitive health through the gut-brain axis has been of great interest.
Dr. Susanne Talcott is working on federally funded projects (USDA, NIH) and collaborates with the dietary supplement and functional food industry on health-related product claims that are supported by unbiased scientific evidence and comply with FDA- and FTC-regulations.",Professor||Professor,Food Science and Technology||Nutrition,https://scholars.library.tamu.edu/vivo/display/ne4324c37
Robert,Taylor,Research Professor,,Research Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ne49b235c
Hays,Rye,Associate Professor,"A fundamental principle of biology is the use of chemical energy in the form of ATP to assemble, disassemble and alter macromolecular structure. Specialized control proteins known as molecular chaperones are often responsible for this activity and have been recognized in recent years to be essential for regulating many aspects of cellular biology. Using a variety of biophysical and biochemical techniques, the Rye lab focuses on three fundamental cellular processes that require molecular chaperones: (1) protein folding (2) protein disaggregation and (3) vesicle trafficking. In each of these cases, large quantities ATP are burned, resulting in molecular organization in the case of protein folding, and molecular disassembly and remodeling in the case of protein disaggregation and vesicle trafficking. We are interested in understanding the detailed biophysical mechanisms that underpin these events. Why are these processes so energetically expensive? Are there any similarities in how the energy is used between these very different molecular processes? Are there general principles of energy transduction in biology that can be gleaned by comparing these examples with other molecular machines, such as cytoskeletal motors? Understanding how molecular chaperones control protein and membrane organization will provide key insights into not only basic cell biology, but will also illuminate aspects of many diseases that spring from aberrant protein and membrane dynamics.",Associate Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/ne7fb85e1
Leif,Andersson,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ne8ae2a28
Thomas,Welsh,Professor,"Areas of research for Dr. Welsh include developing endocrine-based biotechnologies to selectively and precisely regulate growth and reproduction in livestock; in vitro and in vivo methodologies used to identify mechanisms whereby specific hormones regulate the biosynthesis of pituitary, adrenal, gonadal and hypothalamic hormones; and correlative in vivo and in vitro studies conducted using bovine, equine, porcine and ovine animal models.",Professor||Professor,Animal Science||Texas A&M AgriLife Research,https://scholars.library.tamu.edu/vivo/display/neae2cac6
James,Derr,Professor,"Dr. Derr has directed worldwide research projects in wildlife and livestock conservation genetics for over 25 years. This body of work has produced more than 75 scientific publications reporting original research on many different species. For example, Dr. Derr has authored articles on bison, dolphins, domestic and wild cats, elk, pronghorn antelope, sheep, quail, white-tailed and mule deer, whales, domestic livestock and multiple fish species. All of this conservation genetics research has been funded through international, federal, state, NGO and private funding sources including the DSC and DSC Foundation. In addition, Dr. Derr is an impactful educator through his teaching efforts in undergraduate genetic courses to students interested in medicine (human and veterinary) and he has mentored over 100 graduate students in the fields of conservation / population genetics and animal health. One of Dr. Derr's most popular courses is ""Wildlife Conservation Medicine"". This course is designed for first- and second-year veterinary students to travel to South Africa and Botswana to learn how to chemically immobilize, treat and transport everything from African plains game to dangerous game. His efforts with these young veterinarians ensure they graduate with specialized knowledge and skills to handle health care and conservation issues with the tremendous number of exotic wildlife species here in the State of Texas on private ranches and preserves.",Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/nebe46b3d
Charles,Shea,Senior Professor,,Senior Professor,Kinesiology and Sport Management,https://scholars.library.tamu.edu/vivo/display/ned525ce0
Stephen,Smith,Professor,"Dr. Smith teaches meat science, nutrition and physiological nutrition courses. He also conducts research on the growth and development of adipose tissue, particularly in the bovine species. He has investigated the limitation of cattle to marble and has used his background in molecular biology to investigate lipid metabolism in the bovine muscle.",Professor||Professor,Animal Science||Nutrition,https://scholars.library.tamu.edu/vivo/display/nee8e5966
Roger,Smith,Professor,Application of flow cytometry to study of animal disease and clinical veterinary medicine; core flow cytometry laboratory.,Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/nefd6ee54
Tapasree,Roy Sarkar,Assistant Professor,"The dynamic interaction of cancer cells with the tumor microenvironment (TME) is crucial to stimulate the heterogeneity of cancer cells, and to increase multidrug resistance ending in cancer cell progression and metastasis. Understanding the underlying molecular & cellular mechanisms governing these interactions can be used as a novel strategy to disrupt cancer cell-TME interaction and contribute to the development of efficient therapeutic strategies. By integrating cutting-edge cellular and molecular biology, bioinformatics, and bioengineering approaches, our lab is investigating the complexity of TME.",Assistant Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nf08a1119
Joseph,Rutkowski,Assistant Professor,"Current ongoing projects are mostly focused on the Lymphatic Physiology of Metabolic Systems. Herein, we are utilizing an extensive toolkit of genetic mouse models and physiologically-relevant in vitro systems to identify how changes in lymphatic biology impact metabolite transport and whole animal metabolism. Other projects use our toolkit in identifying factors driving the pathology of lymphatic diseases such as generalized lymphatic anomalies (GLA) and lymphedema. Additional collaborative efforts employ our models in renal and pulmonary health.",Assistant Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/nf1902e01
Jay,Maddock,Professor,My research focuses on social ecological approaches to increasing physical activity and the effect of spending time in nature on human health.,Professor||Faculty Fellow,Center for Health Systems and Design||Environmental and Occupational Health,https://scholars.library.tamu.edu/vivo/display/nf33a34f7
Randall,Davis,Regents Professor,"Randall William Davis is an educator and researcher who studies the physiology and behavioral ecology of marine mammals and other aquatic vertebrates. His physiological research focuses on adaptations of marine mammals for deep, prolonged diving. Davis has continually emphasized the importance of studying aquatic animals in their natural environment and has spent many years developing animal-borne instruments that record video and monitor three-dimensional movements, swimming performance and environmental variables to better understand their behavior and ecology. His academic endeavors and 100 research expeditions have taken him to 65 countries and territories on seven continents and all of the world's oceans.
https://en.wikipedia.org/wiki/Randall_William_Davis",Regents Professor||Regents Professor,"Rangeland, Wildlife and Fisheries Management||Wildlife and Fisheries Sciences||Marine Biology",https://scholars.library.tamu.edu/vivo/display/nf5158696
Kathy,Svoboda,Regents Professor,"Dr Svoboda is a well-established senior principal investigator with a broad background in developmental biology and cellular biology. Her research focus is on the cell biology of whole embryonic tissues, including cornea, cartilage, palate. Her lab has been funded from NIH, March of Dimes, Foundations and Private Companies for 3 decades. As a postdoctoral fellow at Harvard Medical School, she carried out cell and molecular biology experiments on developing systems and worked with Dr. Elizabeth Hay when she developed her theories on cell-matrix interactions. As PI or co-Investigator on many previous university- and March of Dimes funded grants (over 30 years of continuous funding), she worked on how cell-matrix interactions change during development. In addition, she was a mentor on two training grants (T32 and KL2) and has successfully administered other NIH supported developmental and cell biology projects (e.g. staffing, research protections, and budget), collaborated with other researchers, and produced peer-reviewed publications from each project.
She has a new project that contributes evidence to the theory that periocular mesenchyme (POM) cells contribute to the development of the ciliary body, trabecular meshwork and the iridocorneal angle. The objective of this project is to determine if Gli1 positive cells contribute to the POM and anterior eye structures by using inducible Gli1-CreERT2; tdTomatoflox (Gli1-tdTomato) mouse model. Experiments were recently completed that demonstrated the Gli1 + cells were also positive for Pitx2, FOXC1, and FOXC2, known markers for periocular mesenchyme during anterior eye development.
She has successfully trained 40 Postdoctoral, Ph.D., M.S. graduate students, undergraduate, medical and dental predoctoral students, and college/high school summer research trainees.",Regents Professor,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/nf7d937ba
Darwin,Prockop,Professor,,Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/nfcfd0990
Phillip,Kramer,Professor and Director,,Professor and Director,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/nffafc708