First name,Last name,Preferred title,Overview,Position,Department,Individual
Yuxiang,Sun,Professor,"Dr. Sun is an expert on ""hunger hormone"" ghrelin. She generated the first set of ghrelin and ghrelin receptor knockout mice, and discovered novel roles of ghrelin signaling in diabetes, thermogenesis, and inflammation. Her laboratory uses state-of-the-art tools to study ghrelin system in energy sensing, metabolism and immunity, and aging. Her work suggests that ghrelin signal might be a promising drug target for obesity, diabetes, inflammation, and Alzheimer's disease.",Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n0228c22e
David,Russell,Professor,"My research focuses on proteomics, lipidomics, biophysical chemistry and application and development of mass spectrometry, such as ""label-free"" nano-particle based biosensors and novel peptide/protein isolation and purification strategies. We are also investigating the structure(s) of model peptides in an effort to better describe folding/unfolding and structure of membrane and intrinsically disordered (IDP) proteins. Peptides take on very different 2?, 3? and 4? structure, which determine or influence bio-activity. In the presence of lipid vesicles peptides can exist as solution-phase species, ""absorbed"" on lipid bilayers or ""inserted"" (as a monomer or multimer) in lipid bilayers. By what mechanism do peptides interact with lipid membranes to affect these structural changes, how do peptide-lipid interactions promote self-assembly to form intermediates that eventually yield aggregates, i.e., amyloid fibrils, or how does metal ion coordination affect the structure of metalloproteins? Mass spectrometry-based experiments, hydrogen/deuterium (H/D) exchange, chemical 'foot-printing' and gas-phase (ion-molecule and ion-ion reaction chemistry) and solution-phase chemical modifications, have expanded our abilities to address such questions, and new instrumental approaches, esp. ion mobility spectrometry (IMS) combined with enhanced molecular dynamics simulations (MDS), have become standard tools for structural-mass spectrometry studies. Over the past several years we have either acquired or developed novel, next-generation IM-MS instruments that are redefining cutting-edge structural-mass spectrometry research as well as cutting-edge computational tools essential to carry out these studies. Our new laboratories in the Interdisciplinary Life Sciences Building (ILSB) provides exciting opportunities for collaborative, interdisciplinary research with chemical-biologists, biochemists and other chemists.",Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/n280e03e6
Shaodong,Guo,Professor and Presidential Impact Fellow,"The long-term goal of our research is to study the molecular mechanisms of insulin signal transduction, insulin resistance and associated cardiovascular dysfunction, aiming at nutritional and therapeutic intervention for control of metabolic and cardiovascular disorders. My laboratory is focused on the study of cellular signaling and gene transcriptional regulation of metabolic homeostasis that are governed by the PI3K->Akt->FoxO pathway, with the hope of understanding how dysregulation of this pathway in insulin/IGF-1 action causes liver damage, cardiovascular dysfunction, and pancreatic beta cell failure, resulting in diabetes, obesity, and organ failure.",Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n2ef8f395
Vladislav,Panin,Professor,"It has been long recognized that glycans play a wide spectrum of essential roles in metazoan organisms, while defects in glycosylation are involved in numerous human diseases and abnormalities, from cancer to brain malformation and defects of immune system. However, the complexity of glycosylation pathways and limitations of genetic and in vivo approaches available for studying glycosylation in higher animals significantly impede the research in mammals. We are using the advantages of Drosophila model system, including its decreased genetic redundancy, powerful arsenal of molecular genetic approaches, and comprehensively characterized development, to elucidate mechanisms underlying the function of glycosylation in development and physiology. We employ a multidisciplinary approach to study the roles of several novel glycosyltransferase genes at molecular, cellular, and organismal levels. Currently, our laboratory is involved in two main projects: one project focuses on studying the function of sialylation in the central nervous system, while another project is aimed at elucidation of molecular mechanisms of protein O-mannosylation.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n337aaa32
Robert,Chapkin,Distinguished Professor,"Research in the Chapkin lab focuses on dietary/microbial modulators related to the prevention of cancer and chronic inflammatory diseases.
Our central goal is to (1) understand cancer chemoprevention at a fundamental level, and (2) to test pharmaceutical agents in combination with dietary/microbial (countermeasures to the Western diet) to more effectively improve gut health and reduce systemic chronic inflammation. Since diet influences gut microbiota composition and metabolite production, to unravel the interrelationships among gut health and the structure of the gut microbial ecosystem, we are in the process of evaluating (using transgenic mouse, Drosophila models and humans) how the gut microbiome modulates intestinal cells, innate immune cells and tumors. As part of this endeavor, we are modeling at the molecular level the dynamic relationship between diet and gut microbe-derived metabolites which modulate chronic inflammation and the hierarchical cellular organization of the intestine, e.g., stem cell niche.",Distinguished Professor||Professor,Biochemistry and Biophysics||Nutrition,https://scholars.library.tamu.edu/vivo/display/n3fbb59f8
Geoffrey,Kapler,Professor and Chair,"Dr. Kapler's broad research interests are concerned with the replication and transmission of eukaryotic chromosomes. The failure to completely replicate the genome during S phase or partially re-replicate chromosomes leads to genome instability- a hallmark of cancer cells. The central questions investigated in the laboratory are concerned with how replication initiation sites are established in chromosomes and how they are regulated during conventional (G1/S/G2/M) and alternative cell cycles, including endoreplication (gap-S-gap-S...) and locus-specific gene amplification. The current focus of the lab is to use high throughput (nascent strand) DNA sequencing to generate a comprehensive map of replication initiation sites under different physiological conditions.",Professor and Chair||Professor,Cell Biology and Genetics||Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n4128afa1
Shannon,Glaser,Professor,"The long-term goal of my research program is to understand how activated (proliferating) cholangiocytes participate in the progression of cholestatic liver diseases and eventual development of cholangiocarcinoma. My research is focused on elucidating the factors (such as, mechanical stress) and intracellular signaling mechanisms that regulate cholangiocyte proliferation and biliary fibrosis during extrahepatic cholestasis.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n424a02f1
Loren,Skow,Professor,Comparative genomics of mammals with emphasis on organization and evolution of the mammalian genome; molecular analysis of the major histocompatibility complex of hoofed animals; genetic mechanisms of inherent resistance to infectious diseases.,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n4326eaa3
Zhenyu,Li,Professor,My research focuses on the mechanism of platelet activation and arterial thrombotic diseases such as heart attack and stroke. We are also interested in the crosstalk between thrombosis and inflammation in sepsis.,Professor,Pharmaceutical Sciences,https://scholars.library.tamu.edu/vivo/display/n4e244e5e
Cynthia,Meininger,Professor,"My research focuses primarily on the vascular complications of diabetes. Using animal models of human diabetes, we have demonstrated that an inability of endothelial cells to produce nitric oxide may be partly responsible for these vascular complications. We are developing a gene/drug therapy approach for treating cardiovascular disease associated with diabetes. Targeted nanoparticles will deliver either the gene for GTPCH or BH4 itself into endothelial cells oxidatively damaged by diabetes to correct endothelial GTPCH deficiency, increase tetrahydrobiopterin levels, restore nitric oxide production and reverse the vascular dysfunction seen in diabetes. Our endothelium-targeting nanoparticle approach will not only reverse the damage caused by disease but will increase antioxidant levels to protect the endothelial cells from future damage and/or dysfunction.",Professor,Medical Physiology,https://scholars.library.tamu.edu/vivo/display/n531a623d
David,Earnest,Professor,"Research in my laboratory employs multidisciplinary approaches to study the cellular and molecular neurobiology of cell-autonomous circadian clocks and the signal transduction pathway responsible for circadian photoentrainment. The aims of current projects are to study: 1) the role of microRNAs (miRNAs) and other signaling molecules in the local temporal coordination of cell- and tissue-specific circadian clocks; 2) mutual interactions between the circadian clock mechanism, inflammatory signaling and metabolism; and 3) the mechanisms linking circadian rhythm disruption with metabolic disorders such as obesity and diabetes, and with pathological changes in neuroprotective responses to stroke.",Professor,Neuroscience and Experimental Therapeutics,https://scholars.library.tamu.edu/vivo/display/n640c528f
Guan,Zhu,Professor,"Our laboratory conducts translational research with an ultimate goal to discover new anti-parasitic therapeutics by targeting metabolic enzymes and other molecules critical or essential to the parasite infection, survival and development, such as those involved in the lipid and energy metabolisms and interacting with host cells in Cryptosporidium and other protozoan parasites. Other research areas include functional genomics and molecular evolution of apicomplexan parasites, and parasitic diseases important to the conservation of wild animals.",Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n6d62f33b
Robert,Burghardt,Professor,"Research in the laboratory is focused on investigating mechanisms by which a variety of biological response modifiers ranging from mechanical signals, hormones and growth factors to environmental chemicals alter cellular signaling pathways and cellular homeostasis.","Professor||Director, Image Analysis Laboratory",School of Veterinary Medicine and Biomedical Sciences||Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n70a3d026
Rosemary,Walzem,Professor,"Dr. Walzem's core research focus within the laboratory is directed towards understanding how the structure of triglyceride-rich lipoproteins influences their ability to carry out specific nutrient delivery tasks. Her studies include identification of mechanisms and regulatory processes that control the assembly of trigylceride-rich lipoproteins in issues, structural studies of lipoproteins themselves and physiological studies to determine substrate properties and metabolic fates of different types of lipoproteins. Diet can significantly alter lipoprotein physiology through multiple mechanisms, and studies of diet effects provides a significant sub-theme to the research program. A variety of species are used to address specific questions, however, avian and human lipoprotein metabolism as it relates to egg production and atherogenesis, respectively, are emphasized.",Professor,Poultry Science,https://scholars.library.tamu.edu/vivo/display/n85cd191f
Daniel,Ebbole,Professor,"Development and pathogenesis share the common features of responding to environmental conditions to execute a program of gene expression resulting in new cell types.
An important question in plant pathogenesis is to understanding the functions of pathogen effectors and their host target(s). Fungal effectors play roles in suppressing host defense mechanisms, however, other biotrophic functions, such as manipulating host physiology to promote nutrient acquisition and cell-to-cell movement are possible. Therefore, identification of the full set of fungal proteins secreted during host invasion is a major effort in plant pathology research. Candidate effectors are generally identified by virtue of i) their expression in planta ii) assessing their activity on the host using purified proteins or by manipulating expression iii) detecting the rapid evolution of effector genes due to selective pressure from the host. My lab is using a combination of these approaches to identify and characterize a gene family of putative effectors from Magnaporthe oryzae, the rice blast fungus and define interactions with monocot hosts.",Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/n86da3f1b
David,Threadgill,Professor,"Our laboratory uses the mouse as an experimental genetic model to investigate factors that contribute to inter-individual differences in health and disease. Ourcurrent research activities include the identification and functional characterization of alleles contributing to cancer susceptibility, the function of theErbbgenefamily in development and disease, and the role of genetic variation in response to environmental stimuli. To support these investigations, we also aredeveloping new genetic tools to support mammalian systems genetic approaches to phenotypes with complex genetic and environmental etiologies.",Director||Professor||Professor||Professor,Cell Biology and Genetics||Institute of Genome Sciences and Society||Biochemistry and Biophysics||Nutrition,https://scholars.library.tamu.edu/vivo/display/n8ee0b54f
Charles,Kenerley,Professor,The long-term goal of my research program is to understand the interactions of Trichoderma species with pathogenic fungi as well as plant hosts to promote crop protection.,Professor,Plant Pathology and Microbiology,https://scholars.library.tamu.edu/vivo/display/n8f925111
James,Sacchettini,Professor,"My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/n90385563
Weston,Porter,Professor,y laboratory is interested in determining the role of factors in normal development and how disruption of these pathways results in associated pathologies.,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n90e6f6c0
Timothy,Phillips,Professor,food safety; molecular toxicology; elucidation of fundamental chemical mechanisms of toxic action/interaction of food-borne carcinogens; mutagens; and developmental toxicants; and development of methods to detect and detoxify foodborne and environmental toxins.,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/n94eef946
Nancy,Ing,Professor,"Dr. Ing's research interests focus on understanding how hormones regulate gene expression in animal tissues. Current research projects investigate the earliest days of pregnancy in the sheep uterus and the regulation of estrogen receptor gene expression, as well as stress hormone effects on gene expression in the stallion testes. Most recently, we have been studying the RNAs in sperm from stallions and honey bees in order to find a pattern consistent with high fertility.",Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/n98a4a111
Jeetain,Mittal,Professor,Dr. Mittal's research focuses on biomolecular self-assembly processes with a specialization in protein phase separation and nanoparticle superlattice design.,Professor,Artie Mcferrin Department of Chemical En,https://scholars.library.tamu.edu/vivo/display/n9c511486
Patrick,Stover,Vice Chancellor and Dean,,Professor||Vice Chancellor and Dean,College of Agriculture and Life Sciences||Nutrition,https://scholars.library.tamu.edu/vivo/display/na2e4838e
Siegfried,Musser,Professor,"The primary focus of my laboratory is to decipher how proteins partition into different sub-compartments of the cell. Cellular membranes serve to compartmentalize biochemical reactions to specific microenvironments. Proteins cross these membranes via a diverse array of protein translocation systems, or translocons. My laboratory has investigated the detailed molecular function of three different protein transport machineries, the human nuclear pore complex (NPC) and the bacterial Sec and Tat general secretion machineries. We are a biophysics lab and our primary tools for deciphering molecular mechanisms and dynamics are super-resolution imaging and single molecule particle tracking approaches. Our aim is to develop detailed, molecular-scale, mechanistic models of protein transport processes. We recently demonstrated 3D imaging of cargo transport through nuclear pores on the millisecond timescale with 5-15 nm precision in all three dimensions. This will be a major tool going forward for multiple projects.
In 2018, we began a new project on membrane-less organelles, which are micrometer-scale cellular structures known as biomolecular condensates (BMCs) that contain high concentrations of intrinsically disordered proteins and RNA. These BMCs are generally agreed to arise from liquid-liquid phase separation (LLPS), which is the spontaneous partitioning into dense and dilute phases due to favorable interactions between the separating molecules. The high density of aggregation prone proteins in BMCs is thought to lead to the cellular inclusions found in patients with multiple neurological diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Parkinson's and Alzheimer's diseases. We are using super-resolution and single molecule methods to probe the structural and dynamic heterogeneity of condensates formed from the fused in sarcoma (FUS) protein to identify the conditions that lead to solidification of liquid condensates (phase maturation).",Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/nb824aefa
Amanda,Macfarlane,Director Food and Nutrition Evidence Center,,Director Food and Nutrition Evidence Center||Professor,Texas A&M AgriLife Research||Nutrition,https://scholars.library.tamu.edu/vivo/display/nbd1502ad
Nicolaas,Deutz,Professor,"My research background and expertise focus on nutrition, metabolism, and physiology studies involving the use of stable isotope methodologies, both in humans and animals. I also have extensive experience with isotopic calculations, validation and data interpretation.",Professor,Primary Care and Rural Medicine,https://scholars.library.tamu.edu/vivo/display/nbd596655
Paul,Lindahl,Professor,"One of our two current research areas involves iron metabolism in mitochondria. The iron imported into these organelles is assembled into iron-sulfur clusters and heme prosthetic groups. Some of these centers are exported into the cytosol, while others are installed into mitochondrial apo-proteins. All of these processes are regulated in healthy cells, but various genetic mutations giving rise to diseases can cause iron to accumulate (e.g. Friedreich's ataxia) or become depleted (e.g. Sideroblastic anemia). We have developed a biophysical approach involving Mossbauer, electron paramagnetic resonance, and electronic absorption spectroscopy, to study the entire iron content of intact mitochondria in healthy and genetically altered cells. This Systems Biology approach allows us to characterize the ""iron-ome"" of mitochondria at an unprecedented level of detail. We are also using analytical tools (e.g. liquid chromatography) to identify complexes that are involved in ""trafficking"" iron into and out of the organelle.
Our other research area involves mathematical modeling of cellular self-replication on the mechanistic biochemical level. We collaborate on this multidisciplinary NSF-sponsored project with a mathematician at the University of Houston (Professor Jeffrey Morgan). We have developed a modeling framework that facilitates such modeling efforts, and have designed a number of very simple and symbolic in silico cells that exhibit self-replicative behavior. Our minimal in silico cell model includes just 5 components and 5 reactions. A second generation model includes a more realistic mechanism of mitotic regulation. One novel aspect of our approach is that cellular concentration dynamics impact (and are impacted by) cellular geometry. By minimizing membrane bending energies, we are now calculating cell geometry during growth and division. Our results suggest that the ""pinching"" observed in real cells is enforced by cytoskeletal structures.",Professor,Chemistry,https://scholars.library.tamu.edu/vivo/display/nc9ce621b
Vytas,Bankaitis,Professor,"My laboratory is interested in the regulatory interfaces between novel lipid-mediated signal transduction pathways and important cellular functions. The focus of our work is the phosphatidylinositol/ phosphatidylcholine transfer proteins (PITPs), a ubiquitous but enigmatic class of proteins. Ongoing projects in the laboratory derive from a multidisciplinary approach that encompasses biochemical characterization of novel members of the metazoan PITP family, and the application of genetic, molecular and biophysical approaches to detailed structural and functional analyses of PITPs.",E.L. Wehner-Welch Foundation Chair||Professor||Professor,Cell Biology and Genetics||Biochemistry and Biophysics||Chemistry,https://scholars.library.tamu.edu/vivo/display/ncff8dc21
Fen,Wang,Professor,"The laboratory focuses on understanding the molecular basis of cell signaling, and how aberrant cell signaling leads to birth defects and causes cancers. Using in vitro cell culture systems and in vivo mouse models, we study how the fibroblast growth factor (FGF) activates its receptor (FF) tyrosine kinase, and how the activated FF transmits the signals to downstream targets and regulates proliferation, differentiation, homeostasis, and function of the cells, as well as in organogenesis and development, including prostate and cardiovascular system development. The laboratory also employs molecular biology, cell biology, and mouse genetic technologies to study how aberrant FGF signals promote tumor initiation, progression, and metastasis. In addition, how environmental factors contribute to tumorigenesis and congenital birth defects by modulating FGF signal intensity and specificity is also under the scope of our research interests.",Professor,Institute of Biosciences and Technology,https://scholars.library.tamu.edu/vivo/display/nd5ef47ba
Michael,Manson,Professor,"Bacteria have a limited behavioral repertoire. Their most conspicuous behavior is chemotaxis - the pursuit of molecules that are favorable to acquire and the avoidance of chemicals that are best to avoid. The simplicity of bacterial motility and chemotaxis and the amenability of the model species Escherichia coli to genetic, biochemical and physiological manipulation have facilitated rapid advances in understanding the molecular mechanisms of biological energy conversion and signal transduction.
Our laboratory studies the inputs and outputs of chemotaxis. Ligands interact with the periplasmic receptor domain of a chemotactic signal transducer that spans the cell membrane. This interaction is converted into an intracellular signal that is communicated to the flagella. Molecules can be sensed either by binding directly to a receptor or by first interacting with a periplasmic binding protein, which then interacts with a receptor.",Professor||Professor,Biology||Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/ne190242a
Julian,Leibowitz,Professor,We have two projects in my lab. The first project is focused on identifying evolutionarily conserved RNA secondary structures in the coronavirus RNA genome and functionally examining their role in viral replication through reverse genetic and biochemical approaches. We have previously done this for a number of RNA secondary structures contained within the 5? and 3? regions of the genome and shown that they function as cis-acting elements in replication. Studies in my laboratory have identified a structurally dynamic region of the 5'UTR that interacts with the 3'UTR to facilitate transcription.
A second project in my laboratory has been to develop a reverse genetic system for MHV-1. In collaboration with investigators in Toronto and Pennsylvania my laboratory has demonstrated that MHV-1 infection of susceptible mice provides a safe and convenient rodent model for severe coronavirus infections such as SARS and MERS. The development of a reverse genetic system will allow us to investigate the contributions of individual viral genes to the pathogenesis of the severe pulmonary disease caused by this virus.,Professor||Professor,Microbial Pathogenesis and Immunology||Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/ne2185aa0
Feng,Tao,Professor,,Professor,Biomedical Sciences,https://scholars.library.tamu.edu/vivo/display/ne510bbd3
Joe,Arosh,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ne8898820
Leif,Andersson,Professor,,Professor,Veterinary Integrative Biosciences,https://scholars.library.tamu.edu/vivo/display/ne8ae2a28
Wayne,Versaw,Professor,"Compartmentalization of metabolic pathways and other cellular functions is a hallmark of eukaryotic cells. This feature is extreme in plants due to the presence of organelles not found in most other eukaryotes - plastids. Plastids are a diverse group of interrelated organelles that perform a wide range of metabolic functions including photosynthesis, nitrogen and sulfur assimilation and the synthesis of amino acids, starch and fatty acids. These functions are coordinated with metabolic processes in the cytosol through dynamic exchange of metabolites and ions across the plastid inner envelope membrane.
My lab is studying phosphate (Pi) transport processes that link the metabolic pathways in the plastid and cytosol. The concentrations of Pi in the cytosol and plastid stroma influence photosynthesis and the partitioning and storage of fixed carbon. Transporters involved in the movement of Pi across the plastid inner membrane include members of the pPT, PHT2 and PHT4 families. We are using genetics, cell biology, biochemistry and molecular physiology to investigate the function and physiological roles of these transporters. Recent findings suggest that some members of the PHT4 family are targeted to chloroplasts, whereas others function in heterotrophic plastids and one resides in the Golgi apparatus.
Other projects in the lab include the genetic and biochemical characterization of Pi transport processes in the filamentous fungus Neurospora crassa. Mutants with altered phosphate uptake properties have been isolated, and these have led to the identification of Pi transporter genes, as well as genes with putative regulatory functions.",Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nea6b0d01
Ryland,Young,Professor,"Most bacterial viruses (phages) cause lysis of their host cell to release the progeny virions. Large phages elaborate an enzyme (""endolysin"") to degrade the cell wall and also a small membrane protein (""holin""). The holin accumulates in the membrane and then, at a precisely scheduled time, suddenly forms a hole to allow release of endolysin through the cytoplasmic membrane to gain access to the wall. We use molecular genetics and biochemistry to study how this small protein is able to act as a molecular ""clock"" and punch holes in membranes. Small phages make single proteins which cause host lysis in a different way. This strategy is to target the host cell wall synthesis machinery; that is, the virus makes a ""protein antibiotic"" that causes lysis in the same way as antibiotics like penicillin by inhibiting an enzyme in the multi-step pathway of murein biosynthesis. Thus, when the infected cell tries to divide, it blows up, or lyses, because it can't make the new cell wall between the daughter cells. Remarkably, each of three different, small phages blocks a different step in the pathway. These small lysis proteins are models for a completely new class of antibacterial antibiotics. Also, the E. coli SlyD protein is required for this mode of lysis in one case. SlyD is a member of an ubiquitous family of proteins related to human ""immunophilins,"" the targets of immune-suppression drugs. We study SlyD to learn about the role of this class of proteins in biology.",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/nea775348
Stephen,Smith,Professor,"Dr. Smith teaches meat science, nutrition and physiological nutrition courses. He also conducts research on the growth and development of adipose tissue, particularly in the bovine species. He has investigated the limitation of cattle to marble and has used his background in molecular biology to investigate lipid metabolism in the bovine muscle.",Professor||Professor,Animal Science||Nutrition,https://scholars.library.tamu.edu/vivo/display/nee8e5966
Roger,Smith,Professor,Application of flow cytometry to study of animal disease and clinical veterinary medicine; core flow cytometry laboratory.,Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/nefd6ee54
John,Mullet,Professor,"Functional genomics, bioinformatics, and DNA chip technology are fundamentally changing research on biological systems. Knowledge of complete genome sequences and high resolution genome technology provide an extraordinary opportunity to understand complex biological processes and to relate detailed understanding of protein structure and biochemical mechanism to the function of whole organisms and biological systems in nature.
Our research team is helping to build genome maps and DNA diagnostic microarrays/chips for analysis of global gene expression and biodiversity. This new technology is being used to explore the molecular basis of several fundamental plant responses: (1) light responsive genetic systems that help protect plants from damage by high intensity UV/blue light; (2) genetic systems that allow plants to adapt to the environment; (3) genes and signal transduction pathways that help protect plants from insects and disease; and (4) genes that regulate plant development (flowering time, fertility restoration, chloroplast development/number).",Professor,Biochemistry and Biophysics,https://scholars.library.tamu.edu/vivo/display/nf1c81fcb
Darwin,Prockop,Professor,,Professor,Cell Biology and Genetics,https://scholars.library.tamu.edu/vivo/display/nfcfd0990
Matthew,Sachs,Professor,"Understanding the mechanisms by which upstream open reading frames (uORFs) in mRNA transcripts control gene expression is currently the major focus of my laboratory. A substantial component of this work is focused on the uORF-encoded fungal arginine attenuator peptide (AAP). The major goal of this work is to understand the mechanism by which a nascent peptide encoded by this uORF controls the movement of ribosomes on mRNA and regulates gene expression. Control mechanisms mediated by uORFs and nascent peptides exist in mammals, fungi, plants, viruses, and bacteria, but relatively little is known of the molecular details of such control. The AAP is encoded by a uORF in the 5?-leader regions of mRNAs specifying the first enzyme in fungal arginine (Arg) biosynthesis. Synthesis of the AAP rapidly reduces gene expression in response to Arg. AAP-mediated regulation is observed in vivo in both Neurospora crassa and Saccharomyces cerevisiae and in vitro, using fungal, plant and animal extracts. The nascent AAP causes the ribosome to stall when the concentration of Arg is high.",Professor,Biology,https://scholars.library.tamu.edu/vivo/display/nfe74574c