First name,Last name,Preferred title,Overview,Position,Department,Individual
James,Samuel,Regents Professor and Head,"Our laboratory works with the obligate intracellular bacterial pathogen, Coxiella burnetii, the etiologic agent of Q fever and a category B biothreat agent. The long-term goal of this research is to understand the molecular pathogenic mechanisms involved in the host-pathogen interaction. To accomplish this broad goal, project in the lab are designed to test the molecular mechanisms employed by both the host and pathogen. Current pathogen studies include 1) broad survey of proteins secreted via a type 4 secretion system (T4SS) followed by determination of essentiality of each substrate for virulence and detailed analysis of mechanism of host modulation 2) survey of essential virulence loci identified by specific mutant screens, and 3) definition of the relative virulence of phylogenetically distinct isolate groups.",Regents Professor and Head,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n01c3216f
James,Womack,Distinguished Professor,"Comparative mammalian genomics with emphasis on bovids and laboratory animals. Study of evolution of gene families and genomic variation underlying disease resistance. Investigation of genetic mechanisms in innate immunity with focus on livestock, select agents, and agricultural biosecurity.",Distinguished Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n0e1a49e2
Jon,Skare,Regents Professor and Associate Head,"Jon Skare is Regents Professor and Associate Head of the Department of Microbial Pathogenesis and Immunology in the College of Medicine at Texas A&M University. He has been a faculty member at Texas A&M since 1996 and has led a research laboratory centered around the pathogenic mechanisms operative in Borrelia burgdorferi, the spirochetal bacterium that causes Lyme disease. He has published over 50 peer reviewed manuscript, reviews, and book chapters and been funded continuously by the NIH since 1999 with over $20 million dollars in total costs. Dr. Skare has trained ten graduate students, sixteen postdoctoral fellows, and numerous undergraduate students in his research group during his time at Texas A&M. The majority of his postdoctoral trainees and students have gone on to hold academic or industry positions in the medical sciences.
Research interests are focused on microbial pathogenesis with an emphasis in spirochetal infections, particularly Borrelia burgdorferi, the etiologic agent of Lyme disease. Broad training in the molecular biology, genetics, and biochemistry of prokaryotic systems is employed to answer research-related questions. Long-term interests in the lab are centered on understanding how B. burgdorferi promotes its pathogenic potential and persists in the disparate hosts it occupies in nature (e.g., both ticks and mammals). In this regard, the research program is aligned with: (i) regulatory pathways that contribute to the establishment of infection during the arthropod to mammalian transition; (ii) identifying and characterizing surface structures that contribute to the colonization and maintenance of infection via adherence mechanisms; and (iii) the ability of B. burgdorferi and relapsing fever Borrelia to persistently infect hosts in the face of a potent innate and adaptive immune response.",Professor and Associate Head,Microbial Pathogenesis and Immunology,https://scholars.library.tamu.edu/vivo/display/n638ae603
Leslie,Adams,Senior Professor,"My research is focused on the: 1) investigation of the comparative molecular pathogenesis of zoonotic intracellular bacterial pathogens in natural animal models, particularly brucellosis, salmonellosis, and mycobacterial diseases; 2) development of vaccines and host gene expression-based diagnostics for zoonotic and select agent caused diseases, and especially 3) development of in silico host:pathogen interactome predictive models based upon bi-directional in vivo host (bovine/murine) and Brucella spp., Mycobacterium spp.and Salmonella enterica Typhimurium interactions. We developed an in silico computational infection biology model based on actuall temporal in vivo bovine model microarray-based transcriptomic and proteomic profiling of the acute infectious process. We developed a systems biology analysis of both host and pathogen comprehensive transcriptomic and proteomic datasets derived from our in vivo biological model. We computationally fused the datasets based on actual Salmonella, Brucella and Mycobacterium data and computationally predicted bovine host structural proteins to identify maximum likelihoods of host and pathogen protein:protein interactions as the basis for our preliminary in silico interactome model to predict mechanistic genes and linked perturbed cellular pathways.",Senior Professor,Veterinary Pathobiology,https://scholars.library.tamu.edu/vivo/display/n75fee121
Fuller,Bazer,Distinguished Professor,"Dr. Bazer's research in reproductive biology focuses on uterine biology and pregnancy, particularly pregnancy recognition signaling from the conceptus to the maternal uterus by interferon tau and estrogen from ruminant and pig conceptuses, respectively. The roles of uterine secretions as transport proteins, regulatory molecules, growth factors and enzymes and endocrine regulation of their secretion is another major research interest. The endocrinology of pregnancy, especially the roles of lactogenic and growth hormones in fetal-placental development and uterine functions are being studied. The mechanism(s) of action and potential therapeutic value of conceptus interferons and uterine-derived hematopoietic growth factors are areas of research with both pigs and sheep as models for human disease.",Distinguished Professor,Animal Science,https://scholars.library.tamu.edu/vivo/display/n7ad91d50
Masako,Suzuki,Assistant Professor,,Assistant Professor,Nutrition,https://scholars.library.tamu.edu/vivo/display/n9fd0c6a8